LLPS-Mal-3898
HMGCS2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | 3-hydroxy-3-methylglutaryl coenzyme A synthase |
| Gene Name: | HMGCS2 |
| Ensembl Gene: | ENSMLEG00000039182.1 |
| Ensembl Protein: | ENSMLEP00000029983.1 |
| Organism: | Mandrillus leucophaeus |
| Taxa ID: | 9568 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMLET00000053545.1 | ENSMLEP00000029983.1 |
| Ensembl | ENSMLET00000053544.1 | ENSMLEP00000029982.1 |
| UniProt | A0A2K5ZQ89, A0A2K5ZQ89_MANLE | |
| RefSeq | XM_011976907.1, XM_011976908.1 | XP_011832297.1, XP_011832298.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MQRLLTPVKH ILQLTRVMQE ASLTPARLLP AAHQTFSTAS AVPLAKTDTW PKDVGILALE 60 61 VYFPAQYVDQ TDLEKYNNVE AGKYTVGLGQ TRMGFCSVQE DINSLCLTVV QRLMERIQLP 120 121 WDSVGRLEVG TETIIDKSKA VKTVLMELFQ DSGNTDIEGI DTTNACYGGT ASLFNAANWM 180 181 ESSSWDGRYA MVVCGDIAVY PSGNARPTGG AGAVAMLIGP KAPLALERGL RGTHMENVYD 240 241 FYKPNLASEY PVVDGKLSIQ CYLRALDRCY TSYRKKIQNQ WKQAGSDRPF TLDDLQYMIF 300 301 HTPFCKMVQK SLARLMFNDF LSASSDTQTS LYKGLEAFSG LKLEDTYTNK DLDKALLKAS 360 361 QDVFDKKTKA SLYLSTHNGN MYTSSLYGCL ASLLSHHSAQ ELAGSRIGAF SYGSGLAASF 420 421 FSFRVSQDAS PGSPLDKLVS STSDLPKRLA SRKCMSPEEF TEIMNQREQF YHKANFSPPG 480 481 DTNSLFPGTW YLERVDELHR RKYARRPI 508 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCAGCGTC TGTTGACTCC AGTGAAGCAC ATTCTGCAAC TGACAAGAGT GATGCAGGAA 60 61 GCCTCCCTCA CACCTGCTCG CCTGCTCCCA GCAGCCCACC AAACGTTTTC TACAGCCTCT 120 121 GCTGTCCCCC TGGCCAAAAC AGATACTTGG CCAAAAGACG TGGGCATCCT GGCCCTGGAG 180 181 GTCTACTTCC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTATAA CAATGTGGAA 240 241 GCAGGAAAGT ATACAGTGGG CTTGGGCCAG ACTCGTATGG GCTTCTGCTC AGTCCAAGAG 300 301 GACATCAACT CCCTGTGCCT GACGGTGGTG CAACGGCTGA TGGAGCGCAT ACAGCTCCCA 360 361 TGGGACTCAG TGGGCAGGCT GGAAGTAGGC ACTGAGACCA TCATTGACAA GTCCAAAGCT 420 421 GTCAAAACAG TGCTCATGGA ACTCTTCCAG GATTCAGGCA ATACTGACAT TGAGGGCATA 480 481 GATACCACCA ATGCCTGCTA CGGTGGTACT GCCTCCCTCT TCAATGCTGC CAACTGGATG 540 541 GAGTCCAGTT CCTGGGATGG ACTGAGGGGA ACCCATATGG AGAATGTATA TGACTTCTAC 600 601 AAACCAAATT TGGCCTCGGA GTACCCAGTG GTGGATGGGA AGCTTTCCAT CCAGTGCTAC 660 661 TTGCGGGCCT TGGATCGATG TTACACCTCG TACCGTAAAA AAATCCAGAA TCAGTGGAAG 720 721 CAAGCTGGCA GTGATCGACC CTTCACCCTT GACGATTTAC AGTACATGAT CTTTCACACA 780 781 CCCTTTTGCA AGATGGTCCA GAAGTCTCTG GCTCGCCTGA TGTTCAATGA CTTCCTGTCA 840 841 GCCAGCAGTG ACACACAAAC CAGCTTATAC AAGGGGCTGG AGGCTTTCAG CGGGCTAAAG 900 901 CTGGAAGACA CCTACACCAA CAAGGACCTG GATAAAGCAC TTCTAAAGGC CTCTCAGGAC 960 961 GTGTTCGACA AGAAAACCAA GGCCTCCCTT TACCTCTCCA CGCACAATGG GAACATGTAC 1020 1021 ACCTCATCCC TGTACGGGTG CCTGGCCTCA CTTCTGTCCC ACCACTCTGC CCAAGAACTG 1080 1081 GCTGGCTCCA GGATTGGTGC CTTCTCTTAT GGCTCTGGTT TAGCAGCAAG TTTCTTTTCG 1140 1141 TTTCGAGTGT CCCAGGATGC TTCTCCAGGG TCTCCCCTGG ACAAGTTGGT GTCCAGTACA 1200 1201 TCAGACCTGC CAAAGCGCCT AGCCTCCCGA AAGTGTATGT CTCCTGAGGA GTTCACAGAA 1260 1261 ATAATGAACC AAAGAGAGCA ATTCTACCAT AAGGCGAATT TCTCCCCACC TGGTGACACA 1320 1321 AACAGCCTTT TCCCAGGCAC TTGGTACCTG GAGCGAGTGG ACGAGCTGCA TCGCCGGAAG 1380 1381 TATGCCCGGC GTCCCATCTA A 1401 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrion | |
Molecular Function | Hydroxymethylglutaryl-CoA synthase activity | |
Biological Process | Isoprenoid biosynthetic process | |
Biological Process | Sterol biosynthetic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Cea-4438 | Cercocebus atys | 100.0 | 0.0 | 1063 |
| LLPS-Mam-0360 | Macaca mulatta | 99.61 | 0.0 | 1060 |
| LLPS-Paa-4196 | Papio anubis | 99.61 | 0.0 | 1059 |
| LLPS-Maf-0292 | Macaca fascicularis | 99.41 | 0.0 | 1059 |
| LLPS-Chs-2461 | Chlorocebus sabaeus | 99.41 | 0.0 | 1057 |
| LLPS-Man-3525 | Macaca nemestrina | 99.21 | 0.0 | 1058 |
| LLPS-Rhb-1406 | Rhinopithecus bieti | 98.62 | 0.0 | 1051 |
| LLPS-Poa-3767 | Pongo abelii | 97.24 | 0.0 | 1038 |
| LLPS-Nol-3566 | Nomascus leucogenys | 97.24 | 0.0 | 1039 |
| LLPS-Hos-2947 | Homo sapiens | 97.24 | 0.0 | 1039 |
| LLPS-Gog-3675 | Gorilla gorilla | 97.05 | 0.0 | 1035 |
| LLPS-Pap-1662 | Pan paniscus | 96.85 | 0.0 | 1035 |
| LLPS-Pat-3656 | Pan troglodytes | 96.85 | 0.0 | 1035 |
| LLPS-Aon-3942 | Aotus nancymaae | 95.33 | 0.0 | 986 |
| LLPS-Caj-1880 | Callithrix jacchus | 94.49 | 0.0 | 1009 |
| LLPS-Ict-0823 | Ictidomys tridecemlineatus | 90.94 | 0.0 | 978 |
| LLPS-Fec-2651 | Felis catus | 90.35 | 0.0 | 969 |
| LLPS-Aim-4130 | Ailuropoda melanoleuca | 89.76 | 0.0 | 960 |
| LLPS-Eqc-4699 | Equus caballus | 89.57 | 0.0 | 968 |
| LLPS-Orc-4320 | Oryctolagus cuniculus | 89.57 | 0.0 | 963 |
| LLPS-Otg-3208 | Otolemur garnettii | 89.37 | 0.0 | 961 |
| LLPS-Caf-1119 | Canis familiaris | 89.17 | 0.0 | 953 |
| LLPS-Urm-2390 | Ursus maritimus | 89.17 | 0.0 | 956 |
| LLPS-Ran-1708 | Rattus norvegicus | 89.17 | 0.0 | 967 |
| LLPS-Mup-2146 | Mustela putorius furo | 89.17 | 0.0 | 957 |
| LLPS-Cas-3739 | Carlito syrichta | 88.98 | 0.0 | 942 |
| LLPS-Mum-4937 | Mus musculus | 88.78 | 0.0 | 958 |
| LLPS-Dio-0583 | Dipodomys ordii | 88.39 | 0.0 | 939 |
| LLPS-Bot-3674 | Bos taurus | 88.19 | 0.0 | 957 |
| LLPS-Ova-3899 | Ovis aries | 87.99 | 0.0 | 955 |
| LLPS-Mea-3128 | Mesocricetus auratus | 87.6 | 0.0 | 946 |
| LLPS-Sus-3803 | Sus scrofa | 85.15 | 0.0 | 909 |
| LLPS-Tag-2503 | Taeniopygia guttata | 73.98 | 0.0 | 743 |
| LLPS-Meg-1910 | Meleagris gallopavo | 73.12 | 0.0 | 737 |
| LLPS-Tut-1708 | Tursiops truncatus | 71.52 | 0.0 | 664 |
| LLPS-Xet-0524 | Xenopus tropicalis | 68.67 | 0.0 | 691 |
| LLPS-Pes-0328 | Pelodiscus sinensis | 68.66 | 0.0 | 702 |
| LLPS-Icp-1582 | Ictalurus punctatus | 68.44 | 0.0 | 694 |
| LLPS-Gaa-1504 | Gasterosteus aculeatus | 68.26 | 0.0 | 677 |
| LLPS-Fia-0903 | Ficedula albicollis | 68.23 | 0.0 | 698 |
| LLPS-Scm-0059 | Scophthalmus maximus | 68.04 | 0.0 | 687 |
| LLPS-Anp-2768 | Anas platyrhynchos | 68.02 | 0.0 | 697 |
| LLPS-Pof-0173 | Poecilia formosa | 67.83 | 0.0 | 683 |
| LLPS-Tum-0184 | Tuber melanosporum | 67.77 | 1e-55 | 188 |
| LLPS-Xim-1567 | Xiphophorus maculatus | 67.61 | 0.0 | 680 |
| LLPS-Orl-2145 | Oryzias latipes | 67.61 | 0.0 | 681 |
| LLPS-Gaga-0903 | Gallus gallus | 67.59 | 0.0 | 696 |
| LLPS-Ora-0792 | Ornithorhynchus anatinus | 67.59 | 0.0 | 692 |
| LLPS-Mod-0801 | Monodelphis domestica | 67.45 | 0.0 | 691 |
| LLPS-Loa-3273 | Loxodonta africana | 67.45 | 0.0 | 695 |
| LLPS-Lac-1646 | Latimeria chalumnae | 67.43 | 0.0 | 636 |
| LLPS-Orn-0318 | Oreochromis niloticus | 67.38 | 0.0 | 689 |
| LLPS-Fud-1107 | Fukomys damarensis | 67.24 | 0.0 | 689 |
| LLPS-Scf-3655 | Scleropages formosus | 66.81 | 0.0 | 683 |
| LLPS-Myl-0681 | Myotis lucifugus | 66.81 | 0.0 | 691 |
| LLPS-Anc-3520 | Anolis carolinensis | 66.74 | 0.0 | 687 |
| LLPS-Leo-2790 | Lepisosteus oculatus | 66.74 | 0.0 | 689 |
| LLPS-Sah-0563 | Sarcophilus harrisii | 66.74 | 0.0 | 691 |
| LLPS-Asm-0147 | Astyanax mexicanus | 66.67 | 0.0 | 687 |
| LLPS-Dar-0606 | Danio rerio | 66.52 | 0.0 | 680 |
| LLPS-Cap-1728 | Cavia porcellus | 66.38 | 0.0 | 689 |
| LLPS-Ten-2792 | Tetraodon nigroviridis | 65.0 | 0.0 | 635 |
| LLPS-Tar-1158 | Takifugu rubripes | 63.73 | 0.0 | 662 |
| LLPS-Drm-1629 | Drosophila melanogaster | 60.26 | 0.0 | 580 |
| LLPS-Cii-1416 | Ciona intestinalis | 55.53 | 0.0 | 536 |
| LLPS-Cis-0727 | Ciona savignyi | 54.11 | 0.0 | 525 |
| LLPS-Chr-0955 | Chlamydomonas reinhardtii | 52.0 | 3e-20 | 98.6 |
| LLPS-Php-2177 | Physcomitrella patens | 51.87 | 2e-160 | 471 |
| LLPS-Amt-2124 | Amborella trichopoda | 51.14 | 1e-152 | 451 |
| LLPS-Gor-1631 | Gossypium raimondii | 50.77 | 1e-159 | 469 |
| LLPS-Glm-1399 | Glycine max | 50.66 | 6e-158 | 464 |
| LLPS-Lep-1177 | Leersia perrieri | 50.43 | 3e-160 | 471 |
| LLPS-Orbr-1079 | Oryza brachyantha | 50.22 | 7e-162 | 475 |
| LLPS-Mel-0825 | Melampsora laricipopulina | 50.22 | 3e-148 | 442 |
| LLPS-Via-2303 | Vigna angularis | 50.11 | 2e-155 | 458 |
| LLPS-Sem-1815 | Selaginella moellendorffii | 50.11 | 9e-149 | 441 |
| LLPS-Beb-1178 | Beauveria bassiana | 50.0 | 2e-159 | 468 |
| LLPS-Phv-1668 | Phaseolus vulgaris | 50.0 | 2e-156 | 460 |
| LLPS-Nia-1392 | Nicotiana attenuata | 50.0 | 2e-157 | 463 |
| LLPS-Orr-2294 | Oryza rufipogon | 49.89 | 4e-160 | 470 |
| LLPS-Org-0075 | Oryza glaberrima | 49.89 | 4e-160 | 470 |
| LLPS-Ors-1230 | Oryza sativa | 49.89 | 4e-160 | 470 |
| LLPS-Pot-1818 | Populus trichocarpa | 49.89 | 3e-160 | 471 |
| LLPS-Orgl-0787 | Oryza glumaepatula | 49.89 | 5e-160 | 470 |
| LLPS-Orb-2178 | Oryza barthii | 49.89 | 4e-160 | 470 |
| LLPS-Orni-0345 | Oryza nivara | 49.89 | 4e-160 | 470 |
| LLPS-Dac-1527 | Daucus carota | 49.89 | 5e-158 | 465 |
| LLPS-Cus-0542 | Cucumis sativus | 49.78 | 8e-158 | 464 |
| LLPS-Zem-2508 | Zea mays | 49.67 | 2e-153 | 453 |
| LLPS-Sob-2075 | Sorghum bicolor | 49.67 | 1e-158 | 467 |
| LLPS-Ori-0807 | Oryza indica | 49.67 | 3e-152 | 451 |
| LLPS-Met-2252 | Medicago truncatula | 49.57 | 2e-157 | 463 |
| LLPS-Thc-1470 | Theobroma cacao | 49.56 | 1e-158 | 467 |
| LLPS-Orp-0771 | Oryza punctata | 49.45 | 7e-160 | 470 |
| LLPS-Orm-0144 | Oryza meridionalis | 49.24 | 9e-152 | 449 |
| LLPS-Abg-1120 | Absidia glauca | 49.24 | 2e-157 | 463 |
| LLPS-Zyt-1029 | Zymoseptoria tritici | 49.24 | 2e-156 | 461 |
| LLPS-Viv-1917 | Vitis vinifera | 49.23 | 7e-155 | 457 |
| LLPS-Cog-0539 | Colletotrichum gloeosporioides | 49.23 | 3e-162 | 475 |
| LLPS-Brd-2067 | Brachypodium distachyon | 49.23 | 3e-156 | 460 |
| LLPS-Sol-1804 | Solanum lycopersicum | 49.23 | 2e-155 | 458 |
| LLPS-Hea-1005 | Helianthus annuus | 49.23 | 1e-155 | 459 |
| LLPS-Trr-0767 | Trichoderma reesei | 49.14 | 6e-159 | 467 |
| LLPS-Mae-0914 | Manihot esculenta | 49.13 | 8e-159 | 467 |
| LLPS-Fus-0468 | Fusarium solani | 49.13 | 3e-155 | 457 |
| LLPS-Mua-1407 | Musa acuminata | 49.12 | 5e-155 | 457 |
| LLPS-Fuo-0855 | Fusarium oxysporum | 49.02 | 2e-155 | 458 |
| LLPS-Fuv-1436 | Fusarium verticillioides | 49.02 | 5e-155 | 457 |
| LLPS-Coc-0231 | Corchorus capsularis | 49.01 | 5e-154 | 455 |
| LLPS-Tru-1536 | Triticum urartu | 49.01 | 6e-155 | 459 |
| LLPS-Tra-2777 | Triticum aestivum | 49.01 | 2e-156 | 461 |
| LLPS-Phn-1207 | Phaeosphaeria nodorum | 48.92 | 4e-155 | 457 |
| LLPS-Dos-0610 | Dothistroma septosporum | 48.91 | 5e-158 | 464 |
| LLPS-Sot-0912 | Solanum tuberosum | 48.9 | 7e-155 | 457 |
| LLPS-Asf-0361 | Aspergillus flavus | 48.81 | 2e-155 | 458 |
| LLPS-Hov-0017 | Hordeum vulgare | 48.79 | 2e-153 | 458 |
| LLPS-Vir-1754 | Vigna radiata | 48.74 | 4e-143 | 430 |
| LLPS-Prp-1100 | Prunus persica | 48.68 | 3e-151 | 448 |
| LLPS-Miv-1161 | Microbotryum violaceum | 48.68 | 2e-147 | 438 |
| LLPS-Gas-0407 | Galdieria sulphuraria | 48.68 | 5e-153 | 452 |
| LLPS-Usm-1512 | Ustilago maydis | 48.6 | 2e-145 | 432 |
| LLPS-Pytr-1424 | Pyrenophora triticirepentis | 48.59 | 3e-157 | 463 |
| LLPS-Trv-1026 | Trichoderma virens | 48.59 | 1e-158 | 466 |
| LLPS-Asfu-0829 | Aspergillus fumigatus | 48.59 | 4e-155 | 457 |
| LLPS-Aso-1505 | Aspergillus oryzae | 48.59 | 5e-155 | 457 |
| LLPS-Asc-0157 | Aspergillus clavatus | 48.59 | 3e-155 | 458 |
| LLPS-Ast-1367 | Aspergillus terreus | 48.58 | 5e-147 | 436 |
| LLPS-Sei-0826 | Setaria italica | 48.57 | 5e-155 | 457 |
| LLPS-Spr-1149 | Sporisorium reilianum | 48.51 | 3e-145 | 432 |
| LLPS-Scp-0942 | Schizosaccharomyces pombe | 48.46 | 2e-151 | 447 |
| LLPS-Pyt-0570 | Pyrenophora teres | 48.37 | 8e-157 | 462 |
| LLPS-Nec-0903 | Neurospora crassa | 48.37 | 5e-154 | 454 |
| LLPS-Nef-0488 | Neosartorya fischeri | 47.94 | 1e-153 | 454 |
| LLPS-Ved-1566 | Verticillium dahliae | 47.92 | 6e-156 | 459 |
| LLPS-Bro-0240 | Brassica oleracea | 47.92 | 1e-151 | 449 |
| LLPS-Arl-1089 | Arabidopsis lyrata | 47.92 | 1e-152 | 451 |
| LLPS-Asn-0973 | Aspergillus nidulans | 47.84 | 6e-153 | 452 |
| LLPS-Mao-1426 | Magnaporthe oryzae | 47.84 | 7e-155 | 457 |
| LLPS-Scj-0794 | Schizosaccharomyces japonicus | 47.81 | 6e-151 | 446 |
| LLPS-Cogr-0461 | Colletotrichum graminicola | 47.76 | 2e-154 | 456 |
| LLPS-Brn-2794 | Brassica napus | 47.7 | 1e-151 | 448 |
| LLPS-Brr-0869 | Brassica rapa | 47.48 | 5e-151 | 447 |
| LLPS-Coo-1314 | Colletotrichum orbiculare | 47.36 | 5e-157 | 462 |
| LLPS-Art-2558 | Arabidopsis thaliana | 47.26 | 6e-151 | 447 |
| LLPS-Lem-1105 | Leptosphaeria maculans | 47.2 | 6e-152 | 449 |
| LLPS-Asni-0107 | Aspergillus niger | 47.07 | 4e-152 | 450 |
| LLPS-Blg-0322 | Blumeria graminis | 47.05 | 1e-150 | 446 |
| LLPS-Asg-0444 | Ashbya gossypii | 46.96 | 5e-141 | 422 |
| LLPS-Scc-0893 | Schizosaccharomyces cryophilus | 46.71 | 2e-147 | 437 |
| LLPS-Pug-1035 | Puccinia graminis | 46.61 | 3e-139 | 419 |
| LLPS-Kop-0138 | Komagataella pastoris | 46.59 | 3e-135 | 406 |
| LLPS-Scs-0627 | Sclerotinia sclerotiorum | 46.57 | 1e-150 | 446 |
| LLPS-Yal-0441 | Yarrowia lipolytica | 46.39 | 1e-138 | 414 |
| LLPS-Chc-0916 | Chondrus crispus | 46.26 | 8e-132 | 397 |
| LLPS-Map-1130 | Magnaporthe poae | 46.2 | 1e-148 | 441 |
| LLPS-Put-1087 | Puccinia triticina | 46.19 | 1e-138 | 418 |
| LLPS-Gag-0102 | Gaeumannomyces graminis | 46.09 | 4e-147 | 437 |
| LLPS-Sac-1435 | Saccharomyces cerevisiae | 44.92 | 5e-139 | 417 |
| LLPS-Cae-0238 | Caenorhabditis elegans | 43.42 | 1e-108 | 338 |
| LLPS-Cym-1117 | Cyanidioschyzon merolae | 42.86 | 1e-124 | 384 |
| LLPS-Crn-0911 | Cryptococcus neoformans | 41.8 | 4e-129 | 392 |