• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Xim-2863
EIF3D

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit D
Gene Name: EIF3D, EIF3S7
Ensembl Gene: ENSXMAG00000000954.2
Ensembl Protein: ENSXMAP00000000942.2
Organism: Xiphophorus maculatus
Taxa ID: 8083
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION


mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MAKFHAPVIQ  DNPSGWGPCA  VPEKFKDMPY  QPFSKGDRLG  KVADWTGATY  QDKRYTNKYS  60
61    SQFGGGSQYA  YFHEEDETSF  QLVDTAKTQK  TAYQRNRMRF  AQRNLRRDKD  RRNLTQFNMQ  120
121   TLPKSAKQKE  RDRMRLQKKF  QKQFGVRQKW  DQKSQAQLKP  RDSSVEVRSD  WEVKEEMDFP  180
181   RLMKMRYMEV  SDPVDIECCG  ALEYYDKAFD  RITTRNEKQL  KSIKRIFHTV  TTTDDPVIRK  240
241   LAKTQGNVFA  TDAILATLMC  CTRSVNSWDI  IVQRVGNKLF  FDKRDNSDFD  LLTVSETANE  300
301   PPQDEGNSFN  SPRNLAMEAT  YINHNFSQQC  LRMGGERHKF  PNSNPFVEED  MDKSEVASVA  360
361   YRYRHWKLGE  DIDLIVRCEH  DGVMTGASGE  VSFINVKTLN  EWDSRYCNGV  DWRQKLDSQR  420
421   GAVLATELKN  NSYKLARWTC  CAMLAGSEYL  KLGYVSRYHV  KDSSRHVILG  TQQFKPNEFA  480
481   SQINLSMENA  WGILRCVIDI  CRKLDEGKYL  ILKDPNKQVI  RVYSLPEGTF  SSDEEEEEEE  540
541   DEEDEEEEGE  LLVFYFLPLL  LQFVYWEQQK  LLYINNVLKN  VLIFCLLKKH  SYEILILL  598
Nucleotide CDS Sequence (FASTA)
1     ATGGCGAAGT  TTCACGCCCC  TGTCATCCAG  GACAACCCGT  CCGGATGGGG  CCCCTGCGCC  60
61    GTCCCAGAGA  AGTTCAAGGA  CATGCCGTAC  CAACCGTTCA  GCAAAGGAGA  CCGACTGGGG  120
121   AAGGTTGCTG  ACTGGACCGG  AGCAACTTAC  CAAGACAAGA  GATACACGAA  TAAATATTCG  180
181   TCTCAGTTTG  GCGGCGGCAG  TCAGTACGCT  TACTTCCACG  AGGAAGACGA  GACAAGCTTC  240
241   CAGCTGGTGG  ACACGGCCAA  GACGCAGAAG  ACGGCGTACC  AGAGGAACCG  CATGCGCTTT  300
301   GCTCAGAGGA  ACCTGCGCAG  AGACAAAGAC  CGCAGGAATC  TGACCCAGTT  CAACATGCAG  360
361   ACGCTCCCGA  AGAGCGCCAA  GCAGAAGGAG  AGGGATCGGA  TGCGTCTGCA  GAAGAAGTTC  420
421   CAGAAGCAGT  TTGGAGTCCG  ACAGAAGTGG  GACCAGAAGT  CTCAGGCCCA  GCTGAAGCCC  480
481   AGAGACTCGT  CAGTGGAGGT  CCGGAGTGAC  TGGGAGGTGA  AGGAGGAGAT  GGACTTCCCC  540
541   CGACTGATGA  AGATGAGATA  CATGGAGGTG  TCCGACCCGG  TCGACATAGA  GTGCTGCGGC  600
601   GCGCTGGAAT  ACTACGACAA  GGCCTTCGAC  CGCATCACCA  CCCGCAACGA  GAAGCAGCTG  660
661   AAGAGCATCA  AGAGGATCTT  CCACACCGTC  ACCACCACCG  ACGACCCGGT  CATCAGAAAG  720
721   CTGGCCAAGA  CGCAGGGCAA  TGTGTTCGCC  ACCGACGCCA  TCCTGGCCAC  ACTGATGTGC  780
781   TGCACACGCT  CAGTCAACTC  CTGGGACATC  ATCGTCCAGA  GAGTCGGCAA  CAAGCTATTC  840
841   TTCGACAAGA  GGGACAACTC  CGACTTCGAT  CTGCTGACTG  TGAGCGAAAC  GGCCAACGAG  900
901   CCTCCGCAGG  ACGAAGGGAA  CTCCTTCAAC  TCCCCCCGTA  ACCTGGCCAT  GGAGGCCACC  960
961   TACATCAACC  ACAACTTCAG  CCAGCAGTGT  TTACGCATGG  GCGGAGAGAG  ACACAAGTTC  1020
1021  CCCAACTCCA  ACCCGTTTGT  GGAGGAGGAC  ATGGACAAGA  GCGAGGTGGC  GTCTGTGGCG  1080
1081  TACAGGTACC  GCCACTGGAA  GCTGGGGGAA  GACATCGACC  TGATCGTGCG  CTGTGAGCAC  1140
1141  GACGGCGTGA  TGACCGGCGC  CAGTGGAGAA  GTGTCGTTCA  TCAACGTGAA  GACGCTGAAC  1200
1201  GAGTGGGACT  CCAGGTACTG  TAACGGGGTG  GACTGGCGTC  AGAAGCTGGA  CTCCCAGAGA  1260
1261  GGCGCCGTCC  TGGCCACCGA  GCTGAAGAAC  AACAGCTACA  AGCTGGCCCG  CTGGACCTGC  1320
1321  TGCGCCATGC  TGGCCGGCTC  CGAGTACCTG  AAGCTGGGGT  ACGTCTCCCG  CTACCACGTG  1380
1381  AAGGACTCGT  CCCGCCACGT  CATCCTGGGA  ACCCAGCAGT  TCAAACCCAA  CGAGTTTGCC  1440
1441  AGCCAGATCA  ACCTGAGCAT  GGAGAACGCC  TGGGGCATCC  TGCGCTGCGT  CATCGACATC  1500
1501  TGCCGCAAGC  TGGACGAGGG  CAAGTACCTG  ATCCTGAAGG  ACCCCAACAA  GCAAGTGATC  1560
1561  CGGGTCTACA  GCCTGCCTGA  GGGAACCTTC  AGCTCCGACG  AAGAGGAGGA  GGAAGAGGAG  1620
1621  GATGAAGAGG  ACGAGGAGGA  GGAAGATGAA  GAGAATTAA  1659

▼ KEYWORD


ID
Family
Complete proteome
Cytoplasm
Initiation factor
Protein biosynthesis
Reference proteome
RNA-binding

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Molecular Function
MRNA cap binding
Molecular Function
Translation initiation factor activity
Biological Process
Cap-dependent translational initiation
Biological Process
Formation of cytoplasmic translation initiation complex

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pof-0288Poecilia formosa99.620.01090
LLPS-Orn-0224Oreochromis niloticus98.310.01075
LLPS-Tar-2499Takifugu rubripes97.560.01070
LLPS-Scf-2046Scleropages formosus97.560.01074
LLPS-Ten-0898Tetraodon nigroviridis97.370.01068
LLPS-Scm-0385Scophthalmus maximus97.180.01062
LLPS-Asm-0924Astyanax mexicanus96.620.01061
LLPS-Gaa-2485Gasterosteus aculeatus96.620.01058
LLPS-Dar-3011Danio rerio96.430.01061
LLPS-Icp-1986Ictalurus punctatus95.490.01042
LLPS-Orl-1024Oryzias latipes94.930.01044
LLPS-Meg-1230Meleagris gallopavo93.620.0 553
LLPS-Pes-2903Pelodiscus sinensis93.610.01027
LLPS-Fia-2479Ficedula albicollis93.230.01023
LLPS-Gaga-1637Gallus gallus93.050.01021
LLPS-Tag-3257Taeniopygia guttata93.050.01020
LLPS-Anc-1118Anolis carolinensis92.860.01019
LLPS-Mod-3739Monodelphis domestica92.670.01018
LLPS-Leo-3409Lepisosteus oculatus92.51e-74 240
LLPS-Sah-2261Sarcophilus harrisii92.480.01017
LLPS-Aim-2630Ailuropoda melanoleuca92.290.01014
LLPS-Fec-1161Felis catus92.290.01014
LLPS-Urm-3810Ursus maritimus92.290.01014
LLPS-Caf-2014Canis familiaris92.290.01014
LLPS-Mum-3657Mus musculus92.110.01014
LLPS-Mea-3783Mesocricetus auratus92.110.01014
LLPS-Sus-1625Sus scrofa92.110.01014
LLPS-Ran-1225Rattus norvegicus92.110.01014
LLPS-Ova-0807Ovis aries92.110.01014
LLPS-Bot-3680Bos taurus92.110.01014
LLPS-Loa-4471Loxodonta africana92.110.01014
LLPS-Ict-3086Ictidomys tridecemlineatus92.110.01014
LLPS-Orc-1553Oryctolagus cuniculus91.920.01012
LLPS-Cap-0095Cavia porcellus91.920.01013
LLPS-Gog-4141Gorilla gorilla91.730.01011
LLPS-Caj-4346Callithrix jacchus91.730.01010
LLPS-Fud-2154Fukomys damarensis91.730.01013
LLPS-Chs-1975Chlorocebus sabaeus91.730.01010
LLPS-Maf-3286Macaca fascicularis91.730.01011
LLPS-Aon-0903Aotus nancymaae91.730.01011
LLPS-Cea-4551Cercocebus atys91.730.01011
LLPS-Myl-2186Myotis lucifugus91.730.01010
LLPS-Mal-4410Mandrillus leucophaeus91.730.01011
LLPS-Paa-1460Papio anubis91.730.01011
LLPS-Dio-2482Dipodomys ordii91.730.01011
LLPS-Otg-1742Otolemur garnettii91.730.01013
LLPS-Rhb-4374Rhinopithecus bieti91.730.01011
LLPS-Hos-1129Homo sapiens91.730.01011
LLPS-Pap-3608Pan paniscus91.730.01011
LLPS-Pat-4780Pan troglodytes91.730.01011
LLPS-Man-1486Macaca nemestrina91.730.01011
LLPS-Cas-3181Carlito syrichta91.730.01011
LLPS-Nol-2364Nomascus leucogenys91.730.01011
LLPS-Mam-3381Macaca mulatta91.730.01011
LLPS-Eqc-1780Equus caballus91.540.01012
LLPS-Tut-2382Tursiops truncatus91.350.0 998
LLPS-Xet-0896Xenopus tropicalis91.170.01018
LLPS-Lac-3153Latimeria chalumnae88.530.0 991
LLPS-Anp-2996Anas platyrhynchos85.530.0 914
LLPS-Poa-1913Pongo abelii83.830.0 892
LLPS-Ora-0494Ornithorhynchus anatinus80.990.0 867
LLPS-Cii-1655Ciona intestinalis66.110.0 731
LLPS-Cis-0512Ciona savignyi64.10.0 711
LLPS-Drm-0623Drosophila melanogaster59.210.0 645
LLPS-Mup-2657Mustela putorius furo58.736e-167 491
LLPS-Via-2135Vigna angularis53.043e-128 389
LLPS-Orbr-1877Oryza brachyantha52.211e-128 391
LLPS-Dac-2313Daucus carota51.357e-125 387
LLPS-Tum-0865Tuber melanosporum50.532e-89 285
LLPS-Ved-1368Verticillium dahliae48.985e-103 330
LLPS-Php-2446Physcomitrella patens48.527e-161 479
LLPS-Tru-0395Triticum urartu47.674e-121 388
LLPS-Miv-0073Microbotryum violaceum47.144e-107 341
LLPS-Amt-2061Amborella trichopoda45.273e-147 444
LLPS-Sob-2536Sorghum bicolor44.363e-146 442
LLPS-Mel-1160Melampsora laricipopulina44.333e-1480.1
LLPS-Cae-1655Caenorhabditis elegans44.321e-142 432
LLPS-Sem-1792Selaginella moellendorffii44.123e-128 393
LLPS-Lem-1095Leptosphaeria maculans43.976e-98 311
LLPS-Put-1256Puccinia triticina43.876e-91 295
LLPS-Lep-1032Leersia perrieri43.832e-142 433
LLPS-Zem-0300Zea mays43.78e-146 441
LLPS-Prp-2201Prunus persica43.672e-140 427
LLPS-Orni-1287Oryza nivara43.658e-143 434
LLPS-Ori-1561Oryza indica43.658e-143 434
LLPS-Orb-1996Oryza barthii43.658e-143 434
LLPS-Orgl-1154Oryza glumaepatula43.658e-143 434
LLPS-Ors-2150Oryza sativa43.658e-143 434
LLPS-Orp-1597Oryza punctata43.657e-143 434
LLPS-Org-2176Oryza glaberrima43.658e-143 434
LLPS-Orr-1504Oryza rufipogon43.658e-143 434
LLPS-Orm-0984Oryza meridionalis43.658e-143 434
LLPS-Gag-1219Gaeumannomyces graminis43.647e-103 330
LLPS-Brd-1599Brachypodium distachyon43.542e-142 432
LLPS-Viv-1605Vitis vinifera43.546e-141 428
LLPS-Gas-0815Galdieria sulphuraria43.371e-138 421
LLPS-Cus-0362Cucumis sativus43.362e-142 432
LLPS-Sei-2512Setaria italica43.313e-144 437
LLPS-Sol-0114Solanum lycopersicum43.173e-145 440
LLPS-Coc-1094Corchorus capsularis43.098e-141 428
LLPS-Vir-0815Vigna radiata43.046e-138 421
LLPS-Nia-2380Nicotiana attenuata42.995e-145 439
LLPS-Met-1922Medicago truncatula42.913e-142 432
LLPS-Phv-0543Phaseolus vulgaris42.861e-137 419
LLPS-Sot-1983Solanum tuberosum42.86e-143 434
LLPS-Glm-1550Glycine max42.758e-137 417
LLPS-Gor-2060Gossypium raimondii42.271e-141 431
LLPS-Thc-2431Theobroma cacao42.247e-140 426
LLPS-Pot-2623Populus trichocarpa42.154e-139 424
LLPS-Mae-0920Manihot esculenta42.074e-137 419
LLPS-Blg-0787Blumeria graminis41.974e-118 369
LLPS-Tra-2851Triticum aestivum41.793e-137 419
LLPS-Hea-2399Helianthus annuus41.761e-141 430
LLPS-Hov-1957Hordeum vulgare41.563e-136 417
LLPS-Chc-0718Chondrus crispus41.392e-123 382
LLPS-Spr-1159Sporisorium reilianum41.31e-132 407
LLPS-Art-2168Arabidopsis thaliana41.233e-134 412
LLPS-Scc-0597Schizosaccharomyces cryophilus40.794e-135 413
LLPS-Arl-1845Arabidopsis lyrata40.369e-132 405
LLPS-Osl-0456Ostreococcus lucimarinus40.249e-98 311
LLPS-Asfu-0693Aspergillus fumigatus40.046e-118 369
LLPS-Usm-0200Ustilago maydis39.937e-130 400
LLPS-Chr-0650Chlamydomonas reinhardtii39.894e-129 397
LLPS-Nef-1024Neosartorya fischeri39.862e-117 368
LLPS-Scp-0485Schizosaccharomyces pombe39.685e-130 400
LLPS-Beb-0326Beauveria bassiana39.672e-114 360
LLPS-Brn-0441Brassica napus39.66e-125 387
LLPS-Brr-1662Brassica rapa39.64e-125 388
LLPS-Asf-0225Aspergillus flavus39.496e-115 362
LLPS-Aso-1184Aspergillus oryzae39.496e-115 362
LLPS-Trv-0019Trichoderma virens39.484e-116 364
LLPS-Crn-1580Cryptococcus neoformans39.431e-129 398
LLPS-Nec-0345Neurospora crassa39.382e-114 360
LLPS-Bro-1749Brassica oleracea39.328e-124 385
LLPS-Asni-0601Aspergillus niger39.312e-113 358
LLPS-Fus-0084Fusarium solani39.319e-114 358
LLPS-Trr-1436Trichoderma reesei39.131e-112 355
LLPS-Asn-1583Aspergillus nidulans38.663e-114 360
LLPS-Asc-1486Aspergillus clavatus38.663e-113 357
LLPS-Map-0162Magnaporthe poae38.557e-113 356
LLPS-Mua-0097Musa acuminata38.556e-102 325
LLPS-Pug-0543Puccinia graminis38.453e-126 391
LLPS-Pyt-0693Pyrenophora teres38.287e-110 348
LLPS-Phn-1564Phaeosphaeria nodorum38.242e-110 350
LLPS-Coo-1607Colletotrichum orbiculare38.227e-110 348
LLPS-Fuv-1542Fusarium verticillioides38.215e-108 343
LLPS-Scj-0627Schizosaccharomyces japonicus37.999e-122 379
LLPS-Pytr-1636Pyrenophora triticirepentis37.917e-109 345
LLPS-Fuo-0517Fusarium oxysporum37.879e-110 348
LLPS-Mao-1568Magnaporthe oryzae37.792e-113 357
LLPS-Cogr-1431Colletotrichum graminicola37.454e-109 346
LLPS-Abg-0977Absidia glauca37.331e-126 392
LLPS-Zyt-1203Zymoseptoria tritici37.321e-106 340
LLPS-Cog-0457Colletotrichum gloeosporioides37.283e-100 320
LLPS-Dos-1516Dothistroma septosporum36.581e-99 322
LLPS-Cym-1142Cyanidioschyzon merolae34.934e-70 245
LLPS-Yal-0966Yarrowia lipolytica34.662e-96 311
LLPS-Ast-0607Aspergillus terreus31.646e-42 160
LLPS-Kop-1473Komagataella pastoris31.072e-74 254