LLPS-Orl-1771
WDR4
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4 |
| Gene Name: | WDR4, wdr4 |
| Ensembl Gene: | ENSORLG00000020836.2 |
| Ensembl Protein: | ENSORLP00000025804.2 |
| Organism: | Oryzias latipes |
| Taxa ID: | 8090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSORLT00000025805.2 | ENSORLP00000025804.2 |
| UniProt | H2N2W4, H2N2W4_ORYLA |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MFGKVKHRHR VYFSARPLGQ KTHEEETGGN VTSFIGDCAR VCLSVHRRRG NMRTLGFCGD 60 61 WLVTSCGTKL VAVHTKEDRE AFVFDCSLAE KKPKQTKGDD TSEETGNDEV LAVATSASGK 120 121 LLALTDDTKR LVLFGCEPSW RCISTRWVVR RCTALTFSRA EDELLLADKS GDVYSFSVVE 180 181 AQRDGELKLG HLSMLLAVVI SPDDRFIITA DRDEKIRVSH RRSPYNIQAF CLGHRQFVSA 240 241 LHIPAGRPDW LLSGSGDGTV KLWEFESGRQ LQSWELQQDV SAAEQNQNQV HPAADQDAAV 300 301 CSVTSSPDAH HVAILCERDS SRHLFCLDSD GGTGFGPPHM LSLACSPLDV SFDQEGRLWV 360 361 LMDSCEDPVQ VLCCSQSGWQ SLRGGSGGPE LCRVMGGLKP HWSRSEASTR SFQHLFKVSY 420 421 DNVTSYLQKK QQRLEEQLKR RAAQEEKSNK KSRGEESSPE NPEEPENI 468 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTTTGGAA AAGTAAAACA TCGACATAGA GTTTATTTCT CTGCTCGTCC TCTGGGGCAG 60 61 AAAACACACG AAGAAGAGAC TGGAGGAAAC GTGACGTCAT TTATAGGCGA CTGCGCGCGT 120 121 GTCTGTCTTT CGGTGCACAG ACGGCGCGGA AACATGAGGA CCCTGGGCTT CTGTGGAGAC 180 181 TGGCTCGTGA CCAGCTGTGG CACGAAGCTC GTGGCGGTTC ACACGAAGGA GGACAGAGAG 240 241 GCGTTTGTGT TTGACTGCAG CCTCGCTGAG AAGAAGCCGA AACAGACGAA GGGCGATGAC 300 301 ACCAGCGAGG AAACGGGAAA CGACGAGGTG CTCGCCGTCG CCACATCTGC ATCTGGAAAG 360 361 TTGTTGGCGC TGACTGATGA CACGAAGAGG CTGGTCCTGT TTGGCTGTGA GCCCTCGTGG 420 421 AGATGCATCA GCACCAGGTG GGTGGTCAGG AGGTGCACCG CGCTGACCTT CAGCCGGGCG 480 481 GAAGACGAGC TGCTGCTGGC CGACAAGTCT GGAGACGTCT ACAGCTTCTC GGTGGTGGAG 540 541 GCGCAGAGGG ACGGCGAGCT GAAGCTGGGT CACCTGTCCA TGCTGCTGGC TGTGGTCATT 600 601 TCTCCAGACG ACAGGTTCAT CATCACAGCC GACCGCGACG AGAAGATCAG GGTGAGCCAC 660 661 CGGAGATCCC CCTACAACAT CCAGGCCTTC TGCCTCGGCC ATCGACAGTT CGTCAGCGCT 720 721 CTGCACATCC CAGCGGGACG TCCTGATTGG CTACTCTCTG GATCAGGGGA CGGGACCGTG 780 781 AAGCTGTGGG AGTTCGAGTC CGGCCGACAG CTGCAGAGCT GGGAGCTCCA GCAGGACGTG 840 841 TCTGCAGCTG AACAGAACCA GAACCAGGTC CATCCTGCTG CAGACCAGGA TGCAGCTGTT 900 901 TGCAGCGTCA CCAGCTCGCC GGATGCTCAC CACGTGGCCA TTCTGTGTGA GAGAGACTCC 960 961 AGCCGTCATT TGTTCTGTCT GGACTCGGAT GGAGGGACTG GCTTCGGCCC CCCCCACATG 1020 1021 CTGTCTCTGG CCTGCTCTCC TCTGGACGTG AGCTTTGACC AGGAAGGCCG GCTGTGGGTT 1080 1081 CTGATGGACT CCTGTGAGGA CCCGGTCCAA GTCCTCTGCT GCAGTCAGAG CGGCTGGCAG 1140 1141 AGCCTCAGGG GGGGGAGTGG GGGTCCTGAA CTCTGTCGAG TGATGGGAGG TCTGAAGCCC 1200 1201 CACTGGAGCC GTTCTGAGGC GTCCACCAGG AGCTTCCAGC ACCTGTTCAA GGTGAGCTAC 1260 1261 GACAACGTGA CGTCGTACCT GCAGAAGAAG CAGCAGCGGC TGGAGGAGCA GCTGAAGAGG 1320 1321 AGGGCGGCGC AGGAGGAGAA GAGCAACAAG AAGTCCAGGG GGGAGGAGTC CAGCCCGGAG 1380 1381 AACCCGGAGG AACCGGAGAA CATCTGA 1407 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Biological Process | RNA (guanine-N7)-methylation | |
Biological Process | TRNA methylation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Tar-3872 | Takifugu rubripes | 58.95 | 3e-140 | 416 |
| LLPS-Orn-2660 | Oreochromis niloticus | 58.18 | 2e-153 | 450 |
| LLPS-Scm-3423 | Scophthalmus maximus | 57.07 | 7e-151 | 444 |
| LLPS-Pof-3379 | Poecilia formosa | 56.69 | 2e-142 | 422 |
| LLPS-Gaa-0159 | Gasterosteus aculeatus | 55.41 | 1e-139 | 414 |
| LLPS-Dar-4114 | Danio rerio | 54.57 | 1e-133 | 399 |
| LLPS-Icp-2450 | Ictalurus punctatus | 54.28 | 2e-131 | 394 |
| LLPS-Ten-2336 | Tetraodon nigroviridis | 53.85 | 2e-109 | 336 |
| LLPS-Asm-1398 | Astyanax mexicanus | 53.19 | 2e-128 | 386 |
| LLPS-Trr-1169 | Trichoderma reesei | 50.56 | 7e-17 | 87.4 |
| LLPS-Leo-0024 | Lepisosteus oculatus | 50.13 | 6e-120 | 364 |
| LLPS-Trv-1505 | Trichoderma virens | 48.31 | 3e-16 | 85.5 |
| LLPS-Cog-1202 | Colletotrichum gloeosporioides | 45.37 | 1e-15 | 83.6 |
| LLPS-Aon-4160 | Aotus nancymaae | 44.97 | 4e-90 | 287 |
| LLPS-Aim-0502 | Ailuropoda melanoleuca | 44.48 | 1e-79 | 260 |
| LLPS-Otg-4546 | Otolemur garnettii | 44.39 | 8e-82 | 266 |
| LLPS-Sus-4120 | Sus scrofa | 44.36 | 6e-82 | 266 |
| LLPS-Caj-0086 | Callithrix jacchus | 44.21 | 5e-87 | 279 |
| LLPS-Ict-0891 | Ictidomys tridecemlineatus | 44.09 | 4e-89 | 285 |
| LLPS-Mea-4372 | Mesocricetus auratus | 43.99 | 2e-55 | 194 |
| LLPS-Hos-3943 | Homo sapiens | 43.95 | 3e-88 | 282 |
| LLPS-Mam-0463 | Macaca mulatta | 43.95 | 6e-88 | 281 |
| LLPS-Cea-3152 | Cercocebus atys | 43.95 | 4e-88 | 282 |
| LLPS-Mal-4703 | Mandrillus leucophaeus | 43.95 | 6e-88 | 281 |
| LLPS-Dio-3808 | Dipodomys ordii | 43.81 | 3e-73 | 241 |
| LLPS-Man-1283 | Macaca nemestrina | 43.68 | 1e-87 | 281 |
| LLPS-Mum-4648 | Mus musculus | 43.68 | 9e-83 | 270 |
| LLPS-Maf-3681 | Macaca fascicularis | 43.68 | 1e-87 | 281 |
| LLPS-Chs-1889 | Chlorocebus sabaeus | 43.68 | 3e-87 | 280 |
| LLPS-Paa-2665 | Papio anubis | 43.68 | 4e-87 | 279 |
| LLPS-Loa-1988 | Loxodonta africana | 43.54 | 1e-85 | 275 |
| LLPS-Mup-2631 | Mustela putorius furo | 43.5 | 1e-78 | 256 |
| LLPS-Pap-4653 | Pan paniscus | 43.42 | 9e-87 | 278 |
| LLPS-Pat-1945 | Pan troglodytes | 43.42 | 1e-86 | 278 |
| LLPS-Rhb-3781 | Rhinopithecus bieti | 43.42 | 8e-87 | 279 |
| LLPS-Poa-1540 | Pongo abelii | 43.42 | 2e-85 | 275 |
| LLPS-Urm-3804 | Ursus maritimus | 43.17 | 1e-80 | 261 |
| LLPS-Orc-3971 | Oryctolagus cuniculus | 43.16 | 9e-84 | 270 |
| LLPS-Gog-2838 | Gorilla gorilla | 43.16 | 6e-86 | 276 |
| LLPS-Cas-2682 | Carlito syrichta | 43.01 | 1e-78 | 257 |
| LLPS-Nol-4184 | Nomascus leucogenys | 42.63 | 1e-78 | 257 |
| LLPS-Ora-2200 | Ornithorhynchus anatinus | 42.62 | 5e-86 | 276 |
| LLPS-Bot-4670 | Bos taurus | 42.59 | 1e-82 | 270 |
| LLPS-Ova-2677 | Ovis aries | 42.59 | 6e-84 | 271 |
| LLPS-Caf-1214 | Canis familiaris | 42.48 | 9e-83 | 268 |
| LLPS-Fec-4190 | Felis catus | 42.41 | 4e-80 | 262 |
| LLPS-Myl-3186 | Myotis lucifugus | 42.37 | 4e-83 | 268 |
| LLPS-Ran-2400 | Rattus norvegicus | 42.22 | 9e-78 | 256 |
| LLPS-Eqc-3795 | Equus caballus | 41.87 | 3e-77 | 257 |
| LLPS-Cap-3944 | Cavia porcellus | 41.22 | 2e-81 | 267 |
| LLPS-Sah-1154 | Sarcophilus harrisii | 41.13 | 6e-83 | 268 |
| LLPS-Lac-3666 | Latimeria chalumnae | 41.09 | 2e-86 | 278 |
| LLPS-Fia-0576 | Ficedula albicollis | 40.69 | 9e-85 | 272 |
| LLPS-Tag-3486 | Taeniopygia guttata | 40.62 | 4e-85 | 272 |
| LLPS-Fud-1910 | Fukomys damarensis | 40.55 | 5e-80 | 261 |
| LLPS-Anp-3054 | Anas platyrhynchos | 40.46 | 3e-79 | 258 |
| LLPS-Mod-0877 | Monodelphis domestica | 40.43 | 3e-81 | 263 |
| LLPS-Meg-1997 | Meleagris gallopavo | 40.23 | 6e-80 | 259 |
| LLPS-Fus-0166 | Fusarium solani | 39.68 | 2e-14 | 79.7 |
| LLPS-Gaga-1253 | Gallus gallus | 39.68 | 4e-81 | 264 |
| LLPS-Gag-1198 | Gaeumannomyces graminis | 39.49 | 1e-15 | 83.6 |
| LLPS-Drm-1259 | Drosophila melanogaster | 38.82 | 1e-26 | 115 |
| LLPS-Pes-2348 | Pelodiscus sinensis | 38.62 | 2e-81 | 265 |
| LLPS-Anc-3223 | Anolis carolinensis | 38.46 | 3e-70 | 235 |
| LLPS-Asc-1574 | Aspergillus clavatus | 37.74 | 6e-13 | 75.1 |
| LLPS-Crn-1491 | Cryptococcus neoformans | 37.5 | 9e-24 | 108 |
| LLPS-Yal-0107 | Yarrowia lipolytica | 37.13 | 2e-24 | 107 |
| LLPS-Asfu-0525 | Aspergillus fumigatus | 37.11 | 7e-13 | 74.7 |
| LLPS-Met-1329 | Medicago truncatula | 36.7 | 3e-25 | 111 |
| LLPS-Vir-1458 | Vigna radiata | 36.7 | 1e-19 | 95.9 |
| LLPS-Beb-1516 | Beauveria bassiana | 36.47 | 1e-16 | 86.3 |
| LLPS-Nia-1595 | Nicotiana attenuata | 36.32 | 6e-21 | 99.0 |
| LLPS-Mua-0812 | Musa acuminata | 36.23 | 1e-21 | 100 |
| LLPS-Asg-0470 | Ashbya gossypii | 36.2 | 4e-20 | 96.7 |
| LLPS-Mao-0070 | Magnaporthe oryzae | 35.68 | 2e-17 | 89.0 |
| LLPS-Tum-1006 | Tuber melanosporum | 35.37 | 6e-17 | 85.1 |
| LLPS-Phv-2396 | Phaseolus vulgaris | 35.14 | 2e-21 | 100 |
| LLPS-Gor-2456 | Gossypium raimondii | 35.08 | 2e-18 | 91.3 |
| LLPS-Sol-0395 | Solanum lycopersicum | 35.08 | 3e-21 | 99.8 |
| LLPS-Viv-2345 | Vitis vinifera | 34.48 | 2e-22 | 103 |
| LLPS-Glm-2703 | Glycine max | 34.29 | 2e-23 | 105 |
| LLPS-Bro-2116 | Brassica oleracea | 34.22 | 2e-26 | 114 |
| LLPS-Pyt-0111 | Pyrenophora teres | 34.03 | 2e-10 | 67.0 |
| LLPS-Phn-1470 | Phaeosphaeria nodorum | 33.89 | 9e-11 | 67.8 |
| LLPS-Kop-1207 | Komagataella pastoris | 33.71 | 9e-18 | 89.0 |
| LLPS-Cogr-0632 | Colletotrichum graminicola | 33.53 | 3e-14 | 79.3 |
| LLPS-Sot-1802 | Solanum tuberosum | 33.48 | 2e-21 | 100 |
| LLPS-Abg-1557 | Absidia glauca | 33.2 | 5e-33 | 132 |
| LLPS-Nec-0412 | Neurospora crassa | 33.08 | 5e-17 | 87.8 |
| LLPS-Hov-1987 | Hordeum vulgare | 32.93 | 1e-23 | 106 |
| LLPS-Mae-0488 | Manihot esculenta | 32.79 | 2e-21 | 100 |
| LLPS-Map-0133 | Magnaporthe poae | 32.78 | 3e-14 | 79.3 |
| LLPS-Tra-2338 | Triticum aestivum | 32.65 | 6e-23 | 104 |
| LLPS-Coo-0211 | Colletotrichum orbiculare | 32.45 | 3e-13 | 76.3 |
| LLPS-Sem-2387 | Selaginella moellendorffii | 32.32 | 6e-20 | 96.3 |
| LLPS-Sob-0356 | Sorghum bicolor | 32.26 | 1e-20 | 98.2 |
| LLPS-Lem-1090 | Leptosphaeria maculans | 32.02 | 5e-11 | 68.6 |
| LLPS-Asf-0834 | Aspergillus flavus | 31.94 | 3e-15 | 80.9 |
| LLPS-Miv-1492 | Microbotryum violaceum | 31.9 | 3e-12 | 72.8 |
| LLPS-Pot-1107 | Populus trichocarpa | 31.56 | 4e-23 | 105 |
| LLPS-Php-1580 | Physcomitrella patens | 31.52 | 3e-27 | 117 |
| LLPS-Fuv-1174 | Fusarium verticillioides | 31.16 | 3e-15 | 82.0 |
| LLPS-Fuo-1232 | Fusarium oxysporum | 31.08 | 3e-16 | 85.1 |
| LLPS-Zem-2308 | Zea mays | 31.05 | 2e-20 | 97.1 |
| LLPS-Art-2098 | Arabidopsis thaliana | 30.77 | 1e-23 | 106 |
| LLPS-Cae-1864 | Caenorhabditis elegans | 30.49 | 2e-09 | 63.9 |
| LLPS-Arl-2750 | Arabidopsis lyrata | 29.86 | 2e-23 | 105 |
| LLPS-Ved-1349 | Verticillium dahliae | 29.23 | 8e-16 | 84.0 |
| LLPS-Sac-0206 | Saccharomyces cerevisiae | 29.22 | 2e-18 | 91.7 |
| LLPS-Usm-1226 | Ustilago maydis | 29.17 | 9e-06 | 52.4 |
| LLPS-Mel-0681 | Melampsora laricipopulina | 28.99 | 2e-13 | 74.7 |
| LLPS-Brn-2388 | Brassica napus | 28.67 | 6e-23 | 104 |
| LLPS-Scc-1370 | Schizosaccharomyces cryophilus | 28.16 | 5e-14 | 77.8 |
| LLPS-Scs-0369 | Sclerotinia sclerotiorum | 28.16 | 1e-15 | 83.2 |
| LLPS-Asn-0649 | Aspergillus nidulans | 28.16 | 9e-15 | 80.5 |
| LLPS-Brr-1520 | Brassica rapa | 28.07 | 4e-23 | 105 |
| LLPS-Put-0243 | Puccinia triticina | 27.81 | 3e-10 | 66.6 |
| LLPS-Blg-0801 | Blumeria graminis | 27.74 | 1e-17 | 89.4 |
| LLPS-Scj-1182 | Schizosaccharomyces japonicus | 27.56 | 3e-13 | 75.5 |
| LLPS-Asni-1421 | Aspergillus niger | 27.51 | 4e-17 | 87.8 |
| LLPS-Nef-1200 | Neosartorya fischeri | 27.42 | 5e-14 | 78.2 |
| LLPS-Chc-0739 | Chondrus crispus | 27.27 | 4e-14 | 75.9 |
| LLPS-Scp-1597 | Schizosaccharomyces pombe | 26.97 | 6e-14 | 77.8 |
| LLPS-Zyt-0813 | Zymoseptoria tritici | 26.89 | 6e-08 | 58.9 |
| LLPS-Ast-0784 | Aspergillus terreus | 26.21 | 2e-14 | 79.3 |
| LLPS-Aso-1446 | Aspergillus oryzae | 26.06 | 1e-15 | 83.2 |
| LLPS-Osl-0911 | Ostreococcus lucimarinus | 25.77 | 2e-14 | 79.0 |