LLPS-Rhb-0921
PCNA
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Proliferating cell nuclear antigen |
| Gene Name: | PCNA |
| Ensembl Gene: | ENSRBIG00000027580.1 |
| Ensembl Protein: | ENSRBIP00000007375.1 |
| Organism: | Rhinopithecus bieti |
| Taxa ID: | 61621 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, PcG body, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRBIT00000030960.1 | ENSRBIP00000007375.1 |
| UniProt | A0A2K6K7W5, A0A2K6K7W5_RHIBE | |
| RefSeq | XM_017877952.1 | XP_017733441.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MFEARLVQGS ILKKVLEALK DLINEACWDI SSSGVNLQSM DSSHVSLVQL TLRSEGFDTY 60 61 RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVFEAPNQEK VSDYEMKLMD 120 121 LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSHIGDAVVI SCAKDGVKFS ASGELGNGNI 180 181 KLSQTSNVDK EEEAVTIEMN EPVQLTFALR YLNFFTKATP LSSTVTLSMS ADVPLVVEYK 240 241 IADMGHLKYY LAPKIEDEEG S 261 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTTCGAGG CGCGCCTGGT CCAGGGCTCC ATCCTGAAGA AGGTGTTGGA GGCCCTCAAG 60 61 GACCTCATCA ACGAGGCCTG CTGGGATATT AGCTCCAGCG GCGTAAACCT GCAGAGCATG 120 121 GACTCGTCCC ACGTCTCCTT GGTGCAGCTC ACCCTGCGGT CTGAGGGATT CGACACCTAC 180 181 CGCTGCGACC GCAACCTGGC CATGGGCGTG AACCTCACCA GTATGTCCAA AATACTAAAA 240 241 TGCGCCGGCA ATGAAGATAT CATTACACTA AGGGCTGAAG ATAATGCGGA TACCTTGGCG 300 301 CTAGTATTTG AAGCACCAAA CCAGGAGAAA GTTTCAGACT ATGAAATGAA GTTGATGGAT 360 361 TTGGATGTTG AACAACTTGG AATTCCAGAA CAAGAGTACA GCTGTGTAGT AAAGATGCCT 420 421 TCTGGTGAAT TTGCACGTAT ATGCCGAGAT CTCAGCCATA TTGGAGATGC TGTTGTAATT 480 481 TCCTGTGCAA AAGACGGCGT GAAATTTTCT GCAAGTGGAG AACTTGGAAA TGGAAACATT 540 541 AAATTGTCAC AGACAAGTAA TGTCGATAAA GAGGAGGAAG CTGTTACCAT AGAGATGAAT 600 601 GAACCAGTTC AACTAACTTT TGCACTGAGG TACCTGAACT TCTTTACAAA AGCCACTCCA 660 661 CTCTCTTCAA CGGTGACACT CAGTATGTCT GCAGATGTAC CCCTTGTTGT AGAGTATAAA 720 721 ATTGCTGATA TGGGACACTT GAAGTACTAC TTGGCTCCCA AGATCGAGGA TGAAGAAGGA 780 781 TCTTAG 786 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Centrosome | |
Cellular Component | Chromatin | |
Cellular Component | Nuclear body | |
Cellular Component | Nuclear replication fork | |
Cellular Component | PCNA complex | |
Cellular Component | PCNA-p21 complex | |
Molecular Function | Chromatin binding | |
Molecular Function | Damaged DNA binding | |
Molecular Function | Dinucleotide insertion or deletion binding | |
Molecular Function | DNA polymerase binding | |
Molecular Function | DNA polymerase processivity factor activity | |
Molecular Function | Histone acetyltransferase binding | |
Molecular Function | Identical protein binding | |
Molecular Function | MutLalpha complex binding | |
Molecular Function | Purine-specific mismatch base pair DNA N-glycosylase activity | |
Molecular Function | Receptor tyrosine kinase binding | |
Biological Process | Cellular response to UV | |
Biological Process | DNA replication | |
Biological Process | Epithelial cell differentiation | |
Biological Process | Mismatch repair | |
Biological Process | Positive regulation of deoxyribonuclease activity | |
Biological Process | Positive regulation of DNA repair | |
Biological Process | Positive regulation of DNA replication | |
Biological Process | Translesion synthesis |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gog-0796 | Gorilla gorilla | 100.0 | 0.0 | 537 |
| LLPS-Caj-3670 | Callithrix jacchus | 100.0 | 0.0 | 537 |
| LLPS-Chs-1834 | Chlorocebus sabaeus | 100.0 | 0.0 | 537 |
| LLPS-Maf-0658 | Macaca fascicularis | 100.0 | 0.0 | 537 |
| LLPS-Cea-0654 | Cercocebus atys | 100.0 | 0.0 | 537 |
| LLPS-Aon-2545 | Aotus nancymaae | 100.0 | 0.0 | 537 |
| LLPS-Mal-1583 | Mandrillus leucophaeus | 100.0 | 0.0 | 537 |
| LLPS-Paa-3371 | Papio anubis | 100.0 | 0.0 | 537 |
| LLPS-Otg-2882 | Otolemur garnettii | 100.0 | 0.0 | 537 |
| LLPS-Pat-1244 | Pan troglodytes | 100.0 | 0.0 | 537 |
| LLPS-Pap-0932 | Pan paniscus | 100.0 | 0.0 | 537 |
| LLPS-Hos-1546 | Homo sapiens | 100.0 | 0.0 | 537 |
| LLPS-Man-0271 | Macaca nemestrina | 100.0 | 0.0 | 537 |
| LLPS-Cas-1611 | Carlito syrichta | 100.0 | 0.0 | 537 |
| LLPS-Nol-1007 | Nomascus leucogenys | 100.0 | 0.0 | 537 |
| LLPS-Poa-3345 | Pongo abelii | 100.0 | 0.0 | 537 |
| LLPS-Mam-2157 | Macaca mulatta | 100.0 | 0.0 | 537 |
| LLPS-Sus-0330 | Sus scrofa | 99.62 | 0.0 | 534 |
| LLPS-Mup-0399 | Mustela putorius furo | 99.62 | 0.0 | 535 |
| LLPS-Aim-0289 | Ailuropoda melanoleuca | 99.62 | 0.0 | 535 |
| LLPS-Ova-0204 | Ovis aries | 99.62 | 0.0 | 535 |
| LLPS-Fec-0876 | Felis catus | 99.62 | 0.0 | 535 |
| LLPS-Urm-1206 | Ursus maritimus | 99.62 | 0.0 | 536 |
| LLPS-Caf-1057 | Canis familiaris | 99.62 | 0.0 | 535 |
| LLPS-Fud-3690 | Fukomys damarensis | 99.23 | 0.0 | 533 |
| LLPS-Myl-0668 | Myotis lucifugus | 99.23 | 0.0 | 533 |
| LLPS-Bot-0337 | Bos taurus | 99.23 | 0.0 | 533 |
| LLPS-Dio-0815 | Dipodomys ordii | 99.23 | 0.0 | 533 |
| LLPS-Orc-1467 | Oryctolagus cuniculus | 99.23 | 0.0 | 533 |
| LLPS-Loa-0547 | Loxodonta africana | 99.23 | 0.0 | 534 |
| LLPS-Ict-0641 | Ictidomys tridecemlineatus | 99.23 | 0.0 | 533 |
| LLPS-Tut-1862 | Tursiops truncatus | 98.93 | 1e-133 | 382 |
| LLPS-Eqc-0627 | Equus caballus | 98.85 | 0.0 | 532 |
| LLPS-Cap-1036 | Cavia porcellus | 98.85 | 0.0 | 532 |
| LLPS-Mea-0189 | Mesocricetus auratus | 98.47 | 0.0 | 530 |
| LLPS-Ran-2435 | Rattus norvegicus | 98.47 | 0.0 | 531 |
| LLPS-Mum-1776 | Mus musculus | 96.93 | 0.0 | 526 |
| LLPS-Sah-1112 | Sarcophilus harrisii | 96.55 | 0.0 | 522 |
| LLPS-Mod-0764 | Monodelphis domestica | 96.55 | 0.0 | 522 |
| LLPS-Pes-0626 | Pelodiscus sinensis | 94.59 | 0.0 | 513 |
| LLPS-Fia-0430 | Ficedula albicollis | 94.27 | 0.0 | 512 |
| LLPS-Gaga-0381 | Gallus gallus | 94.27 | 0.0 | 511 |
| LLPS-Tag-0150 | Taeniopygia guttata | 94.21 | 0.0 | 511 |
| LLPS-Meg-0220 | Meleagris gallopavo | 94.15 | 8e-142 | 404 |
| LLPS-Leo-1196 | Lepisosteus oculatus | 93.02 | 2e-178 | 499 |
| LLPS-Lac-0313 | Latimeria chalumnae | 92.31 | 4e-180 | 503 |
| LLPS-Asm-0547 | Astyanax mexicanus | 92.25 | 7e-178 | 498 |
| LLPS-Xim-2102 | Xiphophorus maculatus | 91.95 | 4e-177 | 495 |
| LLPS-Orn-2844 | Oreochromis niloticus | 91.95 | 4e-177 | 495 |
| LLPS-Scm-1262 | Scophthalmus maximus | 91.95 | 2e-177 | 496 |
| LLPS-Icp-0014 | Ictalurus punctatus | 91.86 | 4e-176 | 494 |
| LLPS-Scf-2212 | Scleropages formosus | 91.86 | 3e-178 | 498 |
| LLPS-Dar-0442 | Danio rerio | 91.86 | 6e-177 | 495 |
| LLPS-Gaa-1535 | Gasterosteus aculeatus | 91.57 | 8e-177 | 494 |
| LLPS-Pof-0735 | Poecilia formosa | 91.57 | 2e-176 | 495 |
| LLPS-Tar-0370 | Takifugu rubripes | 91.09 | 2e-175 | 491 |
| LLPS-Anc-0455 | Anolis carolinensis | 90.8 | 1e-177 | 497 |
| LLPS-Xet-2647 | Xenopus tropicalis | 90.42 | 7e-179 | 500 |
| LLPS-Ten-0278 | Tetraodon nigroviridis | 90.31 | 1e-174 | 489 |
| LLPS-Orl-1281 | Oryzias latipes | 89.11 | 1e-158 | 450 |
| LLPS-Anp-0707 | Anas platyrhynchos | 82.24 | 2e-146 | 418 |
| LLPS-Cii-1210 | Ciona intestinalis | 74.9 | 4e-149 | 424 |
| LLPS-Drm-0049 | Drosophila melanogaster | 71.04 | 2e-138 | 397 |
| LLPS-Php-0319 | Physcomitrella patens | 67.57 | 2e-133 | 385 |
| LLPS-Gor-0245 | Gossypium raimondii | 67.18 | 2e-133 | 385 |
| LLPS-Coc-1342 | Corchorus capsularis | 66.82 | 3e-112 | 330 |
| LLPS-Arl-0133 | Arabidopsis lyrata | 66.41 | 2e-132 | 382 |
| LLPS-Amt-1156 | Amborella trichopoda | 66.41 | 2e-124 | 362 |
| LLPS-Hea-2290 | Helianthus annuus | 66.02 | 5e-129 | 377 |
| LLPS-Thc-1792 | Theobroma cacao | 66.02 | 3e-131 | 379 |
| LLPS-Glm-0785 | Glycine max | 66.02 | 9e-130 | 375 |
| LLPS-Brn-0915 | Brassica napus | 66.02 | 7e-132 | 381 |
| LLPS-Nia-0999 | Nicotiana attenuata | 66.02 | 3e-130 | 377 |
| LLPS-Mae-0704 | Manihot esculenta | 66.02 | 3e-131 | 379 |
| LLPS-Art-1292 | Arabidopsis thaliana | 66.02 | 5e-132 | 381 |
| LLPS-Pot-0914 | Populus trichocarpa | 66.02 | 1e-130 | 378 |
| LLPS-Prp-0680 | Prunus persica | 66.02 | 8e-130 | 375 |
| LLPS-Phv-0661 | Phaseolus vulgaris | 65.88 | 3e-127 | 369 |
| LLPS-Sol-2160 | Solanum lycopersicum | 65.64 | 2e-130 | 377 |
| LLPS-Cus-0706 | Cucumis sativus | 65.64 | 6e-130 | 376 |
| LLPS-Sot-1610 | Solanum tuberosum | 65.64 | 2e-130 | 377 |
| LLPS-Brr-0435 | Brassica rapa | 65.64 | 6e-131 | 379 |
| LLPS-Viv-1963 | Vitis vinifera | 65.64 | 6e-130 | 376 |
| LLPS-Vir-0235 | Vigna radiata | 65.25 | 2e-128 | 372 |
| LLPS-Via-0604 | Vigna angularis | 65.25 | 2e-128 | 372 |
| LLPS-Dac-0037 | Daucus carota | 64.86 | 2e-129 | 375 |
| LLPS-Bro-1750 | Brassica oleracea | 64.86 | 7e-130 | 376 |
| LLPS-Met-0160 | Medicago truncatula | 64.48 | 1e-126 | 368 |
| LLPS-Sem-1853 | Selaginella moellendorffii | 64.37 | 4e-127 | 369 |
| LLPS-Mua-1641 | Musa acuminata | 63.32 | 4e-126 | 366 |
| LLPS-Brd-1581 | Brachypodium distachyon | 63.32 | 4e-126 | 366 |
| LLPS-Zem-1883 | Zea mays | 62.93 | 8e-125 | 363 |
| LLPS-Tru-0329 | Triticum urartu | 62.73 | 1e-106 | 315 |
| LLPS-Tra-0178 | Triticum aestivum | 62.55 | 1e-124 | 362 |
| LLPS-Orbr-1826 | Oryza brachyantha | 62.55 | 7e-126 | 365 |
| LLPS-Orni-1391 | Oryza nivara | 62.16 | 1e-124 | 363 |
| LLPS-Ori-0624 | Oryza indica | 62.16 | 1e-124 | 363 |
| LLPS-Orb-1748 | Oryza barthii | 62.16 | 1e-124 | 363 |
| LLPS-Sei-0594 | Setaria italica | 62.16 | 2e-123 | 360 |
| LLPS-Orgl-0284 | Oryza glumaepatula | 62.16 | 1e-124 | 363 |
| LLPS-Sob-0496 | Sorghum bicolor | 62.16 | 1e-123 | 360 |
| LLPS-Ors-0622 | Oryza sativa | 62.16 | 1e-124 | 363 |
| LLPS-Orp-0491 | Oryza punctata | 62.16 | 1e-124 | 362 |
| LLPS-Org-0280 | Oryza glaberrima | 62.16 | 1e-124 | 363 |
| LLPS-Orr-0390 | Oryza rufipogon | 62.16 | 1e-124 | 363 |
| LLPS-Orm-0644 | Oryza meridionalis | 62.16 | 1e-124 | 363 |
| LLPS-Lep-0196 | Leersia perrieri | 61.78 | 3e-124 | 361 |
| LLPS-Hov-1519 | Hordeum vulgare | 59.06 | 2e-61 | 197 |
| LLPS-Chr-0018 | Chlamydomonas reinhardtii | 58.3 | 3e-116 | 341 |
| LLPS-Miv-1410 | Microbotryum violaceum | 57.81 | 2e-15 | 80.1 |
| LLPS-Tum-0834 | Tuber melanosporum | 55.6 | 7e-103 | 308 |
| LLPS-Osl-0317 | Ostreococcus lucimarinus | 55.17 | 3e-106 | 316 |
| LLPS-Abg-0099 | Absidia glauca | 55.04 | 2e-102 | 306 |
| LLPS-Ast-0687 | Aspergillus terreus | 55.0 | 5e-88 | 268 |
| LLPS-Nec-0426 | Neurospora crassa | 54.83 | 3e-101 | 303 |
| LLPS-Asfu-0645 | Aspergillus fumigatus | 54.55 | 1e-86 | 264 |
| LLPS-Asc-0079 | Aspergillus clavatus | 54.05 | 4e-103 | 308 |
| LLPS-Gas-0805 | Galdieria sulphuraria | 53.91 | 7e-102 | 305 |
| LLPS-Pug-0394 | Puccinia graminis | 53.85 | 8e-15 | 77.4 |
| LLPS-Put-0046 | Puccinia triticina | 53.85 | 4e-15 | 78.2 |
| LLPS-Aso-0761 | Aspergillus oryzae | 53.67 | 2e-101 | 303 |
| LLPS-Beb-0478 | Beauveria bassiana | 53.67 | 4e-100 | 300 |
| LLPS-Scj-1098 | Schizosaccharomyces japonicus | 53.64 | 1e-102 | 306 |
| LLPS-Phn-0022 | Phaeosphaeria nodorum | 53.64 | 2e-85 | 261 |
| LLPS-Asf-0209 | Aspergillus flavus | 53.28 | 1e-94 | 302 |
| LLPS-Mao-0806 | Magnaporthe oryzae | 52.9 | 7e-99 | 296 |
| LLPS-Pyt-0139 | Pyrenophora teres | 52.69 | 3e-98 | 298 |
| LLPS-Nef-1313 | Neosartorya fischeri | 52.55 | 7e-99 | 296 |
| LLPS-Asni-1152 | Aspergillus niger | 52.51 | 1e-98 | 298 |
| LLPS-Lem-1133 | Leptosphaeria maculans | 52.51 | 7e-100 | 301 |
| LLPS-Blg-1362 | Blumeria graminis | 51.74 | 3e-95 | 287 |
| LLPS-Trr-0914 | Trichoderma reesei | 51.74 | 2e-98 | 295 |
| LLPS-Scp-1076 | Schizosaccharomyces pombe | 51.72 | 1e-99 | 299 |
| LLPS-Fus-0555 | Fusarium solani | 51.57 | 5e-95 | 287 |
| LLPS-Map-0575 | Magnaporthe poae | 51.35 | 3e-96 | 290 |
| LLPS-Trv-0912 | Trichoderma virens | 51.35 | 5e-98 | 295 |
| LLPS-Coo-1258 | Colletotrichum orbiculare | 50.97 | 1e-95 | 288 |
| LLPS-Gag-1399 | Gaeumannomyces graminis | 50.97 | 1e-95 | 288 |
| LLPS-Dos-0772 | Dothistroma septosporum | 50.97 | 6e-98 | 294 |
| LLPS-Ved-0801 | Verticillium dahliae | 50.96 | 1e-90 | 276 |
| LLPS-Cog-0877 | Colletotrichum gloeosporioides | 50.58 | 1e-95 | 288 |
| LLPS-Crn-0977 | Cryptococcus neoformans | 50.24 | 1e-70 | 227 |
| LLPS-Cym-0190 | Cyanidioschyzon merolae | 50.19 | 2e-94 | 285 |
| LLPS-Scc-0465 | Schizosaccharomyces cryophilus | 50.19 | 5e-96 | 290 |
| LLPS-Fuo-0513 | Fusarium oxysporum | 50.19 | 4e-97 | 292 |
| LLPS-Fuv-1069 | Fusarium verticillioides | 49.81 | 4e-96 | 290 |
| LLPS-Zyt-1103 | Zymoseptoria tritici | 49.81 | 1e-95 | 288 |
| LLPS-Cogr-0102 | Colletotrichum graminicola | 49.61 | 4e-92 | 280 |
| LLPS-Cae-1284 | Caenorhabditis elegans | 47.89 | 2e-89 | 273 |
| LLPS-Mel-0891 | Melampsora laricipopulina | 47.33 | 1e-90 | 276 |
| LLPS-Chc-0123 | Chondrus crispus | 46.12 | 3e-80 | 251 |
| LLPS-Yal-0467 | Yarrowia lipolytica | 44.31 | 6e-77 | 241 |
| LLPS-Usm-1148 | Ustilago maydis | 43.25 | 4e-82 | 255 |
| LLPS-Spr-0663 | Sporisorium reilianum | 42.61 | 3e-81 | 253 |
| LLPS-Asg-0815 | Ashbya gossypii | 39.77 | 1e-70 | 224 |
| LLPS-Kop-0594 | Komagataella pastoris | 36.96 | 2e-59 | 195 |
| LLPS-Sac-1163 | Saccharomyces cerevisiae | 35.52 | 3e-61 | 200 |
| LLPS-Ora-1968 | Ornithorhynchus anatinus | 33.49 | 4e-27 | 110 |