LLPS-Bot-3684
PLCG1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1 |
| Gene Name: | PLCG1 |
| Ensembl Gene: | ENSBTAG00000017584.5 |
| Ensembl Protein: | ENSBTAP00000023383.5 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Others |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000023383.5 | ENSBTAP00000023383.5 |
| UniProt | P08487, PLCG1_BOVIN | |
| GeneBank | Y00301 | CAA68406.1 |
| RefSeq | NM_174425.3 | NP_776850.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAGAASPCAN GCGPSAPSDA EVVHLCRSLE VGTVMTLFYS KKSQRPERKT FQVKLETRQI 60 61 TWSRGADKIE GAIDIREIKE IRPGKTSRDF DRYQEDPAFR PDQSHCFVIL YGMEFRLKTL 120 121 SLQATSEDEV NMWIKGLTWL MEDTLQAATP LQIERWLRKQ FYSVDRNRED RISAKDLKNM 180 181 LSQVNYRVPN MRFLRERLTD LEQRTSDITY GQFAQLYRSL MYSAQKTMDL PFLEASALRA 240 241 GERPELCRVS LPEFQQFLLE YQGELWAVDR LQVQEFMLSF LRDPLREIEE PYFFLDEFVT 300 301 FLFSKENSIW NSQLDEVCPD TMNNPLSHYW ISSSHNTYLT GDQFSSESSL EAYARCLRMG 360 361 CRCIELDCWD GPDGMPVIYH GHTLTTKIKF SDVLHTIKEH AFVASEYPVI LSIEDHCSIA 420 421 QQRNMAQYFK KVLGDTLLTK PVDIAADGLP SPNQLKRKIL IKHKKLAEGS AYEEVPTSVM 480 481 YSENDISNSI KNGILYLEDP VNHEWYPHYF VLTSSKIYYS EETSSDQGNE DEEEPKEASG 540 541 STELHSNEKW FHGKLGAGRD GRHIAERLLT EYCIETGAPD GSFLVRESET FVGDYTLSFW 600 601 RNGKVQHCRI HSRQDAGTPK FFLTDNLVFD SLYDLITHYQ QVPLRCNEFE MRLSEPVPQT 660 661 NAHESKEWYH ASLTRAQAEH MLMRVPRDGA FLVRKRNEPN SYAISFRAEG KIKHCRVQQE 720 721 GQTVMLGNSE FDSLVDLISY YEKHPLYRKM KLRYPINEEA LEKIGTAEPD YGALYEGRNP 780 781 GFYVEANPMP TFKCAVKALF DYKAQREDEL TFTKSAIIQN VEKQEGGWWR GDYGGKKQLW 840 841 FPSNYVEEMV SPAALEPERE HLDENSPLGD LLRGVLDVPA CQIAVRPEGK NNRLFVFSIS 900 901 MASVAHWSLD VAADSQEELQ DWVKKIREVA QTADARLTEG KMMERRKKIA LELSELVVYC 960 961 RPVPFDEEKI GTERACYRDM SSFPETKAEK YVNKAKGKKF LQYNRLQLSR IYPKGQRLDS 1020 1021 SNYDPLPMWI CGSQLVALNF QTPDKPMQMN QALFLAGGHC GYVLQPSVMR DEAFDPFDKS 1080 1081 SLRGLEPCAI CIEVLGARHL PKNGRGIVCP FVEIEVAGAE YDSIKQKTEF VVDNGLNPVW 1140 1141 PAKPFHFQIS NPEFAFLRFV VYEEDMFSDQ NFLAQATFPV KGLKTGYRAV PLKNNYSEGL 1200 1201 ELASLLVKID VFPAKQENGD LSPFGGASLR ERSCDASGPL FHGRAREGSF EARYQQPFED 1260 1261 FRISQEHLAD HFDGRDRRTP RRTRVNGDNR L 1291 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGGCG CCGCGTCCCC CTGCGCCAAC GGCTGCGGGC CCAGTGCGCC CTCGGACGCC 60 61 GAGGTGGTGC ACCTCTGCCG CAGCCTCGAG GTGGGCACCG TCATGACTTT GTTCTACTCC 120 121 AAGAAGTCGC AGCGGCCCGA GCGGAAGACC TTCCAGGTCA AGCTGGAGAC GCGGCAGATC 180 181 ACGTGGAGCC GAGGCGCCGA CAAGATAGAG GGGGCCATTG ACATTCGTGA AATCAAGGAG 240 241 ATCCGCCCAG GGAAGACCTC ACGGGACTTC GATCGCTACC AAGAGGATCC TGCTTTTCGA 300 301 CCGGACCAGT CCCACTGCTT CGTCATCCTG TATGGAATGG AATTCCGCCT GAAGACCCTG 360 361 AGCCTCCAAG CCACGTCTGA GGACGAAGTG AACATGTGGA TCAAGGGCCT GACTTGGCTG 420 421 ATGGAGGACA CGTTGCAGGC AGCCACACCC CTGCAGATTG AGAGGTGGCT GCGGAAGCAG 480 481 TTCTACTCAG TGGACCGGAA CCGTGAGGAC CGGATATCGG CCAAGGACCT GAAGAACATG 540 541 CTGTCCCAGG TCAACTACCG GGTCCCCAAC ATGCGCTTCC TCCGGGAGCG GCTGACGGAC 600 601 CTGGAGCAGC GCACCAGTGA CATCACCTAC GGGCAGTTTG CACAGCTGTA CCGCAGCCTC 660 661 ATGTACAGCG CCCAGAAGAC GATGGACCTT CCTTTCCTGG AAGCCAGCGC CCTGAGGGCG 720 721 GGGGAGCGGC CGGAGCTGTG CCGGGTGTCC CTTCCTGAGT TCCAGCAGTT CCTCCTCGAG 780 781 TACCAAGGGG AGCTGTGGGC GGTGGACCGG CTCCAGGTGC AGGAGTTCAT GCTCAGCTTC 840 841 CTCCGAGACC CCTTGCGAGA GATTGAGGAG CCTTACTTCT TCCTGGACGA GTTCGTCACC 900 901 TTCCTGTTCT CCAAGGAGAA CAGCATATGG AACTCGCAGC TAGACGAGGT GTGCCCCGAC 960 961 ACCATGAACA ACCCCCTGTC CCACTACTGG ATCTCCTCCT CGCACAACAC GTACCTGACC 1020 1021 GGGGACCAAT TCTCCAGCGA GTCCTCCCTG GAAGCCTACG CTCGCTGCCT GCGGATGGGC 1080 1081 TGCCGTTGCA TTGAGTTGGA CTGCTGGGAC GGCCCGGATG GGATGCCGGT CATTTACCAT 1140 1141 GGACACACTC TGACCACCAA GATCAAGTTC TCAGACGTCC TGCACACCAT CAAGGAGCAC 1200 1201 GCCTTTGTGG CCTCAGAGTA CCCGGTCATC CTGTCCATCG AGGACCACTG CAGCATTGCC 1260 1261 CAGCAGAGGA ACATGGCCCA GTATTTCAAA AAGGTGCTTG GGGACACACT CCTCACCAAG 1320 1321 CCCGTGGATA TTGCAGCCGA CGGGCTCCCC TCCCCCAACC AGCTCAAGAG GAAGATCCTT 1380 1381 ATCAAGCACA AGAAGTTGGC TGAGGGCAGT GCCTACGAGG AGGTGCCAAC ATCGGTGATG 1440 1441 TACTCTGAGA ACGACATCAG CAACTCCATC AAGAATGGCA TCCTCTACCT GGAAGACCCT 1500 1501 GTGAACCATG AGTGGTACCC CCACTACTTC GTCCTGACCA GCAGCAAGAT CTACTACTCG 1560 1561 GAGGAGACCA GCAGCGACCA GGGCAACGAG GATGAGGAGG AGCCCAAGGA GGCCAGTGGC 1620 1621 AGCACAGAGC TGCACTCCAA CGAGAAGTGG TTCCACGGGA AGCTTGGGGC GGGCCGGGAT 1680 1681 GGGCGGCACA TCGCCGAGCG CCTGCTCACG GAGTACTGCA TTGAGACCGG GGCCCCCGAC 1740 1741 GGCTCCTTCC TTGTGCGCGA GAGCGAGACC TTTGTGGGCG ACTACACTCT GTCCTTCTGG 1800 1801 CGGAATGGCA AAGTGCAGCA CTGCCGGATC CACTCCCGGC AGGACGCAGG CACCCCCAAG 1860 1861 TTCTTCCTGA CGGACAACCT CGTCTTCGAC TCCCTCTATG ACCTCATCAC GCACTACCAG 1920 1921 CAGGTGCCCC TGCGCTGCAA CGAATTTGAG ATGCGCCTCT CAGAGCCGGT CCCGCAGACC 1980 1981 AACGCGCACG AGAGCAAAGA GTGGTACCAC GCCAGCCTGA CCAGAGCGCA GGCCGAGCAC 2040 2041 ATGCTGATGC GTGTACCCAG GGACGGGGCC TTCCTGGTGC GGAAACGGAA CGAGCCCAAC 2100 2101 TCCTACGCCA TCTCCTTCCG GGCTGAGGGC AAGATCAAGC ACTGCCGCGT CCAGCAGGAG 2160 2161 GGCCAGACCG TGATGCTGGG CAACTCAGAG TTTGACAGCC TTGTCGACCT CATCAGCTAC 2220 2221 TACGAGAAGC ACCCACTGTA CCGCAAGATG AAGCTGCGCT ACCCCATCAA CGAGGAGGCT 2280 2281 CTGGAGAAGA TCGGCACAGC TGAGCCTGAC TACGGCGCGC TGTACGAGGG CCGCAACCCT 2340 2341 GGCTTCTATG TGGAGGCGAA CCCCATGCCC ACGTTCAAGT GCGCCGTCAA AGCTCTCTTC 2400 2401 GACTACAAAG CGCAGCGGGA GGACGAGCTG ACATTCACCA AGAGTGCCAT CATCCAGAAC 2460 2461 GTGGAGAAGC AGGAGGGAGG CTGGTGGCGG GGTGACTACG GCGGGAAGAA GCAGCTGTGG 2520 2521 TTCCCTTCAA ACTACGTGGA GGAAATGGTC AGCCCGGCGG CCCTGGAGCC CGAGAGGGAG 2580 2581 CACTTGGACG AGAACAGCCC ACTCGGGGAC TTGCTCCGGG GGGTCCTGGA TGTGCCAGCT 2640 2641 TGTCAGATAG CCGTCCGTCC CGAGGGCAAG AACAACCGGC TGTTCGTCTT CTCCATCAGC 2700 2701 ATGGCCTCGG TGGCACACTG GTCCCTGGAT GTGGCTGCCG ACTCGCAGGA AGAGCTGCAG 2760 2761 GACTGGGTGA AGAAGATCCG GGAGGTGGCG CAGACAGCGG ATGCCAGGCT CACCGAGGGC 2820 2821 AAGATGATGG AGCGGAGGAA GAAGATCGCC CTAGAGCTCT CAGAGCTCGT CGTCTACTGC 2880 2881 CGGCCTGTCC CTTTCGACGA AGAGAAGATT GGCACCGAAC GGGCCTGCTA CCGCGACATG 2940 2941 TCGTCCTTCC CGGAGACCAA GGCCGAGAAG TACGTGAACA AGGCCAAAGG CAAGAAGTTC 3000 3001 CTCCAGTACA ACCGCCTGCA GCTCTCCCGC ATCTACCCTA AGGGCCAGCG GCTGGACTCC 3060 3061 TCCAATTACG ACCCCCTGCC CATGTGGATC TGCGGCAGCC AGCTTGTGGC CCTCAACTTC 3120 3121 CAGACCCCAG ACAAACCCAT GCAGATGAAC CAGGCCCTGT TCCTGGCCGG CGGGCACTGT 3180 3181 GGCTATGTGC TGCAGCCCAG CGTCATGCGC GATGAGGCCT TCGATCCCTT TGACAAGAGC 3240 3241 AGCCTCCGCG GGCTGGAGCC GTGCGCCATC TGCATCGAGG TGCTGGGGGC CCGGCACCTG 3300 3301 CCGAAGAACG GCCGAGGCAT CGTGTGTCCT TTTGTGGAGA TCGAGGTGGC CGGAGCCGAG 3360 3361 TATGACAGCA TCAAGCAGAA GACAGAGTTT GTGGTGGACA ATGGACTGAA CCCCGTGTGG 3420 3421 CCAGCCAAGC CCTTCCACTT CCAGATTAGT AACCCCGAGT TCGCCTTCCT GCGCTTCGTG 3480 3481 GTCTATGAGG AGGACATGTT TAGTGACCAG AACTTCCTAG CTCAGGCTAC CTTCCCAGTG 3540 3541 AAGGGTCTGA AGACAGGCTA CAGAGCGGTG CCTCTGAAGA ACAACTACAG TGAGGGCCTG 3600 3601 GAGCTGGCCT CCCTGCTCGT CAAGATTGAC GTGTTCCCTG CCAAGCAGGA GAACGGCGAC 3660 3661 CTCAGCCCCT TCGGGGGTGC GTCCCTGCGG GAGCGGAGCT GTGACGCCTC GGGCCCGCTG 3720 3721 TTCCACGGCC GGGCCCGGGA GGGCTCCTTT GAAGCTCGCT ACCAGCAGCC CTTTGAGGAC 3780 3781 TTCCGCATCT CCCAGGAGCA TCTCGCAGAC CATTTTGACG GTCGGGATCG CAGGACCCCA 3840 3841 CGCAGGACTC GGGTCAACGG AGACAACCGC CTGTAG 3876 |
▼ KEYWORD
ID | Family |
3D-structure | |
Acetylation | |
Calcium | |
Cell projection | |
Complete proteome | |
Direct protein sequencing | |
Hydrolase | |
Lipid degradation | |
Lipid metabolism | |
Metal-binding | |
Phosphoprotein | |
Reference proteome | |
Repeat | |
SH2 domain | |
SH3 domain | |
Transducer | |
Ubl conjugation
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | COP9 signalosome | |
Cellular Component | Lamellipodium | |
Cellular Component | Plasma membrane | |
Cellular Component | Ruffle | |
Molecular Function | Calcium ion binding | |
Molecular Function | Phosphatidylinositol phospholipase C activity | |
Biological Process | Cellular response to epidermal growth factor stimulus | |
Biological Process | Cellular response to vascular endothelial growth factor stimulus | |
Biological Process | In utero embryonic development | |
Biological Process | Inositol trisphosphate biosynthetic process | |
Biological Process | Phosphatidylinositol-mediated signaling | |
Biological Process | Phospholipid catabolic process | |
Biological Process | Positive regulation of epithelial cell migration | |
Biological Process | Release of sequestered calcium ion into cytosol |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Eqc-4188 | Equus caballus | 98.3 | 0.0 | 2616 |
| LLPS-Caf-3162 | Canis familiaris | 98.28 | 0.0 | 2459 |
| LLPS-Mup-0095 | Mustela putorius furo | 97.91 | 0.0 | 2600 |
| LLPS-Urm-0754 | Ursus maritimus | 97.88 | 0.0 | 2363 |
| LLPS-Chs-3539 | Chlorocebus sabaeus | 97.87 | 0.0 | 1900 |
| LLPS-Otg-1637 | Otolemur garnettii | 97.52 | 0.0 | 2591 |
| LLPS-Sus-3208 | Sus scrofa | 97.46 | 0.0 | 2363 |
| LLPS-Caj-2207 | Callithrix jacchus | 97.37 | 0.0 | 2593 |
| LLPS-Fud-3654 | Fukomys damarensis | 97.21 | 0.0 | 2585 |
| LLPS-Hos-1858 | Homo sapiens | 97.13 | 0.0 | 2589 |
| LLPS-Gog-3703 | Gorilla gorilla | 97.13 | 0.0 | 2583 |
| LLPS-Pat-3398 | Pan troglodytes | 97.06 | 0.0 | 2582 |
| LLPS-Mal-3845 | Mandrillus leucophaeus | 97.02 | 0.0 | 2553 |
| LLPS-Rhb-2260 | Rhinopithecus bieti | 96.98 | 0.0 | 2586 |
| LLPS-Poa-3379 | Pongo abelii | 96.98 | 0.0 | 2514 |
| LLPS-Cea-0959 | Cercocebus atys | 96.98 | 0.0 | 2586 |
| LLPS-Paa-4302 | Papio anubis | 96.98 | 0.0 | 2586 |
| LLPS-Maf-1979 | Macaca fascicularis | 96.9 | 0.0 | 2584 |
| LLPS-Man-4209 | Macaca nemestrina | 96.82 | 0.0 | 2577 |
| LLPS-Myl-0308 | Myotis lucifugus | 96.72 | 0.0 | 2420 |
| LLPS-Ict-2563 | Ictidomys tridecemlineatus | 96.67 | 0.0 | 2576 |
| LLPS-Cas-0571 | Carlito syrichta | 96.66 | 0.0 | 2550 |
| LLPS-Loa-2955 | Loxodonta africana | 96.56 | 0.0 | 2421 |
| LLPS-Mum-3235 | Mus musculus | 96.47 | 0.0 | 2557 |
| LLPS-Dio-2958 | Dipodomys ordii | 96.47 | 0.0 | 2543 |
| LLPS-Ran-4867 | Rattus norvegicus | 96.44 | 0.0 | 2571 |
| LLPS-Mam-3406 | Macaca mulatta | 96.28 | 0.0 | 2558 |
| LLPS-Ova-0565 | Ovis aries | 96.07 | 0.0 | 2398 |
| LLPS-Orc-2919 | Oryctolagus cuniculus | 95.28 | 0.0 | 2515 |
| LLPS-Mea-3613 | Mesocricetus auratus | 94.53 | 0.0 | 2513 |
| LLPS-Aon-2904 | Aotus nancymaae | 93.95 | 0.0 | 2466 |
| LLPS-Mod-2521 | Monodelphis domestica | 93.65 | 0.0 | 2504 |
| LLPS-Pap-2619 | Pan paniscus | 91.75 | 0.0 | 2384 |
| LLPS-Cap-0859 | Cavia porcellus | 90.68 | 0.0 | 2340 |
| LLPS-Nol-1221 | Nomascus leucogenys | 89.87 | 0.0 | 2206 |
| LLPS-Gaga-0160 | Gallus gallus | 88.52 | 0.0 | 2344 |
| LLPS-Meg-3018 | Meleagris gallopavo | 88.33 | 0.0 | 2222 |
| LLPS-Fia-2239 | Ficedula albicollis | 87.76 | 0.0 | 2100 |
| LLPS-Sah-2669 | Sarcophilus harrisii | 87.57 | 0.0 | 1561 |
| LLPS-Anc-3213 | Anolis carolinensis | 86.64 | 0.0 | 2281 |
| LLPS-Pes-0291 | Pelodiscus sinensis | 86.55 | 0.0 | 2284 |
| LLPS-Anp-0423 | Anas platyrhynchos | 86.25 | 0.0 | 2158 |
| LLPS-Tag-2774 | Taeniopygia guttata | 85.61 | 0.0 | 2249 |
| LLPS-Lac-3674 | Latimeria chalumnae | 79.98 | 0.0 | 2018 |
| LLPS-Asm-0642 | Astyanax mexicanus | 77.91 | 0.0 | 1977 |
| LLPS-Xet-0582 | Xenopus tropicalis | 77.62 | 0.0 | 2022 |
| LLPS-Dar-1156 | Danio rerio | 77.14 | 0.0 | 1597 |
| LLPS-Leo-0862 | Lepisosteus oculatus | 77.06 | 0.0 | 2074 |
| LLPS-Icp-3861 | Ictalurus punctatus | 76.01 | 0.0 | 2036 |
| LLPS-Scm-3132 | Scophthalmus maximus | 74.32 | 0.0 | 2001 |
| LLPS-Orn-3875 | Oreochromis niloticus | 74.18 | 0.0 | 1996 |
| LLPS-Tar-3402 | Takifugu rubripes | 74.09 | 0.0 | 2023 |
| LLPS-Orl-0381 | Oryzias latipes | 73.18 | 0.0 | 2003 |
| LLPS-Xim-3401 | Xiphophorus maculatus | 72.32 | 0.0 | 1944 |
| LLPS-Pof-2635 | Poecilia formosa | 71.88 | 0.0 | 1932 |
| LLPS-Scf-2481 | Scleropages formosus | 70.61 | 0.0 | 1844 |
| LLPS-Ten-1521 | Tetraodon nigroviridis | 67.84 | 0.0 | 1705 |
| LLPS-Gaa-1749 | Gasterosteus aculeatus | 66.35 | 0.0 | 1670 |
| LLPS-Ora-2304 | Ornithorhynchus anatinus | 62.63 | 0.0 | 650 |
| LLPS-Cis-1090 | Ciona savignyi | 57.05 | 4e-47 | 185 |
| LLPS-Cii-1372 | Ciona intestinalis | 48.11 | 0.0 | 1087 |
| LLPS-Drm-2105 | Drosophila melanogaster | 41.86 | 0.0 | 897 |
| LLPS-Aim-1666 | Ailuropoda melanoleuca | 39.58 | 1e-47 | 188 |
| LLPS-Tut-0755 | Tursiops truncatus | 39.56 | 4e-46 | 183 |
| LLPS-Fec-0592 | Felis catus | 38.79 | 2e-47 | 187 |
| LLPS-Cae-0899 | Caenorhabditis elegans | 36.39 | 0.0 | 671 |