LLPS-Cap-1516
SPDL1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Protein Spindly; Coiled-coil domain-containing protein 99; Spindle apparatus coiled-coil domain-containing protein 1 |
| Gene Name: | SPDL1, CCDC99 |
| Ensembl Gene: | ENSCPOG00000010816.4 |
| Ensembl Protein: | ENSCPOP00000009711.2 |
| Organism: | Cavia porcellus |
| Taxa ID: | 10141 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCPOT00000010914.3 | ENSCPOP00000009711.2 |
| UniProt | H0VHR9, H0VHR9_CAVPO | |
| GeneBank | AAKN02022798 | |
| RefSeq | XM_003473190.3 | XP_003473238.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEADIIADLR SKLKEVEKER LTAAQYGLQL LESQNELQNQ LDKYRNEMMT MTESYEQDKY 60 61 TLQREVELKS RMLESLNCEC EAIKQQQKVQ LEQLEEQLNR SHGQEMNELK DKLEKLKAEL 120 121 DEARLSEKQL KHKVDHQKEL LAHKSEEIQM MSERVHESMS SEMLALQIEL TNTESMKNTL 180 181 KEEVNELQYR QEQLESLSNN LMRQVERLKE EKEEREKEAV SYYNALEKAR VENQDLQVQL 240 241 NQALQQALDP NSKGNSLFAE VEDRRAAMER QLISMKVKYQ SLKKQNVFNR EQMQRMKLQI 300 301 STLLQMKGSQ TEFEQQERLF AMLEQKNGEI KHLLGEIRNL EKFKNLCESM ESKPSIPGNS 360 361 EVLEDKTYYT DLLQLKLDNL NKENESTKGE LSIQRMKALF ESQRALDIER KLFANARCLQ 420 421 LSESENMKLR AKLDELKLKY EPEEKTEVPV LKKRREVLPV DVTIPKDVCA NNANGEEVSR 480 481 FLPPKEEAES CPNNLEVTSL QLQEPISANT PMASFCPHKD LPVDMQPKKE KKCVKLLDGP 540 541 ADAEALCERS GDSQHSPRLA AEAQLQTEAK EGTEAASKLE KEPCKKLHPI LYVSSKATPE 600 601 TQCPQQ 606 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGGCAG ATATAATTGC AGATCTTCGA AGCAAGCTTA AAGAGGTTGA AAAAGAGCGA 60 61 CTGACAGCTG CACAGTACGG TTTACAACTG CTAGAGAGCC AGAATGAACT GCAGAATCAA 120 121 CTGGATAAAT ACCGTAACGA AATGATGACC ATGACTGAGA GTTATGAACA GGACAAATAC 180 181 ACTCTTCAGC GAGAGGTTGA ACTCAAGAGT CGAATGTTAG AAAGTTTGAA CTGTGAATGT 240 241 GAAGCTATTA AACAGCAACA GAAAGTGCAG CTGGAGCAGT TAGAAGAGCA GCTGAATAGA 300 301 AGCCACGGAC AAGAAATGAA TGAGCTGAAA GATAAGTTAG AAAAACTGAA AGCAGAGTTA 360 361 GACGAAGCAA GGCTTAGTGA AAAGCAATTG AAACATAAAG TAGATCACCA GAAGGAACTC 420 421 CTGGCTCATA AATCAGAGGA AATACAGATG ATGTCTGAGC GTGTACATGA AAGCATGTCT 480 481 TCAGAAATGC TGGCTCTTCA GATTGAGCTG ACTAACACGG AAAGTATGAA GAACACCCTC 540 541 AAAGAAGAAG TAAATGAGCT ACAATACAGA CAGGAACAAC TAGAAAGTCT CAGTAATAAT 600 601 TTAATGCGCC AGGTAGAACG TCTTAAAGAA GAGAAAGAAG AACGGGAGAA AGAAGCAGTT 660 661 TCTTATTACA ATGCCTTAGA GAAAGCTCGG GTAGAAAATC AAGATCTCCA AGTGCAGTTG 720 721 AATCAGGCAC TCCAGCAAGC CTTAGATCCC AACAGTAAAG GCAACTCTTT GTTTGCAGAG 780 781 GTGGAAGATC GAAGGGCAGC AATGGAACGC CAGCTTATAA GTATGAAAGT CAAGTATCAG 840 841 TCCCTAAAGA AGCAAAATGT ATTTAATAGA GAACAGATGC AAAGAATGAA GCTGCAGATT 900 901 TCCACATTGC TACAGATGAA AGGATCTCAG ACTGAATTTG AACAGCAAGA ACGGTTGTTT 960 961 GCCATGTTGG AGCAGAAGAA TGGTGAAATA AAACATCTTT TAGGTGAAAT AAGAAATCTG 1020 1021 GAAAAATTTA AGAATTTATG TGAAAGTATG GAATCTAAGC CTTCCATACC AGGCAACTCT 1080 1081 GAAGTTCTAG AAGATAAAAC CTATTACACA GATTTGCTTC AGCTGAAACT TGACAACTTA 1140 1141 AACAAAGAAA ATGAAAGCAC CAAAGGTGAG CTGTCCATCC AGCGAATGAA AGCGTTATTT 1200 1201 GAGAGCCAGC GGGCCCTGGA TATTGAGCGA AAACTTTTTG CAAATGCAAG ATGCCTTCAG 1260 1261 CTTTCAGAAA GTGAAAATAT GAAACTAAGA GCTAAACTAG ATGAATTAAA GCTGAAGTAT 1320 1321 GAACCTGAAG AGAAAACTGA AGTCCCTGTA CTCAAAAAGA GGCGTGAAGT GCTACCTGTG 1380 1381 GATGTAACCA TCCCTAAAGA TGTATGTGCC AACAATGCCA ATGGGGAAGA AGTTTCTAGA 1440 1441 TTCCTACCTC CCAAAGAGGA GGCAGAGTCC TGTCCTAATA ACTTAGAGGT TACCAGCTTG 1500 1501 CAGTTGCAAG AACCGATTTC TGCAAACACG CCCATGGCCT CTTTCTGTCC TCACAAAGAT 1560 1561 CTGCCAGTGG ATATGCAGCC AAAGAAAGAA AAGAAATGTG TGAAGCTCTT GGATGGCCCA 1620 1621 GCTGATGCGG AGGCCTTGTG TGAAAGAAGC GGAGATAGCC AGCACTCTCC CAGGTTAGCG 1680 1681 GCTGAAGCAC AGCTTCAGAC AGAAGCTAAA GAAGGGACGG AAGCTGCAAG CAAGTTGGAA 1740 1741 AAGGAGCCTT GTAAGAAATT ACACCCTATT CTCTATGTGT CCTCCAAAGC AACTCCAGAG 1800 1801 ACTCAGTGCC CTCAGCAATA A 1821 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Condensed chromosome outer kinetochore | |
Cellular Component | Cytoplasm | |
Cellular Component | Microtubule organizing center | |
Cellular Component | Nucleus | |
Cellular Component | Spindle pole | |
Molecular Function | Enzyme binding | |
Molecular Function | Kinetochore binding | |
Biological Process | Cell division | |
Biological Process | Establishment of mitotic spindle orientation | |
Biological Process | Mitotic metaphase plate congression | |
Biological Process | Mitotic spindle assembly checkpoint | |
Biological Process | Protein localization to kinetochore |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Fud-3787 | Fukomys damarensis | 89.27 | 0.0 | 884 |
| LLPS-Orc-0853 | Oryctolagus cuniculus | 84.49 | 0.0 | 806 |
| LLPS-Paa-4485 | Papio anubis | 84.26 | 0.0 | 734 |
| LLPS-Pap-2404 | Pan paniscus | 84.18 | 0.0 | 820 |
| LLPS-Cea-1676 | Cercocebus atys | 84.18 | 0.0 | 818 |
| LLPS-Rhb-3677 | Rhinopithecus bieti | 84.08 | 0.0 | 736 |
| LLPS-Hos-0529 | Homo sapiens | 84.02 | 0.0 | 816 |
| LLPS-Pat-3467 | Pan troglodytes | 84.02 | 0.0 | 816 |
| LLPS-Mal-3622 | Mandrillus leucophaeus | 84.02 | 0.0 | 815 |
| LLPS-Eqc-2711 | Equus caballus | 83.99 | 0.0 | 813 |
| LLPS-Man-2183 | Macaca nemestrina | 83.9 | 0.0 | 728 |
| LLPS-Maf-4468 | Macaca fascicularis | 83.9 | 0.0 | 729 |
| LLPS-Mam-3579 | Macaca mulatta | 83.86 | 0.0 | 813 |
| LLPS-Chs-1535 | Chlorocebus sabaeus | 83.86 | 0.0 | 810 |
| LLPS-Gog-3698 | Gorilla gorilla | 83.86 | 0.0 | 815 |
| LLPS-Aim-3327 | Ailuropoda melanoleuca | 83.83 | 0.0 | 805 |
| LLPS-Urm-1069 | Ursus maritimus | 83.5 | 0.0 | 800 |
| LLPS-Sus-3950 | Sus scrofa | 83.33 | 0.0 | 801 |
| LLPS-Aon-1202 | Aotus nancymaae | 82.7 | 0.0 | 801 |
| LLPS-Mup-3746 | Mustela putorius furo | 82.67 | 0.0 | 787 |
| LLPS-Fec-2871 | Felis catus | 82.51 | 0.0 | 791 |
| LLPS-Tut-2035 | Tursiops truncatus | 82.51 | 0.0 | 785 |
| LLPS-Otg-0282 | Otolemur garnettii | 82.07 | 0.0 | 783 |
| LLPS-Caj-2305 | Callithrix jacchus | 82.04 | 0.0 | 801 |
| LLPS-Caf-1217 | Canis familiaris | 81.88 | 0.0 | 778 |
| LLPS-Cas-0158 | Carlito syrichta | 80.95 | 0.0 | 768 |
| LLPS-Nol-1518 | Nomascus leucogenys | 80.72 | 0.0 | 781 |
| LLPS-Loa-2085 | Loxodonta africana | 79.89 | 0.0 | 645 |
| LLPS-Myl-3378 | Myotis lucifugus | 78.71 | 0.0 | 751 |
| LLPS-Poa-2828 | Pongo abelii | 78.58 | 0.0 | 764 |
| LLPS-Mea-0354 | Mesocricetus auratus | 78.57 | 1e-124 | 380 |
| LLPS-Bot-4624 | Bos taurus | 78.55 | 0.0 | 741 |
| LLPS-Ova-2298 | Ovis aries | 78.55 | 0.0 | 752 |
| LLPS-Mum-4451 | Mus musculus | 71.64 | 0.0 | 644 |
| LLPS-Ran-4047 | Rattus norvegicus | 71.5 | 0.0 | 633 |
| LLPS-Sah-2716 | Sarcophilus harrisii | 65.58 | 0.0 | 571 |
| LLPS-Mod-0038 | Monodelphis domestica | 64.91 | 0.0 | 550 |
| LLPS-Dio-3852 | Dipodomys ordii | 62.04 | 2e-164 | 488 |
| LLPS-Gaga-3748 | Gallus gallus | 59.02 | 2e-157 | 473 |
| LLPS-Anp-0699 | Anas platyrhynchos | 58.86 | 2e-153 | 462 |
| LLPS-Pes-0446 | Pelodiscus sinensis | 58.86 | 4e-164 | 489 |
| LLPS-Meg-0494 | Meleagris gallopavo | 58.59 | 2e-157 | 472 |
| LLPS-Fia-3462 | Ficedula albicollis | 56.72 | 1e-145 | 442 |
| LLPS-Tag-3310 | Taeniopygia guttata | 56.46 | 2e-144 | 439 |
| LLPS-Xet-2430 | Xenopus tropicalis | 54.78 | 2e-137 | 421 |
| LLPS-Anc-3709 | Anolis carolinensis | 54.74 | 3e-131 | 405 |
| LLPS-Lac-0095 | Latimeria chalumnae | 53.56 | 2e-122 | 382 |
| LLPS-Xim-3642 | Xiphophorus maculatus | 50.85 | 7e-95 | 309 |
| LLPS-Pof-1738 | Poecilia formosa | 50.32 | 7e-89 | 294 |
| LLPS-Scf-3039 | Scleropages formosus | 49.81 | 3e-91 | 299 |
| LLPS-Icp-2108 | Ictalurus punctatus | 49.45 | 7e-80 | 270 |
| LLPS-Ten-3012 | Tetraodon nigroviridis | 48.87 | 5e-86 | 283 |
| LLPS-Gaa-1484 | Gasterosteus aculeatus | 47.94 | 4e-76 | 255 |
| LLPS-Asm-3417 | Astyanax mexicanus | 47.83 | 3e-80 | 270 |
| LLPS-Dar-0166 | Danio rerio | 46.28 | 6e-95 | 310 |
| LLPS-Tar-3206 | Takifugu rubripes | 44.92 | 6e-87 | 288 |
| LLPS-Orl-2119 | Oryzias latipes | 44.41 | 2e-90 | 297 |
| LLPS-Orn-0015 | Oreochromis niloticus | 44.1 | 4e-96 | 313 |
| LLPS-Scm-3490 | Scophthalmus maximus | 43.6 | 1e-92 | 303 |
| LLPS-Leo-0418 | Lepisosteus oculatus | 40.32 | 2e-71 | 248 |
| LLPS-Cii-2131 | Ciona intestinalis | 29.48 | 3e-11 | 70.1 |