• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Caj-1080
GLO1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Lactoylglutathione lyase; Glyoxalase I
Gene Name: GLO1
Ensembl Gene: ENSCJAG00000041239.1
Ensembl Protein: ENSCJAP00000060809.1
Organism: Callithrix jacchus
Taxa ID: 9483
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAEPQPASGG  LTDEAALSCC  SDADPSTKDF  LLQQTMLRVK  DPKKSLDFYT  RVLGMTLIQK  60
61    CDFPSMKFSL  YFLAYEDKND  IPKDKDEKIA  WALSRKATLE  LTHNWGTEDD  ETQSYHNGNS  120
121   DPRGFGHIGI  AVPDVHSACK  RFEELGVKFV  KKPDDGKMKG  LAFIQDPDGY  WIEILNPNKM  180
181   ATII  184
Nucleotide CDS Sequence (FASTA)
1     ATGGCAGAAC  CGCAGCCCGC  GTCCGGCGGC  CTCACCGACG  AGGCCGCTCT  CAGTTGCTGC  60
61    TCCGACGCGG  ACCCCAGTAC  CAAGGATTTC  CTATTGCAGC  AGACCATGCT  ACGAGTCAAG  120
121   GATCCTAAGA  AGTCGCTGGA  TTTTTATACT  AGAGTTCTTG  GAATGACGCT  AATCCAAAAA  180
181   TGTGATTTTC  CTTCTATGAA  ATTTTCACTC  TATTTCTTGG  CTTACGAGGA  TAAAAATGAC  240
241   ATCCCTAAAG  ATAAAGATGA  AAAAATAGCC  TGGGCATTAT  CCAGAAAAGC  TACACTTGAG  300
301   CTGACACACA  ATTGGGGCAC  TGAAGATGAT  GAGACCCAGA  GTTACCACAA  TGGCAATTCA  360
361   GACCCTCGAG  GATTTGGTCA  CATTGGAATT  GCTGTTCCTG  ATGTACACAG  TGCTTGCAAA  420
421   AGGTTTGAAG  AACTGGGAGT  CAAATTTGTG  AAGAAACCTG  ATGATGGTAA  AATGAAAGGC  480
481   CTGGCATTTA  TTCAAGATCC  TGATGGCTAC  TGGATTGAAA  TTTTGAATCC  TAACAAAATG  540
541   GCAACTATAA  TTTAG  555

▼ KEYWORD

ID
Family
Complete proteome
Lyase
Metal-binding
Reference proteome
Zinc

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nucleus
Cellular Component
Plasma membrane
Molecular Function
Lactoylglutathione lyase activity
Molecular Function
Zinc ion binding
Biological Process
Negative regulation of apoptotic process
Biological Process
Osteoclast differentiation
Biological Process
Regulation of transcription by RNA polymerase II

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aon-3560Aotus nancymaae98.095e-112 323
LLPS-Man-0269Macaca nemestrina97.285e-133 377
LLPS-Mam-3790Macaca mulatta97.285e-133 377
LLPS-Cea-4504Cercocebus atys97.285e-133 377
LLPS-Maf-0196Macaca fascicularis97.285e-133 377
LLPS-Mal-1770Mandrillus leucophaeus97.285e-133 377
LLPS-Paa-4159Papio anubis97.285e-133 377
LLPS-Hos-0358Homo sapiens96.741e-131 374
LLPS-Pat-4298Pan troglodytes96.744e-132 375
LLPS-Pap-4311Pan paniscus96.744e-132 375
LLPS-Nol-2630Nomascus leucogenys96.746e-131 372
LLPS-Chs-4347Chlorocebus sabaeus96.746e-132 375
LLPS-Gog-2348Gorilla gorilla96.744e-132 375
LLPS-Poa-4516Pongo abelii96.29e-132 374
LLPS-Cas-3737Carlito syrichta95.113e-130 370
LLPS-Fud-2712Fukomys damarensis94.021e-128 366
LLPS-Dio-2781Dipodomys ordii92.934e-128 365
LLPS-Ran-0738Rattus norvegicus92.932e-127 363
LLPS-Bot-4271Bos taurus92.391e-127 363
LLPS-Myl-1904Myotis lucifugus92.393e-127 363
LLPS-Caf-2015Canis familiaris91.852e-127 363
LLPS-Mum-4739Mus musculus91.857e-126 359
LLPS-Tut-1443Tursiops truncatus91.851e-126 361
LLPS-Mup-3776Mustela putorius furo91.852e-126 360
LLPS-Ova-1773Ovis aries91.853e-127 363
LLPS-Eqc-4768Equus caballus90.761e-124 356
LLPS-Sus-1172Sus scrofa90.222e-123 353
LLPS-Aim-3079Ailuropoda melanoleuca90.227e-124 354
LLPS-Fec-2587Felis catus89.674e-124 355
LLPS-Ict-3114Ictidomys tridecemlineatus89.671e-121 348
LLPS-Mea-3048Mesocricetus auratus89.133e-122 350
LLPS-Cap-4665Cavia porcellus88.592e-122 351
LLPS-Loa-4185Loxodonta africana88.043e-121 347
LLPS-Mod-2383Monodelphis domestica85.258e-115 331
LLPS-Ora-0982Ornithorhynchus anatinus85.062e-110 321
LLPS-Tag-3470Taeniopygia guttata84.522e-97 286
LLPS-Anc-2316Anolis carolinensis84.363e-112 325
LLPS-Anp-1745Anas platyrhynchos83.911e-108 315
LLPS-Urm-2102Ursus maritimus83.539e-101 297
LLPS-Pes-1006Pelodiscus sinensis83.336e-113 326
LLPS-Gaga-0008Gallus gallus83.066e-111 321
LLPS-Sah-2654Sarcophilus harrisii82.81e-111 323
LLPS-Fia-1823Ficedula albicollis82.781e-108 315
LLPS-Otg-4129Otolemur garnettii80.113e-101 296
LLPS-Leo-2641Lepisosteus oculatus78.985e-92 273
LLPS-Rhb-3539Rhinopithecus bieti78.83e-97 285
LLPS-Scm-2017Scophthalmus maximus78.162e-99 294
LLPS-Orn-4121Oreochromis niloticus77.012e-100 294
LLPS-Ten-1745Tetraodon nigroviridis77.012e-100 295
LLPS-Tar-3284Takifugu rubripes77.011e-100 295
LLPS-Asm-2928Astyanax mexicanus76.842e-102 300
LLPS-Lac-2510Latimeria chalumnae76.095e-104 304
LLPS-Gaa-3828Gasterosteus aculeatus75.861e-99 292
LLPS-Icp-1545Ictalurus punctatus75.845e-102 298
LLPS-Scf-1933Scleropages formosus75.715e-101 296
LLPS-Pof-4166Poecilia formosa75.291e-100 295
LLPS-Orl-1531Oryzias latipes75.292e-97 287
LLPS-Xim-4081Xiphophorus maculatus75.293e-100 294
LLPS-Dar-1004Danio rerio74.142e-98 289
LLPS-Drm-1633Drosophila melanogaster69.012e-86 259
LLPS-Sei-1288Setaria italica68.316e-69 213
LLPS-Zem-1916Zea mays68.154e-77 237
LLPS-Sob-2286Sorghum bicolor67.524e-77 237
LLPS-Sot-2108Solanum tuberosum66.888e-75 231
LLPS-Cus-0592Cucumis sativus66.885e-75 230
LLPS-Mae-1128Manihot esculenta66.235e-74 229
LLPS-Nia-1025Nicotiana attenuata66.234e-75 232
LLPS-Sol-0996Solanum lycopersicum66.233e-74 228
LLPS-Orni-2134Oryza nivara66.04e-72 225
LLPS-Orm-0930Oryza meridionalis65.771e-70 225
LLPS-Orgl-2175Oryza glumaepatula65.778e-70 223
LLPS-Chr-0540Chlamydomonas reinhardtii65.363e-83 253
LLPS-Mua-1809Musa acuminata65.228e-77 236
LLPS-Brr-1535Brassica rapa65.04e-76 235
LLPS-Brn-3005Brassica napus65.04e-76 235
LLPS-Sem-2433Selaginella moellendorffii64.813e-78 238
LLPS-Viv-0682Vitis vinifera64.639e-78 239
LLPS-Tru-1859Triticum urartu64.632e-79 241
LLPS-Tra-1288Triticum aestivum64.631e-79 244
LLPS-Brd-1999Brachypodium distachyon64.631e-78 241
LLPS-Pot-1040Populus trichocarpa64.381e-76 236
LLPS-Arl-2268Arabidopsis lyrata64.385e-75 232
LLPS-Phv-0837Phaseolus vulgaris63.984e-75 232
LLPS-Hea-1598Helianthus annuus63.983e-73 228
LLPS-Orbr-2286Oryza brachyantha63.913e-80 245
LLPS-Php-0448Physcomitrella patens63.862e-75 233
LLPS-Xet-3197Xenopus tropicalis63.592e-76 234
LLPS-Glm-0871Glycine max63.351e-75 233
LLPS-Orp-0625Oryza punctata63.012e-80 246
LLPS-Bro-0741Brassica oleracea62.962e-1677.0
LLPS-Prp-0580Prunus persica62.735e-75 232
LLPS-Coc-2209Corchorus capsularis62.733e-73 227
LLPS-Art-2822Arabidopsis thaliana62.582e-71 222
LLPS-Ors-1996Oryza sativa62.432e-80 246
LLPS-Orr-1722Oryza rufipogon62.432e-80 246
LLPS-Org-1316Oryza glaberrima62.433e-80 245
LLPS-Orb-1541Oryza barthii62.433e-80 245
LLPS-Ori-1531Oryza indica62.432e-80 246
LLPS-Hov-1189Hordeum vulgare62.31e-53 176
LLPS-Lep-2195Leersia perrieri62.218e-79 241
LLPS-Via-1074Vigna angularis61.945e-56 183
LLPS-Thc-0130Theobroma cacao61.217e-73 226
LLPS-Gor-0287Gossypium raimondii61.114e-71 222
LLPS-Met-0621Medicago truncatula60.982e-75 233
LLPS-Cii-1894Ciona intestinalis60.85e-79 240
LLPS-Usm-1089Ustilago maydis56.053e-52 171
LLPS-Aso-0769Aspergillus oryzae54.675e-47 162
LLPS-Asf-0357Aspergillus flavus54.675e-47 162
LLPS-Put-0843Puccinia triticina54.191e-48 162
LLPS-Ast-0911Aspergillus terreus53.91e-43 152
LLPS-Spr-0413Sporisorium reilianum53.53e-51 168
LLPS-Amt-0077Amborella trichopoda53.073e-60 194
LLPS-Abg-1171Absidia glauca52.234e-45 162
LLPS-Nef-1612Neosartorya fischeri52.01e-45 159
LLPS-Pug-1137Puccinia graminis51.663e-45 156
LLPS-Asfu-0337Aspergillus fumigatus51.331e-45 159
LLPS-Asc-1449Aspergillus clavatus51.37e-45 157
LLPS-Miv-1391Microbotryum violaceum50.998e-41 141
LLPS-Crn-1562Cryptococcus neoformans50.02e-43 149
LLPS-Asn-1450Aspergillus nidulans50.03e-45 157
LLPS-Asni-1490Aspergillus niger49.675e-42 149
LLPS-Mel-1260Melampsora laricipopulina49.612e-35 127
LLPS-Cogr-0119Colletotrichum graminicola49.329e-40 143
LLPS-Yal-1256Yarrowia lipolytica49.133e-50 171
LLPS-Scj-1140Schizosaccharomyces japonicus49.019e-40 143
LLPS-Gag-0878Gaeumannomyces graminis48.76e-41 147
LLPS-Trr-1230Trichoderma reesei48.327e-44 154
LLPS-Sac-1224Saccharomyces cerevisiae48.36e-39 141
LLPS-Scp-1252Schizosaccharomyces pombe48.19e-35 129
LLPS-Lem-0098Leptosphaeria maculans48.052e-39 142
LLPS-Beb-0747Beauveria bassiana48.03e-38 139
LLPS-Pyt-0917Pyrenophora teres47.621e-39 143
LLPS-Trv-1093Trichoderma virens47.53e-46 160
LLPS-Cog-0734Colletotrichum gloeosporioides47.373e-39 142
LLPS-Coo-0397Colletotrichum orbiculare47.177e-40 143
LLPS-Zyt-0449Zymoseptoria tritici47.132e-41 148
LLPS-Scc-0327Schizosaccharomyces cryophilus46.849e-38 137
LLPS-Pytr-0537Pyrenophora triticirepentis46.752e-39 142
LLPS-Map-1034Magnaporthe poae46.711e-38 140
LLPS-Ved-1094Verticillium dahliae46.453e-39 142
LLPS-Fuo-1213Fusarium oxysporum46.34e-43 153
LLPS-Fuv-0944Fusarium verticillioides46.34e-43 153
LLPS-Fus-1390Fusarium solani46.254e-42 149
LLPS-Phn-0372Phaeosphaeria nodorum46.11e-36 135
LLPS-Mao-1130Magnaporthe oryzae45.814e-39 142
LLPS-Dos-0455Dothistroma septosporum45.756e-37 136
LLPS-Nec-0394Neurospora crassa45.451e-38 141
LLPS-Vir-0363Vigna radiata45.218e-35 127
LLPS-Tum-1505Tuber melanosporum45.215e-37 135
LLPS-Cym-0914Cyanidioschyzon merolae44.945e-39 138
LLPS-Gas-0869Galdieria sulphuraria44.525e-36 134
LLPS-Scs-1004Sclerotinia sclerotiorum44.092e-31 120
LLPS-Asg-0377Ashbya gossypii43.671e-34 130
LLPS-Kop-1117Komagataella pastoris43.237e-30 117
LLPS-Chc-0755Chondrus crispus37.252e-23 100
LLPS-Dac-0240Daucus carota31.616e-1574.7
LLPS-Osl-1135Ostreococcus lucimarinus25.531e-0957.8