LLPS-Meg-3018
PLCG1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma |
| Gene Name: | PLCG1 |
| Ensembl Gene: | ENSMGAG00000003334.2 |
| Ensembl Protein: | ENSMGAP00000003099.2 |
| Organism: | Meleagris gallopavo |
| Taxa ID: | 9103 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMGAT00000003793.2 | ENSMGAP00000003099.2 |
| UniProt | G1MWG7, G1MWG7_MELGA |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 SVDIREIKEI RPGKNSRDFD RYQEDPCFRP DQSHCFVVLY GTEFRLKTLS LQATSEDEVN 60 61 MWIKGLNWLV ADTLRAATPL QIERWLRKQF YTLDRNREDR ISAKDLKNML SQVNYRVPNM 120 121 RFLRERLTDM EQRNGDITYG QFAQLYRSLM FSAQKTMDVP FLDSFSPCAL RGGERSEHFR 180 181 VSLMEFQKFL LEYQRELWAA DSLQVQEFMF NFLRDPLREI DEPYFSLDEF LTFLFSKENS 240 241 IWNSQLDMVC PENMNNPLSH YWISSSHNTY LTGDQFSSES SLEAYARCLR MGCRCIELDC 300 301 WDGPDGMPVI YHGHTLTTKI KFSDVLVTIK EHAFVTSDFP VILSIEDHCS IAQQRNMAQN 360 361 FKKVFGDMLL TKPVDISADG LPSPNQLKRK ILIKHKKLAE GSAYEELPTS VMYSENDISN 420 421 SIKNGILYLE DPINHEWNPH YFVLTSSKIY YSGETTSDQG NEDEEEQKEV SNSTELHSTE 480 481 KWFHGKLGAG RDGRHIAERL LTEYCIETGA PDGSFLVRES ETFVGDYTLS FWRNGKVQHC 540 541 RIHSRQDAGS PKFFLTDNLV FDSLYDLITH YQEVPLRCNE FEMRLTEPVP QTNAHESKEW 600 601 YHANLTRAQA EHMLMRVPRD GAFLVRKRSE PSSYAISFRA EGKIKHCRVQ QEGQTVLLGN 660 661 SEFESLVDLI SYYEKHPLYR KMKLRYPINE ETLEKIGTAE PDYGALYEGR HPGFYVEANP 720 721 MPTFKCAVKA LFDYKAQRED ELTFTKNAII QNVEKQEGGW WRGDYGGKKQ LWFPSNYVEE 780 781 ISSPSSLEPE REQQLDENSP LGDLLGGVLD VPSCQIAIRP EGKNNRLFVF SISMASVSRL 840 841 SLDVAADTHE DLLDWVKKIR EAAQTADARL SEGKMMERRK KIALELSELV VYCRPVPFDE 900 901 EKIGTERACY RDMSSFPETK AEKYVNKIKG KKFLQYNRLQ LSRIYPKGQR LDSSNYDPLP 960 961 MWICGSQLVA LNFQTPDKPM QMNQALFLSS GQCGYVLQPA NMRDDIFDPF DKSTLRGVEP 1020 1021 LSISIEVPGG PGHLPKNGRG IVCPFVEVEV SGAEYDNAKQ KTEIVADNGL NPLWSPKQFH 1080 1081 FQVSNPEFAF LRFVVYEEDM FSDENFLAQA TFLVKGLKTG FRAVPLKNNY SENLELASLL 1140 1141 VKIDIFPSKE NGDISLFGGS MLRERGGDMA SQLLASRARE GSFEVRYQQP FEDFRVSQEQ 1200 1201 LAEHFESRER RALRRTRVNG DNRL 1224 |
| Nucleotide CDS Sequence (FASTA) |
1 TCAGTGGATA TTCGTGAAAT CAAAGAGATT CGTCCTGGAA AGAATTCACG TGATTTTGAC 60 61 CGATACCAGG AGGATCCGTG CTTCCGACCA GACCAGTCCC ATTGCTTCGT GGTCCTGTAC 120 121 GGCACAGAGT TCAGGCTGAA GACCCTCAGC TTACAAGCCA CTTCCGAGGA TGAGGTCAAC 180 181 ATGTGGATCA AGGGACTGAA CTGGCTGGTG GCAGATACTC TGAGGGCTGC CACCCCCCTG 240 241 CAGATCGAAA GGTGGCTCCG GAAGCAGTTC TACACACTGG ACCGCAACCG GGAGGACAGG 300 301 ATCTCTGCCA AGGACCTGAA GAACATGCTG TCCCAGGTCA ACTACCGCGT GCCCAACATG 360 361 AGGTTCCTGA GGGAGCGCCT GACGGACATG GAGCAGAGGA ATGGGGATAT CACATACGGG 420 421 CAATTTGCAC AGCTCTACCG CAGCCTGATG TTCAGTGCCC AGAAAACGAT GGATGTCCCA 480 481 TTCCTAGATA GTTTCTCTCC CTGTGCTCTC AGGGGTGGAG AAAGGTCTGA GCACTTCAGG 540 541 GTGTCGCTGA TGGAGTTCCA GAAGTTCCTG CTCGAGTACC AGAGGGAGCT CTGGGCTGCA 600 601 GACAGCCTTC AGGTACAGGA ATTCATGTTC AACTTTCTGA GGGACCCTTT GAGAGAGATT 660 661 GATGAGCCTT ATTTCTCCCT GGATGAGTTT CTCACCTTCC TGTTTTCCAA AGAGAACAGC 720 721 ATCTGGAACT CACAGCTGGA CATGGTGTGT CCCGAGAACA TGAACAACCC CCTGTCCCAT 780 781 TACTGGATCT CCTCCTCACA CAACACGTAC CTGACGGGGG ATCAGTTCTC GAGCGAATCC 840 841 TCCTTGGAGG CGTACGCCCG CTGCCTGCGC ATGGGGTGCC GCTGTATCGA ACTGGATTGC 900 901 TGGGATGGTC CCGATGGTAT GCCAGTCATC TACCATGGGC ACACCTTAAC CACCAAGATC 960 961 AAGTTCTCTG ATGTCCTGGT CACCATCAAG GAGCATGCCT TTGTCACCTC TGATTTCCCT 1020 1021 GTCATTCTGT CCATTGAGGA CCACTGCAGC ATCGCTCAGC AGAGGAACAT GGCTCAGAAT 1080 1081 TTCAAGAAGG TCTTTGGGGA CATGCTCTTG ACCAAACCTG TAGATATTTC TGCTGACGGC 1140 1141 CTTCCCTCCC CAAACCAACT CAAGAGGAAG ATTCTCATCA AGCACAAGAA ACTGGCAGAG 1200 1201 GGCAGTGCTT ACGAGGAGCT GCCCACTTCT GTTATGTATT CAGAGAATGA CATCAGCAAC 1260 1261 TCCATCAAAA ACGGGATCCT CTACCTGGAA GACCCCATCA ATCACGAGTG GAACCCGCAT 1320 1321 TACTTTGTCC TGACCAGCAG CAAGATCTAT TACTCAGGGG AGACAACCAG CGACCAAGGA 1380 1381 AATGAGGATG AGGAGGAGCA GAAGGAGGTG AGCAACAGCA CTGAGCTGCA TTCCACAGAG 1440 1441 AAGTGGTTCC ACGGCAAGCT GGGAGCAGGG CGCGATGGGC GGCACATTGC TGAGCGGCTG 1500 1501 CTGACAGAGT ACTGCATCGA GACGGGGGCC CCCGATGGCT CCTTCCTCGT CAGGGAGAGC 1560 1561 GAGACCTTTG TTGGGGACTA CACCCTGTCC TTCTGGCGCA ATGGGAAGGT GCAGCACTGC 1620 1621 CGCATCCACT CACGGCAGGA CGCCGGCAGC CCCAAGTTCT TCCTGACAGA CAACCTGGTG 1680 1681 TTTGACAGCC TCTACGACCT CATCACCCAC TACCAGGAGG TGCCGCTGAG GTGCAATGAG 1740 1741 TTCGAGATGA GGCTGACAGA GCCGGTGCCT CAGACCAACG CCCACGAGAG CAAAGAGTGG 1800 1801 TACCACGCCA ACCTCACTCG TGCCCAAGCT GAGCACATGC TGATGCGGGT GCCCCGGGAC 1860 1861 GGAGCCTTCC TGGTGCGCAA GAGGAGCGAA CCCAGCTCTT ACGCCATCTC CTTCAGGGCG 1920 1921 GAAGGGAAGA TCAAGCACTG CCGTGTGCAG CAGGAGGGCC AGACCGTGCT GCTGGGCAAC 1980 1981 TCTGAGTTCG AGAGCCTGGT GGACTTAATC AGCTACTATG AGAAGCACCC GCTGTACCGC 2040 2041 AAGATGAAGC TGAGGTACCC CATCAACGAG GAGACGCTGG AGAAGATAGG GACAGCGGAG 2100 2101 CCGGACTATG GAGCACTCTA CGAGGGACGC CATCCTGGCT TCTATGTAGA GGCCAACCCC 2160 2161 ATGCCGACCT TCAAGTGTGC AGTCAAAGCT CTGTTTGACT ACAAAGCGCA GCGGGAGGAT 2220 2221 GAGCTCACCT TCACCAAAAA TGCCATCATC CAGAATGTGG AGAAGCAGGA AGGAGGCTGG 2280 2281 TGGAGGGGCG ATTATGGTGG CAAGAAGCAG CTGTGGTTCC CTTCCAACTA CGTGGAGGAG 2340 2341 ATCAGCAGCC CCAGCAGCCT GGAGCCAGAG CGGGAGCAGC AGCTGGATGA GAACAGCCCC 2400 2401 CTGGGAGACC TGCTGGGAGG TGTCCTGGAT GTGCCATCTT GCCAGATTGC CATCCGCCCC 2460 2461 GAGGGAAAGA ACAACCGCCT GTTCGTCTTC TCCATTAGCA TGGCCTCCGT GTCACGCTTG 2520 2521 TCCCTTGATG TGGCAGCTGA TACACATGAG GACTTGCTGG ACTGGGTGAA GAAGATCCGG 2580 2581 GAAGCAGCCC AGACAGCTGA TGCACGGCTC TCTGAAGGGA AGATGATGGA GAGGAGGAAG 2640 2641 AAGATCGCCT TGGAGCTTTC AGAGCTAGTG GTCTATTGCC GACCCGTGCC CTTCGATGAA 2700 2701 GAGAAGATCG GCACAGAGAG GGCCTGTTAT CGAGACATGT CCTCCTTCCC TGAGACCAAG 2760 2761 GCAGAGAAGT ACGTCAACAA GATCAAAGGC AAGAAGTTCC TGCAGTACAA CCGCCTGCAG 2820 2821 CTCTCCCGTA TCTACCCCAA GGGCCAGCGC CTCGACTCCT CCAACTACGA CCCCCTGCCC 2880 2881 ATGTGGATCT GCGGCAGCCA GCTGGTGGCC CTCAACTTCC AGACTCCTGA CAAGCCCATG 2940 2941 CAGATGAACC AGGCCTTGTT CCTGTCCAGC GGGCAGTGCG GGTACGTTCT GCAGCCGGCC 3000 3001 AACATGCGGG ACGACATCTT TGACCCCTTT GACAAGAGCA CGCTGCGGGG CGTCGAACCG 3060 3061 CTCTCCATCT CCATCGAGGT CCCTGGGGGG CCCGGGCACC TCCCCAAAAA CGGCAGAGGA 3120 3121 ATCGTTTGTC CCTTTGTGGA GGTGGAGGTT TCTGGGGCAG AGTACGACAA CGCAAAGCAG 3180 3181 AAAACAGAGA TTGTGGCGGA CAACGGCCTG AACCCCCTCT GGAGCCCGAA GCAGTTCCAC 3240 3241 TTCCAGGTCA GCAACCCTGA GTTTGCCTTC CTCCGCTTTG TGGTGTATGA GGAGGACATG 3300 3301 TTCAGCGATG AGAACTTCCT GGCACAGGCG ACTTTCCTGG TGAAAGGCTT GAAGACCGGG 3360 3361 TTCCGAGCCG TACCCCTGAA GAACAACTAC AGTGAGAACC TGGAGCTGGC TTCCCTGCTT 3420 3421 GTCAAGATTG ACATCTTCCC CAGCAAGGAA AATGGTGACA TCAGCCTCTT TGGTGGCTCC 3480 3481 ATGCTGCGGG AGCGAGGCGG GGACATGGCC AGCCAGCTGC TGGCCAGCAG AGCCAGGGAG 3540 3541 GGCTCCTTCG AGGTGAGGTA CCAGCAGCCC TTTGAAGACT TCAGAGTGTC ACAGGAGCAG 3600 3601 CTGGCAGAGC ACTTCGAGAG CCGGGAGCGA AGGGCGCTGC GAAGGACCAG GGTCAACGGG 3660 3661 GACAACCGGC TGTAG 3675 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell-cell junction | |
Cellular Component | COP9 signalosome | |
Cellular Component | Cytosol | |
Cellular Component | Glutamatergic synapse | |
Cellular Component | Lamellipodium | |
Cellular Component | Plasma membrane | |
Cellular Component | Ruffle | |
Cellular Component | Schaffer collateral - CA1 synapse | |
Molecular Function | Calcium ion binding | |
Molecular Function | Glutamate receptor binding | |
Molecular Function | Neurotrophin TRKA receptor binding | |
Molecular Function | Phosphatidylinositol phospholipase C activity | |
Molecular Function | Receptor tyrosine kinase binding | |
Biological Process | Calcium-mediated signaling | |
Biological Process | Cell migration | |
Biological Process | Cellular response to epidermal growth factor stimulus | |
Biological Process | Epidermal growth factor receptor signaling pathway | |
Biological Process | Modulation of chemical synaptic transmission | |
Biological Process | Phospholipid catabolic process | |
Biological Process | Positive regulation of angiogenesis | |
Biological Process | Positive regulation of blood vessel endothelial cell migration | |
Biological Process | Positive regulation of endothelial cell apoptotic process | |
Biological Process | Positive regulation of release of sequestered calcium ion into cytosol | |
Biological Process | Positive regulation of vascular endothelial cell proliferation | |
Biological Process | T cell receptor signaling pathway |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gaga-0160 | Gallus gallus | 97.3 | 0.0 | 2390 |
| LLPS-Fia-2239 | Ficedula albicollis | 94.93 | 0.0 | 2218 |
| LLPS-Anp-0423 | Anas platyrhynchos | 93.8 | 0.0 | 2289 |
| LLPS-Tag-2774 | Taeniopygia guttata | 92.82 | 0.0 | 2255 |
| LLPS-Sah-2669 | Sarcophilus harrisii | 90.71 | 0.0 | 1367 |
| LLPS-Pes-0291 | Pelodiscus sinensis | 88.89 | 0.0 | 2193 |
| LLPS-Chs-3539 | Chlorocebus sabaeus | 88.85 | 0.0 | 1574 |
| LLPS-Anc-3213 | Anolis carolinensis | 88.57 | 0.0 | 2180 |
| LLPS-Mod-2521 | Monodelphis domestica | 88.07 | 0.0 | 2189 |
| LLPS-Otg-1637 | Otolemur garnettii | 87.99 | 0.0 | 2185 |
| LLPS-Caf-3162 | Canis familiaris | 87.91 | 0.0 | 2174 |
| LLPS-Fud-3654 | Fukomys damarensis | 87.83 | 0.0 | 2189 |
| LLPS-Urm-0754 | Ursus maritimus | 87.83 | 0.0 | 2096 |
| LLPS-Caj-2207 | Callithrix jacchus | 87.76 | 0.0 | 2177 |
| LLPS-Eqc-4188 | Equus caballus | 87.67 | 0.0 | 2179 |
| LLPS-Ran-4867 | Rattus norvegicus | 87.66 | 0.0 | 2182 |
| LLPS-Gog-3703 | Gorilla gorilla | 87.66 | 0.0 | 2180 |
| LLPS-Mam-3406 | Macaca mulatta | 87.66 | 0.0 | 2176 |
| LLPS-Pat-3398 | Pan troglodytes | 87.66 | 0.0 | 2179 |
| LLPS-Man-4209 | Macaca nemestrina | 87.66 | 0.0 | 2181 |
| LLPS-Mup-0095 | Mustela putorius furo | 87.59 | 0.0 | 2174 |
| LLPS-Bot-3684 | Bos taurus | 87.59 | 0.0 | 2174 |
| LLPS-Maf-1979 | Macaca fascicularis | 87.59 | 0.0 | 2177 |
| LLPS-Mum-3235 | Mus musculus | 87.57 | 0.0 | 2174 |
| LLPS-Cas-0571 | Carlito syrichta | 87.57 | 0.0 | 2172 |
| LLPS-Mal-3845 | Mandrillus leucophaeus | 87.51 | 0.0 | 2176 |
| LLPS-Paa-4302 | Papio anubis | 87.51 | 0.0 | 2176 |
| LLPS-Cea-0959 | Cercocebus atys | 87.51 | 0.0 | 2176 |
| LLPS-Rhb-2260 | Rhinopithecus bieti | 87.51 | 0.0 | 2176 |
| LLPS-Hos-1858 | Homo sapiens | 87.51 | 0.0 | 2173 |
| LLPS-Myl-0308 | Myotis lucifugus | 87.41 | 0.0 | 2172 |
| LLPS-Poa-3379 | Pongo abelii | 87.35 | 0.0 | 2173 |
| LLPS-Ict-2563 | Ictidomys tridecemlineatus | 87.34 | 0.0 | 2171 |
| LLPS-Cap-0859 | Cavia porcellus | 87.26 | 0.0 | 1993 |
| LLPS-Sus-3208 | Sus scrofa | 87.24 | 0.0 | 2086 |
| LLPS-Dio-2958 | Dipodomys ordii | 87.17 | 0.0 | 2154 |
| LLPS-Loa-2955 | Loxodonta africana | 86.86 | 0.0 | 2147 |
| LLPS-Orc-2919 | Oryctolagus cuniculus | 85.84 | 0.0 | 2123 |
| LLPS-Mea-3613 | Mesocricetus auratus | 85.55 | 0.0 | 2120 |
| LLPS-Pap-2619 | Pan paniscus | 85.14 | 0.0 | 2110 |
| LLPS-Ova-0565 | Ovis aries | 84.98 | 0.0 | 2095 |
| LLPS-Aon-2904 | Aotus nancymaae | 84.43 | 0.0 | 2061 |
| LLPS-Nol-1221 | Nomascus leucogenys | 82.74 | 0.0 | 2021 |
| LLPS-Lac-3674 | Latimeria chalumnae | 80.0 | 0.0 | 1988 |
| LLPS-Asm-0642 | Astyanax mexicanus | 77.92 | 0.0 | 1822 |
| LLPS-Xet-0582 | Xenopus tropicalis | 77.24 | 0.0 | 1871 |
| LLPS-Leo-0862 | Lepisosteus oculatus | 77.19 | 0.0 | 1924 |
| LLPS-Dar-1156 | Danio rerio | 76.29 | 0.0 | 1547 |
| LLPS-Icp-3861 | Ictalurus punctatus | 75.52 | 0.0 | 1878 |
| LLPS-Tar-3402 | Takifugu rubripes | 74.14 | 0.0 | 1887 |
| LLPS-Orn-3875 | Oreochromis niloticus | 74.11 | 0.0 | 1861 |
| LLPS-Scm-3132 | Scophthalmus maximus | 74.06 | 0.0 | 1868 |
| LLPS-Orl-0381 | Oryzias latipes | 73.52 | 0.0 | 1878 |
| LLPS-Xim-3401 | Xiphophorus maculatus | 72.76 | 0.0 | 1808 |
| LLPS-Pof-2635 | Poecilia formosa | 72.11 | 0.0 | 1810 |
| LLPS-Scf-2481 | Scleropages formosus | 68.89 | 0.0 | 1687 |
| LLPS-Ten-1521 | Tetraodon nigroviridis | 66.26 | 0.0 | 1598 |
| LLPS-Gaa-1749 | Gasterosteus aculeatus | 65.89 | 0.0 | 1568 |
| LLPS-Ora-2304 | Ornithorhynchus anatinus | 60.11 | 0.0 | 604 |
| LLPS-Cii-1372 | Ciona intestinalis | 48.38 | 0.0 | 1035 |
| LLPS-Cis-0711 | Ciona savignyi | 42.41 | 0.0 | 876 |
| LLPS-Drm-2105 | Drosophila melanogaster | 42.1 | 0.0 | 858 |
| LLPS-Aim-3685 | Ailuropoda melanoleuca | 39.13 | 1e-44 | 178 |
| LLPS-Tut-0755 | Tursiops truncatus | 38.69 | 2e-41 | 169 |
| LLPS-Fec-0592 | Felis catus | 38.65 | 3e-43 | 174 |
| LLPS-Cae-0899 | Caenorhabditis elegans | 36.03 | 0.0 | 644 |
| LLPS-Scj-0190 | Schizosaccharomyces japonicus | 31.01 | 2e-23 | 112 |