LLPS-Sus-3950
SPDL1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Protein Spindly; Coiled-coil domain-containing protein 99; Spindle apparatus coiled-coil domain-containing protein 1 |
| Gene Name: | SPDL1, CCDC99 |
| Ensembl Gene: | ENSSSCG00000025965.2 |
| Ensembl Protein: | ENSSSCP00000018023.2 |
| Organism: | Sus scrofa |
| Taxa ID: | 9823 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSSSCT00000018523.2 | ENSSSCP00000018023.2 |
| Ensembl | ENSSSCT00000027418.2 | ENSSSCP00000026934.1 |
| UniProt | I3LS43, I3LS43_PIG | |
| GeneBank | AEMK02000102 | |
| RefSeq | XM_003134063.4, XM_005672552.2 | XP_003134111.2, XP_005672609.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MMEADIIADL RCKLKEVEEE RLKAAQYGLQ LVESQNELQN QLDKCRNEMM TMTENYEQEK 60 61 YTLQREVELK SRMLESLSSE CEAIKQQQKM HLEKLEEQLS RSHGQEVNEL KNKLEKLKAE 120 121 LDEARLSEKQ LKHKVDHQKE LLSCKSEEMR ILSERAHESM SSEMLALQIE LTEMESMKTT 180 181 LKEEVNELQY RQEQLELLNT NLMRQVDRLK EEKEEREKEA VSYYNALEKA RVANQDLQVQ 240 241 LDQALQQALD PNSKGNSLFA EVEDRRAAME RQLISMKVKY QSLKKQNAFN REQMQRMKLQ 300 301 ISTLLQMKGS QTEFEQQERL FAMLEQKNGE IKHLLGEIRN LEKFKSLYEG MESKPSANSV 360 361 ALKDDTYYTD LLQIKLDNLN KENENTKGEL SIQRMKALLE SQRALDIERK LFSNERCLQL 420 421 SQSENMKLRA KLDELKLKYE PEERTEVPVL KKRREVLPVD ITTPKDACAN SAVGEGVYRL 480 481 SPQKEEAPAC PNSLEDNSSQ LEKTVSISTS GVILSPHKNL PMDIQPKKEK KCVKLIGVSN 540 541 DSEALSERSG NIPNSPRLAA ESSLQTEVKE GKETASKLEK ATCKKSHPIV YVSSKSTPET 600 601 QCPQQ 605 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGATGGAGG CAGATATAAT AGCAGATCTT CGATGCAAAC TCAAAGAGGT CGAAGAAGAG 60 61 CGACTAAAAG CTGCGCAGTA TGGTTTACAA CTGGTGGAGA GCCAGAATGA ACTGCAGAAT 120 121 CAGCTGGATA AATGTCGTAA TGAAATGATG ACCATGACTG AGAATTATGA ACAAGAAAAA 180 181 TATACTCTTC AGAGAGAAGT TGAGCTCAAG AGTCGAATGT TAGAAAGTTT GAGCTCTGAA 240 241 TGTGAAGCTA TTAAACAGCA ACAAAAAATG CACCTGGAGA AATTAGAAGA ACAACTGAGC 300 301 AGAAGCCATG GACAAGAAGT GAATGAACTA AAAAATAAGT TAGAAAAACT GAAAGCTGAA 360 361 TTAGATGAAG CTCGGCTTAG TGAAAAGCAG CTGAAGCACA AAGTGGATCA TCAGAAGGAA 420 421 CTCCTCTCCT GTAAATCAGA GGAAATGCGG ATACTGTCTG AACGTGCACA TGAAAGCATG 480 481 TCTTCAGAGA TGCTGGCTCT TCAGATTGAG CTGACCGAAA TGGAAAGTAT GAAGACCACC 540 541 CTCAAAGAAG AAGTGAATGA ACTACAGTAC AGACAAGAAC AACTAGAACT TCTTAATACT 600 601 AATCTAATGC GCCAGGTTGA CCGGCTTAAA GAAGAAAAAG AAGAACGAGA GAAAGAAGCA 660 661 GTTTCTTACT ATAATGCCTT AGAGAAAGCT CGAGTAGCAA ATCAGGACCT TCAGGTGCAG 720 721 TTAGACCAAG CACTCCAGCA AGCCTTGGAC CCTAATAGTA AAGGCAACTC TTTGTTTGCA 780 781 GAGGTGGAAG ATCGAAGGGC AGCAATGGAA CGTCAGCTTA TCAGCATGAA AGTCAAATAT 840 841 CAGTCACTAA AGAAGCAAAA TGCATTTAAT AGAGAACAGA TGCAAAGAAT GAAGTTACAA 900 901 ATCTCCACCT TGCTGCAAAT GAAAGGGTCC CAAACTGAAT TTGAACAGCA GGAACGGCTG 960 961 TTTGCCATGT TGGAGCAGAA GAATGGTGAA ATTAAACATC TCTTAGGTGA AATTAGAAAT 1020 1021 CTGGAGAAAT TTAAGAGTTT ATATGAAGGT ATGGAATCTA AGCCTTCAGC CAACTCTGTC 1080 1081 GCCCTGAAAG ATGACACCTA TTACACAGAT TTACTTCAGA TAAAGCTTGA CAACTTAAAC 1140 1141 AAAGAAAATG AAAACACTAA AGGTGAATTG TCCATCCAGC GAATGAAAGC ATTATTAGAG 1200 1201 AGCCAGAGGG CTCTGGATAT TGAGCGAAAA CTTTTTTCAA ATGAAAGGTG CCTCCAGCTT 1260 1261 TCCCAGAGTG AAAATATGAA ACTGAGAGCT AAACTAGATG AGTTAAAATT GAAGTATGAA 1320 1321 CCTGAAGAGA GAACTGAAGT ACCTGTCCTC AAAAAGAGGC GTGAGGTGCT GCCTGTGGAT 1380 1381 ATAACCACCC CTAAGGATGC TTGTGCCAAC AGTGCTGTTG GGGAAGGCGT TTATAGATTA 1440 1441 TCACCTCAGA AAGAGGAGGC ACCGGCCTGT CCTAACAGTT TAGAAGATAA CAGCTCGCAG 1500 1501 TTAGAAAAGA CAGTTTCTAT AAGCACATCA GGAGTCATTC TCTCTCCTCA CAAAAATCTT 1560 1561 CCCATGGATA TTCAACCAAA GAAGGAAAAG AAATGTGTGA AACTTATAGG AGTTTCAAAT 1620 1621 GACTCTGAAG CCCTAAGTGA AAGAAGTGGA AACATCCCTA ACTCTCCCAG CTTATTTTGG 1680 1681 GAGTTGGAGG AGGCCACAAT TGCTTGGGCA GAGTATCCTG GAAGTAAAGT GATGAAGAGA 1740 1741 TTGGAAGGAT GCAAGACTAG AGGCAGAGAG CTGATGTCCA AGTTTCAAAT GAGGAGGATT 1800 1801 TTTACAAGGT AG 1812 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Condensed chromosome outer kinetochore | |
Cellular Component | Cytoplasm | |
Cellular Component | Microtubule organizing center | |
Cellular Component | Nucleus | |
Cellular Component | Spindle pole | |
Molecular Function | Enzyme binding | |
Molecular Function | Kinetochore binding | |
Biological Process | Cell division | |
Biological Process | Establishment of mitotic spindle orientation | |
Biological Process | Mitotic metaphase plate congression | |
Biological Process | Mitotic spindle assembly checkpoint | |
Biological Process | Protein localization to kinetochore |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Tut-2035 | Tursiops truncatus | 93.21 | 0.0 | 984 |
| LLPS-Aim-3327 | Ailuropoda melanoleuca | 91.72 | 0.0 | 969 |
| LLPS-Eqc-2711 | Equus caballus | 91.72 | 0.0 | 975 |
| LLPS-Urm-1069 | Ursus maritimus | 91.39 | 0.0 | 961 |
| LLPS-Mup-3746 | Mustela putorius furo | 91.06 | 0.0 | 957 |
| LLPS-Caf-1217 | Canis familiaris | 90.23 | 0.0 | 951 |
| LLPS-Fec-2871 | Felis catus | 90.23 | 0.0 | 955 |
| LLPS-Gog-3698 | Gorilla gorilla | 89.75 | 0.0 | 948 |
| LLPS-Pat-3467 | Pan troglodytes | 89.75 | 0.0 | 951 |
| LLPS-Chs-1535 | Chlorocebus sabaeus | 89.59 | 0.0 | 943 |
| LLPS-Pap-2404 | Pan paniscus | 89.59 | 0.0 | 948 |
| LLPS-Mal-3622 | Mandrillus leucophaeus | 89.42 | 0.0 | 945 |
| LLPS-Cea-1676 | Cercocebus atys | 89.42 | 0.0 | 946 |
| LLPS-Mam-3579 | Macaca mulatta | 89.42 | 0.0 | 944 |
| LLPS-Hos-0529 | Homo sapiens | 89.26 | 0.0 | 944 |
| LLPS-Paa-4485 | Papio anubis | 89.23 | 0.0 | 853 |
| LLPS-Maf-4468 | Macaca fascicularis | 89.05 | 0.0 | 852 |
| LLPS-Rhb-3677 | Rhinopithecus bieti | 89.05 | 0.0 | 851 |
| LLPS-Aon-1202 | Aotus nancymaae | 88.93 | 0.0 | 947 |
| LLPS-Man-2183 | Macaca nemestrina | 88.87 | 0.0 | 848 |
| LLPS-Caj-2305 | Callithrix jacchus | 88.43 | 0.0 | 943 |
| LLPS-Bot-4624 | Bos taurus | 87.75 | 0.0 | 925 |
| LLPS-Otg-0282 | Otolemur garnettii | 87.6 | 0.0 | 914 |
| LLPS-Ova-2298 | Ovis aries | 87.42 | 0.0 | 928 |
| LLPS-Nol-1518 | Nomascus leucogenys | 87.27 | 0.0 | 902 |
| LLPS-Loa-2085 | Loxodonta africana | 86.08 | 0.0 | 798 |
| LLPS-Orc-0853 | Oryctolagus cuniculus | 85.76 | 0.0 | 906 |
| LLPS-Cas-0158 | Carlito syrichta | 85.39 | 0.0 | 893 |
| LLPS-Myl-3378 | Myotis lucifugus | 85.2 | 0.0 | 895 |
| LLPS-Poa-2828 | Pongo abelii | 84.96 | 0.0 | 872 |
| LLPS-Fud-3787 | Fukomys damarensis | 84.84 | 0.0 | 892 |
| LLPS-Cap-1516 | Cavia porcellus | 83.33 | 0.0 | 861 |
| LLPS-Mea-0354 | Mesocricetus auratus | 80.87 | 4e-140 | 420 |
| LLPS-Ran-4047 | Rattus norvegicus | 73.15 | 0.0 | 690 |
| LLPS-Mum-4451 | Mus musculus | 72.79 | 0.0 | 691 |
| LLPS-Sah-2716 | Sarcophilus harrisii | 67.93 | 0.0 | 658 |
| LLPS-Mod-0038 | Monodelphis domestica | 66.61 | 0.0 | 609 |
| LLPS-Dio-3852 | Dipodomys ordii | 61.91 | 4e-179 | 526 |
| LLPS-Anp-0699 | Anas platyrhynchos | 60.49 | 0.0 | 558 |
| LLPS-Pes-0446 | Pelodiscus sinensis | 60.23 | 0.0 | 569 |
| LLPS-Gaga-3748 | Gallus gallus | 60.03 | 0.0 | 551 |
| LLPS-Meg-0494 | Meleagris gallopavo | 59.74 | 0.0 | 547 |
| LLPS-Tag-3310 | Taeniopygia guttata | 58.1 | 4e-179 | 528 |
| LLPS-Fia-3462 | Ficedula albicollis | 58.03 | 2e-177 | 523 |
| LLPS-Anc-3709 | Anolis carolinensis | 56.14 | 7e-155 | 466 |
| LLPS-Xet-2430 | Xenopus tropicalis | 55.61 | 6e-168 | 499 |
| LLPS-Lac-0095 | Latimeria chalumnae | 55.59 | 4e-157 | 472 |
| LLPS-Asm-3417 | Astyanax mexicanus | 50.21 | 4e-101 | 325 |
| LLPS-Xim-3642 | Xiphophorus maculatus | 49.61 | 2e-115 | 363 |
| LLPS-Gaa-1484 | Gasterosteus aculeatus | 49.54 | 2e-93 | 301 |
| LLPS-Ten-3012 | Tetraodon nigroviridis | 48.58 | 3e-101 | 322 |
| LLPS-Scf-3039 | Scleropages formosus | 48.2 | 1e-114 | 361 |
| LLPS-Dar-0166 | Danio rerio | 47.45 | 3e-112 | 355 |
| LLPS-Pof-1738 | Poecilia formosa | 46.1 | 8e-116 | 364 |
| LLPS-Orn-0015 | Oreochromis niloticus | 46.07 | 8e-120 | 375 |
| LLPS-Orl-2119 | Oryzias latipes | 45.48 | 1e-108 | 345 |
| LLPS-Scm-3490 | Scophthalmus maximus | 44.93 | 1e-107 | 342 |
| LLPS-Icp-2108 | Ictalurus punctatus | 44.26 | 4e-106 | 338 |
| LLPS-Tar-3206 | Takifugu rubripes | 44.13 | 1e-105 | 337 |
| LLPS-Leo-0418 | Lepisosteus oculatus | 41.48 | 5e-91 | 300 |
| LLPS-Cii-2131 | Ciona intestinalis | 30.34 | 1e-18 | 92.8 |