LLPS-Dar-4114
wdr4
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wdr4; WD repeat-containing protein 4 |
| Gene Name: | wdr4, si:ch211-140m22.6 |
| Ensembl Gene: | ENSDARG00000090581.3 |
| Ensembl Protein: | ENSDARP00000109363.1 |
| Organism: | Danio rerio |
| Taxa ID: | 7955 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSDART00000122894.3 | ENSDARP00000109363.1 |
| UniProt | A4IGH4, WDR4_DANRE, B0UXG2 | |
| GeneBank | BC135101, CR361548 | AAI35102.1, CAQ13728.1 |
| Entrez | 570351 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAVVCSKADW FVTSCSTTLV AVNLKQSREP FVFDCSKAEK KPKEADVDNK SAGEGSEEKD 60 61 SDSILAFAIS ASGKHVALTD DHKRLVLFCT EPSWKCISTR WVVRRCTSLA FTQAEDELYV 120 121 ADKSGDVYSF SILEPHKAGE LKLGHLSMLL DVALSPDDKY IITADRDEKI RVSFRRSPYN 180 181 IQAFCLGHTE FVSSLLVPAG HPDWLLSGSG DGTVNVWHYE TGRRLHSVDM RKFGLDSENT 240 241 EKRFAVSRII SSPDGQHVAV QCEGFPSVQL FTVDCGTESL LKPADTLTLP LSPWDVTFDS 300 301 ENQLWVLLES EDMKVLLYRH SEQHWRLCDS ESPELKKVTN ALQTQWHLFK GSVGLESQFK 360 361 HLYKVNFDNM ASYLQKKQER LDLENKKRAA AANGSKPNKK SKTESGPVPQ STS 413 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCTGTAG TGTGTTCAAA AGCTGACTGG TTTGTTACAA GTTGTTCTAC TACTTTAGTT 60 61 GCTGTAAACC TTAAGCAGTC TAGAGAGCCT TTTGTGTTTG ACTGTTCCAA AGCTGAGAAA 120 121 AAACCTAAAG AAGCTGATGT TGATAACAAA AGTGCTGGGG AGGGATCAGA AGAGAAGGAC 180 181 AGTGACAGTA TCCTTGCGTT TGCCATCTCA GCATCTGGAA AGCATGTAGC GCTTACGGAT 240 241 GATCACAAAC GACTTGTTCT CTTCTGCACT GAACCATCAT GGAAGTGCAT TAGTACACGG 300 301 TGGGTTGTGC GGCGGTGCAC TTCTCTTGCA TTTACTCAAG CTGAGGACGA ACTCTATGTG 360 361 GCAGATAAGT CTGGAGATGT GTATTCATTC TCCATTCTGG AGCCACATAA AGCAGGAGAG 420 421 CTGAAGCTGG GACATCTATC TATGTTACTT GATGTGGCTC TTTCCCCAGA TGATAAATAT 480 481 ATCATAACGG CTGACCGAGA TGAGAAGATC AGAGTGAGTT TTCGGCGTTC ACCCTACAAC 540 541 ATTCAGGCTT TCTGTCTGGG CCACACAGAA TTTGTCAGTT CATTGCTTGT GCCTGCAGGG 600 601 CATCCTGACT GGCTTCTCTC AGGTTCAGGA GATGGCACAG TGAATGTCTG GCATTACGAG 660 661 ACTGGTCGCC GATTACACAG TGTGGACATG AGGAAATTCG GGCTTGACTC AGAAAACACA 720 721 GAAAAGAGGT TTGCGGTCAG CCGGATCATC AGTTCACCAG ATGGACAACA TGTCGCTGTT 780 781 CAGTGTGAGG GATTCCCCTC AGTTCAGCTG TTCACAGTGG ATTGTGGGAC AGAGAGCCTC 840 841 CTGAAACCTG CAGACACGCT GACTCTTCCT CTCTCGCCAT GGGACGTGAC CTTTGACTCA 900 901 GAAAACCAGC TGTGGGTTTT GCTGGAGAGT GAAGACATGA AGGTGCTCCT GTATCGACAC 960 961 TCTGAGCAGC ACTGGAGGCT GTGTGACTCT GAGAGCCCTG AACTGAAGAA GGTCACTAAT 1020 1021 GCATTACAGA CTCAATGGCA TCTCTTTAAA GGTTCTGTGG GACTGGAAAG TCAGTTTAAA 1080 1081 CATCTTTATA AAGTGAACTT TGACAATATG GCTTCATACT TACAAAAGAA ACAGGAAAGA 1140 1141 CTAGACCTGG AGAATAAGAA GAGAGCAGCA GCAGCAAATG GCTCAAAACC CAACAAAAAA 1200 1201 AGTAAAACCG AGAGCGGCCC TGTGCCACAA AGCACCAGCT GA 1242 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Cellular Component | TRNA methyltransferase complex | |
Biological Process | TRNA (guanine-N7)-methylation | |
Biological Process | TRNA modification |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asm-1398 | Astyanax mexicanus | 68.03 | 0.0 | 581 |
| LLPS-Icp-2450 | Ictalurus punctatus | 65.64 | 0.0 | 567 |
| LLPS-Leo-0024 | Lepisosteus oculatus | 58.09 | 6e-161 | 466 |
| LLPS-Scm-3423 | Scophthalmus maximus | 55.23 | 5e-152 | 444 |
| LLPS-Orl-1771 | Oryzias latipes | 54.81 | 1e-142 | 422 |
| LLPS-Pof-3379 | Poecilia formosa | 53.81 | 1e-143 | 422 |
| LLPS-Orn-2660 | Oreochromis niloticus | 53.72 | 3e-153 | 447 |
| LLPS-Gaa-0159 | Gasterosteus aculeatus | 53.45 | 1e-138 | 409 |
| LLPS-Tar-3872 | Takifugu rubripes | 53.2 | 3e-138 | 409 |
| LLPS-Ten-2336 | Tetraodon nigroviridis | 51.86 | 1e-113 | 345 |
| LLPS-Pytr-1227 | Pyrenophora triticirepentis | 50.65 | 9e-10 | 63.2 |
| LLPS-Mod-0877 | Monodelphis domestica | 50.42 | 1e-115 | 350 |
| LLPS-Sah-1154 | Sarcophilus harrisii | 49.45 | 8e-111 | 338 |
| LLPS-Ora-2200 | Ornithorhynchus anatinus | 48.95 | 4e-116 | 351 |
| LLPS-Poa-1540 | Pongo abelii | 48.48 | 1e-106 | 328 |
| LLPS-Lac-3666 | Latimeria chalumnae | 48.18 | 1e-114 | 348 |
| LLPS-Dio-3808 | Dipodomys ordii | 48.13 | 5e-106 | 324 |
| LLPS-Pap-4653 | Pan paniscus | 47.92 | 7e-106 | 326 |
| LLPS-Pat-1945 | Pan troglodytes | 47.92 | 9e-106 | 325 |
| LLPS-Trr-1169 | Trichoderma reesei | 47.78 | 4e-15 | 81.3 |
| LLPS-Tag-3486 | Taeniopygia guttata | 47.75 | 6e-113 | 342 |
| LLPS-Hos-3943 | Homo sapiens | 47.65 | 5e-105 | 324 |
| LLPS-Gog-2838 | Gorilla gorilla | 47.65 | 7e-105 | 323 |
| LLPS-Pes-2348 | Pelodiscus sinensis | 47.56 | 3e-106 | 327 |
| LLPS-Cea-3152 | Cercocebus atys | 47.47 | 8e-107 | 328 |
| LLPS-Mum-4648 | Mus musculus | 47.38 | 4e-106 | 328 |
| LLPS-Nol-4184 | Nomascus leucogenys | 47.37 | 2e-98 | 306 |
| LLPS-Mam-0463 | Macaca mulatta | 47.2 | 1e-106 | 328 |
| LLPS-Man-1283 | Macaca nemestrina | 47.2 | 9e-107 | 328 |
| LLPS-Fia-0576 | Ficedula albicollis | 47.2 | 1e-117 | 355 |
| LLPS-Paa-2665 | Papio anubis | 47.2 | 2e-106 | 327 |
| LLPS-Maf-3681 | Macaca fascicularis | 47.2 | 1e-106 | 328 |
| LLPS-Loa-1988 | Loxodonta africana | 47.18 | 2e-110 | 337 |
| LLPS-Cas-2682 | Carlito syrichta | 47.03 | 6e-101 | 313 |
| LLPS-Bot-4670 | Bos taurus | 47.03 | 1e-110 | 340 |
| LLPS-Eqc-3795 | Equus caballus | 47.0 | 8e-102 | 320 |
| LLPS-Cap-3944 | Cavia porcellus | 46.99 | 5e-101 | 315 |
| LLPS-Gaga-1253 | Gallus gallus | 46.97 | 4e-111 | 340 |
| LLPS-Mal-4703 | Mandrillus leucophaeus | 46.93 | 2e-105 | 325 |
| LLPS-Chs-1889 | Chlorocebus sabaeus | 46.93 | 2e-106 | 327 |
| LLPS-Rhb-3781 | Rhinopithecus bieti | 46.67 | 6e-105 | 323 |
| LLPS-Aim-0502 | Ailuropoda melanoleuca | 46.63 | 8e-106 | 325 |
| LLPS-Mup-2631 | Mustela putorius furo | 46.54 | 3e-103 | 318 |
| LLPS-Caj-0086 | Callithrix jacchus | 46.54 | 2e-105 | 325 |
| LLPS-Otg-4546 | Otolemur garnettii | 46.26 | 8e-101 | 313 |
| LLPS-Myl-3186 | Myotis lucifugus | 46.26 | 4e-105 | 323 |
| LLPS-Fuo-1232 | Fusarium oxysporum | 46.24 | 2e-16 | 85.1 |
| LLPS-Ict-0891 | Ictidomys tridecemlineatus | 46.21 | 8e-111 | 338 |
| LLPS-Aon-4160 | Aotus nancymaae | 46.11 | 4e-105 | 324 |
| LLPS-Caf-1214 | Canis familiaris | 46.09 | 2e-103 | 319 |
| LLPS-Urm-3804 | Ursus maritimus | 46.01 | 2e-105 | 324 |
| LLPS-Sus-4120 | Sus scrofa | 45.99 | 1e-108 | 333 |
| LLPS-Meg-1997 | Meleagris gallopavo | 45.91 | 2e-113 | 344 |
| LLPS-Ova-2677 | Ovis aries | 45.91 | 3e-106 | 327 |
| LLPS-Anp-3054 | Anas platyrhynchos | 45.8 | 3e-111 | 340 |
| LLPS-Fud-1910 | Fukomys damarensis | 45.62 | 3e-104 | 322 |
| LLPS-Anc-3223 | Anolis carolinensis | 45.39 | 3e-99 | 309 |
| LLPS-Orc-3971 | Oryctolagus cuniculus | 45.38 | 1e-105 | 325 |
| LLPS-Ran-2400 | Rattus norvegicus | 45.21 | 1e-99 | 311 |
| LLPS-Fec-4190 | Felis catus | 45.03 | 2e-102 | 318 |
| LLPS-Mea-4372 | Mesocricetus auratus | 43.9 | 2e-83 | 266 |
| LLPS-Fuv-1174 | Fusarium verticillioides | 41.74 | 6e-16 | 84.0 |
| LLPS-Gag-1198 | Gaeumannomyces graminis | 40.12 | 1e-19 | 94.7 |
| LLPS-Met-1329 | Medicago truncatula | 38.91 | 5e-27 | 115 |
| LLPS-Lem-1090 | Leptosphaeria maculans | 38.82 | 5e-17 | 86.7 |
| LLPS-Cog-1202 | Colletotrichum gloeosporioides | 38.25 | 8e-20 | 95.5 |
| LLPS-Pot-1107 | Populus trichocarpa | 37.95 | 2e-21 | 99.4 |
| LLPS-Tum-1006 | Tuber melanosporum | 37.8 | 1e-19 | 92.4 |
| LLPS-Nec-0412 | Neurospora crassa | 37.3 | 6e-20 | 95.9 |
| LLPS-Sob-0356 | Sorghum bicolor | 36.44 | 1e-24 | 108 |
| LLPS-Yal-0107 | Yarrowia lipolytica | 36.31 | 1e-20 | 96.7 |
| LLPS-Phn-1470 | Phaeosphaeria nodorum | 35.96 | 8e-15 | 80.1 |
| LLPS-Mao-0070 | Magnaporthe oryzae | 35.96 | 1e-17 | 89.0 |
| LLPS-Map-0133 | Magnaporthe poae | 35.93 | 1e-19 | 95.1 |
| LLPS-Php-1580 | Physcomitrella patens | 35.88 | 1e-30 | 126 |
| LLPS-Drm-1259 | Drosophila melanogaster | 35.79 | 2e-25 | 110 |
| LLPS-Coo-0211 | Colletotrichum orbiculare | 35.61 | 1e-17 | 88.6 |
| LLPS-Mae-0488 | Manihot esculenta | 35.42 | 4e-26 | 112 |
| LLPS-Viv-2345 | Vitis vinifera | 35.39 | 4e-23 | 104 |
| LLPS-Vir-1458 | Vigna radiata | 35.33 | 4e-19 | 93.6 |
| LLPS-Cogr-0632 | Colletotrichum graminicola | 34.62 | 3e-16 | 84.7 |
| LLPS-Fus-0166 | Fusarium solani | 34.55 | 2e-16 | 85.1 |
| LLPS-Glm-2703 | Glycine max | 34.55 | 2e-26 | 113 |
| LLPS-Zem-2308 | Zea mays | 34.17 | 9e-24 | 105 |
| LLPS-Phv-2396 | Phaseolus vulgaris | 34.03 | 9e-24 | 105 |
| LLPS-Hov-1987 | Hordeum vulgare | 33.82 | 1e-26 | 114 |
| LLPS-Beb-1516 | Beauveria bassiana | 33.72 | 1e-17 | 89.0 |
| LLPS-Kop-1207 | Komagataella pastoris | 33.53 | 2e-18 | 90.5 |
| LLPS-Chc-0739 | Chondrus crispus | 33.33 | 3e-16 | 82.0 |
| LLPS-Asc-1574 | Aspergillus clavatus | 33.33 | 2e-16 | 85.5 |
| LLPS-Sol-0395 | Solanum lycopersicum | 33.33 | 3e-28 | 119 |
| LLPS-Trv-1505 | Trichoderma virens | 33.14 | 1e-15 | 82.8 |
| LLPS-Pyt-0111 | Pyrenophora teres | 33.12 | 1e-11 | 70.1 |
| LLPS-Osl-1277 | Ostreococcus lucimarinus | 33.04 | 1e-06 | 54.7 |
| LLPS-Crn-1491 | Cryptococcus neoformans | 32.98 | 5e-19 | 93.2 |
| LLPS-Tra-2338 | Triticum aestivum | 32.5 | 4e-27 | 115 |
| LLPS-Arl-2750 | Arabidopsis lyrata | 32.22 | 5e-25 | 109 |
| LLPS-Abg-1557 | Absidia glauca | 32.11 | 1e-32 | 130 |
| LLPS-Sot-1802 | Solanum tuberosum | 32.0 | 1e-28 | 120 |
| LLPS-Gor-2456 | Gossypium raimondii | 31.93 | 2e-20 | 97.1 |
| LLPS-Asg-0470 | Ashbya gossypii | 31.76 | 2e-21 | 99.8 |
| LLPS-Mua-0812 | Musa acuminata | 31.43 | 3e-21 | 99.0 |
| LLPS-Sac-0206 | Saccharomyces cerevisiae | 31.4 | 3e-17 | 87.4 |
| LLPS-Ved-1349 | Verticillium dahliae | 31.25 | 5e-18 | 90.1 |
| LLPS-Sem-2387 | Selaginella moellendorffii | 31.11 | 3e-21 | 99.4 |
| LLPS-Nia-1595 | Nicotiana attenuata | 30.77 | 4e-25 | 109 |
| LLPS-Blg-0801 | Blumeria graminis | 30.38 | 2e-22 | 103 |
| LLPS-Asn-0649 | Aspergillus nidulans | 29.85 | 5e-17 | 87.0 |
| LLPS-Bro-2116 | Brassica oleracea | 29.75 | 7e-28 | 117 |
| LLPS-Brr-1520 | Brassica rapa | 29.03 | 6e-21 | 98.2 |
| LLPS-Scc-1370 | Schizosaccharomyces cryophilus | 29.0 | 7e-16 | 82.8 |
| LLPS-Asf-0834 | Aspergillus flavus | 28.72 | 4e-20 | 94.4 |
| LLPS-Scs-0369 | Sclerotinia sclerotiorum | 28.71 | 6e-19 | 92.8 |
| LLPS-Cae-1864 | Caenorhabditis elegans | 28.57 | 7e-14 | 77.0 |
| LLPS-Art-2098 | Arabidopsis thaliana | 28.25 | 1e-24 | 108 |
| LLPS-Aso-1446 | Aspergillus oryzae | 28.22 | 8e-22 | 101 |
| LLPS-Asni-1421 | Aspergillus niger | 28.08 | 7e-20 | 95.5 |
| LLPS-Brn-2388 | Brassica napus | 27.94 | 1e-21 | 100 |
| LLPS-Zyt-0813 | Zymoseptoria tritici | 27.92 | 4e-12 | 71.6 |
| LLPS-Asfu-0525 | Aspergillus fumigatus | 27.87 | 9e-21 | 98.2 |
| LLPS-Scp-1597 | Schizosaccharomyces pombe | 27.62 | 3e-15 | 81.3 |
| LLPS-Nef-1200 | Neosartorya fischeri | 27.45 | 7e-20 | 95.5 |
| LLPS-Mel-0681 | Melampsora laricipopulina | 27.11 | 2e-11 | 68.2 |
| LLPS-Put-0243 | Puccinia triticina | 27.1 | 4e-12 | 72.0 |
| LLPS-Ast-0784 | Aspergillus terreus | 27.07 | 4e-16 | 84.3 |
| LLPS-Scj-1182 | Schizosaccharomyces japonicus | 25.66 | 1e-14 | 79.7 |