DrLLPS - Data resource of LLPS

LLPS-Usm-1512
hcs1

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Hydroxymethylglutaryl-CoA synthase
Gene Name:	hcs1, UMAG_05362
Ensembl Gene:	UMAG_05362
Ensembl Protein:	KIS66367
Organism:	Ustilago maydis
Taxa ID:	237631
LLPS Type:	LLPS regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
P-body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Caenorhabditis elegans	LLPS-Cae-0238	P54871	Regulator	P-body	38.60	4e-88	283

▼ FUNCTION

Hydroxymethylglutaryl-CoA synthase involved in the biosynthesis of siderophore ferrichrome A which is contributing to organismal virulence (PubMed:20070524). The first step of ferrichrome A biosynthesis is performed by the HMG-CoA synthase hcs1 which catalyzes the generation of HMG-CoA and CoA using acetoacetyl-CoA and acetyl-CoA as substrates (PubMed:20070524). The enoyl-CoA isomerase/hydratase fer4 then catalyzes the conversion of hcs1-produced HMG-CoA to methylglutaconyl-CoA (PubMed:20070524). The acyltransferase fer5 then fuses the fer4-generated methylglutaconyl-CoA with sid1-generated hydroxyornithine to yield methylglutaconyl hydroxyornithine (PubMed:20070524). Methylglutaconyl hydroxyornithine is then available for use by the NRPS fer3 to generate ferrichrome A (PubMed:20070524).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	KIS66367	KIS66367
UniProt		Q4P3F1, HCS1_USTMA, D4G7A2
GeneBank	CM003158, BN001277	KIS66367.1, CAR97787.1
RefSeq	XM_011393760.1	XP_011392062.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSARPQNVGI KAIEIYFPRR CISEDELEDF DGVAKGKYTI GFGQKYMACT DDREDINSFA 60 61 LSVVSGLLEK NNIDPRSIGR LDVGTETIID KSKSVKTVLM DLFAPSGNMN IEGIDSKNAC 120 121 YGGTAALFNA INWVESSSWD GRDAIVVAGD IAIYAEGSAR PVGGAGSVAM LIGPDAPLVF 180 181 EPAHGTHMSN YWDFYKPNLS SEYPEVDGPE TIQTYLGCLD KAYDAYRLRA AKLKSGAANG 240 241 HSDASSLASI KVDDFDYTLF HSPYSKLVQK GFGRLLYNDF FSDPKNEKYA SIPANFAELD 300 301 RKSTITNKDV EKAFAAFGKE AQQTKLEPGM NTVRRCGNMY TASLYGGLVS LLSNIPSQEI 360 361 QGKRILLYSF GSGAAASMFA IRINGSTEQI VKAVDLKNRL DSMKVVPCQT YVEALKTREA 420 421 THNAVNHKPV GQLENLWPGA YYLENVDHMY RRTYGRIPTN AN 462

Protein Sequence (FASTA)

1     MSARPQNVGI  KAIEIYFPRR  CISEDELEDF  DGVAKGKYTI  GFGQKYMACT  DDREDINSFA  60
61    LSVVSGLLEK  NNIDPRSIGR  LDVGTETIID  KSKSVKTVLM  DLFAPSGNMN  IEGIDSKNAC  120
121   YGGTAALFNA  INWVESSSWD  GRDAIVVAGD  IAIYAEGSAR  PVGGAGSVAM  LIGPDAPLVF  180
181   EPAHGTHMSN  YWDFYKPNLS  SEYPEVDGPE  TIQTYLGCLD  KAYDAYRLRA  AKLKSGAANG  240
241   HSDASSLASI  KVDDFDYTLF  HSPYSKLVQK  GFGRLLYNDF  FSDPKNEKYA  SIPANFAELD  300
301   RKSTITNKDV  EKAFAAFGKE  AQQTKLEPGM  NTVRRCGNMY  TASLYGGLVS  LLSNIPSQEI  360
361   QGKRILLYSF  GSGAAASMFA  IRINGSTEQI  VKAVDLKNRL  DSMKVVPCQT  YVEALKTREA  420
421   THNAVNHKPV  GQLENLWPGA  YYLENVDHMY  RRTYGRIPTN  AN  462

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-1185	Reference proteome
KW-0808	Transferase
KW-0843	Virulence

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0004421	Molecular Function	Hydroxymethylglutaryl-CoA synthase activity
GO:0006084	Biological Process	Acetyl-CoA metabolic process
GO:0006696	Biological Process	Ergosterol biosynthetic process
GO:0010142	Biological Process	Farnesyl diphosphate biosynthetic process, mevalonate pathway
GO:0009405	Biological Process	Pathogenesis

▼ KEGG

uma:UMAG_05362

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Spr-1149	Sporisorium reilianum	93.58	0.0	878
LLPS-Tum-0184	Tuber melanosporum	63.78	3e-49	171
LLPS-Miv-1161	Microbotryum violaceum	59.65	0.0	523
LLPS-Pug-1035	Puccinia graminis	59.29	0.0	546
LLPS-Crn-0911	Cryptococcus neoformans	59.02	0.0	568
LLPS-Put-1087	Puccinia triticina	58.85	0.0	544
LLPS-Mel-0825	Melampsora laricipopulina	58.81	0.0	539
LLPS-Zyt-1029	Zymoseptoria tritici	54.82	2e-174	505
LLPS-Asc-0157	Aspergillus clavatus	54.82	1e-173	503
LLPS-Asfu-0829	Aspergillus fumigatus	54.82	1e-175	508
LLPS-Mao-1426	Magnaporthe oryzae	54.73	2e-170	494
LLPS-Dos-0610	Dothistroma septosporum	54.42	2e-173	502
LLPS-Nef-0488	Neosartorya fischeri	54.39	5e-174	504
LLPS-Scs-0627	Sclerotinia sclerotiorum	54.37	6e-167	486
LLPS-Asf-0361	Aspergillus flavus	54.17	1e-172	500
LLPS-Aso-1505	Aspergillus oryzae	53.95	4e-172	499
LLPS-Beb-1178	Beauveria bassiana	53.73	8e-165	480
LLPS-Map-1130	Magnaporthe poae	53.58	5e-170	494
LLPS-Asni-0107	Aspergillus niger	52.85	2e-172	500
LLPS-Yal-0441	Yarrowia lipolytica	52.43	4e-154	452
LLPS-Trr-0767	Trichoderma reesei	52.41	8e-161	470
LLPS-Nec-0903	Neurospora crassa	52.31	3e-163	476
LLPS-Pyt-0570	Pyrenophora teres	52.31	7e-168	488
LLPS-Pytr-1424	Pyrenophora triticirepentis	52.31	2e-167	487
LLPS-Cog-0539	Colletotrichum gloeosporioides	52.31	5e-161	470
LLPS-Phn-1207	Phaeosphaeria nodorum	52.29	2e-166	484
LLPS-Ast-1367	Aspergillus terreus	52.19	2e-158	463
LLPS-Blg-0322	Blumeria graminis	52.17	9e-161	470
LLPS-Fuv-1436	Fusarium verticillioides	52.1	9e-159	465
LLPS-Gag-0102	Gaeumannomyces graminis	52.01	1e-166	485
LLPS-Asn-0973	Aspergillus nidulans	51.98	7e-165	480
LLPS-Fuo-0855	Fusarium oxysporum	51.98	2e-159	467
LLPS-Trv-1026	Trichoderma virens	51.87	1e-158	464
LLPS-Lem-1105	Leptosphaeria maculans	51.63	2e-166	484
LLPS-Ved-1566	Verticillium dahliae	51.43	2e-158	464
LLPS-Fus-0468	Fusarium solani	51.43	2e-155	456
LLPS-Coo-1314	Colletotrichum orbiculare	51.3	4e-160	469
LLPS-Icp-1582	Ictalurus punctatus	51.29	2e-146	436
LLPS-Ora-0792	Ornithorhynchus anatinus	51.28	3e-147	437
LLPS-Lac-1646	Latimeria chalumnae	51.26	3e-133	402
LLPS-Cogr-0461	Colletotrichum graminicola	51.19	5e-157	461
LLPS-Pes-0328	Pelodiscus sinensis	50.96	9e-149	442
LLPS-Anc-3520	Anolis carolinensis	50.86	4e-146	435
LLPS-Leo-2790	Lepisosteus oculatus	50.85	1e-149	444
LLPS-Mum-4937	Mus musculus	50.75	6e-142	424
LLPS-Xet-0524	Xenopus tropicalis	50.64	2e-145	433
LLPS-Loa-3273	Loxodonta africana	50.64	1e-147	439
LLPS-Abg-1120	Absidia glauca	50.55	9e-146	431
LLPS-Tag-2503	Taeniopygia guttata	50.54	5e-145	430
LLPS-Dio-2516	Dipodomys ordii	50.43	3e-145	432
LLPS-Poa-4436	Pongo abelii	50.43	7e-147	437
LLPS-Orn-0318	Oreochromis niloticus	50.43	3e-146	435
LLPS-Anp-2768	Anas platyrhynchos	50.43	2e-147	438
LLPS-Paa-2071	Papio anubis	50.21	2e-146	436
LLPS-Mal-1252	Mandrillus leucophaeus	50.21	2e-146	436
LLPS-Gaa-1504	Gasterosteus aculeatus	50.21	7e-146	434
LLPS-Caj-2099	Callithrix jacchus	50.21	3e-146	435
LLPS-Gog-4404	Gorilla gorilla	50.21	7e-146	434
LLPS-Aon-2854	Aotus nancymaae	50.21	7e-147	437
LLPS-Sah-0563	Sarcophilus harrisii	50.21	1e-144	431
LLPS-Cea-2629	Cercocebus atys	50.21	2e-146	436
LLPS-Chs-2150	Chlorocebus sabaeus	50.21	2e-146	436
LLPS-Maf-3971	Macaca fascicularis	50.21	2e-146	436
LLPS-Nol-4236	Nomascus leucogenys	50.21	2e-146	435
LLPS-Mam-3846	Macaca mulatta	50.21	2e-146	436
LLPS-Fia-0903	Ficedula albicollis	50.21	4e-146	435
LLPS-Man-4484	Macaca nemestrina	50.21	2e-146	436
LLPS-Fec-0802	Felis catus	50.21	1e-145	434
LLPS-Mod-0801	Monodelphis domestica	50.21	4e-145	432
LLPS-Pap-1637	Pan paniscus	50.21	5e-144	432
LLPS-Pat-4659	Pan troglodytes	50.21	5e-144	432
LLPS-Drm-1629	Drosophila melanogaster	50.11	2e-146	433
LLPS-Orc-3128	Oryctolagus cuniculus	50.0	9e-144	429
LLPS-Otg-2322	Otolemur garnettii	50.0	1e-144	431
LLPS-Hos-3829	Homo sapiens	50.0	5e-145	432
LLPS-Mup-0403	Mustela putorius furo	49.89	6e-144	429
LLPS-Asg-0444	Ashbya gossypii	49.89	8e-147	434
LLPS-Mea-3128	Mesocricetus auratus	49.89	8e-140	418
LLPS-Gaga-0903	Gallus gallus	49.89	6e-145	432
LLPS-Rhb-3716	Rhinopithecus bieti	49.89	2e-145	433
LLPS-Ict-2503	Ictidomys tridecemlineatus	49.79	8e-144	429
LLPS-Caf-2031	Canis familiaris	49.79	4e-144	429
LLPS-Kop-0138	Komagataella pastoris	49.78	4e-139	414
LLPS-Ran-1708	Rattus norvegicus	49.57	2e-141	422
LLPS-Bot-4869	Bos taurus	49.57	2e-144	432
LLPS-Eqc-3556	Equus caballus	49.57	6e-144	429
LLPS-Cap-1728	Cavia porcellus	49.57	8e-144	429
LLPS-Urm-2980	Ursus maritimus	49.57	3e-143	427
LLPS-Meg-1910	Meleagris gallopavo	49.57	5e-141	421
LLPS-Scf-3655	Scleropages formosus	49.46	4e-146	435
LLPS-Aim-3593	Ailuropoda melanoleuca	49.36	6e-143	427
LLPS-Fud-1107	Fukomys damarensis	49.15	7e-142	424
LLPS-Ova-3397	Ovis aries	49.14	4e-143	429
LLPS-Myl-0681	Myotis lucifugus	48.94	3e-142	425
LLPS-Asm-0147	Astyanax mexicanus	48.94	4e-143	427
LLPS-Sus-3258	Sus scrofa	48.93	2e-144	431
LLPS-Pof-0173	Poecilia formosa	48.92	7e-144	429
LLPS-Php-2177	Physcomitrella patens	48.81	1e-135	406
LLPS-Xim-1567	Xiphophorus maculatus	48.49	1e-142	426
LLPS-Sac-1435	Saccharomyces cerevisiae	48.45	2e-144	429
LLPS-Scp-0942	Schizosaccharomyces pombe	48.37	3e-139	415
LLPS-Orl-2145	Oryzias latipes	48.31	6e-140	419
LLPS-Scj-0794	Schizosaccharomyces japonicus	48.02	2e-139	416
LLPS-Dar-0606	Danio rerio	47.67	1e-140	421
LLPS-Glm-1399	Glycine max	47.52	2e-136	407
LLPS-Scm-0059	Scophthalmus maximus	47.45	2e-139	417
LLPS-Cas-3739	Carlito syrichta	47.35	1e-130	394
LLPS-Met-2252	Medicago truncatula	47.3	3e-132	397
LLPS-Sem-1815	Selaginella moellendorffii	47.21	6e-125	378
LLPS-Chr-0955	Chlamydomonas reinhardtii	47.0	1e-19	95.9
LLPS-Ten-2792	Tetraodon nigroviridis	46.7	2e-129	391
LLPS-Phv-1668	Phaseolus vulgaris	46.65	2e-134	402
LLPS-Gor-1631	Gossypium raimondii	46.65	2e-125	380
LLPS-Dac-1527	Daucus carota	46.62	7e-131	394
LLPS-Via-2303	Vigna angularis	46.44	5e-129	389
LLPS-Coc-0231	Corchorus capsularis	46.44	7e-129	389
LLPS-Prp-1100	Prunus persica	46.41	1e-127	385
LLPS-Viv-1917	Vitis vinifera	46.41	5e-128	387
LLPS-Hov-0017	Hordeum vulgare	46.32	4e-127	388
LLPS-Sob-2075	Sorghum bicolor	46.32	3e-131	395
LLPS-Hea-1005	Helianthus annuus	46.3	7e-131	394
LLPS-Cus-0542	Cucumis sativus	46.29	1e-125	380
LLPS-Pot-1818	Populus trichocarpa	46.22	1e-128	388
LLPS-Nia-1129	Nicotiana attenuata	46.12	2e-127	385
LLPS-Brd-2067	Brachypodium distachyon	46.1	1e-129	390
LLPS-Tra-2777	Triticum aestivum	46.1	5e-127	384
LLPS-Lep-1177	Leersia perrieri	46.09	2e-128	387
LLPS-Tar-1158	Takifugu rubripes	46.09	5e-136	410
LLPS-Orbr-1079	Oryza brachyantha	46.07	1e-129	390
LLPS-Orm-2047	Oryza meridionalis	46.05	3e-121	369
LLPS-Sei-0826	Setaria italica	46.0	2e-130	393
LLPS-Tru-1536	Triticum urartu	45.89	4e-126	383
LLPS-Cii-1416	Ciona intestinalis	45.87	9e-134	402
LLPS-Orgl-0787	Oryza glumaepatula	45.82	2e-130	393
LLPS-Orni-0345	Oryza nivara	45.82	2e-130	392
LLPS-Orb-2178	Oryza barthii	45.82	2e-130	392
LLPS-Org-0075	Oryza glaberrima	45.82	2e-130	392
LLPS-Orr-2294	Oryza rufipogon	45.82	3e-130	392
LLPS-Orp-0771	Oryza punctata	45.82	3e-129	390
LLPS-Ors-1230	Oryza sativa	45.82	2e-130	392
LLPS-Vir-1217	Vigna radiata	45.77	2e-123	373
LLPS-Scc-0893	Schizosaccharomyces cryophilus	45.75	5e-129	388
LLPS-Mae-0914	Manihot esculenta	45.75	1e-126	383
LLPS-Cis-0727	Ciona savignyi	45.7	8e-132	397
LLPS-Sol-2041	Solanum lycopersicum	45.69	1e-127	385
LLPS-Zem-1296	Zea mays	45.67	3e-129	390
LLPS-Sot-0912	Solanum tuberosum	45.47	9e-127	383
LLPS-Brn-2658	Brassica napus	45.45	7e-126	381
LLPS-Thc-1470	Theobroma cacao	45.4	1e-128	388
LLPS-Bro-0240	Brassica oleracea	45.24	2e-124	377
LLPS-Ori-0807	Oryza indica	44.47	2e-122	372
LLPS-Brr-0869	Brassica rapa	44.42	2e-122	372
LLPS-Gas-0407	Galdieria sulphuraria	44.35	5e-124	376
LLPS-Arl-1089	Arabidopsis lyrata	44.3	1e-124	378
LLPS-Amt-2124	Amborella trichopoda	44.24	2e-115	353
LLPS-Mua-1407	Musa acuminata	44.06	2e-123	375
LLPS-Art-2558	Arabidopsis thaliana	43.87	2e-123	374
LLPS-Chc-0916	Chondrus crispus	43.63	2e-104	325
LLPS-Cym-1117	Cyanidioschyzon merolae	39.14	1e-101	323
LLPS-Cae-0238	Caenorhabditis elegans	37.72	2e-82	269
LLPS-Tut-1708	Tursiops truncatus	34.97	3e-72	241

LLPS-Usm-1512hcs1

Protein Sequence

Nucleotide Sequence

LLPS-Usm-1512
hcs1