• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Trr-0767
TRIREDRAFT_75589

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: 3-hydroxy-3-methylglutaryl coenzyme A synthase
Gene Name: TRIREDRAFT_75589
Ensembl Gene: TRIREDRAFT_75589
Ensembl Protein: EGR51279
Organism: Trichoderma reesei
Taxa ID: 431241
LLPS Type: Regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-bodyPredicted from orthologs(View)

▼ FUNCTION

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEGR51279EGR51279
UniProtG0RBA5, G0RBA5_HYPJQ
GeneBankGL985058EGR51279.1
RefSeqXM_006962736.1XP_006962798.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAARPQNIGI  KAIEIYFPSQ  YVEQSELEKF  DGVAAGKYTI  GLGQTKMAFC  DDREDIYSMA  60
61    LTVTSRLIKN  YNIDVNSIGR  LEVGTETILD  KSKSVKTVLM  QLFGDNTNIE  GVDTLNACYG  120
121   GTNAFLNSVN  WVESSAWDGR  DAIVVAGDIA  LYAKGAARPT  GGAGAVAILV  GPNAPIVVEP  180
181   GLRGTYMQHA  YDFYKPDLTS  EYPVVDGHFS  LTCYTRALDA  AYRDYNKKEA  RLTNGNANGV  240
241   DSSKTPLDRF  DYLAFHAPTC  KLVQKSYARL  LYHDFLSNAD  LPAFAEVAPE  LRDMDYEKSL  300
301   TDKALEKVFM  TLTKKRYQER  VNPAIQVATL  CGNMYCASVW  GGLASLLSFA  DSKALENKRI  360
361   GLFSYGSGLA  ATFLSLRVVG  NVETIGKTLD  IATRLEARRA  VPPETYDEMC  NLRKQAHLQK  420
421   NYTPKGDVST  IAPGTYYLEK  VDDMFKREYA  VKA  453
Nucleotide CDS Sequence (FASTA)
1     ATGGCCGCCC  GACCTCAGAA  CATTGGCATC  AAGGCCATTG  AGATTTACTT  CCCCAGCCAG  60
61    TATGTCGAGC  AGTCCGAGCT  TGAAAAGTTC  GACGGCGTTG  CCGCCGGCAA  GTACACCATT  120
121   GGTCTCGGCC  AGACCAAGAT  GGCCTTTTGC  GACGACCGCG  AGGACATCTA  CTCAATGGCT  180
181   CTGACCGTCA  CCTCGAGACT  CATCAAGAAC  TACAACATCG  ACGTCAACTC  GATTGGCCGC  240
241   CTCGAGGTCG  GCACCGAGAC  CATCCTGGAC  AAGTCCAAGT  CGGTCAAGAC  GGTGCTGATG  300
301   CAGCTGTTTG  GCGACAACAC  CAACATTGAG  GGCGTCGACA  CCCTCAACGC  CTGCTACGGC  360
361   GGCACAAACG  CCTTCCTCAA  CAGCGTCAAC  TGGGTCGAGT  CGTCCGCCTG  GGACGGCCGC  420
421   GATGCCATTG  TCGTTGCTGG  CGACATTGCC  CTCTACGCAA  AGGGTGCTGC  CCGCCCCACT  480
481   GGTGGCGCCG  GTGCCGTGGC  CATTCTTGTT  GGCCCCAACG  CTCCCATTGT  TGTCGAGCCC  540
541   GGCCTGCGCG  GCACCTACAT  GCAGCACGCC  TACGACTTCT  ACAAGCCCGA  CCTGACCAGC  600
601   GAGTACCCCG  TCGTCGACGG  CCACTTCTCG  CTGACCTGCT  ACACCCGCGC  CCTCGACGCC  660
661   GCCTACCGCG  ACTACAACAA  GAAGGAGGCC  AGGCTGACCA  ATGGCAACGC  CAACGGCGTC  720
721   GACTCCTCCA  AGACGCCTCT  CGACCGCTTC  GACTACCTTG  CCTTCCACGC  CCCCACCTGC  780
781   AAGCTGGTCC  AGAAGTCGTA  CGCCCGACTG  CTGTACCATG  ACTTCCTCAG  CAACGCTGAC  840
841   CTCCCTGCCT  TTGCCGAGGT  GGCCCCTGAG  CTGCGCGACA  TGGACTACGA  AAAGTCCCTG  900
901   ACCGACAAGG  CCCTCGAGAA  GGTCTTCATG  ACGCTCACCA  AGAAGCGCTA  CCAGGAGCGC  960
961   GTCAACCCCG  CCATCCAGGT  CGCCACCCTG  TGCGGCAACA  TGTACTGCGC  CAGCGTCTGG  1020
1021  GGTGGCCTGG  CCAGCCTGCT  GTCCTTTGCC  GACAGCAAGG  CCCTCGAGAA  CAAGCGAATT  1080
1081  GGTCTCTTCA  GCTACGGCTC  CGGCCTGGCC  GCCACCTTCC  TGTCCCTGCG  CGTCGTTGGC  1140
1141  AACGTCGAGA  CCATTGGCAA  GACTCTGGAC  ATTGCCACCC  GTCTGGAGGC  CCGCCGCGCC  1200
1201  GTCCCCCCTG  AGACGTACGA  TGAGATGTGC  AACCTCCGAA  AGCAGGCCCA  CCTCCAGAAG  1260
1261  AACTACACTC  CCAAGGGCGA  CGTCTCCACC  ATCGCTCCCG  GCACCTACTA  CCTGGAGAAG  1320
1321  GTCGACGACA  TGTTCAAGCG  AGAGTATGCC  GTCAAGGCCT  AA  1362

▼ KEYWORD

ID
Family
Complete proteome
Lipid biosynthesis
Lipid metabolism
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
Hydroxymethylglutaryl-CoA synthase activity
Biological Process
Isoprenoid biosynthetic process
Biological Process
Sterol biosynthetic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Trv-1026Trichoderma virens94.260.0 896
LLPS-Beb-1178Beauveria bassiana86.090.0 823
LLPS-Fuo-0855Fusarium oxysporum83.480.0 803
LLPS-Fuv-1436Fusarium verticillioides83.040.0 800
LLPS-Fus-0468Fusarium solani82.560.0 793
LLPS-Cog-0539Colletotrichum gloeosporioides81.90.0 790
LLPS-Mao-1426Magnaporthe oryzae81.80.0 795
LLPS-Nec-0903Neurospora crassa80.840.0 788
LLPS-Coo-1314Colletotrichum orbiculare80.60.0 783
LLPS-Ved-1566Verticillium dahliae80.350.0 774
LLPS-Cogr-0461Colletotrichum graminicola78.570.0 762
LLPS-Map-1130Magnaporthe poae78.190.0 764
LLPS-Gag-0102Gaeumannomyces graminis76.680.0 760
LLPS-Tum-0184Tuber melanosporum75.06e-65 211
LLPS-Scs-0627Sclerotinia sclerotiorum74.070.0 728
LLPS-Blg-0322Blumeria graminis71.430.0 692
LLPS-Pytr-1424Pyrenophora triticirepentis70.020.0 671
LLPS-Pyt-0570Pyrenophora teres69.80.0 672
LLPS-Asfu-0829Aspergillus fumigatus69.630.0 675
LLPS-Asni-0107Aspergillus niger69.570.0 680
LLPS-Asc-0157Aspergillus clavatus69.350.0 677
LLPS-Nef-0488Neosartorya fischeri68.760.0 669
LLPS-Asf-0361Aspergillus flavus68.70.0 665
LLPS-Aso-1505Aspergillus oryzae68.480.0 664
LLPS-Phn-1207Phaeosphaeria nodorum68.410.0 657
LLPS-Asn-0973Aspergillus nidulans67.690.0 654
LLPS-Zyt-1029Zymoseptoria tritici67.470.0 661
LLPS-Ast-1367Aspergillus terreus67.250.0 638
LLPS-Lem-1105Leptosphaeria maculans67.240.0 660
LLPS-Dos-0610Dothistroma septosporum65.20.0 652
LLPS-Scj-0794Schizosaccharomyces japonicus63.090.0 590
LLPS-Scp-0942Schizosaccharomyces pombe61.50.0 577
LLPS-Kop-0138Komagataella pastoris61.330.0 548
LLPS-Sac-1435Saccharomyces cerevisiae60.890.0 566
LLPS-Asg-0444Ashbya gossypii60.890.0 562
LLPS-Yal-0441Yarrowia lipolytica60.840.0 566
LLPS-Scc-0893Schizosaccharomyces cryophilus59.960.0 559
LLPS-Abg-1120Absidia glauca55.111e-171 497
LLPS-Ora-0792Ornithorhynchus anatinus55.089e-166 484
LLPS-Xet-0524Xenopus tropicalis53.84e-166 486
LLPS-Pes-0328Pelodiscus sinensis53.782e-165 484
LLPS-Orn-0318Oreochromis niloticus53.665e-167 488
LLPS-Pof-0173Poecilia formosa53.551e-167 489
LLPS-Fia-0903Ficedula albicollis53.483e-163 478
LLPS-Mod-0801Monodelphis domestica53.362e-162 476
LLPS-Miv-1161Microbotryum violaceum53.322e-170 495
LLPS-Gaga-0903Gallus gallus53.261e-161 475
LLPS-Anp-2768Anas platyrhynchos53.266e-164 480
LLPS-Lac-1646Latimeria chalumnae53.217e-150 444
LLPS-Sah-0563Sarcophilus harrisii53.152e-161 474
LLPS-Tag-0036Taeniopygia guttata53.153e-161 473
LLPS-Gaa-1504Gasterosteus aculeatus53.131e-166 486
LLPS-Icp-1582Ictalurus punctatus53.137e-165 483
LLPS-Xim-1567Xiphophorus maculatus53.123e-166 486
LLPS-Anc-3520Anolis carolinensis53.091e-163 479
LLPS-Drm-1629Drosophila melanogaster53.077e-163 475
LLPS-Loa-3273Loxodonta africana53.045e-164 480
LLPS-Chr-0955Chlamydomonas reinhardtii53.05e-25 112
LLPS-Scm-0059Scophthalmus maximus52.933e-165 483
LLPS-Otg-2322Otolemur garnettii52.937e-162 475
LLPS-Dio-2516Dipodomys ordii52.833e-161 473
LLPS-Leo-2790Lepisosteus oculatus52.86e-166 485
LLPS-Aon-2854Aotus nancymaae52.711e-162 476
LLPS-Poa-4436Pongo abelii52.715e-163 478
LLPS-Urm-2980Ursus maritimus52.712e-161 473
LLPS-Mal-1252Mandrillus leucophaeus52.494e-162 475
LLPS-Paa-2071Papio anubis52.494e-162 475
LLPS-Cea-2629Cercocebus atys52.494e-162 475
LLPS-Maf-3971Macaca fascicularis52.494e-162 475
LLPS-Caj-2099Callithrix jacchus52.497e-162 475
LLPS-Gog-4404Gorilla gorilla52.495e-162 475
LLPS-Mam-3846Macaca mulatta52.494e-162 475
LLPS-Caf-2031Canis familiaris52.491e-161 474
LLPS-Nol-4236Nomascus leucogenys52.494e-162 475
LLPS-Man-4484Macaca nemestrina52.494e-162 475
LLPS-Hos-3829Homo sapiens52.495e-162 475
LLPS-Pap-1637Pan paniscus52.491e-160 474
LLPS-Pat-4659Pan troglodytes52.491e-160 474
LLPS-Usm-1512Ustilago maydis52.412e-167 487
LLPS-Chs-2150Chlorocebus sabaeus52.394e-162 475
LLPS-Pug-1035Puccinia graminis52.335e-159 468
LLPS-Mup-0403Mustela putorius furo52.286e-162 475
LLPS-Orc-3128Oryctolagus cuniculus52.281e-161 475
LLPS-Scf-3655Scleropages formosus52.267e-166 485
LLPS-Aim-3593Ailuropoda melanoleuca52.179e-161 472
LLPS-Rhb-3716Rhinopithecus bieti52.177e-162 475
LLPS-Asm-0147Astyanax mexicanus52.146e-163 478
LLPS-Fud-1107Fukomys damarensis52.062e-160 471
LLPS-Cap-1728Cavia porcellus52.063e-160 471
LLPS-Eqc-3556Equus caballus52.069e-159 467
LLPS-Fec-0802Felis catus52.062e-159 469
LLPS-Dar-0606Danio rerio51.942e-163 479
LLPS-Put-1087Puccinia triticina51.884e-158 466
LLPS-Ran-0771Rattus norvegicus51.842e-159 468
LLPS-Mum-0974Mus musculus51.844e-160 470
LLPS-Ict-2503Ictidomys tridecemlineatus51.842e-160 471
LLPS-Orl-2145Oryzias latipes51.832e-163 478
LLPS-Mel-0825Melampsora laricipopulina51.557e-157 462
LLPS-Php-2177Physcomitrella patens51.542e-154 453
LLPS-Bot-4869Bos taurus51.522e-160 473
LLPS-Ova-3397Ovis aries51.522e-160 473
LLPS-Mea-4383Mesocricetus auratus51.413e-159 468
LLPS-Spr-1149Sporisorium reilianum51.415e-162 473
LLPS-Meg-1910Meleagris gallopavo51.411e-160 471
LLPS-Sus-3258Sus scrofa51.37e-162 475
LLPS-Myl-0681Myotis lucifugus51.192e-159 469
LLPS-Ten-2792Tetraodon nigroviridis50.647e-152 448
LLPS-Tar-1158Takifugu rubripes50.12e-160 472
LLPS-Cas-3739Carlito syrichta49.461e-154 456
LLPS-Sei-0826Setaria italica48.73e-146 433
LLPS-Brd-2067Brachypodium distachyon48.73e-146 433
LLPS-Hov-0017Hordeum vulgare48.592e-144 432
LLPS-Cii-1416Ciona intestinalis48.541e-153 453
LLPS-Mae-0914Manihot esculenta48.471e-144 429
LLPS-Gas-0407Galdieria sulphuraria48.442e-142 423
LLPS-Tra-2777Triticum aestivum48.373e-144 428
LLPS-Lep-1177Leersia perrieri48.281e-141 421
LLPS-Tru-1536Triticum urartu48.274e-144 429
LLPS-Glm-1399Glycine max48.161e-141 421
LLPS-Thc-1470Theobroma cacao48.167e-145 429
LLPS-Orp-0771Oryza punctata48.162e-142 423
LLPS-Gor-1631Gossypium raimondii48.163e-142 422
LLPS-Sob-2075Sorghum bicolor48.161e-144 429
LLPS-Coc-0231Corchorus capsularis48.144e-142 422
LLPS-Met-2252Medicago truncatula48.063e-143 425
LLPS-Cus-0542Cucumis sativus48.032e-141 421
LLPS-Hea-1005Helianthus annuus48.031e-143 426
LLPS-Orgl-0787Oryza glumaepatula47.954e-143 425
LLPS-Orb-2178Oryza barthii47.955e-144 427
LLPS-Orni-0345Oryza nivara47.955e-144 427
LLPS-Orr-2294Oryza rufipogon47.959e-144 426
LLPS-Org-0075Oryza glaberrima47.955e-144 427
LLPS-Ors-1230Oryza sativa47.955e-144 427
LLPS-Nia-1392Nicotiana attenuata47.952e-141 420
LLPS-Orbr-1079Oryza brachyantha47.854e-142 422
LLPS-Cis-0727Ciona savignyi47.81e-151 448
LLPS-Sot-0912Solanum tuberosum47.737e-143 424
LLPS-Zem-1296Zea mays47.732e-143 426
LLPS-Crn-0911Cryptococcus neoformans47.516e-157 461
LLPS-Brr-0869Brassica rapa47.493e-139 415
LLPS-Prp-1100Prunus persica47.489e-141 419
LLPS-Pot-1818Populus trichocarpa47.482e-140 418
LLPS-Brn-2658Brassica napus47.394e-139 414
LLPS-Bro-1975Brassica oleracea47.398e-139 414
LLPS-Phv-1668Phaseolus vulgaris47.291e-141 421
LLPS-Dac-1527Daucus carota47.261e-144 429
LLPS-Orm-2047Oryza meridionalis47.243e-136 407
LLPS-Sol-2041Solanum lycopersicum47.083e-141 420
LLPS-Via-2303Vigna angularis46.947e-140 416
LLPS-Ori-0807Oryza indica46.948e-138 412
LLPS-Viv-1917Vitis vinifera46.942e-139 415
LLPS-Amt-2124Amborella trichopoda46.923e-133 399
LLPS-Arl-1089Arabidopsis lyrata46.742e-138 412
LLPS-Sem-1815Selaginella moellendorffii46.711e-134 403
LLPS-Art-2558Arabidopsis thaliana46.626e-138 411
LLPS-Vir-1754Vigna radiata46.336e-129 392
LLPS-Mua-1407Musa acuminata44.95e-137 409
LLPS-Chc-0916Chondrus crispus42.982e-109 338
LLPS-Cae-0238Caenorhabditis elegans39.741e-98 310
LLPS-Cym-1117Cyanidioschyzon merolae38.319e-110 343
LLPS-Tut-1708Tursiops truncatus38.213e-97 305