LLPS-Mam-3406
PLCG1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma |
| Gene Name: | PLCG1 |
| Ensembl Gene: | ENSMMUG00000005905.3 |
| Ensembl Protein: | ENSMMUP00000056589.1 |
| Organism: | Macaca mulatta |
| Taxa ID: | 9544 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMMUT00000075401.1 | ENSMMUP00000056589.1 |
| Ensembl | ENSMMUT00000073054.1 | ENSMMUP00000055458.1 |
| Ensembl | ENSMMUT00000063848.1 | ENSMMUP00000060792.1 |
| Ensembl | ENSMMUT00000008266.3 | ENSMMUP00000007769.2 |
| UniProt | A0A1D5R8E9, A0A1D5R8E9_MACMU | |
| GeneBank | JSUE03004357 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 ACAVAAPSVG AMAGAASPCA NGCGPGAPSD AEVLHLCRSL EVGTVMTLFY SKKSQRPERK 60 61 TFQVKLETRQ ITWSRGADKI EGAIDIREIK EIRPGKTSRD FDRYQEDPAF RPDQSHCFVI 120 121 LYGMEFRLKT LSLQATSEDE VNMWIKGLTW LMEDTLQAPT PLQIERWLRK QFYSVDRNRE 180 181 DRISAKDLKN MLSQVNYRVP NMRFLRERLT DLEQRSGDIT YGQFAQLYRS LMYSAQKTVH 240 241 EPPLTFSPCR AGERPELCRV SLPEFQQFLL DYQGELWAVD RLQVQEFMLS FLRDPLREIE 300 301 EPYFFLDEFV TFLFSKENSV WNSQLDAVCP DTMNNPLSHY WISSSHNTYL TGDQFSSESS 360 361 LEAYARCLRM GCRCIELDCW DGPDGMPVIY HGHTLTTKIK FSDVLQTIKE HAFVASEYPV 420 421 ILSIEDHCSI AQQRNMAQHF KKVLGDTLLT KPVEISADGL PSPNQLKRKI LIKHKKLAEG 480 481 SAYEEVPTSM MYSENDISNS IKNGILYLED PVNHEWYPHY FVLTSSKIYY SEETSSDQGN 540 541 EDEEEPKEVS SSTELHSNEK WFHGKLGAGR DGRHIAERLL TEYCIETGAP DGSFLVRESE 600 601 TFVGDYTLSF WRNGKVQHCR IHSRQDAGTP KFFLTDNLVF DSLYDLITHY QQVPLRCNEF 660 661 EMRLSEPVPQ TNAHESKEWY HASLTRAQAE HMLMRVPRDG AFLVRKRNEP NSYAISFRAE 720 721 GKIKHCRVQQ EGQTVMLGNS EFDSLVDLIS YYEKHPLYRK MKLRYPINEE ALEKIGTAEP 780 781 DYGALYEGRN PGFYVEANPM PTFKCAVKAL FDYKAQREDE LTFTKSAIIQ NVEKQEGGWW 840 841 RGDYGGKKQL WFPSNYVEEM VNPVALEPER EHLDENSPLG DLLRGVLDVP ACQIAIRPEG 900 901 KNNRLFVFSI SMASVAHWSL DVAADSQEEL QDWVKKIREV AQTADARLTE GKIMERRKKI 960 961 ALELSELVVY CRPVPFDEEK IGTERACYRD MSSFPETKAE KYVNKAKGKK FLQYNRLQLS 1020 1021 RIYPKGQRLD SSNYDPLPMW ICGSQLVALN FQTPDKPMQM NQALFMTGRH CGYVLQPSTM 1080 1081 RDEAFDPFDK SSLRGLEPCA ISVEVLGARH LPKNGRGIVC PFVEIEVAGA EYDSTKQKTE 1140 1141 FVVDNGLNPV WPAKPFHFQI SNPEFAFLRF VVYEEDMFSD QNFLAQATFP VKGLKTGYRA 1200 1201 VPLKNNYSED LELASLLIKI DIFPAKENGD LSPFSGTSLR ERGSDASGQL FHGRAREGSF 1260 1261 ESRYQQPFED FRVSQEHLAD HFDSRERRAP RRTRVNGDNR L 1301 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGGCG CCGCATCCCC CTGCGCCAAC GGCTGCGGGC CCGGCGCGCC CTCGGACGCC 60 61 GAGGTGCTGC ACCTCTGCCG CAGCCTCGAG GTGGGCACCG TCATGACTTT GTTCTACTCC 120 121 AAGAAGTCGC AGCGACCCGA GCGGAAGACC TTCCAGGTCA AGCTGGAGAC GCGCCAGATC 180 181 ACGTGGAGCC GGGGCGCCGA CAAGATAGAG GGGGCCATTG ATATTCGAGA AATCAAGGAG 240 241 ATTCGCCCAG GGAAGACCTC ACGAGACTTT GATCGCTATC AAGAGGACCC CGCTTTCCGG 300 301 CCGGACCAGT CACACTGCTT TGTCATTCTC TATGGAATGG AATTCCGTCT GAAGACGCTG 360 361 AGCCTGCAAG CCACATCTGA GGATGAAGTG AACATGTGGA TCAAGGGCTT AACTTGGCTG 420 421 ATGGAGGATA CATTGCAGGC ACCCACACCC CTGCAGATTG AGAGGTGGCT CCGGAAGCAG 480 481 TTTTACTCAG TGGATCGGAA TCGTGAGGAT CGTATATCAG CCAAGGACCT AAAGAACATG 540 541 CTGTCCCAGG TCAACTACCG GGTCCCCAAC ATGCGCTTCC TCCGAGAGCG GCTAACGGAC 600 601 CTGGAGCAGC GCAGCGGGGA CATCACCTAC GGGCAGTTTG CTCAGCTGTA CCGCAGCCTC 660 661 ATGTACAGCG CCCAGAAGAC GATGGACCTC CCCTTCTTGG AAGCCAGTAC TCTGAGGGCT 720 721 GGGGAGCGGC CGGAGCTTTG CCGAGTGTCC CTTCCTGAGT TCCAGCAGTT CCTTCTTGAC 780 781 TACCAGGGGG AGCTGTGGGC TGTTGATCGC CTCCAGGTGC AGGAGTTCAT GCTCAGCTTC 840 841 CTCCGAGACC CCTTGCGAGA GATCGAGGAG CCATACTTCT TCCTGGATGA GTTTGTCACC 900 901 TTCCTGTTCT CCAAAGAGAA TAGTGTGTGG AACTCACAGC TGGATGCAGT ATGCCCGGAC 960 961 ACCATGAACA ACCCCCTTTC CCACTATTGG ATCTCCTCCT CACACAACAC GTACCTGACC 1020 1021 GGGGACCAGT TCTCCAGTGA GTCCTCCTTG GAAGCCTATG CTCGCTGCCT GCGGATGGGC 1080 1081 TGTCGCTGCA TTGAGTTGGA CTGCTGGGAC GGCCCAGATG GGATGCCAGT TATTTACCAT 1140 1141 GGGCACACCC TTACCACCAA GATCAAGTTC TCAGATGTCC TGCAAACCAT CAAGGAGCAT 1200 1201 GCCTTTGTGG CCTCAGAGTA CCCAGTCATC CTGTCCATTG AGGACCACTG CAGCATTGCC 1260 1261 CAGCAGAGGA ACATGGCCCA GCACTTCAAG AAGGTGCTAG GGGACACACT CCTCACCAAG 1320 1321 CCCGTGGAGA TCTCCGCCGA TGGGCTCCCC TCACCCAACC AGCTTAAGAG GAAGATCCTC 1380 1381 ATCAAGCACA AGAAGCTGGC TGAGGGCAGT GCCTACGAGG AGGTGCCTAC ATCCATGATG 1440 1441 TACTCTGAGA ACGACATCAG CAACTCCATC AAGAATGGCA TCCTCTACCT GGAGGACCCT 1500 1501 GTGAACCATG AATGGTATCC CCACTACTTC GTTCTGACCA GCAGCAAGAT CTACTACTCT 1560 1561 GAGGAGACCA GCAGTGACCA GGGCAACGAG GATGAGGAGG AGCCCAAGGA GGTCAGCAGC 1620 1621 AGCACAGAGC TGCACTCCAA TGAGAAGTGG TTCCATGGGA AGCTAGGGGC AGGGCGTGAC 1680 1681 GGGCGGCACA TCGCTGAGCG CCTGCTCACT GAGTACTGCA TCGAGACCGG GGCCCCTGAC 1740 1741 GGCTCCTTCC TCGTGCGAGA GAGTGAGACC TTCGTGGGCG ACTACACGCT CTCTTTCTGG 1800 1801 CGGAACGGGA AAGTCCAGCA CTGCCGTATC CACTCACGGC AAGATGCTGG GACCCCCAAG 1860 1861 TTCTTCTTGA CAGACAACCT CGTCTTTGAC TCCCTCTATG ACCTCATCAC ACACTACCAG 1920 1921 CAGGTGCCCC TGCGCTGCAA TGAGTTTGAG ATGCGACTTT CAGAGCCTGT CCCACAGACC 1980 1981 AATGCCCATG AGAGCAAAGA GTGGTACCAC GCGAGCCTGA CCAGAGCACA GGCTGAGCAC 2040 2041 ATGCTGATGC GTGTCCCTCG TGATGGGGCC TTCCTGGTGC GGAAGCGGAA TGAGCCCAAC 2100 2101 TCATATGCCA TCTCTTTCCG GGCTGAAGGC AAGATCAAGC ATTGCCGTGT CCAGCAAGAG 2160 2161 GGCCAGACTG TGATGCTAGG GAACTCGGAG TTCGACAGCC TTGTTGACCT CATCAGCTAC 2220 2221 TATGAGAAGC ACCCGCTATA CCGCAAGATG AAGCTGCGCT ATCCAATCAA TGAGGAGGCG 2280 2281 CTGGAGAAGA TTGGCACAGC TGAGCCTGAC TACGGGGCCC TGTATGAGGG ACGCAACCCT 2340 2341 GGCTTCTATG TAGAGGCAAA CCCTATGCCA ACTTTCAAGT GTGCAGTCAA AGCCCTCTTT 2400 2401 GACTACAAGG CCCAGAGGGA GGATGAGCTG ACCTTCACCA AGAGCGCCAT CATCCAGAAT 2460 2461 GTGGAGAAGC AAGAGGGAGG CTGGTGGCGA GGGGACTACG GAGGGAAGAA GCAGCTGTGG 2520 2521 TTCCCATCAA ACTACGTGGA AGAGATGGTC AACCCCGTGG CCCTGGAGCC AGAGAGGGAG 2580 2581 CACTTGGACG AGAACAGCCC CCTAGGGGAC TTGCTGCGGG GGGTCTTGGA TGTGCCGGCT 2640 2641 TGTCAGATTG CCATCCGTCC TGAGGGCAAG AACAACCGGC TCTTCGTCTT CTCCATCAGC 2700 2701 ATGGCGTCGG TGGCCCACTG GTCCCTGGAT GTTGCTGCCG ACTCACAGGA GGAGCTGCAG 2760 2761 GACTGGGTGA AAAAGATCCG TGAAGTGGCC CAGACCGCAG ATGCCAGGCT CACTGAAGGG 2820 2821 AAGATAATGG AACGGAGGAA GAAGATCGCC CTGGAGCTCT CTGAACTTGT TGTCTACTGC 2880 2881 CGGCCTGTTC CCTTCGATGA AGAGAAGATT GGCACAGAAC GTGCTTGCTA CCGGGACATG 2940 2941 TCATCCTTCC CGGAAACCAA GGCTGAGAAA TACGTGAACA AGGCCAAAGG CAAGAAGTTC 3000 3001 CTTCAGTACA ATCGACTGCA GCTCTCCCGC ATCTACCCCA AGGGCCAGCG ACTGGATTCC 3060 3061 TCCAACTACG ATCCTTTGCC CATGTGGATC TGTGGCAGTC AGCTGGTGGC CCTCAACTTC 3120 3121 CAGACCCCTG ACAAGCCTAT GCAGATGAAC CAGGCTCTCT TCATGACGGG CAGGCACTGT 3180 3181 GGCTACGTGC TGCAGCCAAG CACCATGCGG GATGAGGCCT TCGACCCCTT TGACAAGAGC 3240 3241 AGCCTCCGCG GGCTGGAGCC ATGTGCCATC TCTGTTGAGG TGCTGGGTGC CCGACATTTG 3300 3301 CCAAAGAATG GCCGAGGCAT TGTGTGCCCT TTTGTGGAGA TTGAGGTGGC TGGAGCTGAG 3360 3361 TATGACAGCA CCAAGCAGAA GACAGAGTTT GTGGTGGACA ATGGACTCAA CCCTGTATGG 3420 3421 CCGGCCAAGC CCTTCCACTT CCAGATCAGT AACCCTGAAT TTGCCTTTCT GCGCTTTGTG 3480 3481 GTGTATGAGG AAGACATGTT TAGTGACCAG AATTTCCTGG CTCAGGCTAC TTTCCCGGTA 3540 3541 AAAGGCCTGA AGACAGGATA CAGAGCAGTG CCTTTGAAGA ACAACTACAG TGAGGACCTG 3600 3601 GAGTTGGCCT CCCTGCTGAT CAAGATTGAC ATTTTCCCTG CCAAGCAGGA GAATGGTGAC 3660 3661 CTCAGTCCCT TCAGTGGTAC GTCCCTGCGG GAGCGGGGCT CAGATGCCTC AGGCCAGCTG 3720 3721 TTTCACGGCC GAGCCCGGGA AGGCTCCTTT GAATCCCGCT ACCAGCAGCC ATTTGAGGAC 3780 3781 TTCCGCGTCT CCCAGGAGCA TCTTGCAGAC CATTTTGACA GTCGAGAACG AAGGGCCCCA 3840 3841 AGAAGGACTC GGGTCAATGG AGACAACCGC CTCTAG 3876 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell-cell junction | |
Cellular Component | COP9 signalosome | |
Cellular Component | Cytosol | |
Cellular Component | Glutamatergic synapse | |
Cellular Component | Lamellipodium | |
Cellular Component | Plasma membrane | |
Cellular Component | Ruffle | |
Cellular Component | Schaffer collateral - CA1 synapse | |
Molecular Function | Calcium ion binding | |
Molecular Function | Glutamate receptor binding | |
Molecular Function | Neurotrophin TRKA receptor binding | |
Molecular Function | Phosphatidylinositol phospholipase C activity | |
Molecular Function | Receptor tyrosine kinase binding | |
Biological Process | Calcium-mediated signaling | |
Biological Process | Cell migration | |
Biological Process | Cellular response to epidermal growth factor stimulus | |
Biological Process | Epidermal growth factor receptor signaling pathway | |
Biological Process | In utero embryonic development | |
Biological Process | Inositol trisphosphate biosynthetic process | |
Biological Process | Modulation of chemical synaptic transmission | |
Biological Process | Phosphatidylinositol-mediated signaling | |
Biological Process | Phospholipid catabolic process | |
Biological Process | Positive regulation of angiogenesis | |
Biological Process | Positive regulation of blood vessel endothelial cell migration | |
Biological Process | Positive regulation of endothelial cell apoptotic process | |
Biological Process | Positive regulation of epithelial cell migration | |
Biological Process | Positive regulation of release of sequestered calcium ion into cytosol | |
Biological Process | Positive regulation of vascular endothelial cell proliferation | |
Biological Process | Release of sequestered calcium ion into cytosol | |
Biological Process | T cell receptor signaling pathway |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Man-4209 | Macaca nemestrina | 99.38 | 0.0 | 2635 |
| LLPS-Maf-1979 | Macaca fascicularis | 99.3 | 0.0 | 2607 |
| LLPS-Cea-0959 | Cercocebus atys | 99.22 | 0.0 | 2606 |
| LLPS-Paa-4302 | Papio anubis | 99.22 | 0.0 | 2606 |
| LLPS-Mal-3845 | Mandrillus leucophaeus | 99.22 | 0.0 | 2585 |
| LLPS-Rhb-2260 | Rhinopithecus bieti | 99.22 | 0.0 | 2606 |
| LLPS-Gog-3703 | Gorilla gorilla | 99.06 | 0.0 | 2630 |
| LLPS-Chs-3539 | Chlorocebus sabaeus | 99.03 | 0.0 | 1899 |
| LLPS-Pat-3398 | Pan troglodytes | 98.99 | 0.0 | 2629 |
| LLPS-Hos-1858 | Homo sapiens | 98.91 | 0.0 | 2598 |
| LLPS-Poa-3379 | Pongo abelii | 98.81 | 0.0 | 2537 |
| LLPS-Caj-2207 | Callithrix jacchus | 98.36 | 0.0 | 2587 |
| LLPS-Cas-0571 | Carlito syrichta | 98.13 | 0.0 | 2589 |
| LLPS-Otg-1637 | Otolemur garnettii | 97.43 | 0.0 | 2568 |
| LLPS-Eqc-4188 | Equus caballus | 97.43 | 0.0 | 2569 |
| LLPS-Fud-3654 | Fukomys damarensis | 97.19 | 0.0 | 2565 |
| LLPS-Caf-3162 | Canis familiaris | 96.8 | 0.0 | 2413 |
| LLPS-Ict-2563 | Ictidomys tridecemlineatus | 96.73 | 0.0 | 2552 |
| LLPS-Mup-0095 | Mustela putorius furo | 96.65 | 0.0 | 2543 |
| LLPS-Sus-3208 | Sus scrofa | 96.61 | 0.0 | 2326 |
| LLPS-Ran-4867 | Rattus norvegicus | 96.57 | 0.0 | 2548 |
| LLPS-Mum-3235 | Mus musculus | 96.53 | 0.0 | 2542 |
| LLPS-Pap-2619 | Pan paniscus | 96.48 | 0.0 | 2446 |
| LLPS-Urm-0754 | Ursus maritimus | 96.35 | 0.0 | 2319 |
| LLPS-Bot-3684 | Bos taurus | 96.26 | 0.0 | 2543 |
| LLPS-Dio-2958 | Dipodomys ordii | 96.17 | 0.0 | 2541 |
| LLPS-Myl-0308 | Myotis lucifugus | 96.14 | 0.0 | 2404 |
| LLPS-Loa-2955 | Loxodonta africana | 95.5 | 0.0 | 2382 |
| LLPS-Aon-2904 | Aotus nancymaae | 95.18 | 0.0 | 2472 |
| LLPS-Orc-2919 | Oryctolagus cuniculus | 94.57 | 0.0 | 2476 |
| LLPS-Mea-3613 | Mesocricetus auratus | 94.04 | 0.0 | 2477 |
| LLPS-Ova-0565 | Ovis aries | 93.28 | 0.0 | 2334 |
| LLPS-Mod-2521 | Monodelphis domestica | 93.14 | 0.0 | 2471 |
| LLPS-Nol-1221 | Nomascus leucogenys | 91.58 | 0.0 | 2229 |
| LLPS-Cap-0859 | Cavia porcellus | 90.57 | 0.0 | 2324 |
| LLPS-Gaga-0160 | Gallus gallus | 88.36 | 0.0 | 2342 |
| LLPS-Meg-3018 | Meleagris gallopavo | 88.32 | 0.0 | 2221 |
| LLPS-Fia-2239 | Ficedula albicollis | 87.83 | 0.0 | 2100 |
| LLPS-Sah-2669 | Sarcophilus harrisii | 86.88 | 0.0 | 1528 |
| LLPS-Pes-0291 | Pelodiscus sinensis | 86.38 | 0.0 | 2274 |
| LLPS-Anc-3213 | Anolis carolinensis | 86.33 | 0.0 | 2287 |
| LLPS-Anp-0423 | Anas platyrhynchos | 85.91 | 0.0 | 2165 |
| LLPS-Tag-2774 | Taeniopygia guttata | 85.46 | 0.0 | 2236 |
| LLPS-Lac-3674 | Latimeria chalumnae | 79.75 | 0.0 | 2016 |
| LLPS-Xet-0582 | Xenopus tropicalis | 78.02 | 0.0 | 2038 |
| LLPS-Asm-0642 | Astyanax mexicanus | 77.88 | 0.0 | 1960 |
| LLPS-Leo-0862 | Lepisosteus oculatus | 76.92 | 0.0 | 2067 |
| LLPS-Dar-1156 | Danio rerio | 76.2 | 0.0 | 1603 |
| LLPS-Icp-3861 | Ictalurus punctatus | 76.02 | 0.0 | 2026 |
| LLPS-Scm-3132 | Scophthalmus maximus | 74.47 | 0.0 | 2002 |
| LLPS-Tar-3402 | Takifugu rubripes | 74.24 | 0.0 | 2018 |
| LLPS-Orn-3875 | Oreochromis niloticus | 74.09 | 0.0 | 1985 |
| LLPS-Orl-0381 | Oryzias latipes | 73.21 | 0.0 | 1998 |
| LLPS-Xim-3401 | Xiphophorus maculatus | 72.62 | 0.0 | 1941 |
| LLPS-Pof-2635 | Poecilia formosa | 72.1 | 0.0 | 1939 |
| LLPS-Scf-2481 | Scleropages formosus | 70.43 | 0.0 | 1836 |
| LLPS-Ten-1521 | Tetraodon nigroviridis | 67.33 | 0.0 | 1700 |
| LLPS-Gaa-1749 | Gasterosteus aculeatus | 65.75 | 0.0 | 1672 |
| LLPS-Ora-2304 | Ornithorhynchus anatinus | 63.25 | 0.0 | 656 |
| LLPS-Cis-1090 | Ciona savignyi | 56.41 | 6e-47 | 185 |
| LLPS-Cii-1372 | Ciona intestinalis | 47.91 | 0.0 | 1092 |
| LLPS-Drm-2105 | Drosophila melanogaster | 41.33 | 0.0 | 894 |
| LLPS-Tut-0755 | Tursiops truncatus | 38.46 | 4e-45 | 180 |
| LLPS-Aim-3685 | Ailuropoda melanoleuca | 37.99 | 2e-45 | 181 |
| LLPS-Fec-0592 | Felis catus | 37.72 | 3e-46 | 184 |
| LLPS-Cae-0899 | Caenorhabditis elegans | 36.44 | 0.0 | 667 |
| LLPS-Scj-0190 | Schizosaccharomyces japonicus | 32.12 | 4e-25 | 117 |