• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Spr-1149
sr16348

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: 3-hydroxy-3-methylglutaryl coenzyme A synthase
Gene Name: sr16348
Ensembl Gene: sr16348
Ensembl Protein: CBQ70143
Organism: Sporisorium reilianum
Taxa ID: 999809
LLPS Type: Regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-bodyPredicted from orthologs(View)

▼ FUNCTION

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblCBQ70143CBQ70143
UniProtE6ZSD6, E6ZSD6_SPORE
GeneBankFQ311440CBQ70143.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSARPQNVGI  KAIEIYFPRR  CISEDELEDF  DGVAKGKYTI  GFGQKYMACT  DDREDINSFA  60
61    LSVVSGLLEK  NNIDPRSIGR  LDVGTETIID  KSKSVKTVLM  DLFAPSGNNN  IEGIDSKNAC  120
121   YGGTAALFNA  VNWVESSSWD  GRDAIVVAGD  IAIYAEGSAR  PVGGAGAVAM  LIGPDAPLVL  180
181   EPAHGTHMSN  FWDFYKPNLS  SEYPEVDGPE  TIQAYLGCLD  KTYDAYRQRA  AKLRNGAAAA  240
241   NGANGHSDAS  NLASIKVDDF  DYTLFHSPYS  KLVQKGFGRL  LYNDYFSDPK  NDKYASIPAN  300
301   FAELDRKSTI  TNKDVEKAFA  AFGKEAQQTK  LEPGMDTVRR  CGNMYTASLY  GGLVSLLSNI  360
361   PSQEIQGKRV  LLYSFGSGAA  ASMFVIRVNG  STEQLVKAAD  LKNRLASMKV  VPCETYVEAL  420
421   KTREATHNAV  NHKPVGLLEN  LWPGAYYLEN  VDHMYRRTYG  RIPANAN  467

▼ KEYWORD

ID
Family
Complete proteome
Lipid biosynthesis
Lipid metabolism
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
Hydroxymethylglutaryl-CoA synthase activity
Biological Process
Acetyl-CoA metabolic process
Biological Process
Ergosterol biosynthetic process
Biological Process
Farnesyl diphosphate biosynthetic process, mevalonate pathway

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Usm-1512Ustilago maydis93.580.0 904
LLPS-Tum-0184Tuber melanosporum63.781e-49 172
LLPS-Crn-0911Cryptococcus neoformans59.050.0 586
LLPS-Miv-1161Microbotryum violaceum58.550.0 544
LLPS-Mel-0825Melampsora laricipopulina57.520.0 546
LLPS-Pug-1035Puccinia graminis57.30.0 553
LLPS-Put-1087Puccinia triticina57.110.0 550
LLPS-Zyt-1029Zymoseptoria tritici54.012e-176 510
LLPS-Asfu-0829Aspergillus fumigatus53.72e-179 518
LLPS-Dos-0610Dothistroma septosporum53.614e-176 509
LLPS-Mao-1426Magnaporthe oryzae53.481e-170 495
LLPS-Nef-0488Neosartorya fischeri53.261e-177 513
LLPS-Asc-0157Aspergillus clavatus53.261e-175 508
LLPS-Nec-0903Neurospora crassa53.047e-167 486
LLPS-Scs-0627Sclerotinia sclerotiorum53.042e-173 503
LLPS-Phn-1207Phaeosphaeria nodorum52.613e-169 492
LLPS-Blg-0322Blumeria graminis52.472e-166 485
LLPS-Pytr-1424Pyrenophora triticirepentis52.398e-173 501
LLPS-Pyt-0570Pyrenophora teres52.393e-173 502
LLPS-Map-1130Magnaporthe poae52.383e-169 492
LLPS-Cog-0539Colletotrichum gloeosporioides52.174e-166 483
LLPS-Asf-0361Aspergillus flavus51.963e-175 507
LLPS-Yal-0441Yarrowia lipolytica51.861e-158 464
LLPS-Fuo-0855Fusarium oxysporum51.751e-160 470
LLPS-Fuv-1436Fusarium verticillioides51.759e-160 468
LLPS-Aso-1505Aspergillus oryzae51.741e-174 506
LLPS-Beb-1178Beauveria bassiana51.637e-165 481
LLPS-Gag-0102Gaeumannomyces graminis51.593e-167 487
LLPS-Cogr-0461Colletotrichum graminicola51.522e-161 472
LLPS-Trr-0767Trichoderma reesei51.415e-162 473
LLPS-Trv-1026Trichoderma virens51.32e-159 467
LLPS-Coo-1314Colletotrichum orbiculare51.38e-165 481
LLPS-Lem-1105Leptosphaeria maculans51.291e-168 490
LLPS-Asni-0107Aspergillus niger51.096e-175 506
LLPS-Ved-1566Verticillium dahliae50.879e-159 465
LLPS-Pes-0328Pelodiscus sinensis50.533e-151 448
LLPS-Icp-1582Ictalurus punctatus50.536e-150 445
LLPS-Lac-1646Latimeria chalumnae50.456e-138 414
LLPS-Asn-0973Aspergillus nidulans50.442e-168 490
LLPS-Tag-2503Taeniopygia guttata50.421e-152 450
LLPS-Mum-4937Mus musculus50.421e-148 441
LLPS-Mod-0801Monodelphis domestica50.321e-150 446
LLPS-Ora-0792Ornithorhynchus anatinus50.113e-150 446
LLPS-Xet-0524Xenopus tropicalis50.06e-150 445
LLPS-Fus-0468Fusarium solani50.09e-159 465
LLPS-Ast-1367Aspergillus terreus50.01e-161 472
LLPS-Loa-3273Loxodonta africana49.894e-152 450
LLPS-Sah-0563Sarcophilus harrisii49.892e-150 446
LLPS-Ran-1708Rattus norvegicus49.797e-148 439
LLPS-Bot-3674Bos taurus49.793e-146 435
LLPS-Leo-2790Lepisosteus oculatus49.794e-153 453
LLPS-Abg-1120Absidia glauca49.783e-152 448
LLPS-Anc-3520Anolis carolinensis49.684e-149 443
LLPS-Orn-0318Oreochromis niloticus49.685e-150 445
LLPS-Ova-3899Ovis aries49.581e-145 433
LLPS-Gaa-1504Gasterosteus aculeatus49.588e-150 444
LLPS-Poa-4436Pongo abelii49.577e-150 444
LLPS-Drm-1629Drosophila melanogaster49.572e-151 447
LLPS-Fec-0802Felis catus49.474e-150 445
LLPS-Dio-2516Dipodomys ordii49.477e-149 442
LLPS-Anp-2768Anas platyrhynchos49.379e-151 447
LLPS-Nol-4236Nomascus leucogenys49.362e-149 444
LLPS-Mam-3846Macaca mulatta49.362e-149 444
LLPS-Orc-4320Oryctolagus cuniculus49.362e-145 433
LLPS-Man-4484Macaca nemestrina49.362e-149 444
LLPS-Pap-1637Pan paniscus49.364e-147 440
LLPS-Pat-4659Pan troglodytes49.363e-147 441
LLPS-Paa-2071Papio anubis49.362e-149 444
LLPS-Mal-1252Mandrillus leucophaeus49.362e-149 444
LLPS-Caj-2099Callithrix jacchus49.363e-149 443
LLPS-Gog-4404Gorilla gorilla49.368e-149 442
LLPS-Cea-2629Cercocebus atys49.362e-149 444
LLPS-Maf-3971Macaca fascicularis49.362e-149 444
LLPS-Chs-2150Chlorocebus sabaeus49.361e-149 444
LLPS-Mup-0403Mustela putorius furo49.268e-149 442
LLPS-Aon-2854Aotus nancymaae49.265e-150 445
LLPS-Ict-0823Ictidomys tridecemlineatus49.251e-145 433
LLPS-Rhb-3716Rhinopithecus bieti49.153e-149 443
LLPS-Meg-1910Meleagris gallopavo49.151e-148 441
LLPS-Caf-2031Canis familiaris49.042e-148 441
LLPS-Otg-2322Otolemur garnettii49.042e-149 444
LLPS-Urm-2980Ursus maritimus49.048e-148 439
LLPS-Pof-0173Poecilia formosa49.042e-147 439
LLPS-Fia-0903Ficedula albicollis48.952e-149 444
LLPS-Hos-2947Homo sapiens48.941e-145 433
LLPS-Cap-1728Cavia porcellus48.832e-148 441
LLPS-Mea-4383Mesocricetus auratus48.832e-147 438
LLPS-Gaga-0903Gallus gallus48.644e-148 441
LLPS-Eqc-3556Equus caballus48.622e-147 438
LLPS-Aim-3593Ailuropoda melanoleuca48.623e-147 438
LLPS-Xim-1567Xiphophorus maculatus48.621e-146 436
LLPS-Sus-3258Sus scrofa48.625e-149 442
LLPS-Scf-3655Scleropages formosus48.51e-150 447
LLPS-Fud-1107Fukomys damarensis48.412e-146 436
LLPS-Cas-3739Carlito syrichta48.37e-141 421
LLPS-Myl-0681Myotis lucifugus48.212e-146 436
LLPS-Asm-0147Astyanax mexicanus48.22e-146 436
LLPS-Kop-0138Komagataella pastoris48.143e-143 425
LLPS-Asg-0444Ashbya gossypii48.142e-150 444
LLPS-Sac-1435Saccharomyces cerevisiae47.71e-148 440
LLPS-Scm-0059Scophthalmus maximus47.265e-143 427
LLPS-Orl-2145Oryzias latipes47.081e-143 429
LLPS-Glm-1399Glycine max47.011e-140 419
LLPS-Chr-0955Chlamydomonas reinhardtii47.01e-1995.9
LLPS-Viv-1917Vitis vinifera46.99e-135 404
LLPS-Dar-0606Danio rerio46.851e-143 429
LLPS-Via-2303Vigna angularis46.683e-135 405
LLPS-Dac-1527Daucus carota46.682e-136 409
LLPS-Hea-1005Helianthus annuus46.674e-137 410
LLPS-Scj-0794Schizosaccharomyces japonicus46.621e-142 424
LLPS-Cii-1416Ciona intestinalis46.613e-142 424
LLPS-Scp-0942Schizosaccharomyces pombe46.572e-140 418
LLPS-Sem-1815Selaginella moellendorffii46.511e-131 395
LLPS-Coc-0231Corchorus capsularis46.471e-134 404
LLPS-Php-2177Physcomitrella patens46.381e-137 411
LLPS-Met-2252Medicago truncatula46.371e-136 409
LLPS-Prp-1100Prunus persica46.341e-133 401
LLPS-Ten-2792Tetraodon nigroviridis46.194e-133 400
LLPS-Phv-1668Phaseolus vulgaris46.152e-139 416
LLPS-Pot-1818Populus trichocarpa46.068e-134 402
LLPS-Cus-0542Cucumis sativus45.926e-130 392
LLPS-Thc-1470Theobroma cacao45.917e-134 402
LLPS-Tar-1158Takifugu rubripes45.827e-140 420
LLPS-Cis-0727Ciona savignyi45.811e-140 420
LLPS-Scc-0893Schizosaccharomyces cryophilus45.715e-134 401
LLPS-Gor-1631Gossypium raimondii45.672e-131 395
LLPS-Mae-0914Manihot esculenta45.474e-131 394
LLPS-Tra-2777Triticum aestivum45.44e-132 397
LLPS-Vir-1754Vigna radiata45.335e-120 369
LLPS-Tru-1536Triticum urartu45.284e-131 396
LLPS-Sol-1804Solanum lycopersicum45.262e-130 393
LLPS-Bro-0240Brassica oleracea45.181e-132 398
LLPS-Hov-0017Hordeum vulgare45.186e-131 398
LLPS-Brn-2794Brassica napus45.186e-133 399
LLPS-Lep-1177Leersia perrieri45.162e-132 398
LLPS-Orm-2047Oryza meridionalis45.059e-125 378
LLPS-Nia-1129Nicotiana attenuata44.991e-131 396
LLPS-Orbr-1079Oryza brachyantha44.992e-133 400
LLPS-Sob-2075Sorghum bicolor44.975e-135 404
LLPS-Brd-2067Brachypodium distachyon44.971e-133 401
LLPS-Sot-0912Solanum tuberosum44.922e-131 395
LLPS-Org-0075Oryza glaberrima44.873e-134 402
LLPS-Orr-2294Oryza rufipogon44.875e-134 402
LLPS-Orp-0771Oryza punctata44.875e-133 399
LLPS-Ors-1230Oryza sativa44.873e-134 402
LLPS-Orgl-0787Oryza glumaepatula44.872e-134 403
LLPS-Orni-0345Oryza nivara44.873e-134 402
LLPS-Orb-2178Oryza barthii44.873e-134 402
LLPS-Sei-0826Setaria italica44.663e-133 400
LLPS-Arl-1089Arabidopsis lyrata44.542e-131 395
LLPS-Zem-1296Zea mays44.331e-132 399
LLPS-Brr-0869Brassica rapa44.333e-129 390
LLPS-Amt-2124Amborella trichopoda44.323e-120 366
LLPS-Gas-0407Galdieria sulphuraria44.081e-131 395
LLPS-Ori-0807Oryza indica43.872e-127 385
LLPS-Art-2558Arabidopsis thaliana43.785e-130 392
LLPS-Mua-1407Musa acuminata43.287e-129 389
LLPS-Chc-0916Chondrus crispus42.954e-107 333
LLPS-Cym-1117Cyanidioschyzon merolae40.123e-109 343
LLPS-Cae-0238Caenorhabditis elegans38.18e-87 280
LLPS-Tut-1708Tursiops truncatus35.315e-78 256