LLPS-Anc-3709
SPDL1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Protein Spindly; Coiled-coil domain-containing protein 99; Spindle apparatus coiled-coil domain-containing protein 1 |
| Gene Name: | SPDL1, CCDC99 |
| Ensembl Gene: | ENSACAG00000016212.3 |
| Ensembl Protein: | ENSACAP00000015946.3 |
| Organism: | Anolis carolinensis |
| Taxa ID: | 28377 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSACAT00000016264.3 | ENSACAP00000015946.3 |
| UniProt | G1KSB9, G1KSB9_ANOCA |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MLIYYQYPKR RTWQSNKDKV SVQRVRVSKK METDTDTISR LRCQLKEAEE ERRKAAQYGL 60 61 KLVENENLLQ NRLDELQNEM VVLTENFEQE KYTLQREVEL KNRMLGSLNH EYETLKQQQN 120 121 AQLDVLREQL ERAQGQEMNE LKNKVEKLKS ELDEALLSEK QLKHKVDHLK DLLASKSEEL 180 181 RLMSERVHDT MSSEVLNLQL ELLAVEQAKA DLEESLHDLR YSKEQLELGN SNLTNRVARF 240 241 EEEKEEREKD LVSYCNALEK AREMNRDLQM QLDHALQQAL DPSSKGNSLF AEVEDRRADM 300 301 ERCLISTKVK YQLLQKQHTF TREQLQRLKL QMATLLRMKG SQGEHDQLER LQNMLQQKNG 360 361 EIEELLMKMK QLEKSVKGSE NSRAMKPSNT SDGVGFEDGY YTDLLQMKLE NSDKEIENLK 420 421 SELSLQRMKA LFESQRVLEM ERKLHANERQ LETCQSENIH LRVSLDELKI KYEPEDLMRD 480 481 PVSLKKTPVD ILSESVNSRM SSFCEKSCML SQKEEAKLSD ADLKTMFQDV SINTIPSLAV 540 541 EKGNDQAGRK RVKITEEQID RTALNKKDGN DIGASHDNRL ISGPGIKSEE NCAGAAEETS 600 601 KCEKKDIKKM HPRVYMSSKQ CPDTQCAQQ 629 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCTGATTT ATTATCAGTA TCCAAAGAGA AGAACCTGGC AAAGTAACAA AGATAAAGTT 60 61 TCAGTGCAAA GAGTACGAGT GTCAAAGAAA ATGGAGACTG ACACAGATAC AATTTCACGT 120 121 CTTCGGTGTC AGCTCAAAGA AGCCGAGGAG GAAAGAAGAA AAGCAGCACA ATATGGCTTG 180 181 AAGTTGGTGG AGAATGAGAA CTTGCTGCAG AATCGGCTAG ATGAACTACA AAATGAAATG 240 241 GTTGTCCTAA CAGAGAATTT TGAACAAGAA AAATATACTC TACAGAGAGA AGTAGAACTG 300 301 AAGAACAGAA TGTTAGGAAG TTTGAATCAT GAATACGAGA CTCTTAAACA GCAGCAAAAT 360 361 GCACAACTGG ATGTTCTACG TGAACAACTG GAAAGGGCTC AAGGGCAAGA AATGAATGAA 420 421 CTTAAGAATA AGGTGGAAAA ACTGAAATCA GAACTAGATG AAGCACTGCT TAGTGAGAAA 480 481 CAACTGAAAC ACAAAGTAGA TCATCTGAAG GACCTGTTGG CTTCTAAATC AGAAGAACTG 540 541 CGCCTGATGT CAGAACGTGT CCATGACACC ATGTCTTCAG AAGTGCTCAA TCTTCAGCTT 600 601 GAGCTGCTGG CAGTTGAACA GGCAAAGGCA GACCTTGAAG AAAGTTTGCA TGATCTACGG 660 661 TACTCCAAAG AACAGTTGGA ACTTGGAAAC AGCAATCTGA CCAATCGAGT GGCACGTTTT 720 721 GAAGAAGAGA AAGAGGAGAG AGAAAAAGAC CTTGTTTCAT ACTGTAATGC ATTAGAGAAA 780 781 GCCCGTGAGA TGAACAGAGA TCTTCAGATG CAACTTGACC ATGCATTGCA ACAGGCCTTG 840 841 GATCCTTCAA GTAAAGGCAA TTCTTTGTTT GCTGAGGTGG AAGACCGTAG AGCAGACATG 900 901 GAACGTTGTC TGATCAGCAC AAAAGTAAAA TATCAATTGT TACAAAAGCA GCATACTTTC 960 961 ACTAGAGAAC AGCTGCAGAG ACTAAAGCTG CAGATGGCCA CGCTGTTGCG CATGAAAGGT 1020 1021 TCACAGGGCG AACATGATCA GCTTGAACGT TTGCAAAATA TGCTTCAACA AAAGAATGGT 1080 1081 GAAATAGAAG AACTGCTGAT GAAAATGAAG CAACTAGAAA AATCTGTGAA GGGATCTGAA 1140 1141 AATTCAAGAG CAATGAAACC TTCGAACACT TCAGATGGTG TAGGTTTTGA AGATGGGTAT 1200 1201 TATACTGATT TGCTTCAGAT GAAACTCGAG AATTCAGACA AAGAAATAGA AAATTTGAAA 1260 1261 AGCGAATTGT CTTTACAGCG AATGAAGGCT TTGTTTGAAA GTCAGCGAGT CTTGGAAATG 1320 1321 GAACGAAAAC TCCATGCAAA TGAAAGACAA CTTGAGACTT GTCAAAGTGA GAACATACAT 1380 1381 TTGCGTGTGT CGTTGGATGA ATTGAAAATC AAATACGAAC CTGAAGACTT AATGAGAGAT 1440 1441 CCTGTCAGTC TTAAGAAGAC ACCAGTGGAC ATTCTTTCGG AGAGTGTAAA TAGCAGAATG 1500 1501 TCTTCTTTTT GTGAAAAGTC TTGCATGCTG TCTCAAAAGG AGGAAGCAAA ACTAAGTGAT 1560 1561 GCTGATCTGA AGACTATGTT TCAAGACGTA TCAATAAATA CCATTCCCTC TTTAGCAGTG 1620 1621 GAAAAAGGGA ATGATCAAGC TGGAAGGAAA AGAGTTAAAA TTACAGAGGA ACAAATTGAC 1680 1681 AGGACAGCTT TAAATAAGAA AGATGGGAAT GATATTGGAG CATCTCATGA CAACAGGTTG 1740 1741 ATATCTGGAC CTGGAATAAA GTCAGAAGAA AACTGTGCCG GTGCAGCTGA AGAGACAAGT 1800 1801 AAATGTGAGA AGAAAGACAT AAAGAAAATG CACCCAAGGG TATATATGTC CTCCAAACAA 1860 1861 TGTCCTGACA CTCAGTGTGC TCAACAATAA 1890 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Condensed chromosome outer kinetochore | |
Cellular Component | Nucleus | |
Cellular Component | Spindle pole | |
Molecular Function | Enzyme binding | |
Molecular Function | Kinetochore binding | |
Biological Process | Cell division | |
Biological Process | Establishment of mitotic spindle orientation | |
Biological Process | Mitotic metaphase plate congression | |
Biological Process | Mitotic spindle assembly checkpoint | |
Biological Process | Protein localization to kinetochore |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Loa-2085 | Loxodonta africana | 59.36 | 3e-152 | 458 |
| LLPS-Mea-0354 | Mesocricetus auratus | 58.98 | 4e-99 | 315 |
| LLPS-Pes-0446 | Pelodiscus sinensis | 58.62 | 0.0 | 572 |
| LLPS-Rhb-3677 | Rhinopithecus bieti | 58.14 | 3e-156 | 471 |
| LLPS-Anp-0699 | Anas platyrhynchos | 57.89 | 0.0 | 544 |
| LLPS-Meg-0494 | Meleagris gallopavo | 57.89 | 0.0 | 546 |
| LLPS-Gaga-3748 | Gallus gallus | 57.57 | 0.0 | 550 |
| LLPS-Fia-3462 | Ficedula albicollis | 57.57 | 0.0 | 543 |
| LLPS-Man-2183 | Macaca nemestrina | 57.52 | 4e-156 | 470 |
| LLPS-Maf-4468 | Macaca fascicularis | 57.52 | 4e-156 | 470 |
| LLPS-Paa-4485 | Papio anubis | 57.34 | 2e-155 | 468 |
| LLPS-Tag-3310 | Taeniopygia guttata | 57.31 | 0.0 | 545 |
| LLPS-Mam-3579 | Macaca mulatta | 56.51 | 7e-169 | 503 |
| LLPS-Chs-1535 | Chlorocebus sabaeus | 56.51 | 3e-168 | 501 |
| LLPS-Myl-3378 | Myotis lucifugus | 56.37 | 4e-169 | 503 |
| LLPS-Gog-3698 | Gorilla gorilla | 56.35 | 5e-168 | 500 |
| LLPS-Pat-3467 | Pan troglodytes | 56.28 | 2e-168 | 501 |
| LLPS-Pap-2404 | Pan paniscus | 56.28 | 1e-167 | 499 |
| LLPS-Hos-0529 | Homo sapiens | 56.28 | 4e-168 | 501 |
| LLPS-Mod-0038 | Monodelphis domestica | 56.25 | 1e-169 | 504 |
| LLPS-Mal-3622 | Mandrillus leucophaeus | 56.19 | 1e-167 | 499 |
| LLPS-Cea-1676 | Cercocebus atys | 56.19 | 2e-168 | 501 |
| LLPS-Tut-2035 | Tursiops truncatus | 56.14 | 5e-170 | 505 |
| LLPS-Sus-3950 | Sus scrofa | 56.14 | 5e-169 | 503 |
| LLPS-Otg-0282 | Otolemur garnettii | 55.97 | 2e-169 | 504 |
| LLPS-Fec-2871 | Felis catus | 55.95 | 1e-171 | 509 |
| LLPS-Fud-3787 | Fukomys damarensis | 55.86 | 3e-168 | 501 |
| LLPS-Bot-4624 | Bos taurus | 55.63 | 1e-164 | 492 |
| LLPS-Aim-3327 | Ailuropoda melanoleuca | 55.52 | 3e-172 | 511 |
| LLPS-Urm-1069 | Ursus maritimus | 55.5 | 1e-170 | 507 |
| LLPS-Mup-3746 | Mustela putorius furo | 55.48 | 1e-172 | 512 |
| LLPS-Ova-2298 | Ovis aries | 55.46 | 2e-163 | 488 |
| LLPS-Sah-2716 | Sarcophilus harrisii | 55.35 | 1e-169 | 504 |
| LLPS-Cas-0158 | Carlito syrichta | 55.3 | 5e-162 | 485 |
| LLPS-Caf-1217 | Canis familiaris | 55.25 | 5e-169 | 503 |
| LLPS-Scf-3039 | Scleropages formosus | 55.23 | 2e-101 | 327 |
| LLPS-Aon-1202 | Aotus nancymaae | 55.14 | 1e-164 | 492 |
| LLPS-Caj-2305 | Callithrix jacchus | 55.14 | 6e-165 | 492 |
| LLPS-Nol-1518 | Nomascus leucogenys | 55.05 | 4e-159 | 477 |
| LLPS-Eqc-2711 | Equus caballus | 54.89 | 6e-166 | 495 |
| LLPS-Cap-1516 | Cavia porcellus | 54.74 | 3e-163 | 488 |
| LLPS-Orc-0853 | Oryctolagus cuniculus | 54.5 | 1e-165 | 494 |
| LLPS-Poa-2828 | Pongo abelii | 53.42 | 2e-152 | 459 |
| LLPS-Lac-0095 | Latimeria chalumnae | 51.95 | 2e-148 | 450 |
| LLPS-Xet-2430 | Xenopus tropicalis | 50.98 | 7e-158 | 474 |
| LLPS-Xim-3642 | Xiphophorus maculatus | 50.22 | 1e-112 | 356 |
| LLPS-Scm-3490 | Scophthalmus maximus | 50.0 | 5e-102 | 328 |
| LLPS-Ran-4047 | Rattus norvegicus | 49.75 | 3e-123 | 385 |
| LLPS-Asm-3417 | Astyanax mexicanus | 49.05 | 3e-106 | 338 |
| LLPS-Mum-4451 | Mus musculus | 48.95 | 2e-129 | 401 |
| LLPS-Dio-3852 | Dipodomys ordii | 48.55 | 5e-110 | 349 |
| LLPS-Tar-3206 | Takifugu rubripes | 48.48 | 4e-107 | 342 |
| LLPS-Icp-2108 | Ictalurus punctatus | 48.4 | 7e-109 | 347 |
| LLPS-Ten-3012 | Tetraodon nigroviridis | 47.31 | 1e-102 | 327 |
| LLPS-Gaa-1484 | Gasterosteus aculeatus | 47.02 | 2e-89 | 291 |
| LLPS-Pof-1738 | Poecilia formosa | 43.42 | 7e-111 | 352 |
| LLPS-Orl-2119 | Oryzias latipes | 43.38 | 2e-110 | 350 |
| LLPS-Orn-0015 | Oreochromis niloticus | 43.23 | 3e-115 | 364 |
| LLPS-Dar-0166 | Danio rerio | 43.11 | 8e-110 | 349 |
| LLPS-Leo-0418 | Lepisosteus oculatus | 40.26 | 5e-91 | 301 |
| LLPS-Cii-2131 | Ciona intestinalis | 29.65 | 1e-25 | 114 |