• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Pyt-0693
PTT_09130

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit D
Gene Name: PTT_09130
Ensembl Gene: PTT_09130
Ensembl Protein: EFQ93486
Organism: Pyrenophora teres
Taxa ID: 861557
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEFQ93486EFQ93486
UniProtE3RLA4, E3RLA4_PYRTT
GeneBankGL533828EFQ93486.1
RefSeqXM_003298361.1XP_003298409.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAPASLLDLV  SALPDTQTWG  PPVTDETMLD  GVPFAPYSKA  DKLGRMADWT  EGKDRERGGR  60
61    QQYGNRNYRD  QQVYGANQQT  NPFAIQAAEE  EATFSVVDNT  RTSARGRGFG  RGGGTVFRGR  120
121   GGQRGGQAQR  GGRGTFQRVG  GRGGQQYDNQ  RGGRGGRGGR  RFGWRDDKPQ  RNRDASVQVK  180
181   PEWNVKEEID  FSRLSKLNLD  THEGEDIESY  GFLYYYDRSY  DKQPGAKTSE  RRLNVLDRAA  240
241   YNVTTSSDPI  MQELADKDEA  TVFATDGVLS  MLMCATKSVY  SWDLVFTKRN  NKVFIDKRDG  300
301   SSLDMVTVNE  NAADAPLEIS  EGNKDSINSP  GALMLEATHI  NNVFPLQVVS  ESETNKVNMP  360
361   HEHPFYNEEV  ETDPPASKAY  RYRRFDLSLE  KDEEPLHLIV  RTELDAVVKN  NINGEDQYLT  420
421   IKALNEFDNK  AQGAGGALDW  RTKLASQRGA  VLATEMKNNS  CKLARWTVQS  ILAKADTMKL  480
481   GFVSRANPKN  NNDHVILGVL  TNKPRDFAAQ  MALNLNNGWA  IVRTIVDMVL  RMEEGKYVLV  540
541   KDPNKSLLRL  YSVPMHTFEE  EDVEEMQAPA  EEDEE  575
Nucleotide CDS Sequence (FASTA)
1     ATGGCTCCAG  CATCGTTATT  GGACCTCGTG  TCCGCGCTGC  CCGATACCCA  AACATGGGGA  60
61    CCGCCCGTCA  CGGACGAGAC  AATGCTCGAC  GGTGTTCCCT  TTGCGCCCTA  CTCAAAGGCC  120
121   GATAAGTTGG  GTCGTATGGC  CGACTGGACT  GAGGGCAAGG  ACCGCGAGCG  GGGAGGACGC  180
181   CAGCAGTATG  GCAACCGCAA  CTACAGGGAC  CAGCAGGTAT  ACGGCGCGAA  CCAGCAGACC  240
241   AACCCCTTCG  CTATCCAGGC  TGCCGAGGAG  GAGGCTACCT  TCTCCGTTGT  AGACAACACC  300
301   CGAACATCAG  CCCGCGGCCG  AGGATTTGGA  CGAGGAGGCG  GCACTGTTTT  CCGTGGACGA  360
361   GGAGGACAGC  GTGGAGGACA  GGCACAACGC  GGAGGGCGGG  GTACCTTCCA  GCGCGTTGGT  420
421   GGTCGCGGTG  GACAGCAGTA  CGACAACCAG  CGCGGTGGCC  GTGGCGGCAG  GGGAGGACGT  480
481   CGCTTTGGCT  GGAGAGATGA  CAAGCCTCAG  CGCAACCGTG  ACGCTTCCGT  CCAGGTCAAG  540
541   CCTGAGTGGA  ACGTCAAGGA  GGAGATTGAT  TTCTCGCGCC  TCAGCAAGCT  CAACCTGGAT  600
601   ACCCACGAGG  GCGAGGACAT  TGAAAGCTAC  GGATTCCTCT  ACTACTACGA  CCGCAGCTAC  660
661   GACAAGCAAC  CTGGTGCTAA  GACCTCAGAG  CGCAGGCTCA  ACGTTCTCGA  CCGTGCTGCC  720
721   TACAACGTCA  CCACCTCGAG  CGATCCCATC  ATGCAGGAGC  TTGCAGACAA  AGACGAGGCT  780
781   ACCGTCTTTG  CCACCGACGG  CGTCCTATCG  ATGCTCATGT  GCGCCACAAA  ATCCGTCTAC  840
841   TCCTGGGACT  TGGTCTTTAC  CAAGAGGAAC  AACAAGGTCT  TCATTGACAA  GCGCGACGGA  900
901   TCGAGTCTGG  ACATGGTCAC  TGTCAACGAG  AACGCTGCCG  ATGCGCCGCT  CGAGATCTCT  960
961   GAAGGAAATA  AGGACTCTAT  TAACAGCCCG  GGTGCTCTCA  TGCTCGAAGC  CACCCACATC  1020
1021  AACAACGTTT  TCCCTCTCCA  GGTTGTTTCC  GAGTCAGAGA  CCAACAAGGT  CAACATGCCC  1080
1081  CACGAGCACC  CATTCTACAA  CGAAGAGGTT  GAGACCGACC  CACCCGCCTC  CAAGGCTTAC  1140
1141  AGGTATCGCC  GATTCGATCT  GTCCCTGGAG  AAGGACGAGG  AGCCTCTGCA  CTTGATTGTC  1200
1201  CGAACAGAGC  TTGACGCCGT  TGTCAAGAAC  AACATCAACG  GCGAGGATCA  ATACCTGACC  1260
1261  ATCAAGGCAC  TGAACGAGTT  CGACAACAAG  GCCCAAGGTG  CTGGCGGTGC  TCTCGACTGG  1320
1321  AGGACCAAGT  TGGCCAGCCA  AAGGGGTGCT  GTTCTTGCTA  CCGAGATGAA  GAACAACTCT  1380
1381  TGCAAGCTTG  CTCGATGGAC  TGTACAGAGT  ATCTTGGCCA  AGGCTGACAC  CATGAAGCTC  1440
1441  GGCTTCGTAT  CCCGTGCCAA  CCCCAAGAAC  AACAACGACC  ACGTCATTCT  CGGTGTTCTC  1500
1501  ACCAACAAAC  CCCGTGACTT  TGCCGCCCAA  ATGGCACTCA  ACCTTAACAA  CGGATGGGCT  1560
1561  ATCGTCCGTA  CCATTGTTGA  TATGGTACTC  CGCATGGAAG  AGGGCAAGTA  CGTTCTTGTC  1620
1621  AAGGACCCTA  ACAAGTCCCT  TCTCCGCTTG  TACTCGGTGC  CTATGCATAC  CTTCGAGGAA  1680
1681  GAAGATGTTG  AGGAGATGCA  AGCACCGGCC  GAGGAGGATG  AGGAGTAA  1728

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Initiation factor
Protein biosynthesis
Reference proteome
RNA-binding

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Molecular Function
MRNA cap binding
Molecular Function
Translation initiation factor activity
Biological Process
Cap-dependent translational initiation
Biological Process
Formation of cytoplasmic translation initiation complex

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pytr-1636Pyrenophora triticirepentis99.290.0 998
LLPS-Lem-1095Leptosphaeria maculans95.760.0 749
LLPS-Phn-1564Phaeosphaeria nodorum92.010.0 945
LLPS-Zyt-1203Zymoseptoria tritici80.610.0 660
LLPS-Dos-1516Dothistroma septosporum78.790.0 652
LLPS-Blg-0787Blumeria graminis73.40.0 604
LLPS-Map-0162Magnaporthe poae72.590.0 593
LLPS-Gag-1219Gaeumannomyces graminis71.570.0 588
LLPS-Cog-0457Colletotrichum gloeosporioides70.976e-1478.6
LLPS-Ved-1368Verticillium dahliae70.862e-178 523
LLPS-Fus-0084Fusarium solani70.740.0 561
LLPS-Mao-1568Magnaporthe oryzae70.380.0 583
LLPS-Trv-0019Trichoderma virens70.330.0 571
LLPS-Trr-1436Trichoderma reesei69.480.0 568
LLPS-Tum-0865Tuber melanosporum69.11e-134 401
LLPS-Coo-1607Colletotrichum orbiculare68.822e-28 124
LLPS-Fuo-0517Fusarium oxysporum68.690.0 558
LLPS-Fuv-1542Fusarium verticillioides68.690.0 558
LLPS-Nec-0345Neurospora crassa68.690.0 556
LLPS-Beb-0326Beauveria bassiana68.450.0 567
LLPS-Nef-1024Neosartorya fischeri68.02e-33 138
LLPS-Ast-0607Aspergillus terreus68.06e-34 137
LLPS-Cogr-1431Colletotrichum graminicola67.746e-28 122
LLPS-Asfu-0693Aspergillus fumigatus67.01e-32 135
LLPS-Asn-1583Aspergillus nidulans67.02e-33 138
LLPS-Asf-0225Aspergillus flavus67.00.0 551
LLPS-Aso-1184Aspergillus oryzae67.00.0 551
LLPS-Asni-0601Aspergillus niger66.750.0 556
LLPS-Asc-1486Aspergillus clavatus66.580.0 560
LLPS-Usm-0200Ustilago maydis56.333e-145 439
LLPS-Scj-0627Schizosaccharomyces japonicus56.235e-150 451
LLPS-Spr-1159Sporisorium reilianum55.331e-143 435
LLPS-Scp-0485Schizosaccharomyces pombe54.712e-147 444
LLPS-Pug-0543Puccinia graminis53.389e-138 420
LLPS-Scc-0597Schizosaccharomyces cryophilus52.674e-141 428
LLPS-Crn-1580Cryptococcus neoformans51.533e-133 407
LLPS-Miv-0073Microbotryum violaceum51.511e-131 404
LLPS-Put-1256Puccinia triticina51.513e-119 367
LLPS-Mel-1160Melampsora laricipopulina51.431e-134 413
LLPS-Abg-0977Absidia glauca50.126e-128 395
LLPS-Gor-2060Gossypium raimondii50.04e-115 361
LLPS-Zem-0300Zea mays50.09e-109 345
LLPS-Glm-1550Glycine max50.05e-115 360
LLPS-Phv-0543Phaseolus vulgaris49.492e-113 356
LLPS-Sob-2536Sorghum bicolor49.492e-107 341
LLPS-Coc-1094Corchorus capsularis49.234e-114 358
LLPS-Vir-0815Vigna radiata49.232e-112 354
LLPS-Sei-2512Setaria italica49.112e-107 341
LLPS-Mae-0920Manihot esculenta48.976e-113 355
LLPS-Thc-2431Theobroma cacao48.974e-112 353
LLPS-Via-2135Vigna angularis48.958e-109 338
LLPS-Art-2168Arabidopsis thaliana48.724e-110 348
LLPS-Arl-1845Arabidopsis lyrata48.728e-111 350
LLPS-Met-1922Medicago truncatula48.722e-112 353
LLPS-Viv-1605Vitis vinifera48.468e-112 352
LLPS-Cus-0362Cucumis sativus48.464e-112 353
LLPS-Prp-2201Prunus persica48.211e-110 349
LLPS-Bro-1749Brassica oleracea48.074e-109 346
LLPS-Pot-2623Populus trichocarpa47.951e-111 352
LLPS-Amt-2061Amborella trichopoda47.835e-107 339
LLPS-Sem-1792Selaginella moellendorffii47.818e-107 337
LLPS-Dac-2313Daucus carota47.691e-108 344
LLPS-Brr-1662Brassica rapa47.568e-108 342
LLPS-Brn-0441Brassica napus47.566e-108 342
LLPS-Brd-1599Brachypodium distachyon47.566e-107 340
LLPS-Nia-2380Nicotiana attenuata47.443e-109 345
LLPS-Hea-2399Helianthus annuus47.184e-107 340
LLPS-Orbr-1877Oryza brachyantha47.111e-104 328
LLPS-Lep-1032Leersia perrieri47.047e-107 340
LLPS-Sol-0114Solanum lycopersicum46.672e-107 341
LLPS-Sot-1983Solanum tuberosum46.673e-107 340
LLPS-Lac-3153Latimeria chalumnae46.513e-108 342
LLPS-Orp-1597Oryza punctata46.411e-105 337
LLPS-Ors-2150Oryza sativa46.411e-105 337
LLPS-Org-2176Oryza glaberrima46.411e-105 337
LLPS-Orr-1504Oryza rufipogon46.411e-105 337
LLPS-Orm-0984Oryza meridionalis46.411e-105 337
LLPS-Orni-1287Oryza nivara46.411e-105 337
LLPS-Orb-1996Oryza barthii46.411e-105 337
LLPS-Ori-1561Oryza indica46.411e-105 337
LLPS-Orgl-1154Oryza glumaepatula46.411e-105 337
LLPS-Tra-2851Triticum aestivum46.273e-103 330
LLPS-Php-2446Physcomitrella patens46.191e-102 328
LLPS-Tru-0395Triticum urartu45.822e-100 332
LLPS-Hov-1957Hordeum vulgare45.822e-103 331
LLPS-Scf-2046Scleropages formosus45.481e-103 330
LLPS-Yal-0966Yarrowia lipolytica45.361e-1171.2
LLPS-Leo-3409Lepisosteus oculatus45.311e-25 107
LLPS-Asm-0924Astyanax mexicanus45.222e-104 333
LLPS-Meg-1230Meleagris gallopavo45.211e-32 131
LLPS-Orc-1553Oryctolagus cuniculus45.154e-106 337
LLPS-Rhb-4374Rhinopithecus bieti45.153e-106 337
LLPS-Otg-1742Otolemur garnettii45.153e-106 337
LLPS-Man-1486Macaca nemestrina45.153e-106 337
LLPS-Loa-4471Loxodonta africana45.155e-106 336
LLPS-Pat-4780Pan troglodytes45.153e-106 337
LLPS-Pap-3608Pan paniscus45.153e-106 337
LLPS-Urm-3810Ursus maritimus45.153e-106 337
LLPS-Hos-1129Homo sapiens45.153e-106 337
LLPS-Fec-1161Felis catus45.153e-106 337
LLPS-Ict-3086Ictidomys tridecemlineatus45.153e-106 337
LLPS-Nol-2364Nomascus leucogenys45.153e-106 337
LLPS-Cas-3181Carlito syrichta45.153e-106 337
LLPS-Mam-3381Macaca mulatta45.153e-106 337
LLPS-Caf-2014Canis familiaris45.153e-106 337
LLPS-Cap-0095Cavia porcellus45.151e-105 336
LLPS-Fud-2154Fukomys damarensis45.152e-106 337
LLPS-Caj-4346Callithrix jacchus45.153e-106 337
LLPS-Gog-4141Gorilla gorilla45.153e-106 337
LLPS-Aon-0903Aotus nancymaae45.153e-106 337
LLPS-Cea-4551Cercocebus atys45.153e-106 337
LLPS-Sus-1625Sus scrofa45.153e-106 337
LLPS-Mea-3783Mesocricetus auratus45.154e-106 337
LLPS-Maf-3286Macaca fascicularis45.153e-106 337
LLPS-Mum-3657Mus musculus45.154e-106 337
LLPS-Chs-1975Chlorocebus sabaeus45.153e-106 337
LLPS-Paa-1460Papio anubis45.153e-106 337
LLPS-Mal-4410Mandrillus leucophaeus45.153e-106 337
LLPS-Aim-2630Ailuropoda melanoleuca45.153e-106 337
LLPS-Ova-0807Ovis aries45.153e-106 337
LLPS-Myl-2186Myotis lucifugus45.154e-106 337
LLPS-Ran-1225Rattus norvegicus45.154e-106 337
LLPS-Dio-2482Dipodomys ordii45.153e-106 337
LLPS-Bot-3680Bos taurus45.153e-106 337
LLPS-Dar-3011Danio rerio44.961e-103 330
LLPS-Icp-1986Ictalurus punctatus44.963e-102 327
LLPS-Eqc-1780Equus caballus44.92e-105 335
LLPS-Fia-2479Ficedula albicollis44.873e-105 335
LLPS-Tag-3257Taeniopygia guttata44.872e-105 335
LLPS-Gaga-1637Gallus gallus44.873e-105 334
LLPS-Mod-3739Monodelphis domestica44.642e-104 332
LLPS-Sah-2261Sarcophilus harrisii44.643e-104 332
LLPS-Orn-0224Oreochromis niloticus44.442e-102 327
LLPS-Pof-0288Poecilia formosa44.448e-103 328
LLPS-Scm-0385Scophthalmus maximus44.442e-102 327
LLPS-Tar-2499Takifugu rubripes44.442e-102 327
LLPS-Anc-1118Anolis carolinensis44.394e-104 332
LLPS-Tut-2382Tursiops truncatus44.391e-100 322
LLPS-Ten-0898Tetraodon nigroviridis44.334e-102 326
LLPS-Mup-2657Mustela putorius furo44.299e-40 155
LLPS-Orl-1024Oryzias latipes44.274e-102 327
LLPS-Xim-2863Xiphophorus maculatus44.192e-101 326
LLPS-Pes-2903Pelodiscus sinensis44.132e-103 330
LLPS-Gaa-2485Gasterosteus aculeatus43.933e-101 324
LLPS-Gas-0815Galdieria sulphuraria43.881e-97 315
LLPS-Drm-0623Drosophila melanogaster43.882e-103 330
LLPS-Xet-0896Xenopus tropicalis43.412e-101 325
LLPS-Cae-1655Caenorhabditis elegans42.968e-91 297
LLPS-Cii-1655Ciona intestinalis42.461e-93 304
LLPS-Chc-0718Chondrus crispus42.019e-80 267
LLPS-Cis-0512Ciona savignyi41.711e-92 302
LLPS-Chr-0650Chlamydomonas reinhardtii40.623e-86 285
LLPS-Kop-1473Komagataella pastoris40.412e-87 288
LLPS-Mua-0097Musa acuminata39.651e-76 258
LLPS-Poa-1913Pongo abelii39.296e-77 259
LLPS-Osl-0456Ostreococcus lucimarinus39.182e-78 260
LLPS-Anp-2996Anas platyrhynchos38.682e-79 266
LLPS-Ora-0494Ornithorhynchus anatinus38.141e-73 251
LLPS-Cym-1142Cyanidioschyzon merolae32.72e-49 186