• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orc-4320
HMGCS2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: 3-hydroxy-3-methylglutaryl coenzyme A synthase
Gene Name: HMGCS2
Ensembl Gene: ENSOCUG00000005767.3
Ensembl Protein: ENSOCUP00000004996.2
Organism: Oryctolagus cuniculus
Taxa ID: 9986
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-bodyPredicted from orthologs(View)

▼ FUNCTION

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MQRLLTPVRQ  VLRVNTALRE  ASLAPARLLP  AAQQRFSTVS  AAPLAYTDTW  PKDVGILAME  60
61    VYFPAQYVDQ  TDLEKFNNVE  AGKYTVGLGQ  TQMGFCSVQE  DINSLCLTVV  QRLMERTQLP  120
121   WDSVGRLEVG  TETIIDKSKA  VKTVLMELFQ  DSGNTDIEGI  DTTNACYGGT  ASLFNAANWM  180
181   ESSYWDGRYA  LVVCGDIAVY  PDGNARPTGG  AGAVAMLIGP  HAPLALEQGL  RGTHMENAYD  240
241   FYKPNLASEY  PLVDGKLSIQ  CYFRALDRCY  TAYRQKIQKQ  WKRDGIDRPF  TLDDLQYMIF  300
301   HTPFCKMVQK  SLARLVLNDF  LSASDDTQSS  VYKGLEAFRG  LKLEDTYNNK  EVDKALLKAS  360
361   LDTFNKKTKA  SLYLSTHNGN  MYTSSLYGCL  ASLLSHHSAQ  ELAGSRIGAF  SYGSGLAASL  420
421   FSFRVSQDAS  PGSPLEKLVS  SISDLPKRLA  SRKRMSPEEF  TEIMNQREQF  YHKVNFSPPG  480
481   DTKNLFPGTW  YLERVDELHR  RKYARRPI  508
Nucleotide CDS Sequence (FASTA)
1     ATGCAGCGGC  TGTTGACTCC  GGTGAGGCAG  GTCCTACGAG  TGAACACAGC  ACTGCGGGAG  60
61    GCCTCCCTGG  CACCTGCTCG  CCTGCTCCCC  GCAGCCCAGC  AAAGGTTCTC  CACAGTCTCT  120
121   GCTGCCCCCC  TGGCCTATAC  AGATACCTGG  CCAAAGGATG  TGGGCATCCT  CGCCATGGAG  180
181   GTCTACTTCC  CAGCCCAATA  CGTGGACCAG  ACTGACCTGG  AGAAGTTTAA  CAATGTGGAA  240
241   GCAGGAAAGT  ATACCGTGGG  CTTGGGTCAG  ACCCAGATGG  GCTTCTGCTC  GGTCCAGGAG  300
301   GACATCAATT  CCCTCTGCCT  GACAGTAGTG  CAACGGCTGA  TGGAGCGCAC  ACAGCTCCCG  360
361   TGGGACTCCG  TGGGCCGGCT  GGAAGTGGGC  ACAGAGACCA  TCATTGACAA  GTCCAAGGCT  420
421   GTCAAAACGG  TGCTCATGGA  ACTCTTCCAG  GACTCAGGCA  ACACAGACAT  CGAAGGCATA  480
481   GATACCACCA  ATGCCTGCTA  TGGTGGCACT  GCCTCCCTCT  TCAACGCCGC  CAACTGGATG  540
541   GAGTCCAGCT  ATTGGGATGG  TCGCTATGCA  CTGGTGGTCT  GTGGCGACAT  CGCAGTCTAT  600
601   CCTGACGGTA  ATGCCCGACC  TACAGGTGGG  GCTGGAGCTG  TGGCAATGCT  GATTGGGCCC  660
661   CATGCCCCTC  TGGCCTTGGA  GCAAGGGCTT  CGGGGCACCC  ATATGGAGAA  CGCGTATGAC  720
721   TTCTACAAAC  CAAATCTGGC  CTCCGAGTAC  CCGCTGGTGG  ATGGGAAGCT  GTCCATCCAG  780
781   TGCTACTTTC  GGGCACTGGA  TCGATGTTAC  ACAGCATACC  GCCAAAAGAT  CCAGAAGCAG  840
841   TGGAAGCGAG  ACGGCATCGA  CAGACCTTTC  ACCCTCGATG  ATCTGCAGTA  CATGATCTTC  900
901   CACACCCCCT  TTTGCAAGAT  GGTCCAGAAA  TCTCTGGCTC  GCCTGGTGCT  CAATGACTTC  960
961   CTGTCAGCCA  GCGACGACAC  CCAATCCAGC  GTATACAAGG  GGCTGGAGGC  CTTCAGGGGC  1020
1021  CTGAAGCTGG  AAGATACCTA  CAACAACAAG  GAAGTGGATA  AAGCTCTTCT  GAAGGCCTCT  1080
1081  CTGGACACGT  TCAACAAGAA  GACCAAGGCC  TCCCTTTACC  TCTCCACACA  CAACGGGAAC  1140
1141  ATGTACACCT  CATCCCTGTA  TGGGTGCCTG  GCCTCACTCC  TGTCCCACCA  CTCTGCGCAG  1200
1201  GAGTTAGCGG  GCTCCCGGAT  TGGCGCCTTC  TCTTACGGCT  CTGGCTTAGC  AGCAAGCCTT  1260
1261  TTCTCATTCC  GCGTGTCCCA  GGATGCTTCT  CCGGGCTCTC  CTCTGGAGAA  ACTGGTGTCC  1320
1321  AGCATATCAG  ACCTGCCAAA  ACGCCTGGCC  TCCCGGAAGC  GGATGTCTCC  TGAGGAATTC  1380
1381  ACAGAAATAA  TGAACCAAAG  GGAGCAATTC  TACCACAAGG  TGAATTTCTC  ACCACCCGGT  1440
1441  GACACAAAGA  ACCTTTTCCC  AGGCACTTGG  TACCTGGAGC  GAGTGGATGA  GCTCCATCGC  1500
1501  CGGAAGTATG  CCCGGCGTCC  CATCTAG  1527

▼ KEYWORD

ID
Family
Complete proteome
Lipid biosynthesis
Lipid metabolism
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrion
Molecular Function
Hydroxymethylglutaryl-CoA synthase activity
Biological Process
Isoprenoid biosynthetic process
Biological Process
Sterol biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Caj-1880Callithrix jacchus90.350.0 943
LLPS-Aon-3942Aotus nancymaae90.240.0 909
LLPS-Ict-0823Ictidomys tridecemlineatus89.960.0 941
LLPS-Mam-0360Macaca mulatta89.760.0 936
LLPS-Rhb-1406Rhinopithecus bieti89.760.0 933
LLPS-Paa-4196Papio anubis89.760.0 936
LLPS-Mal-3898Mandrillus leucophaeus89.570.0 934
LLPS-Chs-2461Chlorocebus sabaeus89.570.0 934
LLPS-Maf-0292Macaca fascicularis89.570.0 936
LLPS-Cea-4438Cercocebus atys89.570.0 934
LLPS-Man-3525Macaca nemestrina89.370.0 935
LLPS-Pat-3656Pan troglodytes89.170.0 932
LLPS-Pap-1662Pan paniscus89.170.0 932
LLPS-Ran-1708Rattus norvegicus89.170.0 938
LLPS-Nol-3566Nomascus leucogenys88.980.0 931
LLPS-Poa-3767Pongo abelii88.980.0 932
LLPS-Hos-2947Homo sapiens88.980.0 930
LLPS-Mum-4937Mus musculus88.980.0 936
LLPS-Dio-0583Dipodomys ordii88.780.0 934
LLPS-Gog-3675Gorilla gorilla88.780.0 928
LLPS-Otg-3208Otolemur garnettii88.190.0 926
LLPS-Cas-3739Carlito syrichta87.80.0 911
LLPS-Ova-3899Ovis aries87.40.0 912
LLPS-Bot-3674Bos taurus87.40.0 912
LLPS-Fec-2651Felis catus87.20.0 915
LLPS-Mea-3128Mesocricetus auratus87.20.0 923
LLPS-Caf-1119Canis familiaris87.010.0 918
LLPS-Aim-4130Ailuropoda melanoleuca87.010.0 911
LLPS-Eqc-4699Equus caballus86.810.0 912
LLPS-Urm-2390Ursus maritimus86.810.0 914
LLPS-Mup-2146Mustela putorius furo86.810.0 921
LLPS-Sus-3803Sus scrofa85.740.0 889
LLPS-Tag-2503Taeniopygia guttata73.760.0 744
LLPS-Meg-1910Meleagris gallopavo72.690.0 736
LLPS-Xet-0524Xenopus tropicalis69.430.0 690
LLPS-Tut-1708Tursiops truncatus69.410.0 642
LLPS-Icp-1582Ictalurus punctatus68.870.0 699
LLPS-Tum-0184Tuber melanosporum68.69e-56 189
LLPS-Lac-1646Latimeria chalumnae68.420.0 642
LLPS-Pes-0328Pelodiscus sinensis68.310.0 693
LLPS-Leo-2790Lepisosteus oculatus68.260.0 690
LLPS-Anp-2768Anas platyrhynchos67.880.0 691
LLPS-Asm-0147Astyanax mexicanus67.720.0 696
LLPS-Fia-0903Ficedula albicollis67.670.0 689
LLPS-Pof-0173Poecilia formosa67.610.0 683
LLPS-Mod-0801Monodelphis domestica67.530.0 679
LLPS-Gaga-0903Gallus gallus67.450.0 688
LLPS-Ora-0792Ornithorhynchus anatinus67.450.0 681
LLPS-Xim-1567Xiphophorus maculatus67.390.0 680
LLPS-Orn-0318Oreochromis niloticus67.160.0 693
LLPS-Loa-3273Loxodonta africana67.10.0 681
LLPS-Gaa-1504Gasterosteus aculeatus66.950.0 679
LLPS-Anc-3520Anolis carolinensis66.810.0 683
LLPS-Sah-0563Sarcophilus harrisii66.530.0 679
LLPS-Scm-0059Scophthalmus maximus66.520.0 684
LLPS-Scf-3655Scleropages formosus66.520.0 685
LLPS-Dar-0606Danio rerio66.380.0 676
LLPS-Fud-1107Fukomys damarensis66.240.0 671
LLPS-Myl-0681Myotis lucifugus65.810.0 673
LLPS-Orl-2145Oryzias latipes65.460.0 676
LLPS-Cap-1728Cavia porcellus65.380.0 671
LLPS-Ten-2792Tetraodon nigroviridis64.780.0 632
LLPS-Tar-1158Takifugu rubripes62.880.0 660
LLPS-Drm-1629Drosophila melanogaster59.390.0 573
LLPS-Cis-0727Ciona savignyi55.580.0 534
LLPS-Cii-1416Ciona intestinalis55.530.0 537
LLPS-Chr-0955Chlamydomonas reinhardtii51.05e-2097.8
LLPS-Php-2177Physcomitrella patens50.993e-156 460
LLPS-Dos-0610Dothistroma septosporum50.657e-159 467
LLPS-Phn-1207Phaeosphaeria nodorum50.653e-156 460
LLPS-Asc-0157Aspergillus clavatus50.542e-157 463
LLPS-Cog-0539Colletotrichum gloeosporioides50.332e-163 478
LLPS-Zyt-1029Zymoseptoria tritici50.335e-156 460
LLPS-Fuo-0855Fusarium oxysporum50.111e-155 459
LLPS-Beb-1178Beauveria bassiana50.113e-157 462
LLPS-Sem-1815Selaginella moellendorffii50.111e-145 433
LLPS-Fuv-1436Fusarium verticillioides50.111e-155 458
LLPS-Mel-0825Melampsora laricipopulina50.02e-144 432
LLPS-Pytr-1424Pyrenophora triticirepentis49.896e-157 462
LLPS-Miv-1161Microbotryum violaceum49.782e-145 433
LLPS-Asfu-0829Aspergillus fumigatus49.675e-155 457
LLPS-Orbr-1079Oryza brachyantha49.671e-157 464
LLPS-Ast-1367Aspergillus terreus49.671e-146 435
LLPS-Asf-0361Aspergillus flavus49.674e-154 455
LLPS-Pyt-0570Pyrenophora teres49.671e-156 461
LLPS-Lep-1177Leersia perrieri49.671e-155 459
LLPS-Aso-1505Aspergillus oryzae49.461e-153 454
LLPS-Spr-1149Sporisorium reilianum49.362e-145 433
LLPS-Glm-1399Glycine max49.346e-154 454
LLPS-Nec-0903Neurospora crassa49.242e-154 456
LLPS-Gor-1631Gossypium raimondii49.235e-156 460
LLPS-Amt-2124Amborella trichopoda49.23e-146 434
LLPS-Fus-0468Fusarium solani49.134e-154 455
LLPS-Scj-0794Schizosaccharomyces japonicus49.139e-148 438
LLPS-Usm-1512Ustilago maydis49.034e-144 429
LLPS-Trr-0767Trichoderma reesei49.022e-156 460
LLPS-Nef-0488Neosartorya fischeri49.023e-153 452
LLPS-Asn-0973Aspergillus nidulans48.922e-151 448
LLPS-Trv-1026Trichoderma virens48.817e-156 459
LLPS-Hea-1005Helianthus annuus48.89e-155 456
LLPS-Org-0075Oryza glaberrima48.791e-155 459
LLPS-Orr-2294Oryza rufipogon48.791e-155 459
LLPS-Ors-1230Oryza sativa48.791e-155 459
LLPS-Orgl-0787Oryza glumaepatula48.799e-156 459
LLPS-Via-2303Vigna angularis48.793e-153 452
LLPS-Orni-0345Oryza nivara48.791e-155 459
LLPS-Orb-2178Oryza barthii48.791e-155 459
LLPS-Phv-1668Phaseolus vulgaris48.697e-153 452
LLPS-Cus-0542Cucumis sativus48.685e-151 447
LLPS-Pot-1818Populus trichocarpa48.584e-155 457
LLPS-Orp-0771Oryza punctata48.575e-155 457
LLPS-Dac-1527Daucus carota48.573e-154 455
LLPS-Scs-0627Sclerotinia sclerotiorum48.51e-152 451
LLPS-Vir-1217Vigna radiata48.461e-141 421
LLPS-Mae-0914Manihot esculenta48.364e-155 457
LLPS-Zem-2508Zea mays48.351e-147 439
LLPS-Sob-2555Sorghum bicolor48.359e-149 441
LLPS-Viv-1917Vitis vinifera48.352e-151 448
LLPS-Cogr-0461Colletotrichum graminicola48.193e-152 450
LLPS-Asni-0107Aspergillus niger48.161e-152 451
LLPS-Ori-0807Oryza indica48.131e-145 434
LLPS-Mao-1426Magnaporthe oryzae48.064e-152 449
LLPS-Ved-1566Verticillium dahliae48.035e-154 454
LLPS-Gas-0407Galdieria sulphuraria48.022e-149 442
LLPS-Coo-1314Colletotrichum orbiculare47.993e-155 458
LLPS-Abg-1120Absidia glauca47.938e-153 451
LLPS-Mua-1407Musa acuminata47.911e-149 444
LLPS-Lem-1105Leptosphaeria maculans47.851e-150 446
LLPS-Blg-0322Blumeria graminis47.852e-149 443
LLPS-Met-2252Medicago truncatula47.832e-152 450
LLPS-Orm-0144Oryza meridionalis47.715e-145 432
LLPS-Scp-0942Schizosaccharomyces pombe47.78e-145 431
LLPS-Coc-0231Corchorus capsularis47.693e-150 445
LLPS-Sol-1804Solanum lycopersicum47.696e-150 444
LLPS-Nia-1129Nicotiana attenuata47.65e-150 444
LLPS-Thc-1470Theobroma cacao47.68e-154 454
LLPS-Tru-1536Triticum urartu47.473e-150 447
LLPS-Prp-1100Prunus persica47.471e-146 436
LLPS-Tra-2777Triticum aestivum47.478e-151 447
LLPS-Sei-0826Setaria italica47.477e-151 447
LLPS-Map-1130Magnaporthe poae47.451e-149 443
LLPS-Brd-2067Brachypodium distachyon47.252e-149 443
LLPS-Kop-0138Komagataella pastoris47.256e-133 400
LLPS-Hov-0017Hordeum vulgare47.241e-147 442
LLPS-Sot-0912Solanum tuberosum47.162e-149 443
LLPS-Gag-0102Gaeumannomyces graminis47.15e-148 440
LLPS-Chc-0916Chondrus crispus47.064e-131 396
LLPS-Scc-0893Schizosaccharomyces cryophilus46.931e-143 428
LLPS-Pug-1035Puccinia graminis46.641e-138 418
LLPS-Bro-0240Brassica oleracea46.394e-146 434
LLPS-Yal-0441Yarrowia lipolytica46.324e-137 411
LLPS-Put-1087Puccinia triticina46.228e-138 416
LLPS-Arl-1089Arabidopsis lyrata46.177e-146 434
LLPS-Brr-0869Brassica rapa45.951e-145 433
LLPS-Brn-2794Brassica napus45.954e-145 432
LLPS-Asg-0444Ashbya gossypii45.871e-134 405
LLPS-Art-2558Arabidopsis thaliana45.739e-145 431
LLPS-Sac-1435Saccharomyces cerevisiae45.17e-135 407
LLPS-Cym-1117Cyanidioschyzon merolae43.241e-124 384
LLPS-Cae-0238Caenorhabditis elegans42.981e-108 338
LLPS-Crn-0911Cryptococcus neoformans41.72e-128 390