• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Fud-1107
H920_07780

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: 3-hydroxy-3-methylglutaryl coenzyme A synthase
Gene Name: H920_07780
Ensembl Gene: ENSFDAG00000014577.1
Ensembl Protein: ENSFDAP00000005612.1
Organism: Fukomys damarensis
Taxa ID: 885580
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-bodyPredicted from orthologs(View)

▼ FUNCTION


This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MPGSLPLNAE  ACWPKDVGIV  ALEIYFPSQY  VDQTQLEKYD  GVDAGKYTIG  LGQAKMGFCS  60
61    DREDITSLCL  TVVQKLMERN  NLSYDCIGRL  EVGTETIIDK  SKSVKSNLMQ  LFEESGNTDI  120
121   EGIDTTNACY  GGTAAVFNAV  NWIESSSWDG  RYALVVAGDI  AVYATGNARP  TGGAGAVALL  180
181   IGPNAALIFD  RGLRGTHMQH  AYDFYKPDML  SEYPIVDGKL  SIQCYLSALD  RCYSVYRKKI  240
241   RAQWQKEGND  KDFTLNDFGF  MIFHSPYCKL  VQKSLARMML  NDFLNDQNRD  KNTIYSGLEA  300
301   FGDVKLEDTY  FDRDVEKAFM  KASSELFNQK  TKASLLVSNQ  NGNMYTSSVY  GSLASVLAQY  360
361   SPQQLAGKRI  GVFSYGSGLA  ATLYSLRVTQ  DATPGSALDK  ITASLCDLKS  RLDSRTCVVP  420
421   DIFAENMKLR  EDTHHLANYI  PQSSVDSLFE  GTWYLVRVDE  KHRRTYARRP  SPNDDTLDEG  480
481   VGLVHSNTAT  EHIPSPAKKV  PRLPATGTEP  EAAVISNGEH  520
Nucleotide CDS Sequence (FASTA)
1     ATGCCTGGGT  CACTTCCTTT  GAATGCTGAA  GCTTGTTGGC  CAAAAGATGT  GGGAATCGTT  60
61    GCCCTTGAGA  TCTATTTTCC  TTCTCAATAT  GTTGATCAAA  CGCAATTGGA  AAAATACGAT  120
121   GGTGTCGATG  CTGGAAAGTA  TACCATTGGC  TTGGGCCAGG  CGAAGATGGG  CTTCTGCTCA  180
181   GATCGAGAGG  ACATCACCTC  TCTTTGCCTG  ACTGTGGTTC  AGAAACTGAT  GGAAAGAAAT  240
241   AATCTTTCTT  ATGACTGCAT  TGGGCGGCTT  GAGGTTGGAA  CAGAGACAAT  CATCGACAAA  300
301   TCAAAGTCTG  TGAAGAGTAA  TTTAATGCAG  CTATTTGAGG  AATCTGGAAA  TACAGACATA  360
361   GAAGGAATAG  ATACGACTAA  TGCATGCTAT  GGAGGCACAG  CTGCTGTCTT  CAATGCTGTT  420
421   AACTGGATTG  AGTCCAGCTC  TTGGGATGGA  CGGTATGCTC  TGGTAGTTGC  AGGAGATATT  480
481   GCTGTATATG  CCACAGGAAA  TGCCAGACCT  ACAGGTGGAG  CTGGAGCTGT  GGCTCTGCTA  540
541   ATTGGGCCAA  ATGCTGCTTT  AATTTTTGAC  CGAGGGCTTC  GTGGAACACA  TATGCAGCAT  600
601   GCCTATGACT  TTTACAAGCC  TGATATGCTC  TCTGAATATC  CTATAGTAGA  TGGAAAACTC  660
661   TCTATACAGT  GCTACCTCAG  TGCATTAGAC  CGCTGCTATT  CTGTCTACCG  TAAAAAGATC  720
721   CGTGCCCAGT  GGCAGAAAGA  GGGAAATGAT  AAAGATTTTA  CCTTGAATGA  CTTTGGCTTC  780
781   ATGATTTTTC  ACTCACCATA  TTGTAAACTG  GTTCAGAAAT  CCCTAGCTCG  GATGATGCTG  840
841   AATGATTTCC  TTAATGACCA  GAACAGAGAT  AAAAATACTA  TTTATAGCGG  ACTGGAAGCC  900
901   TTTGGGGATG  TTAAATTAGA  AGATACTTAC  TTTGACAGAG  ATGTGGAAAA  GGCATTTATG  960
961   AAGGCCAGTT  CTGAACTCTT  TAATCAAAAA  ACAAAGGCTT  CTTTGCTTGT  ATCAAATCAA  1020
1021  AATGGAAATA  TGTATACATC  TTCAGTATAT  GGTTCCCTTG  CTTCTGTTTT  AGCACAGTAC  1080
1081  TCACCTCAGC  AATTGGCAGG  AAAGAGGATT  GGAGTATTCT  CTTATGGTTC  TGGTTTGGCT  1140
1141  GCCACCCTGT  ATTCTCTTAG  AGTCACTCAA  GATGCCACAC  CAGGGTCTGC  CCTTGATAAA  1200
1201  ATAACAGCAA  GTTTATGTGA  TCTTAAATCA  AGGCTTGACT  CGAGAACTTG  TGTGGTACCT  1260
1261  GACATCTTTG  CTGAAAACAT  GAAGCTCAGA  GAGGACACTC  ATCACTTGGC  CAACTATATT  1320
1321  CCCCAGAGTT  CAGTAGATTC  ACTTTTTGAA  GGAACATGGT  ACCTAGTTAG  AGTGGATGAA  1380
1381  AAGCATAGAA  GAACTTACGC  TCGACGCCCT  TCTCCAAATG  ATGACACTTT  GGACGAGGGA  1440
1441  GTAGGACTTG  TTCATTCAAA  CACAGCAACT  GAGCATATCC  CAAGCCCTGC  TAAGAAAGTG  1500
1501  CCAAGACTTC  CCGCAACAGG  AACAGAACCT  GAAGCAGCTG  TCATTAGTAA  TGGGGAACAT  1560
1561  TAA  1563

▼ KEYWORD


ID
Family
Complete proteome
Lipid biosynthesis
Lipid metabolism
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transferase

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Extracellular region
Molecular Function
Chemokine activity
Molecular Function
Hydroxymethylglutaryl-CoA synthase activity
Biological Process
Immune response
Biological Process
Isoprenoid biosynthetic process
Biological Process
Sterol biosynthetic process

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cap-1728Cavia porcellus96.540.01058
LLPS-Ict-2503Ictidomys tridecemlineatus96.150.01055
LLPS-Caj-2099Callithrix jacchus95.960.01033
LLPS-Orc-3128Oryctolagus cuniculus95.770.01051
LLPS-Maf-3971Macaca fascicularis95.580.01029
LLPS-Cea-2629Cercocebus atys95.580.01029
LLPS-Mal-1252Mandrillus leucophaeus95.580.01029
LLPS-Paa-2071Papio anubis95.580.01029
LLPS-Man-4484Macaca nemestrina95.580.01029
LLPS-Mam-3846Macaca mulatta95.580.01029
LLPS-Chs-2150Chlorocebus sabaeus95.380.01026
LLPS-Aon-2854Aotus nancymaae95.380.01030
LLPS-Otg-2322Otolemur garnettii95.380.01024
LLPS-Caf-2031Canis familiaris95.380.01031
LLPS-Nol-4236Nomascus leucogenys95.380.01028
LLPS-Gog-4404Gorilla gorilla95.190.01022
LLPS-Pap-1637Pan paniscus95.190.01019
LLPS-Pat-4659Pan troglodytes95.190.01019
LLPS-Rhb-3716Rhinopithecus bieti95.190.01025
LLPS-Eqc-3556Equus caballus95.190.01045
LLPS-Aim-3593Ailuropoda melanoleuca95.00.01021
LLPS-Urm-2980Ursus maritimus95.00.01020
LLPS-Hos-3829Homo sapiens95.00.01020
LLPS-Poa-4436Pongo abelii95.00.01019
LLPS-Dio-2516Dipodomys ordii94.810.01018
LLPS-Ran-0771Rattus norvegicus94.810.01042
LLPS-Mup-0403Mustela putorius furo94.810.01026
LLPS-Loa-3273Loxodonta africana94.810.01019
LLPS-Mea-4383Mesocricetus auratus94.620.01038
LLPS-Bot-4869Bos taurus94.420.01019
LLPS-Fec-0802Felis catus94.420.01020
LLPS-Mum-0974Mus musculus94.230.01038
LLPS-Ova-3397Ovis aries94.230.01013
LLPS-Myl-0681Myotis lucifugus93.080.01026
LLPS-Sus-3258Sus scrofa92.120.01019
LLPS-Mod-0801Monodelphis domestica91.540.01016
LLPS-Sah-0563Sarcophilus harrisii90.770.01008
LLPS-Ora-0792Ornithorhynchus anatinus88.680.0 966
LLPS-Gaga-0903Gallus gallus85.550.0 930
LLPS-Pes-0328Pelodiscus sinensis85.250.0 941
LLPS-Fia-0903Ficedula albicollis85.090.0 942
LLPS-Anp-2768Anas platyrhynchos84.510.0 932
LLPS-Tag-0036Taeniopygia guttata84.320.0 924
LLPS-Anc-3520Anolis carolinensis83.720.0 924
LLPS-Meg-2918Meleagris gallopavo81.190.0 733
LLPS-Leo-2790Lepisosteus oculatus80.610.0 899
LLPS-Xet-0524Xenopus tropicalis79.650.0 875
LLPS-Asm-0147Astyanax mexicanus78.50.0 868
LLPS-Dar-0606Danio rerio77.740.0 856
LLPS-Orn-0318Oreochromis niloticus77.670.0 847
LLPS-Scf-3655Scleropages formosus77.540.0 860
LLPS-Icp-1582Ictalurus punctatus77.160.0 858
LLPS-Lac-1646Latimeria chalumnae76.480.0 818
LLPS-Orl-2145Oryzias latipes75.10.0 823
LLPS-Xim-1567Xiphophorus maculatus74.660.0 813
LLPS-Pof-0173Poecilia formosa74.460.0 811
LLPS-Gaa-1504Gasterosteus aculeatus74.40.0 800
LLPS-Scm-0059Scophthalmus maximus74.210.0 804
LLPS-Tar-1158Takifugu rubripes69.650.0 796
LLPS-Ten-2792Tetraodon nigroviridis68.270.0 719
LLPS-Tum-0184Tuber melanosporum66.46e-55 187
LLPS-Drm-1629Drosophila melanogaster64.270.0 613
LLPS-Cas-3739Carlito syrichta64.240.0 653
LLPS-Cii-1416Ciona intestinalis56.780.0 563
LLPS-Cis-0727Ciona savignyi56.750.0 552
LLPS-Chr-0955Chlamydomonas reinhardtii55.567e-24 109
LLPS-Scs-0627Sclerotinia sclerotiorum54.112e-165 484
LLPS-Pyt-0570Pyrenophora teres53.682e-168 492
LLPS-Pytr-1424Pyrenophora triticirepentis53.681e-168 492
LLPS-Abg-1120Absidia glauca53.392e-168 491
LLPS-Lem-1105Leptosphaeria maculans52.891e-165 485
LLPS-Phn-1207Phaeosphaeria nodorum52.698e-162 475
LLPS-Dos-0610Dothistroma septosporum52.612e-167 489
LLPS-Blg-0322Blumeria graminis52.583e-162 476
LLPS-Trv-1026Trichoderma virens52.171e-159 469
LLPS-Tut-1708Tursiops truncatus52.146e-159 466
LLPS-Fuv-1436Fusarium verticillioides52.062e-159 469
LLPS-Trr-0767Trichoderma reesei52.062e-160 471
LLPS-Fus-0468Fusarium solani52.062e-158 466
LLPS-Fuo-0855Fusarium oxysporum52.068e-160 470
LLPS-Zem-1296Zea mays51.973e-162 476
LLPS-Asc-0157Aspergillus clavatus51.842e-162 476
LLPS-Miv-1161Microbotryum violaceum51.849e-160 470
LLPS-Orb-2178Oryza barthii51.632e-159 469
LLPS-Orni-0345Oryza nivara51.632e-159 469
LLPS-Orgl-0787Oryza glumaepatula51.633e-159 469
LLPS-Ors-1230Oryza sativa51.632e-159 469
LLPS-Beb-1178Beauveria bassiana51.632e-160 471
LLPS-Cog-0539Colletotrichum gloeosporioides51.635e-162 475
LLPS-Orr-2294Oryza rufipogon51.633e-159 469
LLPS-Org-0075Oryza glaberrima51.632e-159 469
LLPS-Zyt-1029Zymoseptoria tritici51.511e-164 483
LLPS-Orm-2047Oryza meridionalis51.471e-150 446
LLPS-Hov-0017Hordeum vulgare51.422e-156 466
LLPS-Nec-0903Neurospora crassa51.414e-156 460
LLPS-Sob-2075Sorghum bicolor51.312e-161 474
LLPS-Orp-0771Oryza punctata51.196e-159 468
LLPS-Orbr-1079Oryza brachyantha51.191e-160 472
LLPS-Gor-1631Gossypium raimondii50.992e-158 467
LLPS-Lep-1177Leersia perrieri50.984e-158 466
LLPS-Brd-2067Brachypodium distachyon50.984e-155 458
LLPS-Ori-0807Oryza indica50.771e-152 452
LLPS-Sei-0826Setaria italica50.733e-162 476
LLPS-Mao-1426Magnaporthe oryzae50.652e-154 456
LLPS-Tra-2777Triticum aestivum50.541e-154 457
LLPS-Met-1094Medicago truncatula50.543e-154 456
LLPS-Aso-1263Aspergillus oryzae50.431e-153 454
LLPS-Mae-0914Manihot esculenta50.434e-158 466
LLPS-Kop-0138Komagataella pastoris50.334e-142 424
LLPS-Pot-1818Populus trichocarpa50.224e-156 461
LLPS-Nia-1129Nicotiana attenuata50.229e-156 459
LLPS-Prp-1100Prunus persica50.221e-151 449
LLPS-Cogr-0461Colletotrichum graminicola50.212e-156 461
LLPS-Mua-1407Musa acuminata50.115e-152 451
LLPS-Ved-1566Verticillium dahliae50.114e-156 460
LLPS-Tru-1536Triticum urartu50.113e-153 455
LLPS-Php-2177Physcomitrella patens50.02e-157 464
LLPS-Hea-1005Helianthus annuus50.02e-153 454
LLPS-Yal-0441Yarrowia lipolytica49.894e-148 439
LLPS-Coo-1314Colletotrichum orbiculare49.892e-156 461
LLPS-Asg-0444Ashbya gossypii49.891e-150 446
LLPS-Coc-0231Corchorus capsularis49.895e-154 455
LLPS-Asfu-0829Aspergillus fumigatus49.891e-159 469
LLPS-Glm-1399Glycine max49.782e-155 458
LLPS-Viv-1917Vitis vinifera49.787e-151 447
LLPS-Dac-1527Daucus carota49.572e-154 456
LLPS-Ast-1367Aspergillus terreus49.572e-154 456
LLPS-Cus-0542Cucumis sativus49.562e-153 454
LLPS-Asf-0361Aspergillus flavus49.465e-158 465
LLPS-Sot-0912Solanum tuberosum49.355e-155 457
LLPS-Nef-0488Neosartorya fischeri49.352e-158 467
LLPS-Sol-1804Solanum lycopersicum49.246e-156 460
LLPS-Phv-2292Phaseolus vulgaris49.235e-150 445
LLPS-Map-1130Magnaporthe poae49.155e-153 452
LLPS-Usm-1512Ustilago maydis49.154e-149 443
LLPS-Sem-1815Selaginella moellendorffii49.133e-148 440
LLPS-Brn-2658Brassica napus49.131e-150 446
LLPS-Asn-0973Aspergillus nidulans48.923e-156 461
LLPS-Via-2303Vigna angularis48.917e-154 454
LLPS-Thc-1470Theobroma cacao48.81e-153 454
LLPS-Scj-0794Schizosaccharomyces japonicus48.85e-148 439
LLPS-Bro-0240Brassica oleracea48.692e-148 441
LLPS-Sac-1435Saccharomyces cerevisiae48.587e-146 435
LLPS-Vir-1754Vigna radiata48.533e-140 423
LLPS-Spr-1149Sporisorium reilianum48.412e-146 436
LLPS-Mel-0825Melampsora laricipopulina48.373e-143 430
LLPS-Brr-0869Brassica rapa48.252e-149 443
LLPS-Gag-0102Gaeumannomyces graminis48.144e-151 448
LLPS-Scp-0942Schizosaccharomyces pombe48.142e-146 435
LLPS-Amt-2124Amborella trichopoda48.111e-140 421
LLPS-Gas-0407Galdieria sulphuraria48.024e-149 442
LLPS-Asni-0107Aspergillus niger47.841e-153 454
LLPS-Arl-1089Arabidopsis lyrata47.824e-149 442
LLPS-Pug-1035Puccinia graminis47.713e-142 428
LLPS-Art-2558Arabidopsis thaliana47.67e-149 442
LLPS-Put-1087Puccinia triticina47.288e-142 426
LLPS-Scc-0893Schizosaccharomyces cryophilus46.493e-141 422
LLPS-Crn-0911Cryptococcus neoformans44.23e-132 400
LLPS-Chc-0916Chondrus crispus44.151e-123 377
LLPS-Cae-0238Caenorhabditis elegans42.952e-107 335
LLPS-Cym-1117Cyanidioschyzon merolae41.122e-125 386