• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Gaa-1535

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Proliferating cell nuclear antigen
Ensembl Gene: ENSGACG00000005726.1
Ensembl Protein: ENSGACP00000007613.1
Organism: Gasterosteus aculeatus
Taxa ID: 69293
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, PcG body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSGACT00000007632.1ENSGACP00000007613.1
UniProtG3NQJ7, G3NQJ7_GASAC

▼ SEQUENCE

Protein Sequence (FASTA)
1     MFEARLVQGS  ILKKVLEALK  DLITEACWDV  SSSGISLQSM  DSSHVSLVQL  TLRHDGFDSY  60
61    RCDRNLAMGV  NLSSMSKILK  CAGNEDIITL  RAEDNADTLA  LVFETLNQEK  VSDYEMKLMD  120
121   LDVEQLGIPE  QEYSCVVKMP  SGEFARICRD  LSQIGDAVMI  SCAKDGVKFS  ASGELGTGNV  180
181   KLSQTSNVDK  EDEAVTIEMN  EPVQLIFALN  YLNFFTKATP  LSKTVTLSMS  ADIPLVVEYK  240
241   IADMGHVKYY  LAPKIDEEAS  260
Nucleotide CDS Sequence (FASTA)
1     ATGTTCGAGG  CTCGCCTGGT  CCAGGGCTCC  ATCCTGAAGA  AGGTGCTGGA  GGCGCTGAAG  60
61    GACCTGATCA  CGGAAGCCTG  CTGGGACGTC  AGCTCGTCCG  GCATCTCCCT  GCAGAGCATG  120
121   GACTCCTCTC  ACGTCTCTCT  GGTGCAGCTC  ACCTTGCGGC  ACGACGGCTT  CGACTCGTAC  180
181   CGCTGCGACA  GGAACCTCGC  CATGGGAGTC  AACCTGAGCA  GTATGTCCAA  AATCCTGAAG  240
241   TGTGCAGGAA  ACGAAGACAT  CATCACCCTC  CGAGCAGAAG  ACAATGCGGA  CACGCTCGCC  300
301   CTGGTGTTTG  AGACACTCAA  CCAGGAGAAA  GTGTCAGATT  ACGAGATGAA  GTTGATGGAC  360
361   CTGGATGTGG  AGCAGCTCGG  TATCCCAGAG  CAGGAGTACA  GCTGCGTGGT  GAAGATGCCC  420
421   TCCGGGGAGT  TTGCCCGTAT  CTGCCGTGAC  CTGTCCCAGA  TTGGCGACGC  CGTCATGATC  480
481   TCCTGCGCCA  AGGACGGAGT  CAAGTTCTCC  GCCTCCGGAG  AGCTCGGCAC  CGGAAACGTC  540
541   AAGCTGTCCC  AGACCAGCAA  CGTGGACAAA  GAGGACGAGG  CGGTCACCAT  TGAGATGAAC  600
601   GAGCCCGTCC  AGCTGATCTT  TGCCCTCAAC  TACTTGAACT  TCTTCACCAA  GGCGACGCCG  660
661   CTGTCCAAGA  CGGTGACCCT  CAGCATGTCG  GCCGACATCC  CCCTCGTGGT  GGAGTACAAG  720
721   ATCGCTGATA  TGGGACACGT  GAAATACTAC  CTGGCACCCA  AGATCGACGA  AGAAGCATCT  780
781   TAG  783

▼ KEYWORD

ID
Family
Complete proteome
DNA replication
DNA-binding
Nucleus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Molecular Function
DNA binding
Molecular Function
DNA polymerase processivity factor activity
Biological Process
DNA replication
Biological Process
Regulation of DNA replication
Biological Process
Response to activity
Biological Process
Response to bacterium

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pof-0735Poecilia formosa99.620.0 535
LLPS-Scm-1262Scophthalmus maximus99.620.0 533
LLPS-Xim-2102Xiphophorus maculatus99.230.0 533
LLPS-Orn-2844Oreochromis niloticus99.230.0 533
LLPS-Scf-2235Scleropages formosus98.460.0 527
LLPS-Dar-0442Danio rerio98.460.0 527
LLPS-Tar-0370Takifugu rubripes98.450.0 525
LLPS-Asm-0547Astyanax mexicanus98.080.0 526
LLPS-Icp-0014Ictalurus punctatus98.080.0 525
LLPS-Leo-1196Lepisosteus oculatus98.080.0 526
LLPS-Ten-0278Tetraodon nigroviridis97.670.0 523
LLPS-Orl-1281Oryzias latipes92.893e-169 477
LLPS-Tut-1862Tursiops truncatus91.984e-122 353
LLPS-Caj-3670Callithrix jacchus91.578e-177 494
LLPS-Gog-0796Gorilla gorilla91.578e-177 494
LLPS-Sus-0330Sus scrofa91.573e-176 494
LLPS-Aon-2545Aotus nancymaae91.578e-177 494
LLPS-Cea-0654Cercocebus atys91.578e-177 494
LLPS-Maf-0658Macaca fascicularis91.578e-177 494
LLPS-Chs-1834Chlorocebus sabaeus91.578e-177 494
LLPS-Paa-3371Papio anubis91.578e-177 494
LLPS-Mal-1583Mandrillus leucophaeus91.578e-177 494
LLPS-Ova-0204Ovis aries91.572e-176 494
LLPS-Aim-0289Ailuropoda melanoleuca91.572e-176 494
LLPS-Mup-0399Mustela putorius furo91.572e-176 494
LLPS-Rhb-0921Rhinopithecus bieti91.578e-177 494
LLPS-Otg-2882Otolemur garnettii91.578e-177 494
LLPS-Man-0271Macaca nemestrina91.578e-177 494
LLPS-Loa-0547Loxodonta africana91.575e-177 495
LLPS-Hos-1546Homo sapiens91.578e-177 494
LLPS-Pap-0932Pan paniscus91.578e-177 494
LLPS-Urm-1206Ursus maritimus91.572e-176 495
LLPS-Pat-1244Pan troglodytes91.578e-177 494
LLPS-Fec-0876Felis catus91.572e-176 494
LLPS-Nol-1007Nomascus leucogenys91.578e-177 494
LLPS-Cas-1611Carlito syrichta91.578e-177 494
LLPS-Mam-2157Macaca mulatta91.578e-177 494
LLPS-Caf-1057Canis familiaris91.572e-176 494
LLPS-Poa-3345Pongo abelii91.578e-177 494
LLPS-Eqc-0627Equus caballus91.572e-176 494
LLPS-Fud-3690Fukomys damarensis91.198e-176 492
LLPS-Myl-0668Myotis lucifugus91.199e-176 492
LLPS-Dio-0815Dipodomys ordii91.198e-176 492
LLPS-Bot-0337Bos taurus91.199e-176 492
LLPS-Orc-1467Oryctolagus cuniculus91.198e-176 492
LLPS-Ict-0641Ictidomys tridecemlineatus91.198e-176 492
LLPS-Xet-2647Xenopus tropicalis90.81e-174 489
LLPS-Cap-1036Cavia porcellus90.84e-175 490
LLPS-Meg-0220Meleagris gallopavo90.734e-136 389
LLPS-Lac-0313Latimeria chalumnae90.667e-176 492
LLPS-Mum-1776Mus musculus90.426e-175 490
LLPS-Mea-0189Mesocricetus auratus90.422e-174 488
LLPS-Ran-2435Rattus norvegicus90.426e-175 490
LLPS-Pes-0626Pelodiscus sinensis89.923e-174 488
LLPS-Tag-0150Taeniopygia guttata89.921e-173 487
LLPS-Sah-1112Sarcophilus harrisii89.582e-174 488
LLPS-Mod-0764Monodelphis domestica89.582e-174 488
LLPS-Fia-0430Ficedula albicollis89.532e-173 486
LLPS-Gaga-0381Gallus gallus89.533e-173 486
LLPS-Anc-0455Anolis carolinensis87.981e-170 479
LLPS-Anp-0707Anas platyrhynchos78.435e-138 396
LLPS-Cii-1210Ciona intestinalis74.034e-145 414
LLPS-Drm-0049Drosophila melanogaster68.875e-134 386
LLPS-Hea-2290Helianthus annuus64.345e-125 367
LLPS-Php-0319Physcomitrella patens64.341e-127 370
LLPS-Thc-1792Theobroma cacao63.956e-127 368
LLPS-Arl-0133Arabidopsis lyrata63.952e-127 369
LLPS-Gor-0245Gossypium raimondii63.953e-127 369
LLPS-Brn-0915Brassica napus63.572e-126 367
LLPS-Glm-2189Glycine max63.574e-124 361
LLPS-Sem-2348Selaginella moellendorffii63.573e-123 358
LLPS-Pot-0449Populus trichocarpa63.571e-124 362
LLPS-Art-1292Arabidopsis thaliana63.575e-127 369
LLPS-Coc-1342Corchorus capsularis63.476e-107 316
LLPS-Vir-0235Vigna radiata63.183e-124 361
LLPS-Cus-0706Cucumis sativus63.183e-124 362
LLPS-Via-0604Vigna angularis63.184e-124 361
LLPS-Mae-0704Manihot esculenta63.182e-125 365
LLPS-Amt-1156Amborella trichopoda63.183e-118 346
LLPS-Nia-0999Nicotiana attenuata63.189e-125 363
LLPS-Brr-0435Brassica rapa63.181e-125 365
LLPS-Phv-0661Phaseolus vulgaris63.146e-122 355
LLPS-Sol-2160Solanum lycopersicum62.793e-124 362
LLPS-Met-0160Medicago truncatula62.792e-122 357
LLPS-Sot-1610Solanum tuberosum62.793e-124 362
LLPS-Viv-1963Vitis vinifera62.792e-124 362
LLPS-Prp-0680Prunus persica62.792e-123 359
LLPS-Bro-1750Brassica oleracea62.42e-124 362
LLPS-Mua-1641Musa acuminata62.025e-123 358
LLPS-Dac-0037Daucus carota61.634e-123 358
LLPS-Brd-1581Brachypodium distachyon61.244e-122 356
LLPS-Tra-0178Triticum aestivum60.857e-121 353
LLPS-Orbr-1826Oryza brachyantha60.855e-122 355
LLPS-Orni-1391Oryza nivara60.472e-121 354
LLPS-Orb-1748Oryza barthii60.472e-121 354
LLPS-Ori-0624Oryza indica60.472e-121 354
LLPS-Sei-0594Setaria italica60.473e-119 348
LLPS-Orgl-0284Oryza glumaepatula60.472e-121 354
LLPS-Orp-0491Oryza punctata60.476e-121 353
LLPS-Ors-0622Oryza sativa60.472e-121 354
LLPS-Zem-0573Zea mays60.476e-120 350
LLPS-Org-0280Oryza glaberrima60.472e-121 354
LLPS-Orr-0390Oryza rufipogon60.472e-121 354
LLPS-Orm-0644Oryza meridionalis60.472e-121 354
LLPS-Lep-0196Leersia perrieri60.082e-120 352
LLPS-Sob-0496Sorghum bicolor60.082e-119 349
LLPS-Tru-0329Triticum urartu59.821e-101 302
LLPS-Chr-0018Chlamydomonas reinhardtii59.698e-118 345
LLPS-Hov-1519Hordeum vulgare57.723e-59 192
LLPS-Gas-0805Galdieria sulphuraria55.088e-103 307
LLPS-Osl-0317Ostreococcus lucimarinus54.831e-103 309
LLPS-Tum-0834Tuber melanosporum54.655e-101 303
LLPS-Abg-0099Absidia glauca54.652e-102 306
LLPS-Miv-1410Microbotryum violaceum53.127e-1475.1
LLPS-Scj-1098Schizosaccharomyces japonicus53.12e-101 303
LLPS-Beb-0478Beauveria bassiana51.946e-96 289
LLPS-Asc-0079Aspergillus clavatus51.557e-98 294
LLPS-Nec-0426Neurospora crassa51.552e-95 288
LLPS-Scp-1076Schizosaccharomyces pombe51.557e-99 296
LLPS-Crn-0977Cryptococcus neoformans51.227e-70 225
LLPS-Mao-0806Magnaporthe oryzae51.161e-94 286
LLPS-Asni-1152Aspergillus niger51.169e-95 289
LLPS-Aso-0761Aspergillus oryzae51.162e-96 290
LLPS-Lem-1133Leptosphaeria maculans51.165e-97 294
LLPS-Ast-0687Aspergillus terreus51.143e-82 253
LLPS-Phn-0022Phaeosphaeria nodorum51.147e-82 252
LLPS-Asfu-0645Aspergillus fumigatus51.144e-81 250
LLPS-Map-0575Magnaporthe poae50.787e-94 284
LLPS-Scc-0465Schizosaccharomyces cryophilus50.781e-96 291
LLPS-Asf-0209Aspergillus flavus50.786e-90 290
LLPS-Pug-0394Puccinia graminis50.757e-1474.7
LLPS-Put-0046Puccinia triticina50.756e-1474.7
LLPS-Nef-1313Neosartorya fischeri50.596e-95 286
LLPS-Pyt-0139Pyrenophora teres50.581e-94 289
LLPS-Gag-1399Gaeumannomyces graminis50.393e-93 282
LLPS-Coo-1258Colletotrichum orbiculare50.03e-92 280
LLPS-Fus-0555Fusarium solani49.612e-90 276
LLPS-Cym-0190Cyanidioschyzon merolae49.225e-90 274
LLPS-Blg-1362Blumeria graminis49.229e-91 276
LLPS-Trr-0914Trichoderma reesei49.224e-93 282
LLPS-Ved-0801Verticillium dahliae48.851e-85 263
LLPS-Cog-0877Colletotrichum gloeosporioides48.844e-91 277
LLPS-Trv-0912Trichoderma virens48.842e-92 280
LLPS-Zyt-1103Zymoseptoria tritici48.456e-93 281
LLPS-Cogr-0102Colletotrichum graminicola48.434e-89 271
LLPS-Mel-0891Melampsora laricipopulina48.092e-92 280
LLPS-Fuv-1069Fusarium verticillioides48.064e-90 274
LLPS-Dos-0772Dothistroma septosporum48.062e-92 280
LLPS-Fuo-0513Fusarium oxysporum48.065e-91 276
LLPS-Cae-1284Caenorhabditis elegans47.497e-87 266
LLPS-Chc-0123Chondrus crispus45.742e-77 244
LLPS-Usm-1148Ustilago maydis44.795e-82 254
LLPS-Yal-0467Yarrowia lipolytica44.713e-76 239
LLPS-Spr-0663Sporisorium reilianum44.482e-81 253
LLPS-Asg-0815Ashbya gossypii39.531e-69 221
LLPS-Kop-0594Komagataella pastoris38.133e-61 200
LLPS-Sac-1163Saccharomyces cerevisiae34.112e-57 191
LLPS-Ora-1968Ornithorhynchus anatinus33.033e-27 110