LLPS-Myl-3186
WDR4
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4 |
| Gene Name: | WDR4 |
| Ensembl Gene: | ENSMLUG00000004898.2 |
| Ensembl Protein: | ENSMLUP00000004463.2 |
| Organism: | Myotis lucifugus |
| Taxa ID: | 59463 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMLUT00000004898.2 | ENSMLUP00000004463.2 |
| UniProt | G1P3G7, G1P3G7_MYOLU | |
| GeneBank | AAPE02048459 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 AGLALCGRAL VVRGGSRFLA TTTASSDDDG GLFTYDCSTA EKKSQENKGE DGQPVEKGSD 60 61 TILASTFSKS GSYFALTDDS KRLILFRTKP WQCLSVRTVV RRCTALTFTA SEEKVLVADK 120 121 SGDVYSFSVL EPNECGKLEL GHLSMLLDVA VSPDDRYVLT ADRDEKIRVS WAVAPHNIES 180 181 FCLGHTEFVS RIFVVPDHPE LLLSSSGDCT LRLWEYRRGQ ELHCCHLTGL QEPAGPRSDK 240 241 RFAASRITYW SRDSCVALLC DCVPVVYIFQ LEAPRQQLVY KQQLSFQHRV WDIAFEENRG 300 301 LWVLQDCREA PLVLCRLVDG QWQPVPEDAT VKKVCTQLRG HWAMLEGSAG VDEGFSSLYK 360 361 ATFDNMTTYL KKKEERLQQQ LRKKRHKNPP PGPNGQT 397 |
| Nucleotide CDS Sequence (FASTA) |
1 GCGGGGCTGG CTCTGTGCGG GCGGGCGCTG GTGGTGCGGG GAGGCAGCCG GTTCCTGGCC 60 61 ACCACCACGG CGAGCAGTGA TGATGACGGC GGCCTCTTCA CATATGATTG CAGTACTGCA 120 121 GAAAAGAAGT CACAAGAAAA TAAAGGGGAG GACGGACAGC CCGTGGAGAA GGGGAGTGAC 180 181 ACGATCCTGG CGTCCACCTT CTCCAAGTCT GGCAGCTATT TTGCTTTAAC CGATGACAGT 240 241 AAGCGTCTGA TTCTTTTCCG TACAAAACCA TGGCAATGTC TGAGTGTCAG GACCGTGGTG 300 301 AGGAGGTGTA CAGCCCTGAC GTTCACGGCT TCTGAGGAGA AGGTTTTGGT GGCAGACAAG 360 361 TCTGGGGACG TTTACTCCTT TTCGGTGCTG GAGCCGAATG AATGTGGCAA ACTTGAACTT 420 421 GGGCACCTGT CGATGCTGCT GGATGTGGCT GTGAGTCCTG ACGACCGCTA CGTCCTCACC 480 481 GCTGACCGGG ACGAGAAGAT CCGGGTGAGC TGGGCCGTGG CACCGCACAA CATCGAGTCC 540 541 TTCTGCCTGG GGCACACTGA GTTCGTGAGC CGCATCTTCG TGGTGCCCGA CCACCCTGAG 600 601 CTGCTTCTGT CCTCATCCGG GGACTGCACC CTGAGGCTCT GGGAGTACAG ACGTGGCCAA 660 661 GAGCTGCACT GCTGTCACCT GACCGGCCTG CAGGAGCCAG CGGGGCCCCG GAGCGACAAG 720 721 AGGTTTGCTG CATCCAGGAT CACTTACTGG AGCCGGGACA GCTGTGTGGC GCTGCTGTGT 780 781 GATTGTGTCC CTGTGGTCTA CATCTTCCAG CTGGAGGCCC CCAGGCAGCA GCTGGTTTAC 840 841 AAGCAGCAGC TGTCTTTCCA GCACAGAGTG TGGGACATTG CTTTCGAGGA GAACCGGGGG 900 901 CTGTGGGTGC TGCAGGACTG CCGGGAAGCC CCCCTCGTGC TCTGCAGGCT TGTGGACGGC 960 961 CAGTGGCAGC CTGTGCCTGA AGATGCCACG GTGAAGAAAG TCTGCACGCA GCTCCGCGGG 1020 1021 CACTGGGCCA TGCTGGAAGG CTCTGCTGGC GTGGACGAGG GCTTTAGCAG TCTGTACAAG 1080 1081 GCCACCTTTG ACAACATGAC CACTTACCTG AAGAAGAAAG AGGAGAGGTT GCAACAGCAG 1140 1141 CTTCGGAAGA AGCGGCATAA GAACCCGCCC CCTGGGCCCA ACGGGCAGAC C 1191 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Cellular Component | TRNA methyltransferase complex | |
Molecular Function | TRNA (guanine-N7-)-methyltransferase activity |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Caf-1214 | Canis familiaris | 85.39 | 0.0 | 689 |
| LLPS-Urm-3804 | Ursus maritimus | 83.78 | 0.0 | 640 |
| LLPS-Fec-4190 | Felis catus | 83.12 | 0.0 | 672 |
| LLPS-Sus-4120 | Sus scrofa | 82.32 | 0.0 | 646 |
| LLPS-Aim-0502 | Ailuropoda melanoleuca | 82.12 | 0.0 | 645 |
| LLPS-Bot-4670 | Bos taurus | 81.86 | 0.0 | 649 |
| LLPS-Loa-1988 | Loxodonta africana | 81.66 | 0.0 | 659 |
| LLPS-Eqc-3795 | Equus caballus | 81.56 | 0.0 | 642 |
| LLPS-Cas-2682 | Carlito syrichta | 81.36 | 0.0 | 632 |
| LLPS-Ova-2677 | Ovis aries | 81.33 | 0.0 | 602 |
| LLPS-Mup-2631 | Mustela putorius furo | 80.97 | 0.0 | 625 |
| LLPS-Mam-0463 | Macaca mulatta | 80.6 | 0.0 | 652 |
| LLPS-Maf-3681 | Macaca fascicularis | 80.35 | 0.0 | 652 |
| LLPS-Man-1283 | Macaca nemestrina | 80.35 | 0.0 | 650 |
| LLPS-Otg-4546 | Otolemur garnettii | 80.35 | 0.0 | 642 |
| LLPS-Paa-2665 | Papio anubis | 80.1 | 0.0 | 650 |
| LLPS-Cea-3152 | Cercocebus atys | 79.85 | 0.0 | 650 |
| LLPS-Chs-1889 | Chlorocebus sabaeus | 79.85 | 0.0 | 647 |
| LLPS-Rhb-3781 | Rhinopithecus bieti | 79.85 | 0.0 | 649 |
| LLPS-Aon-4160 | Aotus nancymaae | 79.8 | 0.0 | 651 |
| LLPS-Gog-2838 | Gorilla gorilla | 79.35 | 0.0 | 644 |
| LLPS-Pat-1945 | Pan troglodytes | 79.35 | 0.0 | 644 |
| LLPS-Mal-4703 | Mandrillus leucophaeus | 79.09 | 0.0 | 642 |
| LLPS-Poa-1540 | Pongo abelii | 78.84 | 0.0 | 637 |
| LLPS-Hos-3943 | Homo sapiens | 78.59 | 0.0 | 637 |
| LLPS-Pap-4653 | Pan paniscus | 78.59 | 0.0 | 640 |
| LLPS-Nol-4184 | Nomascus leucogenys | 78.09 | 0.0 | 615 |
| LLPS-Ict-0891 | Ictidomys tridecemlineatus | 77.84 | 0.0 | 629 |
| LLPS-Cap-3944 | Cavia porcellus | 77.72 | 0.0 | 623 |
| LLPS-Orc-3971 | Oryctolagus cuniculus | 77.66 | 0.0 | 633 |
| LLPS-Caj-0086 | Callithrix jacchus | 77.53 | 0.0 | 635 |
| LLPS-Dio-3808 | Dipodomys ordii | 76.23 | 0.0 | 546 |
| LLPS-Fud-1910 | Fukomys damarensis | 75.61 | 0.0 | 637 |
| LLPS-Mum-4648 | Mus musculus | 75.38 | 0.0 | 615 |
| LLPS-Ran-2400 | Rattus norvegicus | 75.38 | 0.0 | 615 |
| LLPS-Mea-4372 | Mesocricetus auratus | 72.04 | 4e-157 | 454 |
| LLPS-Sah-1154 | Sarcophilus harrisii | 71.1 | 0.0 | 583 |
| LLPS-Mod-0877 | Monodelphis domestica | 70.0 | 0.0 | 577 |
| LLPS-Ora-2200 | Ornithorhynchus anatinus | 69.79 | 0.0 | 546 |
| LLPS-Pes-2348 | Pelodiscus sinensis | 61.7 | 3e-170 | 490 |
| LLPS-Anp-3054 | Anas platyrhynchos | 60.27 | 2e-158 | 459 |
| LLPS-Tag-3486 | Taeniopygia guttata | 59.14 | 3e-148 | 431 |
| LLPS-Meg-1997 | Meleagris gallopavo | 58.92 | 6e-162 | 467 |
| LLPS-Fia-0576 | Ficedula albicollis | 58.86 | 1e-156 | 454 |
| LLPS-Gaga-1253 | Gallus gallus | 58.44 | 7e-168 | 484 |
| LLPS-Anc-3223 | Anolis carolinensis | 56.28 | 5e-147 | 431 |
| LLPS-Lac-3666 | Latimeria chalumnae | 54.5 | 2e-137 | 406 |
| LLPS-Leo-0024 | Lepisosteus oculatus | 54.31 | 7e-138 | 407 |
| LLPS-Asm-1398 | Astyanax mexicanus | 49.06 | 3e-112 | 342 |
| LLPS-Phn-1470 | Phaeosphaeria nodorum | 48.81 | 7e-13 | 73.9 |
| LLPS-Scm-3423 | Scophthalmus maximus | 46.85 | 1e-97 | 305 |
| LLPS-Dar-4114 | Danio rerio | 46.26 | 4e-105 | 323 |
| LLPS-Asni-1421 | Aspergillus niger | 45.45 | 4e-12 | 71.6 |
| LLPS-Tar-3872 | Takifugu rubripes | 45.09 | 1e-103 | 320 |
| LLPS-Icp-2450 | Ictalurus punctatus | 44.53 | 2e-104 | 322 |
| LLPS-Ten-2336 | Tetraodon nigroviridis | 44.5 | 7e-85 | 270 |
| LLPS-Orn-2660 | Oreochromis niloticus | 44.25 | 3e-103 | 319 |
| LLPS-Gaa-0159 | Gasterosteus aculeatus | 44.22 | 2e-100 | 310 |
| LLPS-Pytr-1227 | Pyrenophora triticirepentis | 43.9 | 1e-09 | 62.4 |
| LLPS-Asf-0834 | Aspergillus flavus | 43.0 | 6e-13 | 73.6 |
| LLPS-Orl-1771 | Oryzias latipes | 42.53 | 5e-90 | 286 |
| LLPS-Pof-3379 | Poecilia formosa | 42.35 | 4e-96 | 300 |
| LLPS-Gag-1198 | Gaeumannomyces graminis | 41.78 | 5e-19 | 92.8 |
| LLPS-Ast-0784 | Aspergillus terreus | 39.83 | 3e-13 | 75.5 |
| LLPS-Fuo-1232 | Fusarium oxysporum | 39.62 | 6e-12 | 71.2 |
| LLPS-Bro-2116 | Brassica oleracea | 38.67 | 3e-24 | 107 |
| LLPS-Sem-2387 | Selaginella moellendorffii | 38.46 | 3e-23 | 104 |
| LLPS-Php-1580 | Physcomitrella patens | 37.57 | 3e-25 | 110 |
| LLPS-Sob-0356 | Sorghum bicolor | 37.5 | 5e-22 | 100 |
| LLPS-Zem-2308 | Zea mays | 37.5 | 2e-22 | 101 |
| LLPS-Tum-1006 | Tuber melanosporum | 37.34 | 6e-15 | 78.6 |
| LLPS-Arl-2750 | Arabidopsis lyrata | 36.65 | 1e-22 | 102 |
| LLPS-Brn-2388 | Brassica napus | 36.51 | 2e-22 | 102 |
| LLPS-Asc-1574 | Aspergillus clavatus | 36.3 | 3e-12 | 72.0 |
| LLPS-Brr-1520 | Brassica rapa | 36.17 | 4e-22 | 100 |
| LLPS-Art-2098 | Arabidopsis thaliana | 35.82 | 2e-22 | 101 |
| LLPS-Crn-1491 | Cryptococcus neoformans | 35.76 | 2e-18 | 91.3 |
| LLPS-Vir-1458 | Vigna radiata | 35.36 | 2e-19 | 94.4 |
| LLPS-Yal-0107 | Yarrowia lipolytica | 35.29 | 1e-19 | 93.6 |
| LLPS-Scs-0369 | Sclerotinia sclerotiorum | 35.06 | 1e-19 | 94.4 |
| LLPS-Fuv-1174 | Fusarium verticillioides | 34.78 | 5e-12 | 71.6 |
| LLPS-Pot-1107 | Populus trichocarpa | 34.69 | 6e-20 | 95.1 |
| LLPS-Abg-1557 | Absidia glauca | 34.55 | 7e-43 | 159 |
| LLPS-Cog-1202 | Colletotrichum gloeosporioides | 34.51 | 4e-12 | 71.6 |
| LLPS-Viv-2345 | Vitis vinifera | 34.43 | 5e-22 | 100 |
| LLPS-Mae-0488 | Manihot esculenta | 34.3 | 1e-19 | 94.0 |
| LLPS-Ved-1349 | Verticillium dahliae | 34.0 | 1e-15 | 82.4 |
| LLPS-Lem-1090 | Leptosphaeria maculans | 33.99 | 6e-12 | 71.2 |
| LLPS-Phv-2396 | Phaseolus vulgaris | 33.96 | 5e-21 | 97.8 |
| LLPS-Mua-0812 | Musa acuminata | 33.68 | 9e-19 | 91.7 |
| LLPS-Trr-1169 | Trichoderma reesei | 33.57 | 2e-15 | 82.4 |
| LLPS-Map-0133 | Magnaporthe poae | 33.33 | 1e-18 | 91.7 |
| LLPS-Nec-0412 | Neurospora crassa | 33.33 | 7e-17 | 86.3 |
| LLPS-Fus-0166 | Fusarium solani | 33.1 | 1e-11 | 70.1 |
| LLPS-Sol-0395 | Solanum lycopersicum | 32.89 | 6e-24 | 106 |
| LLPS-Mao-0070 | Magnaporthe oryzae | 32.77 | 2e-14 | 79.3 |
| LLPS-Cogr-0632 | Colletotrichum graminicola | 32.69 | 3e-11 | 69.3 |
| LLPS-Sot-1802 | Solanum tuberosum | 32.3 | 1e-22 | 102 |
| LLPS-Coo-0211 | Colletotrichum orbiculare | 32.21 | 2e-10 | 66.6 |
| LLPS-Trv-1505 | Trichoderma virens | 31.47 | 8e-14 | 77.0 |
| LLPS-Gor-2456 | Gossypium raimondii | 31.35 | 6e-18 | 89.4 |
| LLPS-Osl-0911 | Ostreococcus lucimarinus | 30.98 | 1e-12 | 72.8 |
| LLPS-Pyt-0111 | Pyrenophora teres | 30.92 | 5e-12 | 71.2 |
| LLPS-Aso-1446 | Aspergillus oryzae | 30.89 | 9e-17 | 85.9 |
| LLPS-Asg-0470 | Ashbya gossypii | 30.27 | 2e-20 | 96.7 |
| LLPS-Zyt-0813 | Zymoseptoria tritici | 30.24 | 6e-10 | 65.1 |
| LLPS-Beb-1516 | Beauveria bassiana | 29.95 | 3e-14 | 78.6 |
| LLPS-Miv-1492 | Microbotryum violaceum | 29.79 | 1e-10 | 67.0 |
| LLPS-Sac-0206 | Saccharomyces cerevisiae | 29.57 | 4e-17 | 86.7 |
| LLPS-Asfu-0525 | Aspergillus fumigatus | 29.51 | 7e-13 | 73.9 |
| LLPS-Tra-1870 | Triticum aestivum | 29.35 | 2e-10 | 66.6 |
| LLPS-Met-1329 | Medicago truncatula | 29.16 | 8e-25 | 108 |
| LLPS-Asn-0649 | Aspergillus nidulans | 29.15 | 3e-15 | 81.3 |
| LLPS-Kop-1207 | Komagataella pastoris | 29.0 | 1e-16 | 84.7 |
| LLPS-Drm-1259 | Drosophila melanogaster | 28.96 | 2e-30 | 125 |
| LLPS-Chc-0739 | Chondrus crispus | 28.92 | 9e-12 | 68.6 |
| LLPS-Tru-0145 | Triticum urartu | 28.8 | 4e-10 | 65.5 |
| LLPS-Hov-1987 | Hordeum vulgare | 27.81 | 5e-23 | 103 |
| LLPS-Scj-1182 | Schizosaccharomyces japonicus | 27.59 | 4e-11 | 68.6 |
| LLPS-Nef-1200 | Neosartorya fischeri | 27.57 | 6e-11 | 68.2 |
| LLPS-Nia-1595 | Nicotiana attenuata | 27.54 | 1e-26 | 114 |
| LLPS-Glm-2703 | Glycine max | 27.37 | 2e-22 | 102 |
| LLPS-Ori-0511 | Oryza indica | 27.36 | 3e-10 | 65.5 |
| LLPS-Orb-0568 | Oryza barthii | 27.36 | 4e-10 | 65.5 |
| LLPS-Orni-0708 | Oryza nivara | 27.36 | 3e-10 | 65.5 |
| LLPS-Lep-0987 | Leersia perrieri | 27.36 | 2e-10 | 66.2 |
| LLPS-Orgl-0330 | Oryza glumaepatula | 27.36 | 3e-10 | 65.5 |
| LLPS-Orp-0399 | Oryza punctata | 27.36 | 3e-10 | 65.5 |
| LLPS-Orbr-0530 | Oryza brachyantha | 27.36 | 3e-10 | 65.9 |
| LLPS-Org-0637 | Oryza glaberrima | 27.36 | 4e-10 | 65.5 |
| LLPS-Blg-0801 | Blumeria graminis | 27.08 | 2e-22 | 102 |
| LLPS-Cae-1864 | Caenorhabditis elegans | 27.07 | 6e-16 | 82.8 |
| LLPS-Sei-0314 | Setaria italica | 26.78 | 2e-09 | 63.2 |
| LLPS-Scp-1597 | Schizosaccharomyces pombe | 26.56 | 4e-12 | 71.6 |
| LLPS-Scc-1370 | Schizosaccharomyces cryophilus | 25.56 | 1e-09 | 63.9 |
| LLPS-Amt-0482 | Amborella trichopoda | 24.85 | 8e-06 | 52.0 |
| LLPS-Via-1537 | Vigna angularis | 23.53 | 5e-07 | 55.5 |