LLPS-Pap-1200
CDKN3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Cyclin-dependent kinase inhibitor 3 |
| Gene Name: | CDKN3 |
| Ensembl Gene: | ENSPPAG00000041424.1 |
| Ensembl Protein: | ENSPPAP00000037414.1 |
| Organism: | Pan paniscus |
| Taxa ID: | 9597 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSPPAT00000060314.1 | ENSPPAP00000037414.1 |
| Ensembl | ENSPPAT00000060312.1 | ENSPPAP00000037412.1 |
| Ensembl | ENSPPAT00000060327.1 | ENSPPAP00000037427.1 |
| Ensembl | ENSPPAT00000060326.1 | ENSPPAP00000037426.1 |
| Ensembl | ENSPPAT00000060342.1 | ENSPPAP00000037442.1 |
| Ensembl | ENSPPAT00000060322.1 | ENSPPAP00000037422.1 |
| Ensembl | ENSPPAT00000060329.1 | ENSPPAP00000037429.1 |
| Ensembl | ENSPPAT00000060339.1 | ENSPPAP00000037439.1 |
| UniProt | A0A2R9CGT3, A0A2R9CGT3_PANPA | |
| GeneBank | AJFE02112049 | |
| RefSeq | XM_003831698.2 | XP_003831746.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLPLSRVNCS QFLGLCALPG CKFKDVRRNV 60 61 QKDTEELKSC GIQDVFVFCT RGELSKYRVP NLLDLYQQCG IITHHHPIAD GGTPDIASCC 120 121 EIMEELTTCL KNYRKTLIHC YGGLGRSCLV AACLLLYLSD TISPEQAIDS LRDLRGSGAI 180 181 QTIKQYNYLH EFRDKLAAHL SSKDSQSRSV SR 212 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAGCCGC CCAGTTCAAT ACAAACAAGT GAGTTTGACT CATCAGATGA AGAGCCTATT 60 61 GAAGATGAAC AGACTCCAAT TCATATATCA TGGCTACCTT TGTCACGAGT GAATTGTTCT 120 121 CAGTTTCTCG GTTTATGTGC TCTTCCAGGT TGTAAATTTA AAGATGTTAG AAGAAATGTC 180 181 CAAAAAGATA CAGAAGAACT AAAGAGCTGT GGTATACAAG ACGTATTTGT TTTCTGCACC 240 241 AGAGGGGAAC TGTCAAAATA TAGAGTCCCA AACCTTCTGG ATCTCTACCA GCAATGTGGA 300 301 ATTATCACCC ATCATCATCC AATCGCAGAT GGAGGGACTC CTGACATAGC CAGCTGCTGT 360 361 GAAATAATGG AAGAGCTTAC AACCTGCCTT AAAAATTACC GAAAAACCTT AATACACTGC 420 421 TATGGAGGAC TTGGGAGATC TTGTCTTGTA GCTGCTTGTC TCCTACTATA CCTGTCTGAC 480 481 ACAATATCAC CAGAGCAAGC CATAGACAGC CTGCGAGACC TAAGAGGATC CGGGGCAATA 540 541 CAGACCATCA AGCAATACAA TTATCTTCAT GAGTTTCGGG ACAAATTAGC TGCACATCTA 600 601 TCATCAAAAG ATTCACAATC AAGATCTGTA TCAAGATAA 639 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Perinuclear region of cytoplasm | |
Molecular Function | Protein serine/threonine phosphatase activity | |
Molecular Function | Protein tyrosine phosphatase activity | |
Biological Process | Cell cycle arrest |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-4798 | Pan troglodytes | 100.0 | 2e-147 | 416 |
| LLPS-Hos-0410 | Homo sapiens | 99.0 | 4e-146 | 413 |
| LLPS-Gog-1968 | Gorilla gorilla | 99.0 | 4e-146 | 413 |
| LLPS-Poa-4008 | Pongo abelii | 98.0 | 2e-144 | 408 |
| LLPS-Mam-4642 | Macaca mulatta | 98.0 | 2e-144 | 408 |
| LLPS-Man-4309 | Macaca nemestrina | 98.0 | 2e-144 | 408 |
| LLPS-Paa-3810 | Papio anubis | 98.0 | 2e-144 | 408 |
| LLPS-Maf-2321 | Macaca fascicularis | 98.0 | 2e-144 | 408 |
| LLPS-Cea-3245 | Cercocebus atys | 97.99 | 6e-143 | 405 |
| LLPS-Chs-0016 | Chlorocebus sabaeus | 97.5 | 3e-143 | 405 |
| LLPS-Rhb-3006 | Rhinopithecus bieti | 97.0 | 2e-143 | 406 |
| LLPS-Nol-0524 | Nomascus leucogenys | 96.5 | 9e-133 | 379 |
| LLPS-Mal-4735 | Mandrillus leucophaeus | 96.48 | 2e-131 | 376 |
| LLPS-Caj-0546 | Callithrix jacchus | 94.5 | 5e-139 | 395 |
| LLPS-Aon-0246 | Aotus nancymaae | 93.5 | 3e-138 | 393 |
| LLPS-Urm-3573 | Ursus maritimus | 92.96 | 9e-136 | 387 |
| LLPS-Sus-4649 | Sus scrofa | 92.93 | 4e-123 | 355 |
| LLPS-Caf-1991 | Canis familiaris | 92.5 | 4e-136 | 387 |
| LLPS-Fec-3080 | Felis catus | 92.46 | 2e-135 | 386 |
| LLPS-Mup-3866 | Mustela putorius furo | 92.46 | 6e-135 | 384 |
| LLPS-Tut-2455 | Tursiops truncatus | 91.46 | 1e-132 | 379 |
| LLPS-Eqc-0766 | Equus caballus | 91.0 | 3e-133 | 380 |
| LLPS-Loa-0957 | Loxodonta africana | 90.95 | 7e-131 | 374 |
| LLPS-Ran-1975 | Rattus norvegicus | 90.95 | 1e-132 | 379 |
| LLPS-Otg-2517 | Otolemur garnettii | 90.86 | 2e-131 | 376 |
| LLPS-Aim-1953 | Ailuropoda melanoleuca | 90.82 | 3e-131 | 375 |
| LLPS-Cas-1056 | Carlito syrichta | 90.31 | 2e-129 | 370 |
| LLPS-Orc-0339 | Oryctolagus cuniculus | 89.95 | 2e-132 | 378 |
| LLPS-Mea-2153 | Mesocricetus auratus | 89.95 | 5e-122 | 352 |
| LLPS-Ict-3582 | Ictidomys tridecemlineatus | 88.94 | 6e-121 | 349 |
| LLPS-Mum-4691 | Mus musculus | 88.94 | 7e-121 | 349 |
| LLPS-Dio-3772 | Dipodomys ordii | 88.32 | 4e-84 | 254 |
| LLPS-Fud-3213 | Fukomys damarensis | 85.93 | 7e-125 | 359 |
| LLPS-Cap-0463 | Cavia porcellus | 85.43 | 2e-116 | 337 |
| LLPS-Sah-2454 | Sarcophilus harrisii | 84.0 | 1e-116 | 338 |
| LLPS-Mod-2438 | Monodelphis domestica | 83.5 | 2e-115 | 335 |
| LLPS-Ova-4404 | Ovis aries | 75.38 | 5e-100 | 294 |
| LLPS-Pes-1849 | Pelodiscus sinensis | 75.29 | 2e-92 | 275 |
| LLPS-Fia-2705 | Ficedula albicollis | 73.02 | 1e-100 | 298 |
| LLPS-Bot-2606 | Bos taurus | 72.86 | 1e-95 | 283 |
| LLPS-Tag-2358 | Taeniopygia guttata | 71.57 | 1e-103 | 305 |
| LLPS-Meg-2572 | Meleagris gallopavo | 70.19 | 4e-84 | 255 |
| LLPS-Myl-4186 | Myotis lucifugus | 69.9 | 1e-90 | 270 |
| LLPS-Anc-3570 | Anolis carolinensis | 68.88 | 1e-95 | 285 |
| LLPS-Gaga-4024 | Gallus gallus | 68.72 | 6e-93 | 278 |
| LLPS-Lac-1141 | Latimeria chalumnae | 68.21 | 2e-90 | 271 |
| LLPS-Scf-3730 | Scleropages formosus | 65.98 | 1e-91 | 275 |
| LLPS-Ora-3491 | Ornithorhynchus anatinus | 65.48 | 1e-88 | 267 |
| LLPS-Orn-1558 | Oreochromis niloticus | 64.95 | 2e-89 | 269 |
| LLPS-Gaa-2746 | Gasterosteus aculeatus | 64.2 | 3e-81 | 248 |
| LLPS-Tar-1170 | Takifugu rubripes | 63.07 | 6e-82 | 249 |
| LLPS-Scm-3080 | Scophthalmus maximus | 62.76 | 2e-90 | 271 |
| LLPS-Leo-1705 | Lepisosteus oculatus | 62.56 | 3e-92 | 276 |
| LLPS-Xim-4118 | Xiphophorus maculatus | 62.43 | 1e-86 | 262 |
| LLPS-Pof-1709 | Poecilia formosa | 61.86 | 2e-90 | 271 |
| LLPS-Orl-2219 | Oryzias latipes | 60.91 | 6e-85 | 257 |
| LLPS-Dar-1225 | Danio rerio | 60.82 | 5e-84 | 255 |
| LLPS-Asm-0191 | Astyanax mexicanus | 60.82 | 2e-80 | 246 |
| LLPS-Ten-3697 | Tetraodon nigroviridis | 60.23 | 3e-77 | 238 |
| LLPS-Icp-2350 | Ictalurus punctatus | 59.49 | 7e-81 | 247 |
| LLPS-Anp-2112 | Anas platyrhynchos | 53.91 | 3e-29 | 111 |
| LLPS-Abg-1040 | Absidia glauca | 27.75 | 5e-08 | 55.8 |