LLPS-Nol-1221
PLCG1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma |
| Gene Name: | PLCG1 |
| Ensembl Gene: | ENSNLEG00000006479.3 |
| Ensembl Protein: | ENSNLEP00000007890.2 |
| Organism: | Nomascus leucogenys |
| Taxa ID: | 61853 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSNLET00000008268.3 | ENSNLEP00000007890.2 |
| UniProt | G1R3W8, G1R3W8_NOMLE | |
| GeneBank | ADFV01004166, ADFV01004165, ADFV01004167 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 DIREIKEIRP GKTSRDFDRY QEDPAFRPDQ SHCFVILYGM EFRLKTLSLQ ATSEDEVNMW 60 61 IKGLTWLMED TLQAPTPLQI ERWLRKQFYS VDRNREDRIS AKDLKNMLSQ VNYRVPNMRF 120 121 LRERLTDLEQ RSGDITYGQF AQLYRSLMYS AQKTMDLPFL EASTLRAGER PELCRVSLPE 180 181 FQQFLLDYQG ELWAVDRLQV QEFMLSFLRD PLREIEEPYF FLDEFVTFLF SKENSVWNSQ 240 241 LDAVCLDTMN NPLSHYWISS SHNTYLTGDQ FSSESSLEAY ARCLRMGCRC IELDCWDGPD 300 301 GMPVIYHGHT LTTKIKFSDV LLTIKEHAFV ASEYPVILSI EDHCSIAQQR NMAQHFKKVL 360 361 GDTLLTKPVE ISADGLPSPN QLKRKILIKH KKLAEGSAYE EVPTSMMYSE NDISNSIKNG 420 421 ILYLEDPVNH EWYPHYFVLT SSKIYYSEET SSDQGNEDEE EPKEVSSSTE LHSNEKWFHG 480 481 KLGAGRDGRH IAERLLTEYC IETGAPDGSF LVRESETFVG DYTLSFWRNG KVQHCRIHSR 540 541 QDAGTPKFFL TDNLVFDSLY DLITHYQQVP LRCNEFEMRL SEPVPQTNAH ESKEWYHASL 600 601 TRAQAEHMLM RVPRDGAFLV RKRNEPNSYA ISFRAEGKIK HCRVQQEGQT VMLGNSEFDS 660 661 LVDLISYYEK HPLYRKMKLR YPINEEALEK IGTAEPDYGA LYEGRNPGFY VEANPMPTFK 720 721 CAVKALFDYK AQREDELTFT KSAIIQNVEK QEGGWWRGDY GGKKQLWFPS NYVERWSTPT 780 781 HLSQCLQCGL LSALALPAIR PEGKNNRLFV FSISMASVAH WSLDVAADSQ EELQDWVKKI 840 841 REVAQTADAR LTEGKIMERR KKIALELSEL VVYCRPVPFD EEKIGTERAC YRDMSSFPET 900 901 KAEKYVNKAK GKKFLQYNRL QLSRIYPKGQ RLDSSNYDPL PMWICGSQLV ALNFQTPDKP 960 961 MQMNQALFMT GRHCGYVLQP SNMRDEAFDP FDKSSLRGLE PCAISIEVLG ARHLPKNGRG 1020 1021 IVCPFVEIEV AGAEYDSTKQ VRTIPGGSAP AILLAGRGWA PCSVPRGLRA RLFLLLGYRA 1080 1081 VPLKNNYSED LELASLLIKI DIFPAKQENG DLSPFSGTSL RERGSDASGQ LFHGRTREGS 1140 1141 FESRYQQPFE DFRISQEHLA DHFDSRERRA PRRTRVNGDN RL 1182 |
| Nucleotide CDS Sequence (FASTA) |
1 GATATTCGCG AAATTAAGGA GATCCGCCCG GGGAAGACCT CACGGGACTT TGATCGCTAT 60 61 CAAGAGGACC CAGCTTTCCG GCCGGACCAG TCACATTGCT TTGTCATTCT CTATGGAATG 120 121 GAATTTCGCC TGAAAACGCT GAGCCTGCAA GCCACATCTG AGGATGAAGT GAACATGTGG 180 181 ATCAAGGGCT TAACTTGGCT GATGGAGGAT ACATTGCAGG CACCCACACC CCTGCAGATA 240 241 GAGAGGTGGC TCCGGAAGCA GTTTTACTCA GTGGATCGGA ATCGTGAGGA TCGTATATCA 300 301 GCCAAGGACC TGAAGAACAT GCTGTCCCAG GTCAACTACC GGGTCCCCAA CATGCGCTTC 360 361 CTCCGAGAGC GGCTGACGGA CCTGGAGCAG CGCAGCGGGG ACATCACCTA CGGGCAGTTT 420 421 GCTCAGCTGT ACCGCAGCCT CATGTACAGC GCCCAGAAGA CGATGGACCT CCCCTTCTTG 480 481 GAAGCCAGTA CTCTGAGGGC TGGGGAGCGG CCGGAGCTTT GCCGAGTGTC CCTTCCTGAG 540 541 TTCCAGCAGT TCCTTCTTGA CTACCAGGGG GAGCTGTGGG CTGTTGATCG CCTCCAGGTG 600 601 CAAGAGTTCA TGCTCAGCTT CCTCCGAGAC CCCTTACGAG AGATCGAGGA GCCATACTTC 660 661 TTCCTGGATG AGTTTGTCAC CTTCCTGTTC TCCAAAGAGA ACAGTGTGTG GAACTCACAG 720 721 CTGGATGCAG TATGCCTGGA CACCATGAAC AACCCTCTTT CCCACTACTG GATCTCCTCC 780 781 TCACACAACA CGTACCTGAC CGGGGACCAG TTCTCCAGTG AGTCCTCCTT GGAAGCCTAT 840 841 GCTCGCTGCC TGCGGATGGG CTGTCGCTGC ATTGAGTTGG ACTGCTGGGA CGGCCCGGAT 900 901 GGGATGCCAG TTATTTACCA TGGGCACACC CTTACCACCA AGATCAAGTT CTCAGATGTC 960 961 CTGCTCACCA TCAAGGAGCA TGCCTTTGTG GCCTCAGAGT ACCCAGTCAT CCTGTCCATT 1020 1021 GAGGACCACT GCAGCATTGC CCAGCAGAGG AACATGGCCC AGCACTTCAA GAAGGTGCTG 1080 1081 GGGGACACAC TCCTCACCAA GCCCGTGGAG ATCTCTGCCG ATGGGCTCCC CTCACCCAAC 1140 1141 CAGCTTAAGA GGAAGATCCT CATCAAGCAC AAGAAGCTGG CTGAGGGCAG TGCCTACGAG 1200 1201 GAGGTGCCTA CCTCCATGAT GTATTCTGAG AACGACATCA GCAACTCCAT CAAGAATGGC 1260 1261 ATCCTCTACC TGGAGGACCC TGTGAACCAC GAATGGTATC CCCACTACTT TGTTCTGACC 1320 1321 AGCAGCAAGA TCTACTACTC TGAGGAGACC AGCAGTGACC AGGGCAACGA GGATGAGGAG 1380 1381 GAGCCCAAGG AGGTCAGCAG CAGCACAGAG CTGCACTCCA ATGAGAAGTG GTTCCATGGG 1440 1441 AAGCTAGGGG CAGGGCGTGA TGGGCGTCAC ATCGCTGAGC GCCTGCTCAC TGAGTACTGC 1500 1501 ATCGAGACCG GAGCCCCTGA TGGCTCCTTC CTCGTGCGAG AGAGTGAGAC CTTCGTGGGC 1560 1561 GACTACACGC TCTCTTTCTG GCGGAACGGG AAAGTCCAGC ACTGCCGTAT CCACTCCCGG 1620 1621 CAAGATGCTG GGACCCCCAA GTTCTTCTTG ACAGACAACC TCGTCTTTGA CTCCCTCTAT 1680 1681 GACCTCATCA CGCACTACCA GCAGGTGCCC CTGCGCTGTA ATGAGTTTGA GATGAGACTT 1740 1741 TCAGAGCCTG TCCCACAGAC CAACGCCCAT GAGAGCAAAG AGTGGTACCA CGCGAGCCTG 1800 1801 ACCAGAGCAC AGGCTGAGCA CATGCTAATG CGCGTCCCTC GTGATGGGGC CTTCCTGGTG 1860 1861 CGGAAGCGGA ATGAGCCCAA CTCATATGCC ATCTCTTTCC GGGCTGAGGG CAAGATCAAG 1920 1921 CATTGCCGTG TCCAGCAAGA GGGCCAGACA GTGATGCTAG GGAACTCGGA GTTCGACAGC 1980 1981 CTTGTTGACC TCATCAGCTA CTATGAGAAA CACCCGCTGT ACCGCAAGAT GAAGCTGCGC 2040 2041 TATCCCATCA ACGAGGAGGC ACTGGAGAAG ATTGGCACAG CTGAGCCTGA CTACGGGGCC 2100 2101 CTGTATGAGG GACGCAACCC TGGCTTCTAT GTAGAGGCAA ACCCTATGCC AACTTTCAAG 2160 2161 TGTGCGGTCA AAGCCCTCTT TGACTACAAG GCCCAGAGGG AGGACGAGCT GACCTTCACC 2220 2221 AAGAGCGCCA TCATCCAGAA TGTGGAGAAG CAAGAGGGAG GCTGGTGGCG AGGGGACTAC 2280 2281 GGAGGGAAGA AGCAGCTGTG GTTCCCATCA AACTACGTGG AGAGATGGTC AACCCCAACT 2340 2341 CATTTGAGCC AGTGCCTGCA GTGTGGACTG TTATCTGCTC TCGCCCTCCC AGCCATCCGT 2400 2401 CCTGAGGGCA AGAACAACCG GCTCTTCGTC TTCTCCATCA GCATGGCGTC GGTGGCCCAC 2460 2461 TGGTCCCTGG ATGTTGCTGC CGACTCACAG GAGGAGCTGC AGGACTGGGT GAAAAAGATC 2520 2521 CGTGAAGTGG CCCAGACCGC AGATGCCAGG CTCACTGAAG GGAAGATAAT GGAACGGAGG 2580 2581 AAGAAGATTG CCCTGGAGCT CTCTGAACTT GTCGTCTACT GCCGGCCTGT TCCCTTCGAT 2640 2641 GAAGAGAAGA TTGGCACAGA ACGTGCTTGC TACCGGGACA TGTCATCCTT CCCGGAAACC 2700 2701 AAGGCTGAGA AATACGTGAA CAAGGCCAAA GGCAAGAAGT TCCTTCAGTA CAATCGACTG 2760 2761 CAGCTCTCCC GCATCTACCC CAAGGGCCAG CGACTGGATT CCTCCAACTA CGATCCTTTG 2820 2821 CCCATGTGGA TCTGTGGCAG TCAGCTCGTG GCCCTCAACT TCCAGACCCC TGACAAGCCT 2880 2881 ATGCAGATGA ACCAGGCCCT CTTCATGACA GGCAGGCACT GTGGCTATGT GCTGCAGCCA 2940 2941 AGCAACATGC GGGATGAGGC CTTTGACCCC TTTGACAAGA GCAGCCTCCG TGGGCTGGAG 3000 3001 CCATGTGCCA TCTCTATTGA GGTGCTGGGG GCCCGACATC TGCCAAAGAA TGGCAGAGGC 3060 3061 ATTGTGTGTC CTTTTGTGGA GATTGAGGTG GCTGGAGCTG AGTATGACAG CACCAAACAG 3120 3121 GTGAGGACCA TTCCTGGAGG CAGTGCCCCT GCAATCTTGC TGGCAGGGCG GGGCTGGGCC 3180 3181 CCTTGCTCTG TCCCTCGTGG GCTGAGGGCC AGGCTTTTCC TCCTCCTAGG ATACAGAGCA 3240 3241 GTGCCTTTGA AGAACAACTA CAGCGAGGAC CTGGAGTTGG CCTCCCTGCT GATCAAGATT 3300 3301 GATATTTTCC CTGCCAAGCA GGAGAATGGT GACCTCAGTC CCTTCAGTGG TACGTCCCTG 3360 3361 CGGGAGCGGG GCTCAGATGC CTCAGGCCAG CTGTTTCACG GCCGAACCCG GGAAGGCTCC 3420 3421 TTTGAATCCC GCTACCAGCA GCCATTTGAG GACTTCCGCA TCTCCCAGGA ACATCTCGCA 3480 3481 GACCATTTTG ACAGTCGAGA ACGAAGGGCC CCAAGAAGGA CTCGGGTCAA TGGAGACAAC 3540 3541 CGCCTCTAG 3549 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell-cell junction | |
Cellular Component | COP9 signalosome | |
Cellular Component | Cytosol | |
Cellular Component | Glutamatergic synapse | |
Cellular Component | Lamellipodium | |
Cellular Component | Plasma membrane | |
Cellular Component | Ruffle | |
Cellular Component | Schaffer collateral - CA1 synapse | |
Molecular Function | Calcium ion binding | |
Molecular Function | Glutamate receptor binding | |
Molecular Function | Neurotrophin TRKA receptor binding | |
Molecular Function | Phosphatidylinositol phospholipase C activity | |
Molecular Function | Receptor tyrosine kinase binding | |
Biological Process | Calcium-mediated signaling | |
Biological Process | Cell migration | |
Biological Process | Cellular response to epidermal growth factor stimulus | |
Biological Process | Epidermal growth factor receptor signaling pathway | |
Biological Process | In utero embryonic development | |
Biological Process | Modulation of chemical synaptic transmission | |
Biological Process | Phospholipid catabolic process | |
Biological Process | Positive regulation of angiogenesis | |
Biological Process | Positive regulation of blood vessel endothelial cell migration | |
Biological Process | Positive regulation of endothelial cell apoptotic process | |
Biological Process | Positive regulation of release of sequestered calcium ion into cytosol | |
Biological Process | Positive regulation of vascular endothelial cell proliferation | |
Biological Process | T cell receptor signaling pathway |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Chs-3539 | Chlorocebus sabaeus | 96.3 | 0.0 | 1693 |
| LLPS-Sah-2669 | Sarcophilus harrisii | 94.36 | 0.0 | 1424 |
| LLPS-Rhb-2260 | Rhinopithecus bieti | 92.4 | 0.0 | 2243 |
| LLPS-Paa-4302 | Papio anubis | 92.4 | 0.0 | 2243 |
| LLPS-Mal-3845 | Mandrillus leucophaeus | 92.4 | 0.0 | 2248 |
| LLPS-Cea-0959 | Cercocebus atys | 92.4 | 0.0 | 2243 |
| LLPS-Hos-1858 | Homo sapiens | 92.31 | 0.0 | 2239 |
| LLPS-Maf-1979 | Macaca fascicularis | 92.31 | 0.0 | 2243 |
| LLPS-Gog-3703 | Gorilla gorilla | 92.31 | 0.0 | 2235 |
| LLPS-Man-4209 | Macaca nemestrina | 92.23 | 0.0 | 2236 |
| LLPS-Pat-3398 | Pan troglodytes | 92.23 | 0.0 | 2234 |
| LLPS-Poa-3379 | Pongo abelii | 92.15 | 0.0 | 2239 |
| LLPS-Caj-2207 | Callithrix jacchus | 91.91 | 0.0 | 2234 |
| LLPS-Mam-3406 | Macaca mulatta | 91.46 | 0.0 | 2211 |
| LLPS-Pap-2619 | Pan paniscus | 90.93 | 0.0 | 2186 |
| LLPS-Eqc-4188 | Equus caballus | 90.84 | 0.0 | 2212 |
| LLPS-Otg-1637 | Otolemur garnettii | 90.56 | 0.0 | 2195 |
| LLPS-Caf-3162 | Canis familiaris | 90.43 | 0.0 | 2197 |
| LLPS-Fud-3654 | Fukomys damarensis | 90.35 | 0.0 | 2197 |
| LLPS-Sus-3208 | Sus scrofa | 90.33 | 0.0 | 2113 |
| LLPS-Cas-0571 | Carlito syrichta | 90.16 | 0.0 | 2174 |
| LLPS-Ran-4867 | Rattus norvegicus | 90.11 | 0.0 | 2184 |
| LLPS-Ict-2563 | Ictidomys tridecemlineatus | 89.9 | 0.0 | 2180 |
| LLPS-Mup-0095 | Mustela putorius furo | 89.9 | 0.0 | 2181 |
| LLPS-Mum-3235 | Mus musculus | 89.83 | 0.0 | 2175 |
| LLPS-Urm-0754 | Ursus maritimus | 89.78 | 0.0 | 2102 |
| LLPS-Bot-3684 | Bos taurus | 89.74 | 0.0 | 2186 |
| LLPS-Myl-0308 | Myotis lucifugus | 89.62 | 0.0 | 2174 |
| LLPS-Loa-2955 | Loxodonta africana | 89.43 | 0.0 | 2165 |
| LLPS-Dio-2958 | Dipodomys ordii | 88.71 | 0.0 | 2143 |
| LLPS-Aon-2904 | Aotus nancymaae | 88.36 | 0.0 | 2112 |
| LLPS-Orc-2919 | Oryctolagus cuniculus | 88.3 | 0.0 | 2132 |
| LLPS-Cap-0859 | Cavia porcellus | 87.79 | 0.0 | 1976 |
| LLPS-Mod-2521 | Monodelphis domestica | 87.52 | 0.0 | 2142 |
| LLPS-Mea-3613 | Mesocricetus auratus | 87.1 | 0.0 | 2119 |
| LLPS-Ova-0565 | Ovis aries | 86.93 | 0.0 | 2112 |
| LLPS-Gaga-0160 | Gallus gallus | 83.07 | 0.0 | 2036 |
| LLPS-Meg-3018 | Meleagris gallopavo | 82.74 | 0.0 | 2025 |
| LLPS-Fia-2239 | Ficedula albicollis | 82.58 | 0.0 | 1918 |
| LLPS-Pes-0291 | Pelodiscus sinensis | 81.2 | 0.0 | 1982 |
| LLPS-Anc-3213 | Anolis carolinensis | 81.0 | 0.0 | 2004 |
| LLPS-Anp-0423 | Anas platyrhynchos | 80.59 | 0.0 | 1969 |
| LLPS-Tag-2774 | Taeniopygia guttata | 80.46 | 0.0 | 1953 |
| LLPS-Lac-3674 | Latimeria chalumnae | 75.29 | 0.0 | 1835 |
| LLPS-Asm-0642 | Astyanax mexicanus | 73.48 | 0.0 | 1689 |
| LLPS-Xet-0582 | Xenopus tropicalis | 72.95 | 0.0 | 1738 |
| LLPS-Leo-0862 | Lepisosteus oculatus | 72.9 | 0.0 | 1811 |
| LLPS-Icp-3861 | Ictalurus punctatus | 71.97 | 0.0 | 1775 |
| LLPS-Dar-1156 | Danio rerio | 71.02 | 0.0 | 1431 |
| LLPS-Scm-3132 | Scophthalmus maximus | 70.34 | 0.0 | 1747 |
| LLPS-Tar-3402 | Takifugu rubripes | 70.14 | 0.0 | 1766 |
| LLPS-Orn-3875 | Oreochromis niloticus | 70.02 | 0.0 | 1728 |
| LLPS-Orl-0381 | Oryzias latipes | 69.48 | 0.0 | 1751 |
| LLPS-Xim-3401 | Xiphophorus maculatus | 68.53 | 0.0 | 1705 |
| LLPS-Pof-2635 | Poecilia formosa | 67.88 | 0.0 | 1686 |
| LLPS-Scf-2481 | Scleropages formosus | 65.7 | 0.0 | 1579 |
| LLPS-Ten-1521 | Tetraodon nigroviridis | 63.33 | 0.0 | 1486 |
| LLPS-Gaa-1749 | Gasterosteus aculeatus | 62.11 | 0.0 | 1457 |
| LLPS-Cis-1090 | Ciona savignyi | 56.41 | 2e-46 | 182 |
| LLPS-Ora-2304 | Ornithorhynchus anatinus | 53.93 | 2e-165 | 509 |
| LLPS-Cii-1372 | Ciona intestinalis | 45.43 | 0.0 | 940 |
| LLPS-Drm-2105 | Drosophila melanogaster | 41.61 | 0.0 | 804 |
| LLPS-Tut-0755 | Tursiops truncatus | 39.78 | 5e-26 | 119 |
| LLPS-Aim-1666 | Ailuropoda melanoleuca | 38.89 | 6e-27 | 122 |
| LLPS-Cae-0714 | Caenorhabditis elegans | 38.4 | 4e-17 | 91.3 |
| LLPS-Fec-0592 | Felis catus | 38.27 | 8e-27 | 122 |
| LLPS-Scj-0190 | Schizosaccharomyces japonicus | 34.97 | 2e-15 | 85.9 |