LLPS-Fia-3462
SPDL1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Protein Spindly; Coiled-coil domain-containing protein 99; Spindle apparatus coiled-coil domain-containing protein 1 |
| Gene Name: | SPDL1, CCDC99 |
| Ensembl Gene: | ENSFALG00000009682.1 |
| Ensembl Protein: | ENSFALP00000010093.1 |
| Organism: | Ficedula albicollis |
| Taxa ID: | 59894 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSFALT00000010133.1 | ENSFALP00000010093.1 |
| UniProt | U3K4Y9, U3K4Y9_FICAL | |
| GeneBank | AGTO01021631 | |
| RefSeq | XM_005053855.2 | XP_005053912.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEAETILSLK QQLKEAENER RKAAQYGLHL LESQTEVQNK LDQTCCELTE KTEKFEQEKY 60 61 TLQREIELKN RMLESLNFEC DSLKQQQNVQ LDKQKEQLDR AYGQEISDLK NKLENLKAEL 120 121 DETRLSEKQL RQKVEHQKEI IAAKSEELHL MSERVHETMS SEMLNLQIEL TELQSQKAND 180 181 EEKLNELQCS KEQLELVNSN LRNQLEQLQG EKEEREKEVV FYCNALEKAR EANQELQVQL 240 241 DHAVQQSLDP TSKGNSLFAE VEDRRAEMER QLISVKVKYQ SLQKQHAFSR EQLQRMKLQM 300 301 ATLLQLKGSQ AEFDQLERLQ SMLEQKNGEI EDLLMKVRQL EKFKSLYENM EESRPANGAK 360 361 GSDSENGYYA DLLQIKLDNS NKEMETLKNE LSLQRMKALY ESQRVLEFER KLFTNERHLQ 420 421 TCQSENMNLR VMLDELKMKY EPEELLKGPK IKKKREKIPV NATCEYFDSK NSPVKETAHT 480 481 QLLSKEVKKM TTKNLEQSGA SPKKQPFQAS PLHTAFQAIR NIVEPERERK RVRIQDENHV 540 541 AFTSNSRSGN NSSSPAVPRL TAESRFETTE EDKRETKIST EKKTQKKKHS TLYVSSKASS 600 601 ETQCAQQ 607 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGGCAG AGACCATTTT AAGTCTTAAA CAGCAACTGA AGGAAGCAGA GAACGAGCGA 60 61 AGAAAGGCAG CACAATATGG TTTGCATTTA CTGGAGTCCC AAACTGAGGT TCAAAATAAG 120 121 CTGGATCAAA CATGCTGTGA ATTGACTGAG AAAACTGAGA AATTTGAACA AGAGAAATAC 180 181 ACTCTTCAGA GAGAAATTGA ACTCAAGAAT CGAATGTTGG AAAGCTTGAA TTTTGAGTGT 240 241 GATTCCCTTA AGCAACAGCA AAACGTGCAA CTGGACAAAC AGAAAGAACA GCTTGACAGA 300 301 GCCTATGGAC AAGAAATCAG TGACCTTAAA AATAAGTTGG AGAACCTGAA AGCAGAACTG 360 361 GATGAAACAC GCCTCTCAGA GAAACAACTG AGACAAAAAG TGGAGCATCA GAAGGAAATA 420 421 ATTGCTGCCA AATCAGAAGA ACTGCACCTG ATGTCTGAGC GTGTGCATGA GACCATGTCT 480 481 TCAGAAATGC TCAACCTGCA GATAGAGCTC ACTGAGCTCC AGAGTCAGAA GGCCAATGAT 540 541 GAAGAAAAGC TGAACGAGCT GCAGTGCAGT AAAGAACAGT TGGAGCTTGT GAACAGTAAC 600 601 TTACGGAACC AACTGGAGCA GCTGCAGGGG GAAAAAGAAG AGAGGGAAAA AGAAGTTGTT 660 661 TTTTACTGTA ATGCATTAGA GAAAGCTCGT GAGGCTAATC AGGAGCTTCA GGTTCAGCTG 720 721 GATCATGCAG TGCAACAATC TTTGGACCCT ACAAGTAAAG GCAATTCTCT CTTTGCTGAG 780 781 GTGGAGGACC GTAGGGCAGA AATGGAACGA CAGCTGATCA GTGTGAAAGT AAAATATCAA 840 841 TCTCTACAAA AACAACATGC ATTCAGTAGA GAACAATTGC AAAGAATGAA GCTGCAAATG 900 901 GCTACACTGC TACAGCTGAA GGGCTCTCAG GCAGAATTTG ATCAGCTGGA ACGCTTACAG 960 961 TCCATGTTAG AGCAAAAGAA TGGTGAAATA GAAGATCTTC TTATGAAAGT GAGGCAGCTA 1020 1021 GAAAAATTTA AGAGTTTATA TGAGAATATG GAGGAGTCCA GACCTGCTAA TGGTGCGAAA 1080 1081 GGAAGTGATT CTGAAAATGG CTACTATGCA GATTTACTGC AAATTAAACT TGACAACTCA 1140 1141 AACAAGGAAA TGGAAACACT GAAAAATGAA CTATCCCTGC AGAGAATGAA AGCTCTGTAT 1200 1201 GAGAGCCAAA GGGTCCTGGA GTTTGAAAGG AAGCTCTTCA CAAACGAGAG GCATTTGCAG 1260 1261 ACTTGTCAGA GTGAGAATAT GAACCTGCGG GTTATGCTGG ATGAGCTGAA AATGAAATAT 1320 1321 GAACCTGAAG AATTACTTAA AGGGCCTAAA ATTAAAAAGA AGAGGGAGAA AATTCCAGTG 1380 1381 AATGCGACTT GTGAATACTT TGACAGCAAA AACAGTCCAG TGAAAGAAAC TGCTCACACT 1440 1441 CAATTGCTAA GTAAGGAGGT GAAAAAGATG ACTACCAAGA ACCTGGAGCA AAGTGGTGCT 1500 1501 TCTCCAAAAA AACAGCCTTT CCAAGCATCC CCACTACATA CAGCTTTCCA GGCAATACGA 1560 1561 AACATCGTTG AACCTGAAAG AGAAAGAAAG AGAGTTAGAA TTCAAGATGA GAATCATGTC 1620 1621 GCCTTTACTT CGAATAGCAG AAGTGGAAAC AATTCCTCAT CTCCAGCTGT CCCCAGGTTA 1680 1681 ACAGCTGAAT CCAGATTTGA AACTACAGAA GAAGATAAGA GAGAAACTAA AATCTCAACA 1740 1741 GAGAAGAAAA CACAGAAGAA GAAACATTCC ACATTGTATG TATCTTCTAA GGCAAGTTCT 1800 1801 GAAACTCAGT GTGCTCAGCA ATAA 1824 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Condensed chromosome outer kinetochore | |
Cellular Component | Nucleus | |
Cellular Component | Spindle pole | |
Molecular Function | Enzyme binding | |
Molecular Function | Kinetochore binding | |
Biological Process | Cell division | |
Biological Process | Establishment of mitotic spindle orientation | |
Biological Process | Mitotic metaphase plate congression | |
Biological Process | Mitotic spindle assembly checkpoint | |
Biological Process | Protein localization to kinetochore |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Tag-3310 | Taeniopygia guttata | 94.74 | 0.0 | 988 |
| LLPS-Anp-0699 | Anas platyrhynchos | 82.07 | 0.0 | 836 |
| LLPS-Meg-0494 | Meleagris gallopavo | 80.76 | 0.0 | 809 |
| LLPS-Gaga-3748 | Gallus gallus | 80.26 | 0.0 | 822 |
| LLPS-Sah-2716 | Sarcophilus harrisii | 74.09 | 0.0 | 600 |
| LLPS-Pes-0446 | Pelodiscus sinensis | 71.8 | 0.0 | 735 |
| LLPS-Loa-2085 | Loxodonta africana | 68.18 | 5e-170 | 503 |
| LLPS-Anc-3709 | Anolis carolinensis | 68.11 | 1e-178 | 528 |
| LLPS-Rhb-3677 | Rhinopithecus bieti | 66.36 | 1e-171 | 509 |
| LLPS-Paa-4485 | Papio anubis | 66.36 | 3e-171 | 508 |
| LLPS-Man-2183 | Macaca nemestrina | 66.14 | 1e-170 | 507 |
| LLPS-Maf-4468 | Macaca fascicularis | 66.14 | 1e-170 | 506 |
| LLPS-Mea-0354 | Mesocricetus auratus | 62.61 | 2e-112 | 349 |
| LLPS-Mod-0038 | Monodelphis domestica | 61.53 | 0.0 | 580 |
| LLPS-Dio-3852 | Dipodomys ordii | 60.23 | 2e-130 | 401 |
| LLPS-Eqc-2711 | Equus caballus | 58.29 | 0.0 | 539 |
| LLPS-Tut-2035 | Tursiops truncatus | 58.22 | 0.0 | 536 |
| LLPS-Sus-3950 | Sus scrofa | 58.03 | 0.0 | 536 |
| LLPS-Otg-0282 | Otolemur garnettii | 57.84 | 0.0 | 533 |
| LLPS-Fec-2871 | Felis catus | 57.8 | 0.0 | 539 |
| LLPS-Urm-1069 | Ursus maritimus | 57.7 | 0.0 | 536 |
| LLPS-Mup-3746 | Mustela putorius furo | 57.68 | 0.0 | 533 |
| LLPS-Myl-3378 | Myotis lucifugus | 57.54 | 3e-178 | 526 |
| LLPS-Aim-3327 | Ailuropoda melanoleuca | 57.54 | 0.0 | 536 |
| LLPS-Gog-3698 | Gorilla gorilla | 57.12 | 1e-178 | 526 |
| LLPS-Caf-1217 | Canis familiaris | 57.05 | 5e-178 | 525 |
| LLPS-Caj-2305 | Callithrix jacchus | 56.79 | 2e-177 | 523 |
| LLPS-Cap-1516 | Cavia porcellus | 56.72 | 2e-171 | 508 |
| LLPS-Cea-1676 | Cercocebus atys | 56.63 | 3e-177 | 523 |
| LLPS-Fud-3787 | Fukomys damarensis | 56.56 | 6e-176 | 520 |
| LLPS-Mal-3622 | Mandrillus leucophaeus | 56.46 | 1e-176 | 521 |
| LLPS-Ova-2298 | Ovis aries | 56.45 | 6e-176 | 520 |
| LLPS-Orc-0853 | Oryctolagus cuniculus | 56.39 | 0.0 | 535 |
| LLPS-Chs-1535 | Chlorocebus sabaeus | 56.38 | 2e-177 | 523 |
| LLPS-Pat-3467 | Pan troglodytes | 56.22 | 3e-178 | 526 |
| LLPS-Hos-0529 | Homo sapiens | 56.22 | 2e-177 | 524 |
| LLPS-Mam-3579 | Macaca mulatta | 56.06 | 8e-177 | 522 |
| LLPS-Pap-2404 | Pan paniscus | 56.06 | 3e-178 | 526 |
| LLPS-Aon-1202 | Aotus nancymaae | 56.02 | 1e-175 | 519 |
| LLPS-Bot-4624 | Bos taurus | 55.97 | 3e-176 | 521 |
| LLPS-Scf-3039 | Scleropages formosus | 55.66 | 2e-108 | 344 |
| LLPS-Nol-1518 | Nomascus leucogenys | 53.66 | 5e-163 | 486 |
| LLPS-Lac-0095 | Latimeria chalumnae | 53.62 | 7e-155 | 466 |
| LLPS-Cas-0158 | Carlito syrichta | 53.57 | 2e-170 | 506 |
| LLPS-Xet-2430 | Xenopus tropicalis | 53.33 | 6e-173 | 512 |
| LLPS-Poa-2828 | Pongo abelii | 53.31 | 4e-158 | 473 |
| LLPS-Orn-0015 | Oreochromis niloticus | 53.29 | 2e-120 | 377 |
| LLPS-Icp-2108 | Ictalurus punctatus | 52.64 | 9e-117 | 366 |
| LLPS-Dar-0166 | Danio rerio | 52.18 | 8e-111 | 351 |
| LLPS-Asm-3417 | Astyanax mexicanus | 52.18 | 1e-116 | 365 |
| LLPS-Mum-4451 | Mus musculus | 52.04 | 4e-142 | 433 |
| LLPS-Orl-2119 | Oryzias latipes | 51.85 | 6e-108 | 343 |
| LLPS-Ten-3012 | Tetraodon nigroviridis | 51.52 | 9e-109 | 342 |
| LLPS-Ran-4047 | Rattus norvegicus | 51.38 | 4e-142 | 432 |
| LLPS-Scm-3490 | Scophthalmus maximus | 51.36 | 2e-107 | 342 |
| LLPS-Pof-1738 | Poecilia formosa | 50.58 | 2e-109 | 348 |
| LLPS-Xim-3642 | Xiphophorus maculatus | 50.46 | 3e-115 | 362 |
| LLPS-Tar-3206 | Takifugu rubripes | 50.45 | 5e-114 | 359 |
| LLPS-Gaa-1484 | Gasterosteus aculeatus | 49.66 | 3e-109 | 342 |
| LLPS-Leo-0418 | Lepisosteus oculatus | 47.48 | 2e-91 | 301 |
| LLPS-Cii-2131 | Ciona intestinalis | 29.89 | 2e-30 | 128 |