• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Kop-0594
PAS_chr3_0233

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Proliferating cell nuclear antigen
Gene Name: PAS_chr3_0233
Ensembl Gene: PAS_chr3_0233
Ensembl Protein: CAY70256
Organism: Komagataella pastoris
Taxa ID: 644223
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, PcG body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblCAY70256CAY70256
UniProtC4R3Y4, C4R3Y4_KOMPG
GeneBankFN392321CAY70256.1
RefSeqXM_002492404.1XP_002492449.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLEGKFEEAS  LLKKIVEAMK  DCVSSCNFNC  TENGISVQAV  DNSRVLLISL  LIEKDTFEEY  60
61    RCDRNITLGV  GLGSLSKIIG  NGANSDYLTI  SADDDADKLN  IIFEDKVKDK  ISEYNLKLLD  120
121   IDADLLDVGP  MDTDATITLP  SADFAKICKD  MKVLSESLQI  IVTKDSALFQ  SVGDIGTGNI  180
181   VIRPKTDIDH  PEESVTISLD  KPIDLSFGSK  YLSDIIKATS  LSQKVTIKLT  DQSPGVFEYK  240
241   LPSGYLRFYL  APKFDESN  258
Nucleotide CDS Sequence (FASTA)
1     ATGTTAGAAG  GAAAGTTTGA  AGAAGCTTCT  TTGTTGAAAA  AGATCGTTGA  GGCCATGAAA  60
61    GATTGTGTCA  GTAGCTGTAA  CTTCAACTGC  ACTGAAAACG  GTATTTCTGT  CCAAGCAGTC  120
121   GACAACTCTC  GTGTCCTTTT  GATTTCCCTA  TTGATTGAAA  AGGATACTTT  TGAAGAGTAC  180
181   AGATGTGATC  GTAATATCAC  TCTAGGTGTT  GGTCTGGGTA  GCTTGAGTAA  AATCATTGGA  240
241   AATGGAGCCA  ACAGCGACTA  CTTAACTATT  TCTGCTGACG  ATGATGCGGA  CAAATTAAAC  300
301   ATTATCTTCG  AAGACAAAGT  CAAAGACAAA  ATCAGTGAGT  ACAACTTGAA  ACTATTAGAT  360
361   ATTGATGCAG  ATTTATTAGA  CGTGGGTCCT  ATGGATACTG  ATGCCACCAT  TACGCTCCCT  420
421   TCTGCAGATT  TTGCTAAAAT  TTGCAAAGAT  ATGAAAGTGT  TGAGTGAATC  TCTACAAATC  480
481   ATCGTAACGA  AAGACTCCGC  CCTTTTCCAG  AGTGTTGGAG  ATATTGGAAC  AGGAAACATT  540
541   GTAATCAGAC  CAAAGACTGA  CATTGACCAT  CCTGAGGAGT  CTGTTACAAT  TAGTTTGGAC  600
601   AAACCAATCG  ATTTGAGTTT  TGGTTCCAAG  TATCTGAGCG  ATATTATAAA  GGCTACATCA  660
661   TTATCGCAAA  AAGTTACCAT  TAAGCTAACG  GACCAGTCAC  CGGGGGTGTT  TGAATATAAG  720
721   CTTCCAAGTG  GGTACCTGAG  GTTTTACCTA  GCTCCTAAGT  TTGACGAAAG  TAACTAA  777

▼ KEYWORD

ID
Family
Complete proteome
DNA replication
DNA-binding
Nucleus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nuclear chromatin
Cellular Component
Nuclear replication fork
Cellular Component
Nucleoplasm
Cellular Component
PCNA complex
Cellular Component
Site of double-strand break
Molecular Function
DNA binding
Molecular Function
DNA polymerase processivity factor activity
Biological Process
Error-free translesion synthesis
Biological Process
Error-prone translesion synthesis
Biological Process
Mitotic DNA replication lagging strand elongation
Biological Process
Positive regulation of cellular protein catabolic process
Biological Process
Positive regulation of DNA-directed DNA polymerase activity
Biological Process
UV-damage excision repair

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asg-0815Ashbya gossypii52.532e-90 275
LLPS-Sac-1163Saccharomyces cerevisiae51.951e-87 268
LLPS-Nef-1313Neosartorya fischeri49.013e-81 251
LLPS-Asfu-0645Aspergillus fumigatus48.65e-63 203
LLPS-Aso-0761Aspergillus oryzae48.433e-81 252
LLPS-Mao-0806Magnaporthe oryzae48.248e-76 238
LLPS-Trr-0914Trichoderma reesei48.243e-74 234
LLPS-Trv-0912Trichoderma virens48.241e-74 234
LLPS-Asc-0079Aspergillus clavatus48.035e-79 246
LLPS-Asf-0209Aspergillus flavus47.665e-73 244
LLPS-Beb-0478Beauveria bassiana47.642e-73 231
LLPS-Pyt-0139Pyrenophora teres47.459e-74 235
LLPS-Asni-1152Aspergillus niger47.246e-79 248
LLPS-Fuv-1069Fusarium verticillioides47.242e-72 229
LLPS-Nec-0426Neurospora crassa47.241e-74 234
LLPS-Blg-1362Blumeria graminis47.248e-74 233
LLPS-Ast-0687Aspergillus terreus47.21e-61 199
LLPS-Map-0575Magnaporthe poae47.081e-73 232
LLPS-Lem-1133Leptosphaeria maculans46.851e-74 237
LLPS-Cogr-0102Colletotrichum graminicola46.853e-73 231
LLPS-Gag-1399Gaeumannomyces graminis46.694e-73 231
LLPS-Fuo-0513Fusarium oxysporum46.462e-72 229
LLPS-Fus-0555Fusarium solani46.066e-72 228
LLPS-Mae-0704Manihot esculenta45.917e-75 236
LLPS-Ved-0801Verticillium dahliae45.71e-68 219
LLPS-Thc-1792Theobroma cacao45.532e-74 234
LLPS-Cog-0877Colletotrichum gloeosporioides45.492e-72 229
LLPS-Yal-0467Yarrowia lipolytica45.453e-67 216
LLPS-Zyt-1103Zymoseptoria tritici45.285e-71 225
LLPS-Dos-0772Dothistroma septosporum45.288e-72 227
LLPS-Prp-0680Prunus persica45.143e-73 231
LLPS-Scp-1076Schizosaccharomyces pombe44.966e-75 235
LLPS-Tum-0834Tuber melanosporum44.923e-73 232
LLPS-Crn-0977Cryptococcus neoformans44.746e-48 168
LLPS-Scc-0465Schizosaccharomyces cryophilus44.663e-73 231
LLPS-Scj-1098Schizosaccharomyces japonicus44.571e-73 232
LLPS-Hea-1678Helianthus annuus44.366e-73 230
LLPS-Cus-0706Cucumis sativus44.362e-71 226
LLPS-Nia-0999Nicotiana attenuata44.367e-73 230
LLPS-Viv-1963Vitis vinifera44.363e-72 229
LLPS-Gor-0245Gossypium raimondii44.361e-72 230
LLPS-Miv-1410Microbotryum violaceum44.21e-41 155
LLPS-Phn-0022Phaeosphaeria nodorum44.192e-55 184
LLPS-Dac-0037Daucus carota43.972e-72 229
LLPS-Glm-0785Glycine max43.974e-72 228
LLPS-Arl-0133Arabidopsis lyrata43.972e-73 231
LLPS-Brr-0435Brassica rapa43.976e-73 230
LLPS-Art-1292Arabidopsis thaliana43.974e-73 231
LLPS-Coo-1258Colletotrichum orbiculare43.922e-69 221
LLPS-Brn-0915Brassica napus43.583e-72 229
LLPS-Sol-2160Solanum lycopersicum43.587e-71 225
LLPS-Sot-1610Solanum tuberosum43.587e-71 225
LLPS-Pot-0449Populus trichocarpa43.583e-72 229
LLPS-Bro-1750Brassica oleracea43.581e-71 227
LLPS-Coc-1342Corchorus capsularis43.587e-58 191
LLPS-Met-0160Medicago truncatula43.192e-70 224
LLPS-Tra-0178Triticum aestivum43.195e-69 220
LLPS-Amt-2085Amborella trichopoda43.195e-65 210
LLPS-Phv-0661Phaseolus vulgaris42.913e-69 221
LLPS-Mua-1641Musa acuminata42.411e-68 219
LLPS-Vir-0235Vigna radiata42.413e-70 223
LLPS-Brd-1581Brachypodium distachyon42.413e-69 221
LLPS-Via-0604Vigna angularis42.413e-70 223
LLPS-Sob-0496Sorghum bicolor42.412e-69 221
LLPS-Orbr-1826Oryza brachyantha42.415e-69 220
LLPS-Zem-0573Zea mays42.413e-69 221
LLPS-Hov-0274Hordeum vulgare42.391e-2193.6
LLPS-Tru-0329Triticum urartu42.24e-55 183
LLPS-Sem-1853Selaginella moellendorffii42.023e-67 216
LLPS-Sei-0594Setaria italica42.022e-68 219
LLPS-Abg-0099Absidia glauca42.024e-62 202
LLPS-Lep-0196Leersia perrieri42.022e-68 219
LLPS-Orni-1391Oryza nivara41.632e-68 219
LLPS-Php-0319Physcomitrella patens41.638e-68 217
LLPS-Orb-1748Oryza barthii41.632e-68 219
LLPS-Ori-0624Oryza indica41.632e-68 219
LLPS-Orgl-0284Oryza glumaepatula41.632e-68 219
LLPS-Orp-0491Oryza punctata41.636e-68 218
LLPS-Ors-0622Oryza sativa41.632e-68 219
LLPS-Org-0280Oryza glaberrima41.632e-68 219
LLPS-Orm-0644Oryza meridionalis41.632e-68 219
LLPS-Orr-0390Oryza rufipogon41.632e-68 219
LLPS-Gas-0805Galdieria sulphuraria41.411e-63 206
LLPS-Cym-0190Cyanidioschyzon merolae41.346e-59 194
LLPS-Pug-0394Puccinia graminis41.275e-1063.2
LLPS-Put-0046Puccinia triticina41.274e-1063.2
LLPS-Cii-1210Ciona intestinalis40.081e-60 199
LLPS-Mel-0891Melampsora laricipopulina39.253e-64 208
LLPS-Asm-0547Astyanax mexicanus38.914e-62 202
LLPS-Leo-1196Lepisosteus oculatus38.917e-62 202
LLPS-Cae-1284Caenorhabditis elegans38.764e-53 179
LLPS-Drm-0049Drosophila melanogaster38.767e-64 207
LLPS-Icp-0014Ictalurus punctatus38.528e-61 200
LLPS-Scf-2212Scleropages formosus38.522e-62 203
LLPS-Xim-2102Xiphophorus maculatus38.521e-61 201
LLPS-Orn-2844Oreochromis niloticus38.521e-61 201
LLPS-Dar-0442Danio rerio38.522e-61 201
LLPS-Scm-1262Scophthalmus maximus38.526e-62 202
LLPS-Ten-0278Tetraodon nigroviridis38.222e-61 201
LLPS-Gaa-1535Gasterosteus aculeatus38.133e-61 200
LLPS-Pof-0735Poecilia formosa38.131e-60 200
LLPS-Anc-0455Anolis carolinensis38.132e-60 198
LLPS-Chr-0018Chlamydomonas reinhardtii37.848e-60 197
LLPS-Tar-0370Takifugu rubripes37.841e-60 199
LLPS-Fia-0430Ficedula albicollis37.842e-60 198
LLPS-Tag-0150Taeniopygia guttata37.843e-60 197
LLPS-Gaga-0381Gallus gallus37.843e-60 197
LLPS-Lac-0313Latimeria chalumnae37.742e-61 201
LLPS-Xet-2647Xenopus tropicalis37.741e-59 196
LLPS-Orl-1281Oryzias latipes37.51e-52 179
LLPS-Pes-0626Pelodiscus sinensis37.451e-59 196
LLPS-Meg-0220Meleagris gallopavo37.071e-44 155
LLPS-Fud-3690Fukomys damarensis36.964e-59 194
LLPS-Caj-3670Callithrix jacchus36.962e-59 195
LLPS-Gog-0796Gorilla gorilla36.962e-59 195
LLPS-Sus-0330Sus scrofa36.964e-59 195
LLPS-Cea-0654Cercocebus atys36.962e-59 195
LLPS-Aon-2545Aotus nancymaae36.962e-59 195
LLPS-Maf-0658Macaca fascicularis36.962e-59 195
LLPS-Mum-1776Mus musculus36.961e-58 194
LLPS-Chs-1834Chlorocebus sabaeus36.962e-59 195
LLPS-Paa-3371Papio anubis36.962e-59 195
LLPS-Mal-1583Mandrillus leucophaeus36.962e-59 195
LLPS-Mup-0399Mustela putorius furo36.963e-59 195
LLPS-Aim-0289Ailuropoda melanoleuca36.963e-59 195
LLPS-Ova-0204Ovis aries36.964e-59 195
LLPS-Dio-0815Dipodomys ordii36.964e-59 194
LLPS-Orc-1467Oryctolagus cuniculus36.964e-59 194
LLPS-Rhb-0921Rhinopithecus bieti36.962e-59 195
LLPS-Otg-2882Otolemur garnettii36.962e-59 195
LLPS-Man-0271Macaca nemestrina36.962e-59 195
LLPS-Loa-0547Loxodonta africana36.961e-59 196
LLPS-Hos-1546Homo sapiens36.962e-59 195
LLPS-Pat-1244Pan troglodytes36.962e-59 195
LLPS-Urm-1206Ursus maritimus36.967e-59 195
LLPS-Pap-0932Pan paniscus36.962e-59 195
LLPS-Fec-0876Felis catus36.963e-59 195
LLPS-Nol-1007Nomascus leucogenys36.962e-59 195
LLPS-Ict-0641Ictidomys tridecemlineatus36.964e-59 194
LLPS-Cas-1611Carlito syrichta36.962e-59 195
LLPS-Mam-2157Macaca mulatta36.962e-59 195
LLPS-Poa-3345Pongo abelii36.962e-59 195
LLPS-Caf-1057Canis familiaris36.963e-59 195
LLPS-Cap-1036Cavia porcellus36.966e-59 194
LLPS-Eqc-0627Equus caballus36.683e-59 195
LLPS-Tut-1862Tursiops truncatus36.611e-34 129
LLPS-Sah-1112Sarcophilus harrisii36.586e-59 194
LLPS-Mea-0189Mesocricetus auratus36.583e-58 192
LLPS-Myl-0668Myotis lucifugus36.582e-58 193
LLPS-Ran-2435Rattus norvegicus36.582e-58 193
LLPS-Bot-0337Bos taurus36.582e-58 193
LLPS-Mod-0764Monodelphis domestica36.586e-59 194
LLPS-Osl-0317Ostreococcus lucimarinus36.547e-53 179
LLPS-Chc-0123Chondrus crispus36.431e-47 167
LLPS-Anp-0707Anas platyrhynchos34.732e-42 151
LLPS-Usm-1148Ustilago maydis34.271e-51 176
LLPS-Spr-0663Sporisorium reilianum33.685e-51 174