LLPS-Tag-2774
PLCG1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma |
| Gene Name: | PLCG1 |
| Ensembl Gene: | ENSTGUG00000004737.1 |
| Ensembl Protein: | ENSTGUP00000004946.1 |
| Organism: | Taeniopygia guttata |
| Taxa ID: | 59729 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSTGUT00000004995.1 | ENSTGUP00000004946.1 |
| UniProt | H0Z304, H0Z304_TAEGU | |
| GeneBank | ABQF01028635, ABQF01028638, ABQF01028641, ABQF01028639, ABQF01028640, ABQF01028636, ABQF01028637, ABQF01028642 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 GPGAPSEAEA AQLCRSLEVG TVMTLFYSKK SQRPERKTFQ VKLETRQVTW SRGSEKVEGA 60 61 VDIREIKEIR PGRNSRDFDR YQEDPCFRPD HSHCFVVLYG TEFRLKTLSL QATSEDEVNM 120 121 WIKGLNWLVA DTLRAPTPLQ IKRWLRKQFY SLDRNREDRI PSGGIKSCLV FLTYFSARHS 180 181 LSHAELPDVE QRNGDITYGQ FAQLYRSLMF SAQKTMDVPF LERQCLWGTE RSEHFRVSLL 240 241 ELQKFLLEYQ RELWAADTLQ VQEFMFNFLR DPLREIDEPY FSLDEFLTFL FSKENSIWNS 300 301 QLDMVCLENM NNPLSHYWIS SSHNTYLTGD QFSSESSLEA YARCLRMGCR CIELDCWDGP 360 361 DGMPVIYHGH TLTTKIKFSD VLVTIKEHAF VTSDFPVILS IEDHCSIAQQ RNMAQNFKKV 420 421 FGDMLLTKPV DISADGLPSP NQLKRKILIK HKKLAEGSAY EELPTSVMYS ENDISNSIKN 480 481 GILYLEDPIN HEWNPHYFVL TSSKIYYSGE TTSDQGNEDE EEQKEVSNST ELHSEKCFHG 540 541 KLGAGTGRHI AERLLTKILI KTGAPDGSFL VRESETFVGD YTLSFWRNGK VQHCRIHSRQ 600 601 DAGSPKFFLT DNLVFDSLYD LITHYQEVPL RCNEFEMRLT EPVPQTNAHE SKEWYHANLT 660 661 RAQAEHMLMR VPRDGAFLVR KRSEPSSYAI SFRAEGKIKH CRVQQEGQTV LLGNSEFESL 720 721 VDLISYYEKH PLYRKMKLRY PINEETLEKI GTAEPDYGAL YEGRHPGFYV EANPMPTFKC 780 781 AVKALFDYKA QREDELTFTK NAIIQNVEKQ EGGWWRGDYG GKKQLWFPSN YVEEITSPSS 840 841 LEPEREQLDE NSPLGDLLGG VLDVPSCQIA IRPEGKNNRL FVFSISMSSV SRLSLDVAAD 900 901 THEDLLDWVK KIREAAQTAD ARLSEGKMME RRKKIALELS ELVVYCRPVP FDEEKIGTER 960 961 ACYRDMSSFP ETKAEKYVNK IKGKKFLQYN RLQLSRIYPK GQRLDSSNYD PLPMWICGSQ 1020 1021 LVALNFQTPD KPMQMNQALF MSSGQCGYVL QPTNMRDDIF DPFDKSTLRG TEPLSISIEV 1080 1081 LGARHLPKNG RGIVCPFVEV EVSGAEYDNA KQKTEIVADN GLNPLWTPKQ FHFQVSNPEF 1140 1141 AFLRFVVYEE DMFSDENFLA QATFLVKGLK TGFRAVPLKN NYSENLELAS LLVKIDIFPC 1200 1201 KQENGEINLF NASSLRERAG DGSSQLLASR GREGSFELRY QQPFEDFRVS PEQLADHFES 1260 1261 RERRVLRRTR VNGDNRL 1277 |
| Nucleotide CDS Sequence (FASTA) |
1 GGCCCCGGGG CGCCCAGCGA GGCGGAGGCG GCGCAGCTCT GCCGCAGCTT GGAGGTGGGC 60 61 ACCGTCATGA CCCTCTTCTA CTCCAAAAAG TCGCAGCGAC CCGAGCGGAA AACTTTCCAG 120 121 GTGAAGCTGG AGACGCGGCA GGTCACCTGG AGCCGCGGCT CCGAGAAGGT GGAGGGGGCC 180 181 GTGGATATTC GTGAGATCAA AGAGATCCGT CCAGGCAGGA ACTCCCGTGA TTTTGACCGC 240 241 TACCAGGAGG ATCCGTGTTT CCGACCTGAC CACTCGCACT GCTTCGTTGT CCTCTACGGC 300 301 ACCGAATTCC GGCTGAAGAC CCTCAGCTTG CAGGCCACTT CTGAGGATGA GGTCAATATG 360 361 TGGATCAAGG GGCTGAACTG GTTGGTGGCA GACACGCTGA GGGCACCCAC CCCCCTGCAG 420 421 ATTAAAAGGT GGCTCCGGAA GCAGTTCTAC TCCCTGGATC GCAACCGGGA GGACAGAATC 480 481 CCGAGCGGAG GTATTAAAAG CTGTCTTGTT TTCCTGACCT ATTTCTCAGC TAGACATTCC 540 541 TTAAGCCATG CAGAGTTACC TGATGTGGAG CAGAGGAACG GGGACATCAC GTACGGGCAG 600 601 TTTGCACAGC TCTACCGCAG CCTGATGTTC AGCGCCCAGA AAACCATGGA TGTCCCGTTC 660 661 TTGGAAAGGC AGTGCCTCTG GGGTACAGAA AGGTCTGAGC ACTTCAGGGT GTCACTGCTG 720 721 GAGCTGCAGA AGTTTTTGCT GGAGTACCAG AGGGAGCTCT GGGCTGCAGA TACCCTTCAG 780 781 GTACAGGAAT TCATGTTCAA CTTCCTGAGA GACCCTTTGA GGGAGATTGA CGAGCCTTAC 840 841 TTCTCCCTGG ACGAATTTCT CACCTTCCTG TTTTCCAAAG AGAACAGCAT CTGGAACTCA 900 901 CAACTGGACA TGGTGTGTCT GGAGAACATG AACAACCCTC TCTCCCATTA CTGGATCTCC 960 961 TCCTCACACA ACACGTACCT GACGGGGGAT CAGTTCTCGA GCGAGTCCTC GCTGGAGGCC 1020 1021 TACGCCCGCT GCCTGCGCAT GGGCTGCCGC TGCATCGAGC TGGATTGCTG GGACGGTCCT 1080 1081 GATGGCATGC CGGTCATCTA CCACGGACAC ACCTTAACCA CCAAGATCAA GTTCTCTGAT 1140 1141 GTCTTGGTCA CTATTAAGGA GCACGCCTTT GTCACCTCTG ATTTCCCTGT CATTCTGTCC 1200 1201 ATTGAGGACC ACTGCAGCAT TGCTCAGCAG AGGAACATGG CTCAGAATTT TAAGAAGGTT 1260 1261 TTTGGAGACA TGCTCTTGAC CAAACCAGTC GATATTTCTG CTGATGGCCT TCCATCTCCA 1320 1321 AACCAGCTCA AGAGGAAGAT TCTCATCAAG CACAAGAAGC TGGCAGAGGG CAGTGCTTAC 1380 1381 GAGGAGCTGC CCACGTCGGT GATGTACTCA GAGAATGACA TCAGCAACTC CATCAAGAAT 1440 1441 GGGATCCTCT ACCTGGAAGA CCCCATCAAT CATGAGTGGA ACCCACATTA CTTTGTGCTG 1500 1501 ACCAGCAGCA AGATCTATTA TTCTGGGGAG ACAACCAGTG ACCAAGGAAA CGAGGATGAG 1560 1561 GAAGAGCAAA AGGAGGTGAG CAACAGCACG GAGCTTCACT CCGAGAAGTG TTTCCACGGG 1620 1621 AAGCTGGGAG CGGGCACGGG GCGGCACATC GCGGAGCGGC TGCTGACGAA GATTCTCATC 1680 1681 AAGACAGGGG CCCCCGACGG CTCCTTCCTC GTCAGAGAGA GCGAGACCTT CGTAGGAGAC 1740 1741 TACACCCTCT CCTTCTGGCG CAACGGGAAG GTGCAGCACT GCCGGATCCA CTCGCGGCAG 1800 1801 GATGCCGGCA GCCCCAAGTT CTTCCTGACG GACAACCTGG TGTTCGACAG CCTCTACGAC 1860 1861 CTCATCACCC ACTACCAGGA GGTGCCACTG AGGTGCAACG AGTTTGAGAT GAGGCTGACG 1920 1921 GAGCCAGTGC CACAGACCAA TGCCCACGAG AGCAAAGAGT GGTACCACGC CAACCTCACG 1980 1981 CGGGCCCAGG CCGAGCACAT GCTGATGCGG GTGCCCCGCG ACGGAGCCTT CCTGGTGCGC 2040 2041 AAGAGGAGCG AGCCCAGCTC CTATGCCATC TCCTTCAGGG CAGAAGGGAA GATCAAGCAC 2100 2101 TGCCGGGTGC AGCAGGAGGG CCAGACCGTG CTGCTGGGCA ACTCTGAATT CGAGAGCCTG 2160 2161 GTGGACTTGA TCAGCTACTA CGAGAAGCAC CCGCTGTACC GCAAGATGAA GCTGCGCTAC 2220 2221 CCCATCAACG AGGAGACCCT GGAGAAGATT GGGACAGCGG AGCCGGACTA TGGAGCCCTG 2280 2281 TACGAGGGAC GCCACCCTGG GTTCTATGTG GAAGCCAACC CCATGCCCAC CTTCAAGTGT 2340 2341 GCAGTCAAAG CCCTGTTTGA CTACAAGGCA CAGAGGGAAG ACGAGCTCAC CTTCACCAAA 2400 2401 AATGCCATCA TCCAGAATGT GGAGAAACAG GAAGGAGGCT GGTGGAGAGG AGATTATGGT 2460 2461 GGCAAAAAGC AGCTGTGGTT CCCTTCCAAC TATGTAGAGG AAATTACCAG TCCCAGTAGC 2520 2521 CTGGAGCCAG AGCGGGAGCA GCTGGATGAG AACAGCCCCC TGGGAGACCT GCTCGGAGGG 2580 2581 GTCCTGGACG TGCCCTCCTG CCAGATCGCC ATCCGCCCCG AGGGGAAGAA CAATCGCCTC 2640 2641 TTCGTCTTCT CCATCAGCAT GTCCTCGGTG TCACGCCTGT CCCTGGACGT GGCGGCCGAC 2700 2701 ACGCACGAGG ACCTGCTGGA CTGGGTGAAG AAGATCCGGG AGGCAGCTCA GACAGCTGAT 2760 2761 GCCAGGCTCT CTGAAGGGAA GATGATGGAG AGGAGAAAGA AGATTGCCCT GGAGCTTTCA 2820 2821 GAACTGGTGG TCTATTGCCG ACCTGTGCCC TTTGATGAAG AGAAGATCGG CACAGAGAGG 2880 2881 GCCTGTTACC GGGACATGTC CTCCTTTCCC GAGACCAAGG CAGAAAAGTA CGTCAACAAG 2940 2941 ATCAAGGGCA AGAAGTTCCT GCAGTACAAC CGCCTGCAGC TCTCCCGCAT CTACCCCAAG 3000 3001 GGCCAGCGCC TCGACTCCTC CAACTACGAC CCCCTGCCCA TGTGGATCTG TGGCAGCCAG 3060 3061 CTGGTGGCAC TCAACTTCCA GACCCCGGAC AAACCCATGC AGATGAACCA GGCCTTGTTC 3120 3121 ATGTCCAGTG GCCAGTGTGG GTACGTCCTG CAGCCAACCA ACATGAGGGA TGACATCTTT 3180 3181 GACCCCTTTG ACAAGAGCAC GTTGCGGGGC ACAGAACCAC TCTCCATCTC CATTGAGGTC 3240 3241 CTGGGGGCCC GGCACCTTCC CAAAAATGGA AGGGGAATTG TTTGTCCTTT CGTGGAGGTG 3300 3301 GAGGTGTCTG GTGCTGAGTA TGACAATGCC AAGCAGAAAA CAGAGATCGT GGCTGACAAC 3360 3361 GGCCTGAACC CTCTCTGGAC CCCGAAGCAG TTCCACTTTC AGGTCAGCAA CCCCGAGTTT 3420 3421 GCCTTCCTCC GCTTCGTGGT GTATGAGGAG GACATGTTCA GCGACGAGAA CTTCCTGGCT 3480 3481 CAGGCCACCT TCCTGGTGAA AGGCCTGAAG ACAGGTTTCC GAGCTGTTCC CCTCAAGAAC 3540 3541 AACTACAGTG AGAACCTGGA GCTGGCTTCT CTGCTTGTCA AGATAGACAT TTTCCCTTGC 3600 3601 AAGCAGGAAA ATGGCGAAAT AAACCTCTTC AATGCTTCAT CCCTACGGGA ACGAGCAGGG 3660 3661 GATGGCTCCA GCCAGCTGCT GGCAAGCAGA GGCAGAGAGG GGTCCTTTGA GCTGCGGTAC 3720 3721 CAGCAGCCTT TCGAGGATTT CCGTGTGTCC CCCGAGCAGC TCGCTGACCA CTTTGAGAGC 3780 3781 CGGGAGCGAA GGGTACTGCG GAGGACCCGG GTCAACGGGG ACAACCGGCT GTAG 3834 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell-cell junction | |
Cellular Component | COP9 signalosome | |
Cellular Component | Cytosol | |
Cellular Component | Glutamatergic synapse | |
Cellular Component | Lamellipodium | |
Cellular Component | Plasma membrane | |
Cellular Component | Ruffle | |
Cellular Component | Schaffer collateral - CA1 synapse | |
Molecular Function | Glutamate receptor binding | |
Molecular Function | Neurotrophin TRKA receptor binding | |
Molecular Function | Phosphatidylinositol phospholipase C activity | |
Molecular Function | Receptor tyrosine kinase binding | |
Biological Process | Calcium-mediated signaling | |
Biological Process | Cell migration | |
Biological Process | Cellular response to epidermal growth factor stimulus | |
Biological Process | Epidermal growth factor receptor signaling pathway | |
Biological Process | Modulation of chemical synaptic transmission | |
Biological Process | Phospholipid catabolic process | |
Biological Process | Positive regulation of angiogenesis | |
Biological Process | Positive regulation of blood vessel endothelial cell migration | |
Biological Process | Positive regulation of endothelial cell apoptotic process | |
Biological Process | Positive regulation of release of sequestered calcium ion into cytosol | |
Biological Process | Positive regulation of vascular endothelial cell proliferation | |
Biological Process | T cell receptor signaling pathway |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Fia-2239 | Ficedula albicollis | 95.52 | 0.0 | 2174 |
| LLPS-Gaga-0160 | Gallus gallus | 94.29 | 0.0 | 2375 |
| LLPS-Meg-3018 | Meleagris gallopavo | 93.71 | 0.0 | 2247 |
| LLPS-Anp-0423 | Anas platyrhynchos | 92.64 | 0.0 | 2205 |
| LLPS-Pes-0291 | Pelodiscus sinensis | 87.88 | 0.0 | 2232 |
| LLPS-Mod-2521 | Monodelphis domestica | 86.32 | 0.0 | 2204 |
| LLPS-Sah-2669 | Sarcophilus harrisii | 86.29 | 0.0 | 1379 |
| LLPS-Chs-3539 | Chlorocebus sabaeus | 86.27 | 0.0 | 1587 |
| LLPS-Anc-3213 | Anolis carolinensis | 86.25 | 0.0 | 2189 |
| LLPS-Urm-0754 | Ursus maritimus | 86.08 | 0.0 | 2010 |
| LLPS-Caj-2207 | Callithrix jacchus | 86.0 | 0.0 | 2199 |
| LLPS-Otg-1637 | Otolemur garnettii | 85.93 | 0.0 | 2194 |
| LLPS-Maf-1979 | Macaca fascicularis | 85.93 | 0.0 | 2202 |
| LLPS-Caf-3162 | Canis familiaris | 85.89 | 0.0 | 2084 |
| LLPS-Eqc-4188 | Equus caballus | 85.85 | 0.0 | 2201 |
| LLPS-Man-4209 | Macaca nemestrina | 85.85 | 0.0 | 2196 |
| LLPS-Hos-1858 | Homo sapiens | 85.85 | 0.0 | 2199 |
| LLPS-Rhb-2260 | Rhinopithecus bieti | 85.85 | 0.0 | 2202 |
| LLPS-Paa-4302 | Papio anubis | 85.85 | 0.0 | 2202 |
| LLPS-Cea-0959 | Cercocebus atys | 85.85 | 0.0 | 2202 |
| LLPS-Gog-3703 | Gorilla gorilla | 85.85 | 0.0 | 2194 |
| LLPS-Mal-3845 | Mandrillus leucophaeus | 85.82 | 0.0 | 2196 |
| LLPS-Pat-3398 | Pan troglodytes | 85.77 | 0.0 | 2194 |
| LLPS-Ran-4867 | Rattus norvegicus | 85.77 | 0.0 | 2192 |
| LLPS-Poa-3379 | Pongo abelii | 85.76 | 0.0 | 2161 |
| LLPS-Mum-3235 | Mus musculus | 85.74 | 0.0 | 2185 |
| LLPS-Mup-0095 | Mustela putorius furo | 85.69 | 0.0 | 2193 |
| LLPS-Bot-3684 | Bos taurus | 85.61 | 0.0 | 2192 |
| LLPS-Fud-3654 | Fukomys damarensis | 85.61 | 0.0 | 2192 |
| LLPS-Mam-3406 | Macaca mulatta | 85.46 | 0.0 | 2177 |
| LLPS-Sus-3208 | Sus scrofa | 85.4 | 0.0 | 2000 |
| LLPS-Myl-0308 | Myotis lucifugus | 85.32 | 0.0 | 2073 |
| LLPS-Cas-0571 | Carlito syrichta | 85.31 | 0.0 | 2174 |
| LLPS-Ict-2563 | Ictidomys tridecemlineatus | 85.3 | 0.0 | 2182 |
| LLPS-Dio-2958 | Dipodomys ordii | 84.97 | 0.0 | 2149 |
| LLPS-Loa-2955 | Loxodonta africana | 84.93 | 0.0 | 2062 |
| LLPS-Orc-2919 | Oryctolagus cuniculus | 84.14 | 0.0 | 2154 |
| LLPS-Mea-3613 | Mesocricetus auratus | 83.76 | 0.0 | 2136 |
| LLPS-Ova-0565 | Ovis aries | 83.03 | 0.0 | 2000 |
| LLPS-Aon-2904 | Aotus nancymaae | 82.98 | 0.0 | 2093 |
| LLPS-Pap-2619 | Pan paniscus | 82.56 | 0.0 | 2079 |
| LLPS-Nol-1221 | Nomascus leucogenys | 80.2 | 0.0 | 1928 |
| LLPS-Cap-0859 | Cavia porcellus | 80.14 | 0.0 | 1973 |
| LLPS-Lac-3674 | Latimeria chalumnae | 79.09 | 0.0 | 1930 |
| LLPS-Xet-0582 | Xenopus tropicalis | 76.27 | 0.0 | 1892 |
| LLPS-Dar-1156 | Danio rerio | 76.24 | 0.0 | 1523 |
| LLPS-Asm-0642 | Astyanax mexicanus | 75.31 | 0.0 | 1840 |
| LLPS-Leo-0862 | Lepisosteus oculatus | 75.04 | 0.0 | 1943 |
| LLPS-Icp-3861 | Ictalurus punctatus | 73.25 | 0.0 | 1896 |
| LLPS-Scm-3132 | Scophthalmus maximus | 72.84 | 0.0 | 1897 |
| LLPS-Orn-3875 | Oreochromis niloticus | 72.45 | 0.0 | 1876 |
| LLPS-Tar-3402 | Takifugu rubripes | 72.23 | 0.0 | 1904 |
| LLPS-Orl-0381 | Oryzias latipes | 71.17 | 0.0 | 1878 |
| LLPS-Xim-3401 | Xiphophorus maculatus | 71.07 | 0.0 | 1830 |
| LLPS-Pof-2635 | Poecilia formosa | 70.53 | 0.0 | 1824 |
| LLPS-Scf-2481 | Scleropages formosus | 67.01 | 0.0 | 1704 |
| LLPS-Ten-1521 | Tetraodon nigroviridis | 65.6 | 0.0 | 1603 |
| LLPS-Gaa-1749 | Gasterosteus aculeatus | 64.96 | 0.0 | 1580 |
| LLPS-Ora-2304 | Ornithorhynchus anatinus | 61.21 | 0.0 | 602 |
| LLPS-Cii-1372 | Ciona intestinalis | 47.95 | 0.0 | 1053 |
| LLPS-Cis-0711 | Ciona savignyi | 42.3 | 0.0 | 899 |
| LLPS-Drm-2105 | Drosophila melanogaster | 41.51 | 0.0 | 887 |
| LLPS-Aim-1666 | Ailuropoda melanoleuca | 39.22 | 1e-45 | 181 |
| LLPS-Tut-0755 | Tursiops truncatus | 39.19 | 5e-44 | 176 |
| LLPS-Fec-0592 | Felis catus | 39.15 | 1e-45 | 181 |
| LLPS-Cae-0899 | Caenorhabditis elegans | 35.85 | 0.0 | 643 |