LLPS-Myl-2186
EIF3D
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Eukaryotic translation initiation factor 3 subunit D |
| Gene Name: | EIF3D, EIF3S7 |
| Ensembl Gene: | ENSMLUG00000015857.2 |
| Ensembl Protein: | ENSMLUP00000014448.2 |
| Organism: | Myotis lucifugus |
| Taxa ID: | 59463 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMLUT00000015861.2 | ENSMLUP00000014448.2 |
| UniProt | G1PTA3, G1PTA3_MYOLU | |
| GeneBank | AAPE02052556 | |
| RefSeq | XM_006105722.2 | XP_006105784.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAKFMTPVIQ DNPSGWGPCA VPEQFRDMPY QPFSKGDRLG KVADWTGTTY QDKRYTNKYS 60 61 SQFGGGSQYA YFHEEDETSF QLVDTARTQK TAYQRNRMRF AQRNLRRDKD RRNMLQFNLQ 120 121 TLPKSAKQKE RERIRLQKKF QKQFGVRQKW DQKSQKPRDS SVEVRSDWEV KEEMDFPQLM 180 181 KMRYLEVSEP QDIECCGGLE YYDKAFDRIT TRSEKPLRSI KRIFHTVTTT DDPVIRKLAK 240 241 TQGNVFATDA ILATLMSCTR SVYSWDIVVQ RVGSKLFFDK RDNSDFDLLT VSETANEPPQ 300 301 DEGNSFNSPR NLAMEATYIN HNFSQQCLRM GKERYNFPNP NPFVEDDMDK NEIASVAYRY 360 361 RRWKLGDDID LIVRCEHDGV MTGANGEVSF INIKTLNEWD SRHCNGVDWR QKLDSQRGAV 420 421 IATELKNNSY KLARWTCCAL LAGSEYLKLG YVSRYHVKDS SRHVILGTQQ FKPNEFASQI 480 481 NLSVENAWGI LRCVIDICMK LEEGKYLILK DPNKQVIRVY SLPDGTFSSD EDDEDEEEEE 540 541 EEEEEEET 548 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCAAAGT TCATGACACC CGTGATCCAG GACAACCCCT CAGGCTGGGG TCCCTGCGCA 60 61 GTCCCCGAGC AGTTTCGGGA TATGCCCTAC CAGCCATTCA GCAAAGGAGA TCGGCTGGGA 120 121 AAGGTTGCAG ACTGGACGGG TACCACATAC CAAGATAAGA GGTACACGAA TAAGTACTCC 180 181 TCTCAGTTTG GTGGTGGAAG TCAGTATGCT TATTTCCACG AGGAGGATGA AACGAGTTTC 240 241 CAGCTGGTGG ACACAGCGCG CACCCAGAAG ACCGCCTACC AGCGGAATCG AATGCGATTT 300 301 GCACAGCGGA ATCTCCGCAG AGACAAAGAT CGACGGAACA TGTTGCAGTT CAATCTGCAG 360 361 ACCCTGCCTA AGAGCGCCAA GCAGAAAGAG AGAGAACGCA TACGACTGCA GAAAAAATTT 420 421 CAGAAACAGT TTGGAGTGAG GCAGAAATGG GACCAAAAAT CACAGAAACC CCGAGACTCT 480 481 TCGGTTGAAG TTCGTAGTGA CTGGGAGGTG AAAGAGGAAA TGGACTTCCC TCAGTTAATG 540 541 AAGATGCGCT ACTTGGAAGT CTCAGAGCCA CAGGACATCG AGTGTTGTGG GGGCCTGGAA 600 601 TACTACGACA AAGCCTTCGA CCGCATCACC ACGAGGAGCG AGAAGCCCCT GAGGAGCATC 660 661 AAGCGCATCT TCCATACCGT CACCACCACA GACGACCCTG TCATCCGAAA GCTGGCAAAA 720 721 ACCCAGGGGA ATGTGTTTGC CACCGACGCC ATTCTGGCCA CTCTGATGAG CTGCACCCGC 780 781 TCCGTGTATT CTTGGGACAT TGTCGTCCAG AGAGTCGGAT CCAAGCTCTT CTTTGACAAG 840 841 AGGGATAACT CTGACTTTGA CCTCCTGACA GTGAGTGAGA CAGCCAACGA GCCCCCTCAA 900 901 GATGAAGGTA ATTCCTTCAA CTCGCCCCGC AACCTGGCCA TGGAAGCAAC CTACATCAAC 960 961 CACAACTTCT CCCAGCAGTG CCTGAGGATG GGGAAAGAAA GGTACAACTT CCCCAACCCA 1020 1021 AACCCGTTTG TGGAAGATGA CATGGATAAG AATGAAATCG CCTCTGTTGC ATACCGGTAC 1080 1081 CGCAGGTGGA AGCTTGGAGA CGACATTGAC CTGATTGTCC GTTGTGAGCA TGATGGTGTC 1140 1141 ATGACCGGAG CCAATGGGGA AGTGTCCTTC ATCAACATCA AGACTCTCAA CGAGTGGGAC 1200 1201 TCCAGGCACT GTAATGGTGT TGACTGGCGT CAGAAGCTGG ACTCCCAGCG AGGGGCCGTC 1260 1261 ATTGCCACCG AGCTGAAGAA CAACAGCTAT AAGTTGGCCC GATGGACCTG CTGCGCTTTG 1320 1321 CTGGCTGGAT CCGAGTACCT CAAGCTTGGT TATGTGTCCC GGTACCATGT GAAAGACTCC 1380 1381 TCGCGCCACG TCATCCTGGG CACCCAGCAG TTCAAGCCCA ATGAGTTTGC CAGCCAGATC 1440 1441 AACCTGAGTG TAGAGAACGC CTGGGGCATC CTGCGCTGCG TCATCGACAT CTGCATGAAG 1500 1501 CTGGAGGAGG GCAAGTACCT CATCCTCAAG GACCCCAATA AGCAGGTCAT CCGAGTCTAC 1560 1561 AGCCTGCCGG ATGGCACCTT CAGTTCCGAC GAGGACGATG AGGATGAGGA AGAGGAGGAG 1620 1621 GAAGAAGAAG AAGAGGAAGA AACTTAA 1647 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Eukaryotic 43S preinitiation complex | |
Cellular Component | Eukaryotic 48S preinitiation complex | |
Cellular Component | Eukaryotic translation initiation factor 3 complex, eIF3m | |
Molecular Function | MRNA cap binding | |
Molecular Function | Translation initiation factor activity | |
Biological Process | Cap-dependent translational initiation | |
Biological Process | Formation of cytoplasmic translation initiation complex | |
Biological Process | IRES-dependent viral translational initiation | |
Biological Process | Positive regulation of mRNA binding | |
Biological Process | Positive regulation of translation | |
Biological Process | Viral translational termination-reinitiation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Bot-3680 | Bos taurus | 99.62 | 0.0 | 1111 |
| LLPS-Ova-0807 | Ovis aries | 99.62 | 0.0 | 1111 |
| LLPS-Sus-1625 | Sus scrofa | 99.62 | 0.0 | 1111 |
| LLPS-Ict-3086 | Ictidomys tridecemlineatus | 99.62 | 0.0 | 1110 |
| LLPS-Aim-2630 | Ailuropoda melanoleuca | 99.43 | 0.0 | 1111 |
| LLPS-Caf-2014 | Canis familiaris | 99.43 | 0.0 | 1110 |
| LLPS-Fec-1161 | Felis catus | 99.43 | 0.0 | 1109 |
| LLPS-Urm-3810 | Ursus maritimus | 99.43 | 0.0 | 1110 |
| LLPS-Dio-2482 | Dipodomys ordii | 99.24 | 0.0 | 1108 |
| LLPS-Ran-1225 | Rattus norvegicus | 99.24 | 0.0 | 1108 |
| LLPS-Mal-4410 | Mandrillus leucophaeus | 99.24 | 0.0 | 1108 |
| LLPS-Paa-1460 | Papio anubis | 99.24 | 0.0 | 1108 |
| LLPS-Chs-1975 | Chlorocebus sabaeus | 99.24 | 0.0 | 1107 |
| LLPS-Mum-3657 | Mus musculus | 99.24 | 0.0 | 1108 |
| LLPS-Maf-3286 | Macaca fascicularis | 99.24 | 0.0 | 1108 |
| LLPS-Mea-3783 | Mesocricetus auratus | 99.24 | 0.0 | 1108 |
| LLPS-Aon-0903 | Aotus nancymaae | 99.24 | 0.0 | 1108 |
| LLPS-Cea-4551 | Cercocebus atys | 99.24 | 0.0 | 1108 |
| LLPS-Gog-4141 | Gorilla gorilla | 99.24 | 0.0 | 1108 |
| LLPS-Caj-4346 | Callithrix jacchus | 99.24 | 0.0 | 1107 |
| LLPS-Cap-0095 | Cavia porcellus | 99.24 | 0.0 | 1109 |
| LLPS-Mam-3381 | Macaca mulatta | 99.24 | 0.0 | 1108 |
| LLPS-Cas-3181 | Carlito syrichta | 99.24 | 0.0 | 1108 |
| LLPS-Nol-2364 | Nomascus leucogenys | 99.24 | 0.0 | 1108 |
| LLPS-Hos-1129 | Homo sapiens | 99.24 | 0.0 | 1108 |
| LLPS-Pap-3608 | Pan paniscus | 99.24 | 0.0 | 1108 |
| LLPS-Pat-4780 | Pan troglodytes | 99.24 | 0.0 | 1108 |
| LLPS-Man-1486 | Macaca nemestrina | 99.24 | 0.0 | 1108 |
| LLPS-Otg-1742 | Otolemur garnettii | 99.24 | 0.0 | 1107 |
| LLPS-Rhb-4374 | Rhinopithecus bieti | 99.24 | 0.0 | 1108 |
| LLPS-Orc-1553 | Oryctolagus cuniculus | 99.24 | 0.0 | 1108 |
| LLPS-Fud-2154 | Fukomys damarensis | 99.05 | 0.0 | 1109 |
| LLPS-Eqc-1780 | Equus caballus | 99.05 | 0.0 | 1107 |
| LLPS-Loa-4471 | Loxodonta africana | 99.05 | 0.0 | 1106 |
| LLPS-Tut-2382 | Tursiops truncatus | 98.68 | 0.0 | 1089 |
| LLPS-Sah-2261 | Sarcophilus harrisii | 98.68 | 0.0 | 1100 |
| LLPS-Mod-3739 | Monodelphis domestica | 98.11 | 0.0 | 1097 |
| LLPS-Pes-2903 | Pelodiscus sinensis | 96.6 | 0.0 | 1088 |
| LLPS-Meg-1230 | Meleagris gallopavo | 95.93 | 0.0 | 595 |
| LLPS-Gaga-1637 | Gallus gallus | 95.85 | 0.0 | 1078 |
| LLPS-Fia-2479 | Ficedula albicollis | 95.66 | 0.0 | 1076 |
| LLPS-Tag-3257 | Taeniopygia guttata | 95.47 | 0.0 | 1073 |
| LLPS-Anc-1118 | Anolis carolinensis | 95.46 | 0.0 | 1078 |
| LLPS-Scf-2046 | Scleropages formosus | 92.86 | 0.0 | 1050 |
| LLPS-Orn-0224 | Oreochromis niloticus | 92.64 | 0.0 | 1045 |
| LLPS-Pof-0288 | Poecilia formosa | 92.11 | 0.0 | 1041 |
| LLPS-Scm-0385 | Scophthalmus maximus | 92.08 | 0.0 | 1041 |
| LLPS-Xim-2863 | Xiphophorus maculatus | 91.73 | 0.0 | 1037 |
| LLPS-Leo-3409 | Lepisosteus oculatus | 91.67 | 2e-77 | 246 |
| LLPS-Gaa-2485 | Gasterosteus aculeatus | 91.32 | 0.0 | 1037 |
| LLPS-Dar-3011 | Danio rerio | 91.17 | 0.0 | 1035 |
| LLPS-Tar-2499 | Takifugu rubripes | 90.98 | 0.0 | 1031 |
| LLPS-Asm-0924 | Astyanax mexicanus | 90.98 | 0.0 | 1039 |
| LLPS-Poa-1913 | Pongo abelii | 90.93 | 0.0 | 984 |
| LLPS-Ten-0898 | Tetraodon nigroviridis | 90.81 | 0.0 | 1029 |
| LLPS-Icp-1986 | Ictalurus punctatus | 90.75 | 0.0 | 1028 |
| LLPS-Orl-1024 | Oryzias latipes | 90.43 | 0.0 | 1029 |
| LLPS-Xet-0896 | Xenopus tropicalis | 90.41 | 0.0 | 1030 |
| LLPS-Lac-3153 | Latimeria chalumnae | 88.72 | 0.0 | 989 |
| LLPS-Anp-2996 | Anas platyrhynchos | 88.49 | 0.0 | 971 |
| LLPS-Ora-0494 | Ornithorhynchus anatinus | 85.64 | 0.0 | 938 |
| LLPS-Cii-1655 | Ciona intestinalis | 64.99 | 0.0 | 719 |
| LLPS-Cis-0512 | Ciona savignyi | 62.64 | 0.0 | 697 |
| LLPS-Mup-2657 | Mustela putorius furo | 61.95 | 1e-179 | 521 |
| LLPS-Drm-0623 | Drosophila melanogaster | 59.2 | 0.0 | 648 |
| LLPS-Via-2135 | Vigna angularis | 52.76 | 2e-127 | 385 |
| LLPS-Orbr-1877 | Oryza brachyantha | 52.76 | 4e-131 | 395 |
| LLPS-Dac-2313 | Daucus carota | 51.35 | 9e-126 | 387 |
| LLPS-Tum-0865 | Tuber melanosporum | 50.88 | 9e-93 | 293 |
| LLPS-Php-2446 | Physcomitrella patens | 49.16 | 9e-163 | 482 |
| LLPS-Ved-1368 | Verticillium dahliae | 48.1 | 2e-102 | 327 |
| LLPS-Tru-0395 | Triticum urartu | 48.02 | 3e-123 | 391 |
| LLPS-Miv-0073 | Microbotryum violaceum | 47.29 | 2e-112 | 353 |
| LLPS-Beb-0326 | Beauveria bassiana | 46.17 | 2e-107 | 340 |
| LLPS-Sem-1792 | Selaginella moellendorffii | 45.96 | 4e-132 | 401 |
| LLPS-Amt-2061 | Amborella trichopoda | 45.09 | 6e-150 | 449 |
| LLPS-Put-1256 | Puccinia triticina | 44.73 | 8e-93 | 298 |
| LLPS-Cae-1655 | Caenorhabditis elegans | 44.7 | 5e-147 | 442 |
| LLPS-Cus-0362 | Cucumis sativus | 44.69 | 7e-146 | 439 |
| LLPS-Sob-2536 | Sorghum bicolor | 44.55 | 4e-148 | 446 |
| LLPS-Prp-2201 | Prunus persica | 44.49 | 5e-143 | 432 |
| LLPS-Mel-1160 | Melampsora laricipopulina | 44.33 | 5e-15 | 82.4 |
| LLPS-Lem-1095 | Leptosphaeria maculans | 44.24 | 2e-99 | 313 |
| LLPS-Sei-2512 | Setaria italica | 44.13 | 1e-146 | 441 |
| LLPS-Gas-0815 | Galdieria sulphuraria | 44.09 | 7e-143 | 431 |
| LLPS-Lep-1032 | Leersia perrieri | 44.04 | 7e-145 | 437 |
| LLPS-Pot-2623 | Populus trichocarpa | 43.93 | 1e-143 | 433 |
| LLPS-Met-1922 | Medicago truncatula | 43.9 | 1e-144 | 436 |
| LLPS-Orp-1597 | Oryza punctata | 43.87 | 5e-145 | 437 |
| LLPS-Gag-1219 | Gaeumannomyces graminis | 43.85 | 5e-105 | 334 |
| LLPS-Viv-1605 | Vitis vinifera | 43.81 | 3e-142 | 429 |
| LLPS-Sol-0114 | Solanum lycopersicum | 43.78 | 2e-150 | 451 |
| LLPS-Vir-0815 | Vigna radiata | 43.75 | 8e-138 | 418 |
| LLPS-Orgl-1154 | Oryza glumaepatula | 43.68 | 5e-145 | 437 |
| LLPS-Ori-1561 | Oryza indica | 43.68 | 5e-145 | 437 |
| LLPS-Orb-1996 | Oryza barthii | 43.68 | 5e-145 | 437 |
| LLPS-Orni-1287 | Oryza nivara | 43.68 | 5e-145 | 437 |
| LLPS-Orm-0984 | Oryza meridionalis | 43.68 | 5e-145 | 437 |
| LLPS-Orr-1504 | Oryza rufipogon | 43.68 | 5e-145 | 437 |
| LLPS-Org-2176 | Oryza glaberrima | 43.68 | 5e-145 | 437 |
| LLPS-Ors-2150 | Oryza sativa | 43.68 | 5e-145 | 437 |
| LLPS-Nia-2380 | Nicotiana attenuata | 43.6 | 4e-150 | 450 |
| LLPS-Phv-0543 | Phaseolus vulgaris | 43.56 | 2e-137 | 417 |
| LLPS-Zem-0300 | Zea mays | 43.52 | 4e-146 | 440 |
| LLPS-Coc-1094 | Corchorus capsularis | 43.51 | 4e-142 | 430 |
| LLPS-Brd-1599 | Brachypodium distachyon | 43.49 | 4e-143 | 432 |
| LLPS-Sot-1983 | Solanum tuberosum | 43.41 | 3e-148 | 446 |
| LLPS-Glm-1550 | Glycine max | 43.13 | 2e-137 | 417 |
| LLPS-Osl-0456 | Ostreococcus lucimarinus | 43.03 | 3e-103 | 324 |
| LLPS-Mae-0920 | Manihot esculenta | 42.86 | 6e-141 | 427 |
| LLPS-Gor-2060 | Gossypium raimondii | 42.73 | 4e-143 | 432 |
| LLPS-Art-2168 | Arabidopsis thaliana | 42.52 | 9e-136 | 414 |
| LLPS-Thc-2431 | Theobroma cacao | 42.47 | 3e-141 | 427 |
| LLPS-Blg-0787 | Blumeria graminis | 42.12 | 4e-121 | 375 |
| LLPS-Chc-0718 | Chondrus crispus | 42.09 | 2e-126 | 388 |
| LLPS-Tra-2851 | Triticum aestivum | 41.97 | 1e-139 | 424 |
| LLPS-Hov-1957 | Hordeum vulgare | 41.88 | 3e-138 | 420 |
| LLPS-Hea-2399 | Helianthus annuus | 41.65 | 5e-141 | 427 |
| LLPS-Arl-1845 | Arabidopsis lyrata | 41.42 | 1e-131 | 403 |
| LLPS-Scp-0485 | Schizosaccharomyces pombe | 41.11 | 2e-136 | 415 |
| LLPS-Usm-0200 | Ustilago maydis | 41.02 | 2e-133 | 407 |
| LLPS-Scc-0597 | Schizosaccharomyces cryophilus | 40.86 | 9e-138 | 418 |
| LLPS-Spr-1159 | Sporisorium reilianum | 40.78 | 8e-133 | 406 |
| LLPS-Asfu-0693 | Aspergillus fumigatus | 40.47 | 8e-119 | 370 |
| LLPS-Nef-1024 | Neosartorya fischeri | 40.29 | 2e-118 | 369 |
| LLPS-Chr-0650 | Chlamydomonas reinhardtii | 40.19 | 1e-130 | 400 |
| LLPS-Brn-0441 | Brassica napus | 40.11 | 5e-128 | 394 |
| LLPS-Brr-1662 | Brassica rapa | 40.11 | 3e-128 | 394 |
| LLPS-Trv-0019 | Trichoderma virens | 40.04 | 3e-118 | 368 |
| LLPS-Trr-1436 | Trichoderma reesei | 39.93 | 2e-116 | 363 |
| LLPS-Map-0162 | Magnaporthe poae | 39.85 | 9e-117 | 364 |
| LLPS-Asni-0601 | Aspergillus niger | 39.75 | 6e-115 | 360 |
| LLPS-Scj-0627 | Schizosaccharomyces japonicus | 39.64 | 9e-129 | 395 |
| LLPS-Bro-1749 | Brassica oleracea | 39.64 | 1e-126 | 390 |
| LLPS-Pyt-0693 | Pyrenophora teres | 39.41 | 3e-115 | 360 |
| LLPS-Pug-0543 | Puccinia graminis | 39.36 | 4e-133 | 407 |
| LLPS-Crn-1580 | Cryptococcus neoformans | 39.2 | 4e-131 | 400 |
| LLPS-Aso-1184 | Aspergillus oryzae | 39.16 | 7e-114 | 357 |
| LLPS-Asf-0225 | Aspergillus flavus | 39.16 | 7e-114 | 357 |
| LLPS-Mao-1568 | Magnaporthe oryzae | 39.07 | 6e-120 | 372 |
| LLPS-Pytr-1636 | Pyrenophora triticirepentis | 39.04 | 5e-114 | 357 |
| LLPS-Phn-1564 | Phaeosphaeria nodorum | 39.0 | 1e-113 | 356 |
| LLPS-Nec-0345 | Neurospora crassa | 38.98 | 2e-114 | 359 |
| LLPS-Fuv-1542 | Fusarium verticillioides | 38.97 | 7e-111 | 349 |
| LLPS-Abg-0977 | Absidia glauca | 38.92 | 2e-132 | 405 |
| LLPS-Fus-0084 | Fusarium solani | 38.83 | 1e-114 | 358 |
| LLPS-Fuo-0517 | Fusarium oxysporum | 38.67 | 3e-112 | 352 |
| LLPS-Coo-1607 | Colletotrichum orbiculare | 38.59 | 7e-111 | 349 |
| LLPS-Asn-1583 | Aspergillus nidulans | 38.55 | 6e-115 | 360 |
| LLPS-Asc-1486 | Aspergillus clavatus | 38.36 | 4e-113 | 355 |
| LLPS-Cog-0457 | Colletotrichum gloeosporioides | 38.27 | 9e-103 | 325 |
| LLPS-Zyt-1203 | Zymoseptoria tritici | 38.24 | 1e-107 | 341 |
| LLPS-Cogr-1431 | Colletotrichum graminicola | 38.18 | 7e-113 | 354 |
| LLPS-Dos-1516 | Dothistroma septosporum | 38.13 | 2e-103 | 330 |
| LLPS-Mua-0097 | Musa acuminata | 36.63 | 7e-100 | 318 |
| LLPS-Cym-1142 | Cyanidioschyzon merolae | 36.52 | 9e-74 | 254 |
| LLPS-Yal-0966 | Yarrowia lipolytica | 34.31 | 1e-93 | 303 |
| LLPS-Ast-0607 | Aspergillus terreus | 31.89 | 9e-42 | 160 |
| LLPS-Kop-1473 | Komagataella pastoris | 31.36 | 9e-77 | 259 |