LLPS-Xim-3642
SPDL1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Protein Spindly; Coiled-coil domain-containing protein 99; Spindle apparatus coiled-coil domain-containing protein 1 |
| Gene Name: | SPDL1, CCDC99 |
| Ensembl Gene: | ENSXMAG00000010982.2 |
| Ensembl Protein: | ENSXMAP00000011010.2 |
| Organism: | Xiphophorus maculatus |
| Taxa ID: | 8083 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSXMAT00000011024.2 | ENSXMAP00000011010.2 |
| Ensembl | ENSXMAT00000030331.1 | ENSXMAP00000023302.1 |
| Ensembl | ENSXMAT00000038429.1 | ENSXMAP00000027847.1 |
| UniProt | M4A966, M4A966_XIPMA |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MPPEEENELL RSQLKQSEEQ ARRAAQAGLD LLKQQDELQE RLEEQRVEMT NALEALEQDK 60 61 YSLQKEVELK TRMLESLQSE YESMKNLQKQ QLQEHQEHLE RSHSVALTEH QNKILTLQSA 120 121 VEEFQLSEKQ LKHKLEVQAE MLSSKMEELH ALNENTQSSM TMEMMEVQLK TMELESAKVE 180 181 LEQTLQESRY RGQQLELSNS HLQRQVERLT EEREREAVSW FNALEKSREL NRDLQIQLDQ 240 241 VLQQAQDPNS RGNSLFAELE DKRAAMERQL ISMKVQHQSL QKMHTFSKQQ MQRMKVQIAT 300 301 LMQLQGSRAD PAQLERLQSM LSEKNAEIQS LMTKLQRLEK METLLKSQPA NPVQAESVGG 360 361 QDETYYTDLL QLKLNNSVKD AERLGDELSL QRMKSLSESQ RALELERKLF TSERLLKQAQ 420 421 SDKIKLQLRV EELQQKYEPK EVKKNPIQRK RKEKLPVDVK PEPDGNVHGE QVVAVEIEET 480 481 DNTKLGREDE NSPAEITAAA QAPEPELKPA KCVKISSDQP DVIPSPRSVL SSYNISLEPQ 540 541 LRFLLLLGAA DAPANTTRYR GTLNLYFFQH RQNVLNSTVI 580 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCCTCCAG AGGAGGAGAA TGAGCTGCTG CGTAGCCAGC TGAAGCAGAG CGAGGAGCAG 60 61 GCCCGTCGGG CCGCCCAGGC AGGTCTGGAC CTGCTGAAGC AGCAGGACGA GCTCCAGGAG 120 121 CGGTTGGAGG AGCAGAGGGT GGAGATGACC AACGCTCTGG AGGCTCTGGA GCAGGACAAG 180 181 TACTCCCTGC AGAAGGAGGT GGAGCTGAAG ACCCGGATGC TGGAGTCTTT GCAGTCGGAA 240 241 TACGAGAGCA TGAAGAACCT GCAGAAACAG CAGCTTCAGG AACATCAGGA ACATCTGGAG 300 301 AGGAGCCACA GCGTGGCTCT GACTGAGCAC CAGAACAAGA TCCTGACGCT GCAGTCTGCT 360 361 GTGGAGGAGT TCCAGCTGAG TGAAAAGCAG CTGAAGCATA AGCTGGAGGT GCAGGCCGAG 420 421 ATGCTGAGCA GCAAGATGGA GGAGCTGCAC GCGCTGAACG AAAACACCCA GAGCTCCATG 480 481 ACGATGGAGA TGATGGAGGT GCAGCTGAAG ACCATGGAGC TGGAGAGCGC TAAGGTGGAG 540 541 CTGGAGCAGA CCCTGCAGGA GAGTCGCTAC AGAGGGCAGC AGCTGGAGCT GAGCAACAGC 600 601 CATCTGCAGA GACAGGTGGA GCGCCTCACC GAGGAGAGGG AGAGGGAAGC CGTGTCCTGG 660 661 TTCAACGCCC TGGAGAAATC TCGAGAACTA AACCGGGATC TGCAGATCCA GTTGGATCAG 720 721 GTTCTTCAGC AGGCCCAGGA CCCAAACAGC CGGGGCAATT CTCTGTTTGC TGAGCTGGAG 780 781 GATAAGAGAG CTGCAATGGA GAGACAGCTC ATCAGCATGA AGGTGCAGCA TCAGTCGCTG 840 841 CAGAAAATGC ACACCTTCAG TAAGCAGCAG ATGCAGCGCA TGAAGGTCCA GATCGCCACT 900 901 CTGATGCAGC TGCAAGGCTC CAGGGCCGAC CCTGCTCAGC TGGAGAGGCT GCAGTCCATG 960 961 CTGTCGGAGA AGAACGCCGA GATCCAGAGT CTGATGACCA AACTACAGAG GCTGGAGAAG 1020 1021 ATGGAGACGT TGCTGAAGTC TCAACCAGCC AATCCCGTCC AAGCAGAATC AGTCGGTGGT 1080 1081 CAGGATGAAA CGTACTACAC TGACCTGCTC CAACTCAAGC TCAACAACTC TGTTAAGGAT 1140 1141 GCCGAGCGGC TGGGAGATGA GCTGTCCTTG CAGAGGATGA AGTCTCTGTC AGAGAGCCAG 1200 1201 AGAGCTCTGG AGCTGGAGAG GAAGCTGTTT ACGTCTGAGC GGCTGCTCAA ACAGGCTCAG 1260 1261 AGTGACAAGA TCAAACTGCA GCTGCGTGTC GAGGAGCTTC AGCAGAAATA TGAACCCAAA 1320 1321 GAGGTGAAGA AGAACCCTAT CCAGAGGAAA AGAAAGGAAA AGCTTCCTGT CGATGTGAAG 1380 1381 CCTGAACCTG ATGGGAACGT TCACGGAGAG CAGGTTGTTG CCGTGGAGAT TGAGGAGACG 1440 1441 GACAATACGA AATTGGGCCG TGAAGATGAA AACAGCCCTG CAGAGATAAC AGCTGCTGCT 1500 1501 CAAGCGCCTG AGCCTGAGCT GAAACCTGCC AAGTGTGTGA AGATCAGCTC TGATCAGCCT 1560 1561 GATGTGATCC CCAGTCCCAG GTCAGTACTG TCATCATACA ACATCAGCTT AGAGCCACAA 1620 1621 CTCAGGTTTC TACTGCTGCT GGGAGCTGCG GATGCACCGG CCAATACGAC CCGGTACAGA 1680 1681 GGAACTTTAA ACCTTTATTT TTTTCAACAC AGACAAAATG TACTGAATTC TACAGTTATT 1740 1741 TAG 1743 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Condensed chromosome outer kinetochore | |
Molecular Function | Kinetochore binding | |
Biological Process | Cell division | |
Biological Process | Mitotic spindle assembly checkpoint | |
Biological Process | Protein localization to kinetochore |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pof-1738 | Poecilia formosa | 89.4 | 0.0 | 791 |
| LLPS-Ten-3012 | Tetraodon nigroviridis | 74.46 | 0.0 | 539 |
| LLPS-Scm-3490 | Scophthalmus maximus | 74.44 | 0.0 | 626 |
| LLPS-Gaa-1484 | Gasterosteus aculeatus | 72.77 | 2e-169 | 496 |
| LLPS-Orn-0015 | Oreochromis niloticus | 72.76 | 0.0 | 598 |
| LLPS-Orl-2119 | Oryzias latipes | 70.02 | 0.0 | 607 |
| LLPS-Tar-3206 | Takifugu rubripes | 67.54 | 0.0 | 548 |
| LLPS-Icp-2108 | Ictalurus punctatus | 57.92 | 4e-135 | 413 |
| LLPS-Asm-3417 | Astyanax mexicanus | 57.61 | 2e-131 | 402 |
| LLPS-Scf-3039 | Scleropages formosus | 57.58 | 4e-140 | 426 |
| LLPS-Xet-2430 | Xenopus tropicalis | 57.45 | 4e-129 | 399 |
| LLPS-Lac-0095 | Latimeria chalumnae | 56.14 | 3e-115 | 363 |
| LLPS-Dar-0166 | Danio rerio | 52.88 | 3e-133 | 409 |
| LLPS-Pes-0446 | Pelodiscus sinensis | 51.43 | 1e-112 | 356 |
| LLPS-Caf-1217 | Canis familiaris | 51.4 | 1e-108 | 345 |
| LLPS-Anp-0699 | Anas platyrhynchos | 51.2 | 8e-111 | 351 |
| LLPS-Cap-1516 | Cavia porcellus | 50.92 | 5e-105 | 336 |
| LLPS-Fia-3462 | Ficedula albicollis | 50.71 | 2e-105 | 337 |
| LLPS-Anc-3709 | Anolis carolinensis | 50.24 | 9e-101 | 325 |
| LLPS-Cas-0158 | Carlito syrichta | 49.88 | 4e-106 | 338 |
| LLPS-Sus-3950 | Sus scrofa | 49.79 | 1e-113 | 358 |
| LLPS-Aon-1202 | Aotus nancymaae | 49.47 | 2e-110 | 350 |
| LLPS-Hos-0529 | Homo sapiens | 49.26 | 3e-112 | 355 |
| LLPS-Gog-3698 | Gorilla gorilla | 49.26 | 4e-112 | 354 |
| LLPS-Pap-2404 | Pan paniscus | 49.16 | 5e-113 | 357 |
| LLPS-Pat-3467 | Pan troglodytes | 49.16 | 4e-113 | 357 |
| LLPS-Otg-0282 | Otolemur garnettii | 49.15 | 8e-112 | 353 |
| LLPS-Leo-0418 | Lepisosteus oculatus | 49.06 | 1e-109 | 348 |
| LLPS-Aim-3327 | Ailuropoda melanoleuca | 48.74 | 1e-110 | 350 |
| LLPS-Urm-1069 | Ursus maritimus | 48.54 | 2e-110 | 350 |
| LLPS-Orc-0853 | Oryctolagus cuniculus | 48.52 | 9e-109 | 345 |
| LLPS-Loa-2085 | Loxodonta africana | 48.3 | 8e-103 | 328 |
| LLPS-Nol-1518 | Nomascus leucogenys | 48.2 | 5e-104 | 333 |
| LLPS-Mod-0038 | Monodelphis domestica | 48.07 | 5e-116 | 364 |
| LLPS-Mea-0354 | Mesocricetus auratus | 47.99 | 4e-57 | 202 |
| LLPS-Dio-3852 | Dipodomys ordii | 47.99 | 9e-84 | 278 |
| LLPS-Fec-2871 | Felis catus | 47.83 | 4e-108 | 344 |
| LLPS-Myl-3378 | Myotis lucifugus | 47.71 | 7e-110 | 348 |
| LLPS-Sah-2716 | Sarcophilus harrisii | 47.53 | 4e-120 | 375 |
| LLPS-Tut-2035 | Tursiops truncatus | 47.24 | 3e-113 | 357 |
| LLPS-Mup-3746 | Mustela putorius furo | 47.02 | 1e-111 | 353 |
| LLPS-Maf-4468 | Macaca fascicularis | 47.01 | 1e-113 | 358 |
| LLPS-Paa-4485 | Papio anubis | 47.01 | 7e-114 | 359 |
| LLPS-Man-2183 | Macaca nemestrina | 46.91 | 9e-114 | 359 |
| LLPS-Mal-3622 | Mandrillus leucophaeus | 46.87 | 1e-113 | 358 |
| LLPS-Eqc-2711 | Equus caballus | 46.81 | 1e-111 | 353 |
| LLPS-Ova-2298 | Ovis aries | 46.72 | 3e-110 | 349 |
| LLPS-Cea-1676 | Cercocebus atys | 46.68 | 7e-114 | 358 |
| LLPS-Bot-4624 | Bos taurus | 46.68 | 7e-113 | 356 |
| LLPS-Rhb-3677 | Rhinopithecus bieti | 46.63 | 2e-112 | 355 |
| LLPS-Mum-4451 | Mus musculus | 46.52 | 2e-83 | 279 |
| LLPS-Chs-1535 | Chlorocebus sabaeus | 46.4 | 2e-114 | 360 |
| LLPS-Mam-3579 | Macaca mulatta | 46.21 | 9e-114 | 358 |
| LLPS-Gaga-3748 | Gallus gallus | 46.02 | 6e-112 | 354 |
| LLPS-Fud-3787 | Fukomys damarensis | 45.88 | 2e-103 | 331 |
| LLPS-Caj-2305 | Callithrix jacchus | 45.87 | 7e-109 | 346 |
| LLPS-Tag-3310 | Taeniopygia guttata | 45.86 | 8e-102 | 327 |
| LLPS-Meg-0494 | Meleagris gallopavo | 45.44 | 3e-109 | 347 |
| LLPS-Poa-2828 | Pongo abelii | 43.18 | 3e-97 | 314 |
| LLPS-Ran-4047 | Rattus norvegicus | 42.74 | 8e-79 | 266 |
| LLPS-Cii-2131 | Ciona intestinalis | 28.19 | 2e-18 | 92.4 |