LLPS-Pes-1849
CDKN3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Cyclin-dependent kinase inhibitor 3 |
| Gene Name: | CDKN3 |
| Ensembl Gene: | ENSPSIG00000012166.1 |
| Ensembl Protein: | ENSPSIP00000013543.1 |
| Organism: | Pelodiscus sinensis |
| Taxa ID: | 13735 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSPSIT00000013607.1 | ENSPSIP00000013543.1 |
| UniProt | K7FZT3, K7FZT3_PELSI | |
| GeneBank | AGCU01038255, AGCU01038256, AGCU01038254, AGCU01038253 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MWLALSSVNC SQFLGVCSLP GCRFKDVRRN LQKDIEELKR HGIQDIFVLC TKGELSKYRV 60 61 PLLLDSYQHH GIIVHHHPIP DGDTPDITKC CTILEELKGC LETNRKTLIH CFGGLGRSCL 120 121 IVACLLLQLS DAMEPQEAIE TLRDLRGSGA IQTIKQYNYL HDFRENLAAH LSTKDAILRS 180 181 VSR 183 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTGGTTAG CCCTGTCGTC TGTCAATTGT TCTCAGTTTC TGGGAGTATG TTCTCTGCCC 60 61 GGTTGTAGAT TCAAGGATGT TAGAAGAAAT CTTCAGAAAG ATATAGAAGA ATTGAAGAGG 120 121 CATGGGATAC AAGATATATT TGTGCTCTGT ACCAAAGGAG AACTTTCAAA ATATCGGGTG 180 181 CCACTCTTAC TAGACTCCTA TCAGCACCAT GGGATTATTG TGCATCACCA TCCTATTCCT 240 241 GATGGAGACA CTCCTGACAT CACCAAATGC TGTACTATTC TGGAAGAACT AAAGGGCTGT 300 301 CTGGAAACCA ACAGGAAAAC ATTAATACAC TGTTTTGGAG GACTTGGACG TTCATGTCTC 360 361 ATAGTTGCAT GTCTTCTACT TCAATTATCT GATGCAATGG AACCTCAAGA GGCAATAGAG 420 421 ACTCTCAGAG ACTTACGAGG ATCTGGGGCA ATACAAACAA TAAAGCAATA CAACTATCTC 480 481 CATGACTTTC GAGAGAACCT GGCTGCACAT CTGTCAACAA AAGATGCAAT ATTAAGATCA 540 541 GTATCACGAT AA 552 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Perinuclear region of cytoplasm | |
Molecular Function | Protein serine/threonine phosphatase activity | |
Molecular Function | Protein tyrosine phosphatase activity | |
Biological Process | Cell cycle arrest |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mod-2438 | Monodelphis domestica | 80.77 | 7e-94 | 279 |
| LLPS-Sah-2454 | Sarcophilus harrisii | 80.22 | 5e-94 | 279 |
| LLPS-Gaga-4024 | Gallus gallus | 77.47 | 3e-91 | 272 |
| LLPS-Cas-1056 | Carlito syrichta | 76.92 | 9e-84 | 253 |
| LLPS-Loa-0957 | Loxodonta africana | 76.74 | 2e-83 | 252 |
| LLPS-Eqc-0766 | Equus caballus | 76.47 | 3e-84 | 254 |
| LLPS-Tag-2358 | Taeniopygia guttata | 76.37 | 2e-89 | 268 |
| LLPS-Urm-3573 | Ursus maritimus | 76.33 | 8e-83 | 251 |
| LLPS-Cea-3245 | Cercocebus atys | 75.74 | 2e-81 | 247 |
| LLPS-Aim-1953 | Ailuropoda melanoleuca | 75.74 | 2e-82 | 250 |
| LLPS-Meg-2572 | Meleagris gallopavo | 75.72 | 3e-82 | 249 |
| LLPS-Sus-4649 | Sus scrofa | 75.32 | 1e-70 | 219 |
| LLPS-Aon-0246 | Aotus nancymaae | 75.29 | 8e-81 | 246 |
| LLPS-Caf-1991 | Canis familiaris | 75.27 | 3e-89 | 267 |
| LLPS-Fec-3080 | Felis catus | 75.15 | 1e-81 | 248 |
| LLPS-Ict-3582 | Ictidomys tridecemlineatus | 75.15 | 7e-75 | 231 |
| LLPS-Fud-3213 | Fukomys damarensis | 75.15 | 3e-80 | 244 |
| LLPS-Mup-3866 | Mustela putorius furo | 75.15 | 2e-82 | 250 |
| LLPS-Tut-2455 | Tursiops truncatus | 75.15 | 4e-81 | 246 |
| LLPS-Pap-1200 | Pan paniscus | 74.73 | 2e-87 | 263 |
| LLPS-Pat-4798 | Pan troglodytes | 74.73 | 2e-87 | 263 |
| LLPS-Hos-0410 | Homo sapiens | 74.73 | 2e-87 | 263 |
| LLPS-Man-4309 | Macaca nemestrina | 74.73 | 4e-87 | 262 |
| LLPS-Poa-4008 | Pongo abelii | 74.73 | 4e-87 | 262 |
| LLPS-Mam-4642 | Macaca mulatta | 74.73 | 4e-87 | 262 |
| LLPS-Gog-1968 | Gorilla gorilla | 74.73 | 4e-87 | 262 |
| LLPS-Maf-2321 | Macaca fascicularis | 74.73 | 4e-87 | 262 |
| LLPS-Chs-0016 | Chlorocebus sabaeus | 74.73 | 4e-87 | 261 |
| LLPS-Paa-3810 | Papio anubis | 74.73 | 4e-87 | 262 |
| LLPS-Caj-0546 | Callithrix jacchus | 74.71 | 3e-80 | 244 |
| LLPS-Orc-0339 | Oryctolagus cuniculus | 74.56 | 1e-80 | 245 |
| LLPS-Ran-1975 | Rattus norvegicus | 74.56 | 2e-81 | 247 |
| LLPS-Mal-4735 | Mandrillus leucophaeus | 74.56 | 5e-72 | 223 |
| LLPS-Rhb-3006 | Rhinopithecus bieti | 74.18 | 1e-86 | 261 |
| LLPS-Cap-0463 | Cavia porcellus | 73.96 | 4e-71 | 221 |
| LLPS-Mea-2153 | Mesocricetus auratus | 73.96 | 2e-72 | 224 |
| LLPS-Otg-2517 | Otolemur garnettii | 73.63 | 1e-87 | 263 |
| LLPS-Fia-2705 | Ficedula albicollis | 73.63 | 1e-84 | 256 |
| LLPS-Nol-0524 | Nomascus leucogenys | 73.63 | 7e-78 | 238 |
| LLPS-Mum-4691 | Mus musculus | 73.37 | 8e-73 | 225 |
| LLPS-Anc-3570 | Anolis carolinensis | 72.53 | 2e-80 | 245 |
| LLPS-Dio-3772 | Dipodomys ordii | 72.3 | 1e-63 | 200 |
| LLPS-Lac-1141 | Latimeria chalumnae | 71.04 | 4e-77 | 236 |
| LLPS-Scf-3730 | Scleropages formosus | 65.03 | 2e-74 | 229 |
| LLPS-Pof-1709 | Poecilia formosa | 63.39 | 1e-74 | 230 |
| LLPS-Ora-3491 | Ornithorhynchus anatinus | 63.19 | 3e-68 | 213 |
| LLPS-Leo-1705 | Lepisosteus oculatus | 62.84 | 8e-74 | 228 |
| LLPS-Icp-2350 | Ictalurus punctatus | 62.5 | 1e-70 | 219 |
| LLPS-Xim-4118 | Xiphophorus maculatus | 62.3 | 2e-70 | 219 |
| LLPS-Orl-2219 | Oryzias latipes | 61.75 | 4e-70 | 219 |
| LLPS-Scm-3080 | Scophthalmus maximus | 61.2 | 3e-71 | 222 |
| LLPS-Orn-1558 | Oreochromis niloticus | 60.99 | 4e-70 | 218 |
| LLPS-Dar-1225 | Danio rerio | 60.66 | 3e-69 | 216 |
| LLPS-Asm-0191 | Astyanax mexicanus | 60.66 | 1e-68 | 214 |
| LLPS-Ten-3697 | Tetraodon nigroviridis | 59.56 | 1e-66 | 209 |
| LLPS-Tar-1170 | Takifugu rubripes | 59.56 | 4e-68 | 213 |
| LLPS-Gaa-2746 | Gasterosteus aculeatus | 58.7 | 8e-65 | 205 |
| LLPS-Ova-4404 | Ovis aries | 58.58 | 3e-62 | 197 |
| LLPS-Bot-2606 | Bos taurus | 56.21 | 2e-58 | 187 |
| LLPS-Myl-4186 | Myotis lucifugus | 54.44 | 1e-56 | 182 |
| LLPS-Anp-2112 | Anas platyrhynchos | 52.17 | 5e-26 | 102 |