LLPS-Dar-1225
cdkn3

▼ OVERVIEW

Status: Unreviewed
Protein Name: Cyclin-dependent kinase inhibitor 3
Gene Name: cdkn3
Ensembl Gene: ENSDARG00000039130.8
Ensembl Protein: ENSDARP00000057154.6
Organism: Danio rerio
Taxa ID: 7955
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSDART00000057155.8ENSDARP00000057154.6
UniProtB8A6D9, B8A6D9_DANRE
GeneBankBX927407
RefSeqNM_001145681.1NP_001139153.1
Entrez402796

▼ SEQUENCE

Protein Sequence (FASTA)
1     MRTSEFDSSD  EEDFGEEETT  PFQISWLSLS  MVECSQSLGI  CSLPGCRYKE  NRRNLQKDVA  60
61    EMCDQGVEDV  FVFCTRGELV  RYRVPCLLEV  YSQRGLRVHH  FPFPDGGAPE  LYQCSCVLEE  120
121   LKDCLQNQRR  TVIHCYGGLG  RSGLIAACLL  LQLSVSMTPS  TALEILRELR  GAGAIQTVKQ  180
181   YNFLHEFREK  FEAYQETKER  LAERSVSR  208
Nucleotide CDS Sequence (FASTA)
1     ATGAGGACAA  GTGAGTTTGA  TTCATCTGAC  GAAGAGGATT  TTGGTGAAGA  GGAAACGACA  60
61    CCTTTTCAGA  TCTCATGGTT  ATCTCTGTCA  ATGGTGGAGT  GCTCCCAGTC  TCTTGGCATC  120
121   TGTTCTCTAC  CTGGGTGCAG  ATATAAAGAA  AACAGAAGAA  ACCTGCAGAA  AGATGTTGCC  180
181   GAGATGTGTG  ATCAGGGTGT  GGAGGATGTG  TTTGTGTTCT  GCACCAGAGG  AGAGCTGGTG  240
241   CGCTACAGAG  TGCCGTGTCT  GCTAGAGGTT  TATTCTCAAA  GGGGTCTCAG  AGTCCATCAC  300
301   TTCCCCTTCC  CTGACGGTGG  AGCTCCAGAG  CTTTATCAGT  GCAGCTGCGT  TCTGGAGGAG  360
361   CTCAAGGACT  GCCTGCAAAA  CCAACGCAGA  ACTGTCATAC  ATTGTTATGG  AGGTCTGGGA  420
421   CGCTCTGGGC  TGATTGCTGC  ATGTTTGCTG  CTGCAGCTCT  CTGTGTCCAT  GACACCCAGC  480
481   ACAGCTCTGG  AGATCCTGCG  GGAGCTGAGA  GGAGCCGGAG  CCATTCAGAC  TGTCAAACAA  540
541   TACAACTTCC  TTCATGAGTT  TCGGGAGAAG  TTTGAAGCAT  ATCAGGAAAC  CAAAGAGCGG  600
601   CTCGCAGAGA  GATCTGTGTC  CAGATGA  627

▼ KEYWORD

ID
Family
Cell cycle
Complete proteome
Cytoplasm
Hydrolase
Protein phosphatase
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Perinuclear region of cytoplasm
Molecular Function
Protein serine/threonine phosphatase activity
Molecular Function
Protein tyrosine phosphatase activity
Biological Process
Cell cycle arrest

▼ KEGG


▼ ANNOTATION

Disorder
D2P2IUPred2A
Interaction
RAINMIST
Physicochemical
AAindex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asm-0191Astyanax mexicanus83.332e-109 319
LLPS-Scf-3730Scleropages formosus77.962e-101 299
LLPS-Icp-2350Ictalurus punctatus77.542e-101 299
LLPS-Leo-1705Lepisosteus oculatus75.681e-96 287
LLPS-Scm-3080Scophthalmus maximus74.194e-96 286
LLPS-Orn-1558Oreochromis niloticus73.668e-94 280
LLPS-Pof-1709Poecilia formosa72.041e-94 282
LLPS-Gaa-2746Gasterosteus aculeatus71.661e-92 277
LLPS-Xim-4118Xiphophorus maculatus70.972e-93 279
LLPS-Tar-1170Takifugu rubripes70.432e-90 271
LLPS-Orl-2219Oryzias latipes67.741e-84 257
LLPS-Ten-3697Tetraodon nigroviridis67.26e-85 257
LLPS-Lac-1141Latimeria chalumnae62.92e-78 241
LLPS-Sus-4649Sus scrofa62.423e-68 214
LLPS-Ran-1975Rattus norvegicus62.219e-79 241
LLPS-Orc-0339Oryctolagus cuniculus61.639e-76 234
LLPS-Mum-4691Mus musculus61.632e-70 220
LLPS-Mea-2153Mesocricetus auratus61.631e-69 218
LLPS-Eqc-0766Equus caballus61.055e-76 234
LLPS-Urm-3573Ursus maritimus61.055e-77 237
LLPS-Fec-3080Felis catus61.051e-76 236
LLPS-Mup-3866Mustela putorius furo61.056e-77 237
LLPS-Cea-3245Cercocebus atys61.052e-75 233
LLPS-Fia-2705Ficedula albicollis60.753e-78 241
LLPS-Pes-1849Pelodiscus sinensis60.665e-80 244
LLPS-Aim-1953Ailuropoda melanoleuca60.473e-76 235
LLPS-Caj-0546Callithrix jacchus60.474e-74 230
LLPS-Aon-0246Aotus nancymaae60.474e-74 230
LLPS-Anc-3570Anolis carolinensis60.224e-72 224
LLPS-Mal-4735Mandrillus leucophaeus59.883e-67 212
LLPS-Tut-2455Tursiops truncatus59.884e-75 232
LLPS-Fud-3213Fukomys damarensis59.887e-75 231
LLPS-Tag-2358Taeniopygia guttata59.681e-77 239
LLPS-Caf-1991Canis familiaris59.687e-80 244
LLPS-Otg-2517Otolemur garnettii59.682e-80 245
LLPS-Sah-2454Sarcophilus harrisii59.683e-73 227
LLPS-Loa-0957Loxodonta africana59.434e-75 232
LLPS-Cas-1056Carlito syrichta59.39e-75 231
LLPS-Ict-3582Ictidomys tridecemlineatus59.39e-70 218
LLPS-Poa-4008Pongo abelii59.142e-77 238
LLPS-Mam-4642Macaca mulatta59.142e-77 238
LLPS-Pat-4798Pan troglodytes59.145e-77 237
LLPS-Pap-1200Pan paniscus59.145e-77 237
LLPS-Mod-2438Monodelphis domestica59.144e-73 227
LLPS-Man-4309Macaca nemestrina59.142e-77 238
LLPS-Paa-3810Papio anubis59.142e-77 238
LLPS-Maf-2321Macaca fascicularis59.142e-77 238
LLPS-Chs-0016Chlorocebus sabaeus59.142e-77 238
LLPS-Dio-3772Dipodomys ordii58.781e-59 191
LLPS-Cap-0463Cavia porcellus58.726e-68 214
LLPS-Meg-2572Meleagris gallopavo58.621e-70 221
LLPS-Rhb-3006Rhinopithecus bieti58.67e-77 237
LLPS-Hos-0410Homo sapiens58.65e-77 237
LLPS-Gog-1968Gorilla gorilla58.63e-76 235
LLPS-Gaga-4024Gallus gallus58.383e-76 235
LLPS-Nol-0524Nomascus leucogenys58.064e-69 217
LLPS-Ora-3491Ornithorhynchus anatinus54.842e-62 200
LLPS-Ova-4404Ovis aries48.262e-48 162
LLPS-Anp-2112Anas platyrhynchos46.612e-2499.0
LLPS-Bot-2606Bos taurus46.514e-47 159
LLPS-Myl-4186Myotis lucifugus44.771e-45 155
LLPS-Abg-1040Absidia glauca32.02e-0857.0
LLPS-Chr-1143Chlamydomonas reinhardtii31.04e-0753.9
LLPS-Cae-1573Caenorhabditis elegans29.62e-0754.7