LLPS-Art-2427
LSM5
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Sm-like protein LSM5 |
| Gene Name: | LSM5, SAD1, At5g48870, K24G6.21 |
| Ensembl Gene: | AT5G48870 |
| Ensembl Protein: | AT5G48870.1 |
| Organism: | Arabidopsis thaliana |
| Taxa ID: | 3702 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of LSM protein complexes, which are involved in RNA processing. Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by promoting decapping and leading to accurate 5'-3' mRNA decay. The cytoplasmic LSM1-LSM7 complex regulates developmental gene expression by the decapping of specific development-related transcripts. Component of the nuclear LSM2-LSM8 complex which is involved splicing nuclear mRNAs. LSM2-LSM8 binds directly to the U6 small nuclear RNAs (snRNAs) and is essential for accurate splicing of selected development-related mRNAs through the stabilization of the spliceosomal U6 snRNA. Plays a critical role in the regulation of development-related gene expression (PubMed:23221597, PubMed:23620288). Involved in the control of plant sensitivity to abscisic acid (ABA) and drought (PubMed:11740939). Functions with ABH1 as negative regulator of ABA signaling in guard cells (PubMed:12427994). Required for regulation of splicing efficiency of many stress-responsive genes under stress conditions (PubMed:24393432). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | AT5G48870.1 | AT5G48870.1 |
| UniProt | Q9FKB0, LSM5_ARATH, Q0WMZ9 | |
| GeneBank | AY034896, BT025700, JQ612715, CP002688, AK229657, AB012242 | ABF82603.1, BAF01501.1, AED95735.1, AFJ05005.1, BAB09440.1, AAK61592.1 |
| RefSeq | NM_124264.4 | NP_199698.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MANNPSQLLP SELIDRCIGS KIWVIMKGDK ELVGILKGFD VYVNMVLEDV TEYEITAEGR 60 61 RVTKLDQILL NGNNIAILVP GGSPEDGE 88 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGAACA ATCCTTCACA GCTTCTTCCT TCAGAGCTAA TCGATAGGTG TATAGGGTCT 60 61 AAGATTTGGG TGATAATGAA AGGAGATAAG GAGCTCGTTG GTATTCTCAA AGGATTCGAT 120 121 GTTTATGTCA ACATGGTTCT TGAAGATGTC ACCGAATATG AGATTACGGC AGAAGGAAGA 180 181 CGGGTCACAA AGCTTGATCA GATTCTACTC AATGGCAACA ACATCGCCAT TCTGGTGCCA 240 241 GGTGGGTCTC CCGAAGATGG AGAATGA 267 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Lsm1-7-Pat1 complex | |
Cellular Component | Spliceosomal complex | |
Cellular Component | U4/U6 x U5 tri-snRNP complex | |
Cellular Component | U6 snRNP | |
Molecular Function | RNA binding | |
Biological Process | MRNA processing | |
Biological Process | Response to abscisic acid | |
Biological Process | Response to water deprivation | |
Biological Process | RNA splicing |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| PTM | ||||
| dbPTM | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | ||||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Arl-1995 | Arabidopsis lyrata | 98.86 | 1e-56 | 176 |
| LLPS-Phv-1406 | Phaseolus vulgaris | 96.47 | 8e-54 | 168 |
| LLPS-Amt-0758 | Amborella trichopoda | 95.92 | 1e-26 | 99.0 |
| LLPS-Met-0170 | Medicago truncatula | 95.29 | 6e-53 | 166 |
| LLPS-Vir-0984 | Vigna radiata | 95.29 | 3e-53 | 167 |
| LLPS-Via-1005 | Vigna angularis | 95.29 | 3e-53 | 167 |
| LLPS-Thc-0968 | Theobroma cacao | 95.29 | 6e-53 | 166 |
| LLPS-Glm-0575 | Glycine max | 95.29 | 3e-53 | 167 |
| LLPS-Coc-0518 | Corchorus capsularis | 95.29 | 6e-53 | 166 |
| LLPS-Prp-0937 | Prunus persica | 95.29 | 1e-52 | 166 |
| LLPS-Mae-1618 | Manihot esculenta | 95.29 | 6e-53 | 166 |
| LLPS-Pot-0099 | Populus trichocarpa | 94.19 | 3e-51 | 162 |
| LLPS-Cus-0567 | Cucumis sativus | 94.12 | 3e-52 | 165 |
| LLPS-Hea-1018 | Helianthus annuus | 94.12 | 4e-52 | 166 |
| LLPS-Gor-2142 | Gossypium raimondii | 94.12 | 2e-52 | 165 |
| LLPS-Sei-1880 | Setaria italica | 94.05 | 6e-50 | 162 |
| LLPS-Brd-1237 | Brachypodium distachyon | 94.05 | 1e-50 | 160 |
| LLPS-Orgl-0233 | Oryza glumaepatula | 94.05 | 1e-50 | 160 |
| LLPS-Lep-1120 | Leersia perrieri | 94.05 | 2e-50 | 160 |
| LLPS-Orni-0528 | Oryza nivara | 94.05 | 1e-50 | 160 |
| LLPS-Orb-1807 | Oryza barthii | 94.05 | 1e-50 | 160 |
| LLPS-Ori-0964 | Oryza indica | 94.05 | 1e-50 | 160 |
| LLPS-Zem-0066 | Zea mays | 94.05 | 2e-50 | 160 |
| LLPS-Orr-0559 | Oryza rufipogon | 94.05 | 1e-50 | 160 |
| LLPS-Orm-0856 | Oryza meridionalis | 94.05 | 1e-50 | 160 |
| LLPS-Orbr-2170 | Oryza brachyantha | 94.05 | 1e-50 | 160 |
| LLPS-Sob-1690 | Sorghum bicolor | 94.05 | 2e-50 | 160 |
| LLPS-Ors-1347 | Oryza sativa | 94.05 | 1e-50 | 160 |
| LLPS-Orp-1853 | Oryza punctata | 94.05 | 1e-50 | 160 |
| LLPS-Sol-0254 | Solanum lycopersicum | 93.42 | 9e-43 | 154 |
| LLPS-Brn-1565 | Brassica napus | 93.1 | 1e-51 | 163 |
| LLPS-Bro-2383 | Brassica oleracea | 93.1 | 1e-51 | 163 |
| LLPS-Brr-1725 | Brassica rapa | 93.1 | 1e-51 | 163 |
| LLPS-Hov-0897 | Hordeum vulgare | 92.94 | 3e-50 | 161 |
| LLPS-Tra-1102 | Triticum aestivum | 92.94 | 1e-50 | 160 |
| LLPS-Sot-0955 | Solanum tuberosum | 92.94 | 7e-52 | 164 |
| LLPS-Mua-1049 | Musa acuminata | 92.94 | 5e-52 | 164 |
| LLPS-Org-1178 | Oryza glaberrima | 91.8 | 4e-32 | 112 |
| LLPS-Viv-0837 | Vitis vinifera | 91.76 | 2e-51 | 162 |
| LLPS-Sem-1325 | Selaginella moellendorffii | 90.59 | 1e-50 | 160 |
| LLPS-Php-0590 | Physcomitrella patens | 90.36 | 3e-49 | 160 |
| LLPS-Tru-1522 | Triticum urartu | 90.32 | 3e-32 | 113 |
| LLPS-Mod-3518 | Monodelphis domestica | 86.21 | 1e-09 | 55.1 |
| LLPS-Dac-1866 | Daucus carota | 82.65 | 5e-49 | 157 |
| LLPS-Scm-3458 | Scophthalmus maximus | 80.0 | 6e-16 | 70.9 |
| LLPS-Osl-0398 | Ostreococcus lucimarinus | 78.31 | 8e-42 | 138 |
| LLPS-Cis-0832 | Ciona savignyi | 76.83 | 1e-39 | 132 |
| LLPS-Cii-1238 | Ciona intestinalis | 76.54 | 6e-39 | 130 |
| LLPS-Aon-3380 | Aotus nancymaae | 76.54 | 1e-39 | 133 |
| LLPS-Tag-2207 | Taeniopygia guttata | 76.25 | 4e-39 | 131 |
| LLPS-Sus-0121 | Sus scrofa | 76.06 | 3e-33 | 116 |
| LLPS-Pes-1665 | Pelodiscus sinensis | 76.06 | 4e-33 | 115 |
| LLPS-Anp-0652 | Anas platyrhynchos | 76.06 | 4e-33 | 115 |
| LLPS-Ran-0520 | Rattus norvegicus | 75.31 | 4e-39 | 131 |
| LLPS-Paa-1565 | Papio anubis | 75.31 | 4e-39 | 131 |
| LLPS-Mal-1589 | Mandrillus leucophaeus | 75.31 | 4e-39 | 131 |
| LLPS-Aim-2592 | Ailuropoda melanoleuca | 75.31 | 4e-39 | 131 |
| LLPS-Myl-2656 | Myotis lucifugus | 75.31 | 4e-39 | 131 |
| LLPS-Ova-0909 | Ovis aries | 75.31 | 4e-39 | 131 |
| LLPS-Tut-0806 | Tursiops truncatus | 75.31 | 4e-39 | 131 |
| LLPS-Dio-1888 | Dipodomys ordii | 75.31 | 4e-39 | 131 |
| LLPS-Bot-1025 | Bos taurus | 75.31 | 4e-39 | 131 |
| LLPS-Gog-1067 | Gorilla gorilla | 75.31 | 4e-39 | 131 |
| LLPS-Fud-0218 | Fukomys damarensis | 75.31 | 4e-39 | 131 |
| LLPS-Icp-1580 | Ictalurus punctatus | 75.31 | 2e-39 | 132 |
| LLPS-Caj-1959 | Callithrix jacchus | 75.31 | 1e-38 | 132 |
| LLPS-Mea-1035 | Mesocricetus auratus | 75.31 | 4e-39 | 131 |
| LLPS-Maf-2662 | Macaca fascicularis | 75.31 | 4e-39 | 131 |
| LLPS-Mum-3948 | Mus musculus | 75.31 | 4e-39 | 131 |
| LLPS-Cea-0657 | Cercocebus atys | 75.31 | 4e-39 | 131 |
| LLPS-Leo-1421 | Lepisosteus oculatus | 75.31 | 2e-39 | 132 |
| LLPS-Gaga-0143 | Gallus gallus | 75.31 | 3e-39 | 132 |
| LLPS-Cas-1382 | Carlito syrichta | 75.31 | 4e-39 | 131 |
| LLPS-Ict-2066 | Ictidomys tridecemlineatus | 75.31 | 4e-39 | 131 |
| LLPS-Nol-1059 | Nomascus leucogenys | 75.31 | 4e-39 | 131 |
| LLPS-Caf-3272 | Canis familiaris | 75.31 | 2e-38 | 129 |
| LLPS-Cap-2955 | Cavia porcellus | 75.31 | 4e-39 | 131 |
| LLPS-Otg-2650 | Otolemur garnettii | 75.31 | 4e-39 | 131 |
| LLPS-Orc-1433 | Oryctolagus cuniculus | 75.31 | 4e-39 | 131 |
| LLPS-Rhb-2768 | Rhinopithecus bieti | 75.31 | 4e-39 | 131 |
| LLPS-Pat-0895 | Pan troglodytes | 75.31 | 4e-39 | 131 |
| LLPS-Pof-0082 | Poecilia formosa | 75.31 | 2e-39 | 132 |
| LLPS-Urm-0890 | Ursus maritimus | 75.31 | 2e-38 | 130 |
| LLPS-Pap-2526 | Pan paniscus | 75.31 | 4e-39 | 131 |
| LLPS-Hos-1835 | Homo sapiens | 75.31 | 4e-39 | 131 |
| LLPS-Meg-0190 | Meleagris gallopavo | 75.31 | 3e-39 | 132 |
| LLPS-Fec-0702 | Felis catus | 75.31 | 4e-39 | 131 |
| LLPS-Man-0158 | Macaca nemestrina | 75.31 | 4e-39 | 131 |
| LLPS-Loa-3155 | Loxodonta africana | 75.31 | 4e-39 | 131 |
| LLPS-Xet-1921 | Xenopus tropicalis | 74.67 | 2e-35 | 121 |
| LLPS-Mup-3550 | Mustela putorius furo | 74.12 | 4e-37 | 129 |
| LLPS-Scf-3471 | Scleropages formosus | 74.12 | 2e-39 | 132 |
| LLPS-Cae-1122 | Caenorhabditis elegans | 74.12 | 1e-37 | 127 |
| LLPS-Dar-0709 | Danio rerio | 74.12 | 2e-39 | 132 |
| LLPS-Gaa-0324 | Gasterosteus aculeatus | 74.07 | 9e-39 | 130 |
| LLPS-Ere-0696 | Erinaceus europaeus | 73.68 | 5e-21 | 84.3 |
| LLPS-Fia-2712 | Ficedula albicollis | 73.68 | 2e-33 | 117 |
| LLPS-Orl-2666 | Oryzias latipes | 73.49 | 5e-38 | 130 |
| LLPS-Ten-1182 | Tetraodon nigroviridis | 72.94 | 4e-39 | 131 |
| LLPS-Lac-2117 | Latimeria chalumnae | 72.94 | 1e-39 | 132 |
| LLPS-Mam-0114 | Macaca mulatta | 71.76 | 3e-38 | 129 |
| LLPS-Anc-2158 | Anolis carolinensis | 70.59 | 1e-19 | 80.5 |
| LLPS-Poa-4486 | Pongo abelii | 70.59 | 2e-37 | 127 |
| LLPS-Abg-1384 | Absidia glauca | 70.51 | 4e-33 | 115 |
| LLPS-Tum-0199 | Tuber melanosporum | 70.13 | 1e-30 | 109 |
| LLPS-Ved-0622 | Verticillium dahliae | 70.13 | 3e-29 | 105 |
| LLPS-Asfu-1082 | Aspergillus fumigatus | 70.13 | 9e-29 | 104 |
| LLPS-Trr-1271 | Trichoderma reesei | 70.13 | 6e-30 | 107 |
| LLPS-Drm-1010 | Drosophila melanogaster | 70.0 | 3e-34 | 119 |
| LLPS-Asn-1165 | Aspergillus nidulans | 68.83 | 3e-28 | 104 |
| LLPS-Scs-0835 | Sclerotinia sclerotiorum | 68.83 | 4e-29 | 105 |
| LLPS-Trv-1108 | Trichoderma virens | 68.83 | 1e-29 | 107 |
| LLPS-Zyt-0225 | Zymoseptoria tritici | 68.75 | 5e-31 | 110 |
| LLPS-Usm-0548 | Ustilago maydis | 67.9 | 1e-29 | 107 |
| LLPS-Spr-1331 | Sporisorium reilianum | 67.9 | 2e-29 | 107 |
| LLPS-Nec-0441 | Neurospora crassa | 67.53 | 7e-30 | 107 |
| LLPS-Map-0932 | Magnaporthe poae | 67.53 | 1e-29 | 107 |
| LLPS-Gag-0908 | Gaeumannomyces graminis | 67.53 | 1e-29 | 107 |
| LLPS-Asc-1296 | Aspergillus clavatus | 67.53 | 8e-29 | 104 |
| LLPS-Beb-1032 | Beauveria bassiana | 67.53 | 6e-28 | 102 |
| LLPS-Dos-0847 | Dothistroma septosporum | 67.5 | 3e-30 | 108 |
| LLPS-Nef-1335 | Neosartorya fischeri | 66.67 | 2e-15 | 70.1 |
| LLPS-Asf-1355 | Aspergillus flavus | 66.23 | 1e-27 | 102 |
| LLPS-Blg-0349 | Blumeria graminis | 66.23 | 9e-29 | 104 |
| LLPS-Mao-1394 | Magnaporthe oryzae | 66.23 | 2e-29 | 106 |
| LLPS-Cogr-1131 | Colletotrichum graminicola | 66.23 | 4e-29 | 105 |
| LLPS-Fuv-0096 | Fusarium verticillioides | 65.85 | 8e-30 | 107 |
| LLPS-Fus-0306 | Fusarium solani | 65.85 | 9e-30 | 107 |
| LLPS-Asm-1594 | Astyanax mexicanus | 65.48 | 6e-32 | 113 |
| LLPS-Xim-0733 | Xiphophorus maculatus | 65.43 | 5e-32 | 113 |
| LLPS-Gas-0063 | Galdieria sulphuraria | 65.06 | 7e-33 | 115 |
| LLPS-Crn-0805 | Cryptococcus neoformans | 64.94 | 9e-29 | 104 |
| LLPS-Phn-0239 | Phaeosphaeria nodorum | 64.94 | 7e-24 | 92.4 |
| LLPS-Ast-0586 | Aspergillus terreus | 64.94 | 2e-27 | 101 |
| LLPS-Coo-0296 | Colletotrichum orbiculare | 64.63 | 3e-29 | 106 |
| LLPS-Pug-0677 | Puccinia graminis | 64.63 | 2e-29 | 107 |
| LLPS-Lem-0416 | Leptosphaeria maculans | 64.56 | 1e-24 | 94.4 |
| LLPS-Miv-0016 | Microbotryum violaceum | 64.29 | 8e-29 | 105 |
| LLPS-Tar-1013 | Takifugu rubripes | 61.46 | 1e-31 | 113 |
| LLPS-Ora-2255 | Ornithorhynchus anatinus | 61.33 | 3e-28 | 103 |
| LLPS-Eqc-3453 | Equus caballus | 61.18 | 5e-28 | 102 |
| LLPS-Scj-0516 | Schizosaccharomyces japonicus | 61.04 | 7e-24 | 92.0 |
| LLPS-Asni-1218 | Aspergillus niger | 60.38 | 5e-12 | 60.8 |
| LLPS-Pyt-0195 | Pyrenophora teres | 59.52 | 4e-21 | 85.1 |
| LLPS-Scp-1037 | Schizosaccharomyces pombe | 56.96 | 5e-23 | 89.7 |
| LLPS-Yal-0424 | Yarrowia lipolytica | 55.84 | 3e-19 | 80.1 |
| LLPS-Scc-0912 | Schizosaccharomyces cryophilus | 54.43 | 5e-22 | 87.4 |
| LLPS-Asg-0446 | Ashbya gossypii | 49.37 | 2e-18 | 77.8 |
| LLPS-Pytr-1282 | Pyrenophora triticirepentis | 48.53 | 3e-08 | 51.2 |
| LLPS-Cym-0422 | Cyanidioschyzon merolae | 46.25 | 1e-20 | 84.3 |
| LLPS-Sac-0285 | Saccharomyces cerevisiae | 45.12 | 2e-14 | 68.2 |
| LLPS-Kop-0427 | Komagataella pastoris | 41.56 | 2e-12 | 62.4 |
| LLPS-Nia-0082 | Nicotiana attenuata | 36.36 | 3e-06 | 47.4 |