LLPS-Ten-2336
WDR4
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4 |
| Gene Name: | WDR4 |
| Ensembl Gene: | ENSTNIG00000004246.1 |
| Ensembl Protein: | ENSTNIP00000006871.1 |
| Organism: | Tetraodon nigroviridis |
| Taxa ID: | 99883 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSTNIT00000007023.1 | ENSTNIP00000006871.1 |
| UniProt | H3CF47, H3CF47_TETNG |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 FVFDCSSAER KPKSSKDENS GAAEETGSDR ILAFCTSPSG KLLALTDDSK RLVLLTCEPS 60 61 WRRLSTRRFV ARRSTSLHFT NAEDELLVAD KSGDVYPFSV ADAGGGELLM GHLSMLLAVT 120 121 TSPDDRYIIT ADRDEKIRVS HRACPYNIRS FCLGHQQFVS ALLVPPTHPC WLLSGSGDGT 180 181 IKLWDYERGR RLQSCDITAP ETLADLSFPR VHTVSRVCGS ADGRLVAVVC ERVSVVHFFT 240 241 LRPDGEHRLV PHSRLPLPHC PLDLTFDPEG RLWVLLDREV GSAAGLHPPP VVMWLLQVDP 300 301 EDSHLTRVTE VFREHWETLE AALRTSARLE HLQKESFDNV AAYLQKKQQR LAGQQKRAGP 360 361 PGAGALKRAK MAEAARLTC 379 |
| Nucleotide CDS Sequence (FASTA) |
1 TTTGTGTTCG ACTGCAGCTC AGCAGAGAGG AAACCAAAAA GCTCCAAGGA TGAAAACAGC 60 61 GGAGCCGCAG AGGAGACAGG AAGTGACCGG ATCCTGGCCT TCTGCACGTC TCCATCCGGA 120 121 AAGCTGCTGG CGCTGACGGA TGACAGCAAG AGGCTGGTGC TGCTCACCTG TGAGCCGTCG 180 181 TGGCGCCGCC TCAGCACCAG GAGGTTCGTG GCGAGGAGAA GCACATCGCT GCACTTCACC 240 241 AACGCCGAGG ACGAGCTGCT GGTGGCGGAC AAGTCAGGTG ACGTGTACCC CTTCTCCGTG 300 301 GCGGACGCAG GGGGAGGCGA GCTGCTGATG GGTCACCTGT CCATGCTGTT GGCTGTGACC 360 361 ACGTCACCTG ACGACAGGTA CATCATCACC GCCGACCGCG ACGAGAAGAT CAGAGTGAGC 420 421 CACCGCGCGT GTCCGTACAA CATCCGCTCC TTCTGTCTGG GGCATCAGCA GTTCGTGAGC 480 481 GCCCTGCTGG TCCCGCCCAC TCACCCCTGC TGGCTGCTCT CGGGGTCGGG GGATGGAACA 540 541 ATAAAGCTGT GGGATTACGA GCGCGGCCGC CGGCTGCAGA GCTGTGACAT CACAGCGCCC 600 601 GAGACCCTGG CTGACCTCTC GTTTCCCAGA GTGCATACGG TGTCCCGGGT GTGCGGCTCT 660 661 GCTGACGGCC GGTTGGTGGC TGTTGTGTGT GAGAGGGTGT CGGTGGTGCA CTTCTTCACC 720 721 CTCCGCCCCG ACGGTGAGCA CCGGCTGGTT CCCCACAGCA GGCTGCCCCT CCCACACTGC 780 781 CCTCTGGACC TGACCTTTGA CCCCGAGGGT CGCCTGTGGG TGCTGCTGGA CCGTGAGGTA 840 841 GGCTCCGCTG CAGGTCTACA CCCTCCGCCA GTGGTGATGT GGCTTCTGCA GGTGGACCCT 900 901 GAGGACAGTC ACCTGACCAG AGTGACGGAG GTCTTCAGAG AGCACTGGGA GACCCTAGAG 960 961 GCGGCGCTGA GGACGAGCGC CCGCCTGGAG CACCTGCAGA AGGAGAGCTT TGACAACGTG 1020 1021 GCAGCGTACC TGCAGAAGAA GCAGCAGAGG CTGGCGGGCC AGCAGAAGAG GGCGGGGCCT 1080 1081 CCCGGCGCCG GCGCCCTCAA ACGAGCAAAG ATGGCGGAAG CGGCTAGACT CACCTGC 1137 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Biological Process | RNA (guanine-N7)-methylation | |
Biological Process | TRNA methylation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Tar-3872 | Takifugu rubripes | 74.41 | 0.0 | 533 |
| LLPS-Scm-3423 | Scophthalmus maximus | 63.22 | 4e-150 | 439 |
| LLPS-Orn-2660 | Oreochromis niloticus | 59.79 | 3e-146 | 428 |
| LLPS-Gaa-0159 | Gasterosteus aculeatus | 58.22 | 8e-134 | 395 |
| LLPS-Pof-3379 | Poecilia formosa | 54.87 | 1e-122 | 367 |
| LLPS-Orl-1771 | Oryzias latipes | 53.17 | 6e-117 | 355 |
| LLPS-Icp-2450 | Ictalurus punctatus | 52.09 | 9e-122 | 366 |
| LLPS-Dar-4114 | Danio rerio | 51.86 | 1e-113 | 345 |
| LLPS-Asm-1398 | Astyanax mexicanus | 51.81 | 3e-124 | 372 |
| LLPS-Phn-1470 | Phaeosphaeria nodorum | 48.81 | 6e-12 | 70.9 |
| LLPS-Leo-0024 | Lepisosteus oculatus | 48.15 | 1e-107 | 329 |
| LLPS-Fec-4190 | Felis catus | 45.7 | 4e-84 | 270 |
| LLPS-Mup-2631 | Mustela putorius furo | 45.55 | 5e-86 | 273 |
| LLPS-Lem-1090 | Leptosphaeria maculans | 45.26 | 3e-12 | 72.0 |
| LLPS-Ict-0891 | Ictidomys tridecemlineatus | 45.18 | 4e-91 | 286 |
| LLPS-Hos-3943 | Homo sapiens | 44.82 | 5e-90 | 284 |
| LLPS-Man-1283 | Macaca nemestrina | 44.82 | 6e-90 | 283 |
| LLPS-Maf-3681 | Macaca fascicularis | 44.82 | 4e-90 | 284 |
| LLPS-Aim-0502 | Ailuropoda melanoleuca | 44.59 | 5e-85 | 271 |
| LLPS-Paa-2665 | Papio anubis | 44.56 | 2e-89 | 282 |
| LLPS-Myl-3186 | Myotis lucifugus | 44.5 | 6e-85 | 270 |
| LLPS-Caf-1214 | Canis familiaris | 44.44 | 3e-85 | 271 |
| LLPS-Mam-0463 | Macaca mulatta | 44.42 | 1e-90 | 286 |
| LLPS-Urm-3804 | Ursus maritimus | 44.33 | 1e-84 | 269 |
| LLPS-Scs-0369 | Sclerotinia sclerotiorum | 44.33 | 2e-15 | 82.0 |
| LLPS-Cas-2682 | Carlito syrichta | 44.29 | 6e-79 | 255 |
| LLPS-Fud-1910 | Fukomys damarensis | 44.21 | 4e-83 | 266 |
| LLPS-Mum-4648 | Mus musculus | 44.21 | 2e-88 | 281 |
| LLPS-Otg-4546 | Otolemur garnettii | 44.16 | 4e-84 | 268 |
| LLPS-Chs-1889 | Chlorocebus sabaeus | 44.16 | 2e-90 | 285 |
| LLPS-Mal-4703 | Mandrillus leucophaeus | 44.16 | 1e-90 | 285 |
| LLPS-Rhb-3781 | Rhinopithecus bieti | 44.04 | 9e-89 | 281 |
| LLPS-Lac-3666 | Latimeria chalumnae | 44.02 | 2e-87 | 277 |
| LLPS-Dio-3808 | Dipodomys ordii | 44.01 | 5e-76 | 246 |
| LLPS-Loa-1988 | Loxodonta africana | 43.98 | 1e-85 | 273 |
| LLPS-Aon-4160 | Aotus nancymaae | 43.98 | 3e-85 | 271 |
| LLPS-Cea-3152 | Cercocebus atys | 43.9 | 7e-90 | 283 |
| LLPS-Bot-4670 | Bos taurus | 43.86 | 6e-84 | 270 |
| LLPS-Cap-3944 | Cavia porcellus | 43.79 | 8e-79 | 256 |
| LLPS-Pat-1945 | Pan troglodytes | 43.64 | 5e-89 | 281 |
| LLPS-Gog-2838 | Gorilla gorilla | 43.64 | 4e-89 | 281 |
| LLPS-Caj-0086 | Callithrix jacchus | 43.52 | 2e-86 | 274 |
| LLPS-Tag-3486 | Taeniopygia guttata | 43.42 | 5e-85 | 269 |
| LLPS-Ova-2677 | Ovis aries | 43.39 | 4e-81 | 261 |
| LLPS-Pap-4653 | Pan paniscus | 43.38 | 1e-87 | 278 |
| LLPS-Ran-2400 | Rattus norvegicus | 43.23 | 2e-85 | 273 |
| LLPS-Orc-3971 | Oryctolagus cuniculus | 43.12 | 7e-83 | 265 |
| LLPS-Poa-1540 | Pongo abelii | 43.12 | 6e-86 | 273 |
| LLPS-Mea-4372 | Mesocricetus auratus | 42.91 | 2e-65 | 218 |
| LLPS-Anp-3054 | Anas platyrhynchos | 42.9 | 2e-86 | 274 |
| LLPS-Sus-4120 | Sus scrofa | 42.89 | 3e-82 | 264 |
| LLPS-Ora-2200 | Ornithorhynchus anatinus | 42.41 | 6e-87 | 275 |
| LLPS-Nol-4184 | Nomascus leucogenys | 42.34 | 6e-81 | 260 |
| LLPS-Fia-0576 | Ficedula albicollis | 42.2 | 5e-91 | 285 |
| LLPS-Eqc-3795 | Equus caballus | 42.08 | 6e-78 | 256 |
| LLPS-Sah-1154 | Sarcophilus harrisii | 41.67 | 6e-81 | 259 |
| LLPS-Mod-0877 | Monodelphis domestica | 41.62 | 3e-81 | 261 |
| LLPS-Gaga-1253 | Gallus gallus | 41.36 | 2e-88 | 280 |
| LLPS-Pes-2348 | Pelodiscus sinensis | 40.46 | 3e-78 | 253 |
| LLPS-Coo-0211 | Colletotrichum orbiculare | 40.12 | 4e-16 | 84.0 |
| LLPS-Cogr-0632 | Colletotrichum graminicola | 40.0 | 4e-17 | 86.7 |
| LLPS-Meg-1997 | Meleagris gallopavo | 39.84 | 5e-88 | 277 |
| LLPS-Yal-0107 | Yarrowia lipolytica | 39.52 | 7e-24 | 105 |
| LLPS-Anc-3223 | Anolis carolinensis | 38.52 | 4e-69 | 229 |
| LLPS-Cog-1202 | Colletotrichum gloeosporioides | 38.41 | 3e-16 | 84.0 |
| LLPS-Gag-1198 | Gaeumannomyces graminis | 38.22 | 4e-20 | 95.9 |
| LLPS-Trr-1169 | Trichoderma reesei | 37.93 | 5e-21 | 98.6 |
| LLPS-Mao-0070 | Magnaporthe oryzae | 37.93 | 4e-20 | 95.9 |
| LLPS-Pyt-0111 | Pyrenophora teres | 37.5 | 2e-12 | 72.8 |
| LLPS-Fus-0166 | Fusarium solani | 37.06 | 7e-19 | 92.0 |
| LLPS-Tum-1006 | Tuber melanosporum | 37.04 | 6e-19 | 89.7 |
| LLPS-Blg-0801 | Blumeria graminis | 36.54 | 9e-18 | 88.6 |
| LLPS-Ved-1349 | Verticillium dahliae | 36.26 | 7e-18 | 89.0 |
| LLPS-Beb-1516 | Beauveria bassiana | 35.93 | 4e-18 | 89.7 |
| LLPS-Drm-1259 | Drosophila melanogaster | 35.82 | 2e-28 | 119 |
| LLPS-Bro-2116 | Brassica oleracea | 35.32 | 2e-22 | 101 |
| LLPS-Asni-1421 | Aspergillus niger | 35.29 | 5e-15 | 80.5 |
| LLPS-Asg-0470 | Ashbya gossypii | 35.15 | 1e-20 | 96.7 |
| LLPS-Abg-1557 | Absidia glauca | 35.02 | 1e-30 | 125 |
| LLPS-Met-1329 | Medicago truncatula | 35.0 | 7e-23 | 102 |
| LLPS-Mae-0488 | Manihot esculenta | 34.68 | 7e-23 | 102 |
| LLPS-Ast-0784 | Aspergillus terreus | 34.46 | 2e-16 | 84.3 |
| LLPS-Sem-2387 | Selaginella moellendorffii | 33.98 | 3e-21 | 98.6 |
| LLPS-Chc-0739 | Chondrus crispus | 33.79 | 2e-15 | 79.3 |
| LLPS-Nec-0412 | Neurospora crassa | 33.68 | 2e-16 | 84.7 |
| LLPS-Glm-2703 | Glycine max | 33.47 | 4e-23 | 103 |
| LLPS-Map-0133 | Magnaporthe poae | 33.33 | 6e-20 | 95.1 |
| LLPS-Asf-0834 | Aspergillus flavus | 33.33 | 5e-17 | 85.1 |
| LLPS-Kop-1207 | Komagataella pastoris | 33.33 | 2e-18 | 89.7 |
| LLPS-Crn-1491 | Cryptococcus neoformans | 33.17 | 3e-20 | 96.7 |
| LLPS-Zyt-0813 | Zymoseptoria tritici | 33.14 | 1e-10 | 66.6 |
| LLPS-Viv-2345 | Vitis vinifera | 33.05 | 8e-17 | 85.5 |
| LLPS-Nia-1595 | Nicotiana attenuata | 33.04 | 7e-20 | 94.4 |
| LLPS-Trv-1505 | Trichoderma virens | 32.89 | 5e-20 | 95.5 |
| LLPS-Sob-0356 | Sorghum bicolor | 32.82 | 9e-21 | 97.1 |
| LLPS-Fuo-1232 | Fusarium oxysporum | 32.75 | 7e-18 | 89.4 |
| LLPS-Brn-2388 | Brassica napus | 32.67 | 6e-23 | 103 |
| LLPS-Pot-1107 | Populus trichocarpa | 32.63 | 1e-18 | 90.9 |
| LLPS-Zem-2308 | Zea mays | 32.21 | 2e-21 | 99.0 |
| LLPS-Phv-2396 | Phaseolus vulgaris | 32.13 | 1e-18 | 90.9 |
| LLPS-Fuv-1174 | Fusarium verticillioides | 32.11 | 2e-18 | 90.9 |
| LLPS-Sol-0395 | Solanum lycopersicum | 32.11 | 5e-21 | 97.4 |
| LLPS-Php-1580 | Physcomitrella patens | 32.03 | 2e-23 | 104 |
| LLPS-Tra-2338 | Triticum aestivum | 31.91 | 1e-19 | 93.6 |
| LLPS-Hov-1987 | Hordeum vulgare | 31.62 | 1e-19 | 94.0 |
| LLPS-Art-2098 | Arabidopsis thaliana | 31.6 | 7e-21 | 97.1 |
| LLPS-Mua-0812 | Musa acuminata | 31.58 | 2e-17 | 87.8 |
| LLPS-Nef-1200 | Neosartorya fischeri | 31.54 | 4e-16 | 83.6 |
| LLPS-Asn-0649 | Aspergillus nidulans | 31.28 | 2e-13 | 75.5 |
| LLPS-Sot-1802 | Solanum tuberosum | 31.06 | 3e-20 | 95.5 |
| LLPS-Cae-1864 | Caenorhabditis elegans | 30.73 | 8e-13 | 73.6 |
| LLPS-Gor-2456 | Gossypium raimondii | 30.51 | 2e-16 | 84.7 |
| LLPS-Arl-2750 | Arabidopsis lyrata | 30.17 | 4e-21 | 97.8 |
| LLPS-Aso-1446 | Aspergillus oryzae | 30.13 | 5e-17 | 86.7 |
| LLPS-Brr-1520 | Brassica rapa | 30.09 | 1e-23 | 105 |
| LLPS-Mel-0681 | Melampsora laricipopulina | 30.0 | 2e-12 | 71.2 |
| LLPS-Vir-1458 | Vigna radiata | 29.89 | 6e-18 | 89.7 |
| LLPS-Miv-1492 | Microbotryum violaceum | 29.7 | 2e-11 | 69.3 |
| LLPS-Asfu-0525 | Aspergillus fumigatus | 29.1 | 9e-15 | 79.7 |
| LLPS-Scc-1370 | Schizosaccharomyces cryophilus | 28.78 | 5e-16 | 83.2 |
| LLPS-Osl-0911 | Ostreococcus lucimarinus | 28.47 | 2e-11 | 68.9 |
| LLPS-Put-0243 | Puccinia triticina | 28.14 | 8e-12 | 70.5 |
| LLPS-Scp-1597 | Schizosaccharomyces pombe | 28.05 | 1e-15 | 81.6 |
| LLPS-Asc-1574 | Aspergillus clavatus | 27.06 | 4e-13 | 74.3 |
| LLPS-Scj-1182 | Schizosaccharomyces japonicus | 26.72 | 6e-11 | 67.8 |
| LLPS-Spr-0288 | Sporisorium reilianum | 26.6 | 6e-06 | 52.4 |
| LLPS-Sac-0206 | Saccharomyces cerevisiae | 25.69 | 2e-16 | 84.3 |