LLPS-Pat-1244
PCNA
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Proliferating cell nuclear antigen |
| Gene Name: | PCNA, CK820_G0017530 |
| Ensembl Gene: | ENSPTRG00000013222.4 |
| Ensembl Protein: | ENSPTRP00000022674.2 |
| Organism: | Pan troglodytes |
| Taxa ID: | 9598 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, PcG body, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSPTRT00000024578.3 | ENSPTRP00000022674.2 |
| UniProt | H2QJX3, H2QJX3_PANTR, A0A2J8MSJ1 | |
| GeneBank | GABC01009690, GABF01006002, GABD01004837, NBAG03000245, GABF01006001, GABD01004838, AACZ04064986 | , JAA28262.1, JAA16143.1, PNI62496.1, JAA01648.1, JAA28263.1, PNI62497.1, JAA16144.1 |
| RefSeq | XM_001165515.4 | XP_001165515.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MFEARLVQGS ILKKVLEALK DLINEACWDI SSSGVNLQSM DSSHVSLVQL TLRSEGFDTY 60 61 RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVFEAPNQEK VSDYEMKLMD 120 121 LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSHIGDAVVI SCAKDGVKFS ASGELGNGNI 180 181 KLSQTSNVDK EEEAVTIEMN EPVQLTFALR YLNFFTKATP LSSTVTLSMS ADVPLVVEYK 240 241 IADMGHLKYY LAPKIEDEEG S 261 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTTCGAGG CGCGCCTGGT CCAGGGCTCC ATCCTCAAGA AGGTGTTGGA GGCACTCAAG 60 61 GACCTCATCA ACGAGGCCTG CTGGGACATT AGCTCCAGCG GCGTAAACCT GCAGAGCATG 120 121 GACTCGTCCC ACGTCTCTTT GGTGCAGCTC ACCCTGCGGT CTGAGGGCTT CGACACCTAC 180 181 CGCTGCGACC GCAACCTGGC CATGGGCGTG AACCTCACCA GTATGTCCAA AATCCTCAAA 240 241 TGCGCCGGCA ATGAAGATAT CATTACACTA AGGGCCGAAG ATAACGCGGA TACCTTGGCG 300 301 CTGGTATTTG AAGCACCAAA CCAGGAGAAA GTTTCAGACT ATGAAATGAA GTTGATGGAC 360 361 TTAGATGTTG AACAACTTGG AATTCCAGAA CAGGAGTACA GCTGTGTAGT AAAGATGCCT 420 421 TCTGGTGAAT TTGCACGTAT ATGCCGAGAT CTCAGCCATA TTGGAGATGC TGTTGTAATT 480 481 TCCTGTGCAA AAGACGGAGT GAAATTTTCT GCAAGTGGAG AACTTGGAAA TGGAAACATT 540 541 AAATTGTCAC AGACAAGTAA TGTCGATAAA GAGGAGGAAG CTGTTACCAT AGAGATGAAT 600 601 GAACCAGTTC AACTAACTTT TGCACTGAGG TACCTGAACT TCTTTACAAA AGCCACTCCA 660 661 CTCTCTTCAA CGGTGACACT CAGTATGTCT GCAGATGTAC CCCTTGTTGT AGAGTATAAA 720 721 ATTGCTGATA TGGGACACTT AAAATACTAC TTGGCTCCCA AGATCGAGGA TGAAGAAGGA 780 781 TCTTAG 786 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Centrosome | |
Cellular Component | Chromatin | |
Cellular Component | Nuclear body | |
Cellular Component | Nuclear replication fork | |
Cellular Component | Nucleus | |
Cellular Component | PCNA complex | |
Cellular Component | PCNA-p21 complex | |
Molecular Function | Chromatin binding | |
Molecular Function | Damaged DNA binding | |
Molecular Function | Dinucleotide insertion or deletion binding | |
Molecular Function | DNA polymerase binding | |
Molecular Function | DNA polymerase processivity factor activity | |
Molecular Function | Histone acetyltransferase binding | |
Molecular Function | Identical protein binding | |
Molecular Function | MutLalpha complex binding | |
Molecular Function | Purine-specific mismatch base pair DNA N-glycosylase activity | |
Molecular Function | Receptor tyrosine kinase binding | |
Biological Process | Cellular response to UV | |
Biological Process | Epithelial cell differentiation | |
Biological Process | Leading strand elongation | |
Biological Process | Mismatch repair | |
Biological Process | Positive regulation of deoxyribonuclease activity | |
Biological Process | Positive regulation of DNA repair | |
Biological Process | Positive regulation of DNA replication | |
Biological Process | Translesion synthesis |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Paa-3371 | Papio anubis | 100.0 | 0.0 | 537 |
| LLPS-Mal-1583 | Mandrillus leucophaeus | 100.0 | 0.0 | 537 |
| LLPS-Gog-0796 | Gorilla gorilla | 100.0 | 0.0 | 537 |
| LLPS-Caj-3670 | Callithrix jacchus | 100.0 | 0.0 | 537 |
| LLPS-Chs-1834 | Chlorocebus sabaeus | 100.0 | 0.0 | 537 |
| LLPS-Maf-0658 | Macaca fascicularis | 100.0 | 0.0 | 537 |
| LLPS-Cea-0654 | Cercocebus atys | 100.0 | 0.0 | 537 |
| LLPS-Aon-2545 | Aotus nancymaae | 100.0 | 0.0 | 537 |
| LLPS-Cas-1611 | Carlito syrichta | 100.0 | 0.0 | 537 |
| LLPS-Nol-1007 | Nomascus leucogenys | 100.0 | 0.0 | 537 |
| LLPS-Poa-3345 | Pongo abelii | 100.0 | 0.0 | 537 |
| LLPS-Mam-2157 | Macaca mulatta | 100.0 | 0.0 | 537 |
| LLPS-Otg-2882 | Otolemur garnettii | 100.0 | 0.0 | 537 |
| LLPS-Rhb-0921 | Rhinopithecus bieti | 100.0 | 0.0 | 537 |
| LLPS-Hos-1546 | Homo sapiens | 100.0 | 0.0 | 537 |
| LLPS-Pap-0932 | Pan paniscus | 100.0 | 0.0 | 537 |
| LLPS-Man-0271 | Macaca nemestrina | 100.0 | 0.0 | 537 |
| LLPS-Mup-0399 | Mustela putorius furo | 99.62 | 0.0 | 535 |
| LLPS-Aim-0289 | Ailuropoda melanoleuca | 99.62 | 0.0 | 535 |
| LLPS-Ova-0204 | Ovis aries | 99.62 | 0.0 | 535 |
| LLPS-Sus-0330 | Sus scrofa | 99.62 | 0.0 | 534 |
| LLPS-Caf-1057 | Canis familiaris | 99.62 | 0.0 | 535 |
| LLPS-Fec-0876 | Felis catus | 99.62 | 0.0 | 535 |
| LLPS-Urm-1206 | Ursus maritimus | 99.62 | 0.0 | 536 |
| LLPS-Myl-0668 | Myotis lucifugus | 99.23 | 0.0 | 533 |
| LLPS-Bot-0337 | Bos taurus | 99.23 | 0.0 | 533 |
| LLPS-Dio-0815 | Dipodomys ordii | 99.23 | 0.0 | 533 |
| LLPS-Fud-3690 | Fukomys damarensis | 99.23 | 0.0 | 533 |
| LLPS-Ict-0641 | Ictidomys tridecemlineatus | 99.23 | 0.0 | 533 |
| LLPS-Orc-1467 | Oryctolagus cuniculus | 99.23 | 0.0 | 533 |
| LLPS-Loa-0547 | Loxodonta africana | 99.23 | 0.0 | 534 |
| LLPS-Tut-1862 | Tursiops truncatus | 98.93 | 1e-133 | 382 |
| LLPS-Cap-1036 | Cavia porcellus | 98.85 | 0.0 | 532 |
| LLPS-Eqc-0627 | Equus caballus | 98.85 | 0.0 | 532 |
| LLPS-Ran-2435 | Rattus norvegicus | 98.47 | 0.0 | 531 |
| LLPS-Mea-0189 | Mesocricetus auratus | 98.47 | 0.0 | 530 |
| LLPS-Mum-1776 | Mus musculus | 96.93 | 0.0 | 526 |
| LLPS-Sah-1112 | Sarcophilus harrisii | 96.55 | 0.0 | 522 |
| LLPS-Mod-0764 | Monodelphis domestica | 96.55 | 0.0 | 522 |
| LLPS-Pes-0626 | Pelodiscus sinensis | 94.59 | 0.0 | 513 |
| LLPS-Gaga-0381 | Gallus gallus | 94.27 | 0.0 | 511 |
| LLPS-Fia-0430 | Ficedula albicollis | 94.27 | 0.0 | 512 |
| LLPS-Tag-0150 | Taeniopygia guttata | 94.21 | 0.0 | 511 |
| LLPS-Meg-0220 | Meleagris gallopavo | 94.15 | 8e-142 | 404 |
| LLPS-Leo-1196 | Lepisosteus oculatus | 93.02 | 2e-178 | 499 |
| LLPS-Lac-0313 | Latimeria chalumnae | 92.31 | 4e-180 | 503 |
| LLPS-Asm-0547 | Astyanax mexicanus | 92.25 | 7e-178 | 498 |
| LLPS-Xim-2102 | Xiphophorus maculatus | 91.95 | 4e-177 | 495 |
| LLPS-Orn-2844 | Oreochromis niloticus | 91.95 | 4e-177 | 495 |
| LLPS-Scm-1262 | Scophthalmus maximus | 91.95 | 2e-177 | 496 |
| LLPS-Scf-2212 | Scleropages formosus | 91.86 | 3e-178 | 498 |
| LLPS-Icp-0014 | Ictalurus punctatus | 91.86 | 4e-176 | 494 |
| LLPS-Dar-0442 | Danio rerio | 91.86 | 6e-177 | 495 |
| LLPS-Gaa-1535 | Gasterosteus aculeatus | 91.57 | 8e-177 | 494 |
| LLPS-Pof-0735 | Poecilia formosa | 91.57 | 2e-176 | 495 |
| LLPS-Tar-0370 | Takifugu rubripes | 91.09 | 2e-175 | 491 |
| LLPS-Anc-0455 | Anolis carolinensis | 90.8 | 1e-177 | 497 |
| LLPS-Xet-2647 | Xenopus tropicalis | 90.42 | 7e-179 | 500 |
| LLPS-Ten-0278 | Tetraodon nigroviridis | 90.31 | 1e-174 | 489 |
| LLPS-Orl-1281 | Oryzias latipes | 89.11 | 1e-158 | 450 |
| LLPS-Anp-0707 | Anas platyrhynchos | 82.24 | 2e-146 | 418 |
| LLPS-Cii-1210 | Ciona intestinalis | 74.9 | 4e-149 | 424 |
| LLPS-Drm-0049 | Drosophila melanogaster | 71.04 | 2e-138 | 397 |
| LLPS-Php-0319 | Physcomitrella patens | 67.57 | 2e-133 | 385 |
| LLPS-Gor-0245 | Gossypium raimondii | 67.18 | 2e-133 | 385 |
| LLPS-Coc-1342 | Corchorus capsularis | 66.82 | 3e-112 | 330 |
| LLPS-Arl-0133 | Arabidopsis lyrata | 66.41 | 2e-132 | 382 |
| LLPS-Amt-1156 | Amborella trichopoda | 66.41 | 2e-124 | 362 |
| LLPS-Hea-2290 | Helianthus annuus | 66.02 | 5e-129 | 377 |
| LLPS-Thc-1792 | Theobroma cacao | 66.02 | 3e-131 | 379 |
| LLPS-Glm-2189 | Glycine max | 66.02 | 2e-129 | 375 |
| LLPS-Brn-0915 | Brassica napus | 66.02 | 7e-132 | 381 |
| LLPS-Prp-0680 | Prunus persica | 66.02 | 8e-130 | 375 |
| LLPS-Nia-0999 | Nicotiana attenuata | 66.02 | 3e-130 | 377 |
| LLPS-Mae-0704 | Manihot esculenta | 66.02 | 3e-131 | 379 |
| LLPS-Art-1292 | Arabidopsis thaliana | 66.02 | 5e-132 | 381 |
| LLPS-Pot-0914 | Populus trichocarpa | 66.02 | 1e-130 | 378 |
| LLPS-Phv-0661 | Phaseolus vulgaris | 65.88 | 3e-127 | 369 |
| LLPS-Cus-0706 | Cucumis sativus | 65.64 | 6e-130 | 376 |
| LLPS-Sot-1610 | Solanum tuberosum | 65.64 | 2e-130 | 377 |
| LLPS-Sol-2160 | Solanum lycopersicum | 65.64 | 2e-130 | 377 |
| LLPS-Brr-0435 | Brassica rapa | 65.64 | 6e-131 | 379 |
| LLPS-Viv-1963 | Vitis vinifera | 65.64 | 6e-130 | 376 |
| LLPS-Vir-0235 | Vigna radiata | 65.25 | 2e-128 | 372 |
| LLPS-Via-0604 | Vigna angularis | 65.25 | 2e-128 | 372 |
| LLPS-Dac-0037 | Daucus carota | 64.86 | 2e-129 | 375 |
| LLPS-Bro-1750 | Brassica oleracea | 64.86 | 7e-130 | 376 |
| LLPS-Met-0160 | Medicago truncatula | 64.48 | 1e-126 | 368 |
| LLPS-Sem-1853 | Selaginella moellendorffii | 64.37 | 4e-127 | 369 |
| LLPS-Brd-1581 | Brachypodium distachyon | 63.32 | 4e-126 | 366 |
| LLPS-Mua-1641 | Musa acuminata | 63.32 | 4e-126 | 366 |
| LLPS-Zem-1883 | Zea mays | 62.93 | 8e-125 | 363 |
| LLPS-Tru-0329 | Triticum urartu | 62.73 | 1e-106 | 315 |
| LLPS-Tra-0178 | Triticum aestivum | 62.55 | 1e-124 | 362 |
| LLPS-Orbr-1826 | Oryza brachyantha | 62.55 | 7e-126 | 365 |
| LLPS-Sei-0594 | Setaria italica | 62.16 | 2e-123 | 360 |
| LLPS-Orgl-0284 | Oryza glumaepatula | 62.16 | 1e-124 | 363 |
| LLPS-Orni-1391 | Oryza nivara | 62.16 | 1e-124 | 363 |
| LLPS-Ori-0624 | Oryza indica | 62.16 | 1e-124 | 363 |
| LLPS-Orb-1748 | Oryza barthii | 62.16 | 1e-124 | 363 |
| LLPS-Org-0280 | Oryza glaberrima | 62.16 | 1e-124 | 363 |
| LLPS-Orm-0644 | Oryza meridionalis | 62.16 | 1e-124 | 363 |
| LLPS-Orr-0390 | Oryza rufipogon | 62.16 | 1e-124 | 363 |
| LLPS-Sob-0496 | Sorghum bicolor | 62.16 | 1e-123 | 360 |
| LLPS-Ors-0622 | Oryza sativa | 62.16 | 1e-124 | 363 |
| LLPS-Orp-0491 | Oryza punctata | 62.16 | 1e-124 | 362 |
| LLPS-Lep-0196 | Leersia perrieri | 61.78 | 3e-124 | 361 |
| LLPS-Hov-1519 | Hordeum vulgare | 59.06 | 2e-61 | 197 |
| LLPS-Chr-0018 | Chlamydomonas reinhardtii | 58.3 | 3e-116 | 341 |
| LLPS-Miv-1410 | Microbotryum violaceum | 57.81 | 2e-15 | 80.1 |
| LLPS-Tum-0834 | Tuber melanosporum | 55.6 | 7e-103 | 308 |
| LLPS-Osl-0317 | Ostreococcus lucimarinus | 55.17 | 3e-106 | 316 |
| LLPS-Abg-0099 | Absidia glauca | 55.04 | 2e-102 | 306 |
| LLPS-Ast-0687 | Aspergillus terreus | 55.0 | 5e-88 | 268 |
| LLPS-Nec-0426 | Neurospora crassa | 54.83 | 3e-101 | 303 |
| LLPS-Asfu-0645 | Aspergillus fumigatus | 54.55 | 1e-86 | 264 |
| LLPS-Asc-0079 | Aspergillus clavatus | 54.05 | 4e-103 | 308 |
| LLPS-Gas-0805 | Galdieria sulphuraria | 53.91 | 7e-102 | 305 |
| LLPS-Put-0046 | Puccinia triticina | 53.85 | 4e-15 | 78.2 |
| LLPS-Pug-0394 | Puccinia graminis | 53.85 | 8e-15 | 77.4 |
| LLPS-Aso-0761 | Aspergillus oryzae | 53.67 | 2e-101 | 303 |
| LLPS-Beb-0478 | Beauveria bassiana | 53.67 | 4e-100 | 300 |
| LLPS-Scj-1098 | Schizosaccharomyces japonicus | 53.64 | 1e-102 | 306 |
| LLPS-Phn-0022 | Phaeosphaeria nodorum | 53.64 | 2e-85 | 261 |
| LLPS-Asf-0209 | Aspergillus flavus | 53.28 | 1e-94 | 302 |
| LLPS-Mao-0806 | Magnaporthe oryzae | 52.9 | 7e-99 | 296 |
| LLPS-Pyt-0139 | Pyrenophora teres | 52.69 | 3e-98 | 298 |
| LLPS-Nef-1313 | Neosartorya fischeri | 52.55 | 7e-99 | 296 |
| LLPS-Lem-1133 | Leptosphaeria maculans | 52.51 | 7e-100 | 301 |
| LLPS-Asni-1152 | Aspergillus niger | 52.51 | 1e-98 | 298 |
| LLPS-Blg-1362 | Blumeria graminis | 51.74 | 3e-95 | 287 |
| LLPS-Trr-0914 | Trichoderma reesei | 51.74 | 2e-98 | 295 |
| LLPS-Scp-1076 | Schizosaccharomyces pombe | 51.72 | 1e-99 | 299 |
| LLPS-Fus-0555 | Fusarium solani | 51.57 | 5e-95 | 287 |
| LLPS-Map-0575 | Magnaporthe poae | 51.35 | 3e-96 | 290 |
| LLPS-Trv-0912 | Trichoderma virens | 51.35 | 5e-98 | 295 |
| LLPS-Coo-1258 | Colletotrichum orbiculare | 50.97 | 1e-95 | 288 |
| LLPS-Gag-1399 | Gaeumannomyces graminis | 50.97 | 1e-95 | 288 |
| LLPS-Dos-0772 | Dothistroma septosporum | 50.97 | 6e-98 | 294 |
| LLPS-Ved-0801 | Verticillium dahliae | 50.96 | 1e-90 | 276 |
| LLPS-Cog-0877 | Colletotrichum gloeosporioides | 50.58 | 1e-95 | 288 |
| LLPS-Crn-0977 | Cryptococcus neoformans | 50.24 | 1e-70 | 227 |
| LLPS-Cym-0190 | Cyanidioschyzon merolae | 50.19 | 2e-94 | 285 |
| LLPS-Scc-0465 | Schizosaccharomyces cryophilus | 50.19 | 5e-96 | 290 |
| LLPS-Fuo-0513 | Fusarium oxysporum | 50.19 | 4e-97 | 292 |
| LLPS-Zyt-1103 | Zymoseptoria tritici | 49.81 | 1e-95 | 288 |
| LLPS-Fuv-1069 | Fusarium verticillioides | 49.81 | 4e-96 | 290 |
| LLPS-Cogr-0102 | Colletotrichum graminicola | 49.61 | 4e-92 | 280 |
| LLPS-Cae-1284 | Caenorhabditis elegans | 47.89 | 2e-89 | 273 |
| LLPS-Mel-0891 | Melampsora laricipopulina | 47.33 | 1e-90 | 276 |
| LLPS-Chc-0123 | Chondrus crispus | 46.12 | 3e-80 | 251 |
| LLPS-Yal-0467 | Yarrowia lipolytica | 44.31 | 6e-77 | 241 |
| LLPS-Usm-1148 | Ustilago maydis | 43.25 | 4e-82 | 255 |
| LLPS-Spr-0663 | Sporisorium reilianum | 42.61 | 3e-81 | 253 |
| LLPS-Asg-0815 | Ashbya gossypii | 39.77 | 1e-70 | 224 |
| LLPS-Kop-0594 | Komagataella pastoris | 36.96 | 2e-59 | 195 |
| LLPS-Sac-1163 | Saccharomyces cerevisiae | 35.52 | 3e-61 | 200 |
| LLPS-Ora-1968 | Ornithorhynchus anatinus | 33.49 | 4e-27 | 110 |