• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orn-2844
pcna

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Proliferating cell nuclear antigen
Gene Name: pcna
Ensembl Gene: ENSONIG00000014433.1
Ensembl Protein: ENSONIP00000018147.1
Organism: Oreochromis niloticus
Taxa ID: 8128
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, PcG body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MFEARLVQGS  ILKKVLEALK  DLITEACWDV  SSSGISLQSM  DSSHVSLVQL  TLRHDGFDSY  60
61    RCDRNLAMGV  NLSSMSKILK  CAGNEDIITL  RAEDNADTLA  LVFETLNQEK  VSDYEMKLMD  120
121   LDVEQLGIPE  QEYSCVVKMP  SGEFARICRD  LSQIGDAVMI  SCAKDGVKFS  ASGELGTGNI  180
181   KLSQTSNVDK  EDEAVTIEMN  EPVQLIFALN  YLNFFTKATP  LSKTVTLSMS  ADIPLVVEYK  240
241   IADMGHIKYY  LAPKIDEEAS  260
Nucleotide CDS Sequence (FASTA)
1     ATGTTCGAGG  CTCGCCTGGT  CCAGGGCTCC  ATCCTGAAGA  AGGTGCTGGA  GGCTCTGAAG  60
61    GATCTGATCA  CAGAAGCCTG  CTGGGACGTC  AGCTCGTCCG  GCATCTCCCT  GCAGAGCATG  120
121   GACTCCTCTC  ACGTCTCCCT  GGTGCAGCTC  ACCCTGCGGC  ACGATGGCTT  CGACTCGTAC  180
181   CGCTGCGATA  GGAACCTCGC  CATGGGAGTC  AACCTGAGCA  GTATGTCAAA  AATCTTGAAG  240
241   TGTGCCGGAA  ATGAAGACAT  CATCACCCTC  AGAGCAGAAG  ACAATGCAGA  CACGCTCGCT  300
301   CTCGTCTTTG  AGACTCTCAA  CCAGGAGAAG  GTGTCAGATT  ATGAGATGAA  GCTGATGGAC  360
361   CTGGATGTGG  AGCAGCTTGG  TATTCCGGAG  CAGGAGTACA  GCTGTGTGGT  GAAGATGCCC  420
421   TCCGGGGAGT  TCGCTCGCAT  CTGCCGTGAC  CTTTCACAGA  TCGGCGACGC  CGTCATGATC  480
481   TCCTGCGCCA  AGGATGGAGT  CAAGTTCTCC  GCCTCAGGCG  AGCTGGGCAC  AGGAAACATC  540
541   AAGCTGTCCC  AGACCAGCAA  TGTGGACAAA  GAGGACGAGG  CTGTTACGAT  TGAGATGAAT  600
601   GAACCCGTCC  AGCTGATCTT  TGCCCTCAAC  TACCTGAACT  TCTTCACCAA  GGCCACGCCG  660
661   CTCTCCAAGA  CCGTCACCCT  CAGCATGTCC  GCTGATATCC  CCCTGGTGGT  GGAGTACAAG  720
721   ATTGCTGACA  TGGGGCACAT  CAAATACTAC  CTGGCACCGA  AGATCGATGA  GGAGGCTTCT  780
781   TAA  783

▼ KEYWORD

ID
Family
Complete proteome
DNA replication
DNA-binding
Nucleus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Molecular Function
DNA binding
Molecular Function
DNA polymerase processivity factor activity
Biological Process
DNA replication
Biological Process
Regulation of DNA replication
Biological Process
Response to activity
Biological Process
Response to bacterium

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Xim-2102Xiphophorus maculatus100.00.0 534
LLPS-Pof-0735Poecilia formosa99.620.0 535
LLPS-Gaa-1535Gasterosteus aculeatus99.230.0 533
LLPS-Scm-1262Scophthalmus maximus98.850.0 531
LLPS-Icp-0014Ictalurus punctatus98.850.0 526
LLPS-Dar-0442Danio rerio98.460.0 526
LLPS-Tar-0370Takifugu rubripes98.450.0 525
LLPS-Asm-0547Astyanax mexicanus98.080.0 526
LLPS-Leo-1196Lepisosteus oculatus98.080.0 526
LLPS-Scf-2235Scleropages formosus97.690.0 525
LLPS-Ten-0278Tetraodon nigroviridis97.670.0 523
LLPS-Orl-1281Oryzias latipes92.893e-169 477
LLPS-Tut-1862Tursiops truncatus92.512e-122 354
LLPS-Nol-1007Nomascus leucogenys91.954e-177 495
LLPS-Cas-1611Carlito syrichta91.954e-177 495
LLPS-Mam-2157Macaca mulatta91.954e-177 495
LLPS-Eqc-0627Equus caballus91.956e-177 495
LLPS-Poa-3345Pongo abelii91.954e-177 495
LLPS-Caf-1057Canis familiaris91.957e-177 495
LLPS-Rhb-0921Rhinopithecus bieti91.954e-177 495
LLPS-Otg-2882Otolemur garnettii91.954e-177 495
LLPS-Loa-0547Loxodonta africana91.953e-177 496
LLPS-Man-0271Macaca nemestrina91.954e-177 495
LLPS-Fec-0876Felis catus91.957e-177 495
LLPS-Hos-1546Homo sapiens91.954e-177 495
LLPS-Pat-1244Pan troglodytes91.954e-177 495
LLPS-Urm-1206Ursus maritimus91.951e-176 496
LLPS-Pap-0932Pan paniscus91.954e-177 495
LLPS-Mup-0399Mustela putorius furo91.957e-177 495
LLPS-Aim-0289Ailuropoda melanoleuca91.957e-177 495
LLPS-Ova-0204Ovis aries91.951e-176 494
LLPS-Paa-3371Papio anubis91.954e-177 495
LLPS-Mal-1583Mandrillus leucophaeus91.954e-177 495
LLPS-Caj-3670Callithrix jacchus91.954e-177 495
LLPS-Gog-0796Gorilla gorilla91.954e-177 495
LLPS-Sus-0330Sus scrofa91.951e-176 495
LLPS-Cea-0654Cercocebus atys91.954e-177 495
LLPS-Aon-2545Aotus nancymaae91.954e-177 495
LLPS-Chs-1834Chlorocebus sabaeus91.954e-177 495
LLPS-Maf-0658Macaca fascicularis91.954e-177 495
LLPS-Ict-0641Ictidomys tridecemlineatus91.573e-176 493
LLPS-Orc-1467Oryctolagus cuniculus91.573e-176 493
LLPS-Myl-0668Myotis lucifugus91.575e-176 493
LLPS-Bot-0337Bos taurus91.575e-176 493
LLPS-Dio-0815Dipodomys ordii91.573e-176 493
LLPS-Fud-3690Fukomys damarensis91.573e-176 493
LLPS-Meg-0220Meleagris gallopavo91.223e-136 390
LLPS-Cap-1036Cavia porcellus91.191e-175 491
LLPS-Ran-2435Rattus norvegicus90.83e-175 491
LLPS-Mum-1776Mus musculus90.83e-175 491
LLPS-Mea-0189Mesocricetus auratus90.88e-175 489
LLPS-Lac-0313Latimeria chalumnae90.669e-176 492
LLPS-Tag-0150Taeniopygia guttata90.314e-174 488
LLPS-Pes-0626Pelodiscus sinensis90.311e-174 489
LLPS-Xet-2647Xenopus tropicalis90.043e-174 488
LLPS-Gaga-0381Gallus gallus89.921e-173 487
LLPS-Fia-0430Ficedula albicollis89.928e-174 487
LLPS-Mod-0764Monodelphis domestica89.193e-174 488
LLPS-Sah-1112Sarcophilus harrisii89.193e-174 488
LLPS-Anc-0455Anolis carolinensis88.376e-171 480
LLPS-Anp-0707Anas platyrhynchos78.823e-138 397
LLPS-Cii-1210Ciona intestinalis74.813e-145 415
LLPS-Drm-0049Drosophila melanogaster69.652e-134 387
LLPS-Php-0319Physcomitrella patens65.125e-128 371
LLPS-Gor-0245Gossypium raimondii64.731e-127 370
LLPS-Arl-0133Arabidopsis lyrata64.739e-128 370
LLPS-Thc-1792Theobroma cacao64.732e-127 369
LLPS-Coc-1342Corchorus capsularis64.383e-107 317
LLPS-Art-1292Arabidopsis thaliana64.342e-127 369
LLPS-Hea-2290Helianthus annuus64.345e-125 367
LLPS-Brn-0915Brassica napus64.345e-127 368
LLPS-Nia-0999Nicotiana attenuata63.954e-125 363
LLPS-Mae-0704Manihot esculenta63.956e-126 366
LLPS-Brr-0435Brassica rapa63.955e-126 366
LLPS-Prp-0680Prunus persica63.577e-124 360
LLPS-Amt-1156Amborella trichopoda63.572e-118 347
LLPS-Pot-0449Populus trichocarpa63.572e-124 362
LLPS-Viv-1963Vitis vinifera63.579e-125 363
LLPS-Sem-2348Selaginella moellendorffii63.574e-123 358
LLPS-Glm-2189Glycine max63.573e-124 361
LLPS-Bro-1750Brassica oleracea63.187e-125 363
LLPS-Vir-0235Vigna radiata63.183e-124 362
LLPS-Cus-0706Cucumis sativus63.183e-124 361
LLPS-Via-0604Vigna angularis63.184e-124 361
LLPS-Phv-0661Phaseolus vulgaris63.146e-122 355
LLPS-Met-0160Medicago truncatula62.792e-122 357
LLPS-Sot-1610Solanum tuberosum62.792e-124 362
LLPS-Mua-1641Musa acuminata62.792e-123 359
LLPS-Sol-2160Solanum lycopersicum62.792e-124 362
LLPS-Dac-0037Daucus carota62.41e-123 360
LLPS-Brd-1581Brachypodium distachyon62.022e-122 357
LLPS-Orbr-1826Oryza brachyantha61.632e-122 357
LLPS-Tra-0178Triticum aestivum61.633e-121 354
LLPS-Org-0280Oryza glaberrima61.241e-121 355
LLPS-Zem-0573Zea mays61.242e-120 352
LLPS-Orr-0390Oryza rufipogon61.241e-121 355
LLPS-Orm-0644Oryza meridionalis61.241e-121 355
LLPS-Orp-0491Oryza punctata61.243e-121 354
LLPS-Ors-0622Oryza sativa61.241e-121 355
LLPS-Sei-0594Setaria italica61.249e-120 350
LLPS-Orgl-0284Oryza glumaepatula61.241e-121 355
LLPS-Orni-1391Oryza nivara61.241e-121 355
LLPS-Ori-0624Oryza indica61.241e-121 355
LLPS-Orb-1748Oryza barthii61.241e-121 355
LLPS-Sob-0496Sorghum bicolor60.856e-120 350
LLPS-Lep-0196Leersia perrieri60.858e-121 353
LLPS-Tru-0329Triticum urartu60.735e-102 303
LLPS-Chr-0018Chlamydomonas reinhardtii58.912e-117 344
LLPS-Hov-1519Hordeum vulgare57.722e-59 192
LLPS-Osl-0317Ostreococcus lucimarinus54.839e-104 309
LLPS-Miv-1410Microbotryum violaceum54.694e-1475.9
LLPS-Gas-0805Galdieria sulphuraria54.691e-102 307
LLPS-Abg-0099Absidia glauca54.652e-102 306
LLPS-Tum-0834Tuber melanosporum53.881e-100 302
LLPS-Scj-1098Schizosaccharomyces japonicus53.12e-101 303
LLPS-Nec-0426Neurospora crassa51.949e-96 288
LLPS-Beb-0478Beauveria bassiana51.557e-96 289
LLPS-Scp-1076Schizosaccharomyces pombe51.557e-99 296
LLPS-Asc-0079Aspergillus clavatus51.169e-98 294
LLPS-Aso-0761Aspergillus oryzae50.782e-96 290
LLPS-Lem-1133Leptosphaeria maculans50.787e-97 294
LLPS-Mao-0806Magnaporthe oryzae50.783e-94 285
LLPS-Asni-1152Aspergillus niger50.781e-94 288
LLPS-Scc-0465Schizosaccharomyces cryophilus50.781e-96 291
LLPS-Crn-0977Cryptococcus neoformans50.731e-69 225
LLPS-Phn-0022Phaeosphaeria nodorum50.689e-82 251
LLPS-Asfu-0645Aspergillus fumigatus50.684e-81 249
LLPS-Ast-0687Aspergillus terreus50.684e-82 253
LLPS-Asf-0209Aspergillus flavus50.397e-90 289
LLPS-Map-0575Magnaporthe poae50.397e-94 284
LLPS-Nef-1313Neosartorya fischeri50.26e-95 286
LLPS-Pyt-0139Pyrenophora teres50.191e-94 289
LLPS-Gag-1399Gaeumannomyces graminis50.03e-93 282
LLPS-Coo-1258Colletotrichum orbiculare49.614e-92 280
LLPS-Put-0046Puccinia triticina49.259e-1473.9
LLPS-Pug-0394Puccinia graminis49.251e-1374.3
LLPS-Fus-0555Fusarium solani49.213e-90 275
LLPS-Trr-0914Trichoderma reesei48.846e-93 281
LLPS-Blg-1362Blumeria graminis48.849e-91 276
LLPS-Cym-0190Cyanidioschyzon merolae48.847e-90 274
LLPS-Ved-0801Verticillium dahliae48.462e-85 262
LLPS-Trv-0912Trichoderma virens48.453e-92 280
LLPS-Cog-0877Colletotrichum gloeosporioides48.454e-91 277
LLPS-Zyt-1103Zymoseptoria tritici48.067e-93 281
LLPS-Cogr-0102Colletotrichum graminicola48.035e-89 271
LLPS-Dos-0772Dothistroma septosporum47.672e-92 280
LLPS-Fuo-0513Fusarium oxysporum47.675e-91 276
LLPS-Fuv-1069Fusarium verticillioides47.675e-90 274
LLPS-Mel-0891Melampsora laricipopulina47.335e-92 279
LLPS-Cae-1284Caenorhabditis elegans47.19e-87 266
LLPS-Chc-0123Chondrus crispus45.353e-77 244
LLPS-Usm-1148Ustilago maydis44.447e-82 254
LLPS-Yal-0467Yarrowia lipolytica44.315e-76 238
LLPS-Spr-0663Sporisorium reilianum44.142e-81 253
LLPS-Asg-0815Ashbya gossypii39.152e-69 221
LLPS-Kop-0594Komagataella pastoris38.521e-61 201
LLPS-Ora-1968Ornithorhynchus anatinus33.941e-27 111
LLPS-Sac-1163Saccharomyces cerevisiae33.723e-57 190