LLPS-Paa-0624
RPN1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 |
| Gene Name: | RPN1 |
| Ensembl Gene: | ENSPANG00000007909.2 |
| Ensembl Protein: | ENSPANP00000001641.1 |
| Organism: | Papio anubis |
| Taxa ID: | 9555 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Stress granule, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSPANT00000000691.2 | ENSPANP00000001641.1 |
| UniProt | A0A096MPI1, A0A096MPI1_PAPAN | |
| GeneBank | AHZZ02002672, AHZZ02002671 | |
| RefSeq | XM_003906902.2 | XP_003906951.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEAPVARLFL LLLLGSWTPA PGSASSEAPP LINEDVKRTV DLSSHLAKVT AEVVLAHLGG 60 61 SSTSRATSFL LALEPELEAR LAHLGVQVKG EDEEDNNLEV RETKIKGKSG RFFIVKLPVA 120 121 LDPGAKISVI VETVYTHVLQ PYPTQITQSE KQFVVFEGNH YFYSPYPTKT QTMRVKLASR 180 181 NVESYTKLGN PTRSEDLLDY GPFRDVPAYS QDTFKVHYEN NSPFLTITSM TRVIEVSHWG 240 241 NIAVEENVDL KHTGAVLKGP FSRYDYQRQP DSGISSIRSF KTILPAAAQD VYYRDEIGNV 300 301 STSHLLILDD SVEMEIRPRF PLFGGWKTHY IVGYNLPSYE YLYNLGDQYA LKMRFVDHVF 360 361 DEQVIDSLTV KIILPEGAKN IEIDSPYEIS RAPDELHYTY LDTFGRPVIV AYKKNLVEQH 420 421 IQDIVVHYTF NKVLMLQEPL LVVAAFYILF FTVIIYVRLD FSITKDPAAE ARMKVACITE 480 481 QVLTLVNKRI GLYRHFDETV NRYKQSRDIS TLNSGKKSLE TEHKALTSEI ALLQSRLKTE 540 541 GSDLCDRVSE MQKLDAQVKE LVLKSAVEAE RLVAGKLKKD TYIENEKLIS GKRQELVTKI 600 601 DHILDAL 607 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGGCGC CAGTCGCCCG CTTGTTTCTG CTCCTGTTGC TCGGGTCCTG GACCCCGGCG 60 61 CCAGGCAGTG CCTCCTCCGA GGCACCGCCG CTGATCAACG AGGACGTGAA GCGCACAGTG 120 121 GACCTAAGCA GCCACCTGGC TAAGGTGACG GCCGAGGTGG TCCTGGCGCA CCTGGGCGGC 180 181 AGCTCCACGT CCCGAGCTAC CTCTTTCCTT CTGGCTTTGG AGCCTGAGCT CGAGGCTCGG 240 241 CTGGCGCACC TGGGCGTGCA GGTGAAGGGA GAAGATGAGG AAGACAACAA TTTGGAAGTA 300 301 CGTGAAACCA AAATTAAGGG TAAAAGTGGG AGATTCTTCA TAGTCAAGCT CCCAGTTGCC 360 361 CTTGATCCTG GGGCCAAGAT TTCAGTCATT GTGGAAACAG TCTACACCCA TGTGCTTCAG 420 421 CCGTATCCAA CCCAGATCAC CCAGTCAGAG AAACAGTTTG TGGTGTTTGA GGGGAACCAT 480 481 TATTTCTACT CTCCCTATCC AACGAAGACA CAAACCATGC GTGTGAAGCT TGCCTCTCGA 540 541 AATGTGGAGA GCTACACCAA ACTGGGGAAC CCCACACGCT CCGAGGACCT ACTGGATTAT 600 601 GGGCCTTTCA GAGATGTCCC TGCCTATAGT CAGGATACTT TTAAAGTACA TTATGAGAAC 660 661 AACAGCCCTT TCCTGACCAT CACCAGCATG ACCCGAGTCA TTGAAGTCTC TCACTGGGGT 720 721 AATATTGCTG TGGAAGAAAA TGTGGACTTG AAGCACACAG GAGCTGTGCT TAAGGGGCCT 780 781 TTCTCACGTT ATGATTACCA GAGACAGCCA GATAGTGGAA TATCCTCCAT CCGTTCTTTT 840 841 AAGACCATCC TCCCTGCTGC TGCCCAGGAT GTTTACTACA GGGATGAGAT TGGCAATGTT 900 901 TCCACCAGCC ACCTCCTTAT TTTGGATGAC TCTGTAGAGA TGGAAATCCG GCCTCGCTTC 960 961 CCTCTCTTTG GCGGGTGGAA GACTCATTAC ATCGTTGGCT ACAACCTCCC AAGCTATGAG 1020 1021 TACCTCTATA ATTTGGGTGA CCAGTATGCA CTGAAGATGA GGTTTGTAGA CCATGTGTTT 1080 1081 GATGAACAAG TGATAGATTC TCTGACTGTG AAGATCATCC TGCCTGAAGG AGCCAAGAAC 1140 1141 ATTGAAATCG ATAGTCCCTA TGAAATCAGC CGTGCCCCAG ATGAGCTGCA CTACACCTAT 1200 1201 CTGGACACAT TCGGCCGCCC TGTGATTGTT GCCTACAAGA AAAATCTGGT AGAACAGCAC 1260 1261 ATTCAGGACA TTGTGGTCCA CTACACGTTC AACAAGGTGC TCATGCTGCA GGAGCCCCTG 1320 1321 CTGGTGGTGG CGGCCTTCTA CATCCTGTTC TTCACCGTCA TCATCTATGT TCGGCTGGAC 1380 1381 TTCTCCATCA CTAAGGATCC GGCCGCAGAA GCCAGGATGA AGGTAGCCTG CATCACAGAG 1440 1441 CAGGTCTTGA CCTTGGTCAA CAAGAGAATA GGCCTTTACC GTCACTTTGA CGAGACTGTC 1500 1501 AATAGGTACA AGCAATCCCG GGACATCTCC ACCCTCAACA GTGGCAAGAA GAGCCTGGAG 1560 1561 ACCGAACACA AGGCCTTGAC CAGTGAGATT GCACTGCTGC AGTCCAGGCT GAAGACAGAG 1620 1621 GGCTCTGATC TGTGTGACAG AGTGAGCGAA ATGCAGAAGC TGGATGCACA GGTCAAGGAG 1680 1681 CTGGTGCTGA AGTCGGCGGT GGAGGCTGAG CGCCTGGTGG CTGGCAAGCT CAAGAAAGAC 1740 1741 ACGTACATTG AGAATGAGAA GCTCATCTCA GGAAAGCGCC AGGAGCTGGT CACCAAGATC 1800 1801 GACCACATCC TGGATGCCCT GTAG 1824 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Integral component of membrane | |
Cellular Component | Rough endoplasmic reticulum | |
Molecular Function | Dolichyl-diphosphooligosaccharide-protein glycotransferase activity | |
Biological Process | Protein N-linked glycosylation via asparagine |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mam-3995 | Macaca mulatta | 100.0 | 0.0 | 1165 |
| LLPS-Aon-4087 | Aotus nancymaae | 100.0 | 3e-114 | 363 |
| LLPS-Maf-1094 | Macaca fascicularis | 100.0 | 0.0 | 1165 |
| LLPS-Mal-3537 | Mandrillus leucophaeus | 100.0 | 0.0 | 814 |
| LLPS-Cea-0408 | Cercocebus atys | 99.84 | 0.0 | 1166 |
| LLPS-Chs-0180 | Chlorocebus sabaeus | 99.84 | 0.0 | 1166 |
| LLPS-Poa-1009 | Pongo abelii | 99.41 | 0.0 | 1044 |
| LLPS-Rhb-1358 | Rhinopithecus bieti | 99.01 | 0.0 | 1158 |
| LLPS-Pat-1433 | Pan troglodytes | 98.85 | 0.0 | 1154 |
| LLPS-Hos-1291 | Homo sapiens | 98.68 | 0.0 | 1151 |
| LLPS-Nol-1156 | Nomascus leucogenys | 98.52 | 0.0 | 1150 |
| LLPS-Cas-3098 | Carlito syrichta | 98.48 | 0.0 | 807 |
| LLPS-Loa-3398 | Loxodonta africana | 97.57 | 0.0 | 1129 |
| LLPS-Otg-1428 | Otolemur garnettii | 97.4 | 0.0 | 1127 |
| LLPS-Aim-2958 | Ailuropoda melanoleuca | 97.23 | 0.0 | 1126 |
| LLPS-Urm-0141 | Ursus maritimus | 97.12 | 0.0 | 1053 |
| LLPS-Fec-3269 | Felis catus | 97.05 | 0.0 | 1126 |
| LLPS-Caj-1780 | Callithrix jacchus | 96.59 | 0.0 | 1106 |
| LLPS-Orc-4031 | Oryctolagus cuniculus | 96.38 | 0.0 | 1137 |
| LLPS-Mup-3450 | Mustela putorius furo | 96.21 | 0.0 | 1141 |
| LLPS-Eqc-2088 | Equus caballus | 95.89 | 0.0 | 1129 |
| LLPS-Caf-0051 | Canis familiaris | 95.88 | 0.0 | 1138 |
| LLPS-Sus-1378 | Sus scrofa | 95.84 | 0.0 | 1112 |
| LLPS-Mum-4056 | Mus musculus | 95.84 | 0.0 | 1118 |
| LLPS-Fud-2682 | Fukomys damarensis | 95.78 | 0.0 | 1096 |
| LLPS-Ran-1204 | Rattus norvegicus | 95.49 | 0.0 | 1116 |
| LLPS-Gog-1870 | Gorilla gorilla | 95.24 | 0.0 | 1142 |
| LLPS-Mea-4314 | Mesocricetus auratus | 95.15 | 0.0 | 1110 |
| LLPS-Bot-3444 | Bos taurus | 94.45 | 0.0 | 1099 |
| LLPS-Cap-3127 | Cavia porcellus | 94.07 | 0.0 | 1099 |
| LLPS-Myl-4035 | Myotis lucifugus | 93.91 | 0.0 | 1111 |
| LLPS-Man-0989 | Macaca nemestrina | 93.87 | 0.0 | 1029 |
| LLPS-Pap-1556 | Pan paniscus | 91.27 | 0.0 | 1076 |
| LLPS-Ora-0057 | Ornithorhynchus anatinus | 89.36 | 0.0 | 615 |
| LLPS-Meg-1815 | Meleagris gallopavo | 88.87 | 0.0 | 964 |
| LLPS-Pes-0990 | Pelodiscus sinensis | 88.68 | 0.0 | 977 |
| LLPS-Tag-0725 | Taeniopygia guttata | 88.1 | 0.0 | 963 |
| LLPS-Mod-1022 | Monodelphis domestica | 87.69 | 0.0 | 1015 |
| LLPS-Gaga-2017 | Gallus gallus | 86.59 | 0.0 | 1003 |
| LLPS-Sah-3080 | Sarcophilus harrisii | 86.48 | 0.0 | 1003 |
| LLPS-Dio-3263 | Dipodomys ordii | 85.38 | 0.0 | 896 |
| LLPS-Ova-1052 | Ovis aries | 84.05 | 0.0 | 1002 |
| LLPS-Anp-1575 | Anas platyrhynchos | 84.0 | 0.0 | 995 |
| LLPS-Anc-3055 | Anolis carolinensis | 83.88 | 0.0 | 972 |
| LLPS-Fia-0374 | Ficedula albicollis | 83.42 | 0.0 | 978 |
| LLPS-Xet-0497 | Xenopus tropicalis | 81.46 | 0.0 | 959 |
| LLPS-Lac-1608 | Latimeria chalumnae | 80.07 | 0.0 | 955 |
| LLPS-Leo-2009 | Lepisosteus oculatus | 76.6 | 0.0 | 835 |
| LLPS-Icp-0139 | Ictalurus punctatus | 73.48 | 0.0 | 882 |
| LLPS-Dar-0592 | Danio rerio | 73.31 | 0.0 | 878 |
| LLPS-Asm-2653 | Astyanax mexicanus | 72.96 | 0.0 | 872 |
| LLPS-Orn-1488 | Oreochromis niloticus | 72.27 | 0.0 | 891 |
| LLPS-Scm-2478 | Scophthalmus maximus | 72.07 | 0.0 | 886 |
| LLPS-Scf-0792 | Scleropages formosus | 71.92 | 0.0 | 882 |
| LLPS-Gaa-2647 | Gasterosteus aculeatus | 71.75 | 0.0 | 879 |
| LLPS-Orl-0732 | Oryzias latipes | 71.58 | 0.0 | 883 |
| LLPS-Xim-0128 | Xiphophorus maculatus | 71.58 | 0.0 | 892 |
| LLPS-Pof-0429 | Poecilia formosa | 71.26 | 0.0 | 880 |
| LLPS-Tar-3389 | Takifugu rubripes | 71.23 | 0.0 | 881 |
| LLPS-Ten-2170 | Tetraodon nigroviridis | 71.06 | 0.0 | 879 |
| LLPS-Cii-1298 | Ciona intestinalis | 56.28 | 2e-170 | 500 |
| LLPS-Cis-1651 | Ciona savignyi | 52.74 | 0.0 | 597 |
| LLPS-Drm-0499 | Drosophila melanogaster | 45.58 | 6e-136 | 412 |
| LLPS-Cae-1532 | Caenorhabditis elegans | 39.96 | 4e-119 | 373 |
| LLPS-Vir-0090 | Vigna radiata | 38.81 | 3e-90 | 295 |
| LLPS-Abg-1264 | Absidia glauca | 38.64 | 6e-44 | 162 |
| LLPS-Orgl-0380 | Oryza glumaepatula | 38.62 | 6e-101 | 322 |
| LLPS-Cus-2286 | Cucumis sativus | 37.47 | 3e-99 | 322 |
| LLPS-Sol-1009 | Solanum lycopersicum | 36.78 | 3e-88 | 289 |
| LLPS-Brd-0070 | Brachypodium distachyon | 36.11 | 5e-101 | 326 |
| LLPS-Coc-1176 | Corchorus capsularis | 36.06 | 7e-102 | 328 |
| LLPS-Ors-1703 | Oryza sativa | 36.04 | 1e-102 | 330 |
| LLPS-Orr-1232 | Oryza rufipogon | 36.04 | 1e-102 | 330 |
| LLPS-Orni-0384 | Oryza nivara | 36.04 | 1e-102 | 330 |
| LLPS-Ori-0202 | Oryza indica | 36.04 | 1e-102 | 330 |
| LLPS-Org-0742 | Oryza glaberrima | 35.84 | 5e-102 | 329 |
| LLPS-Orm-1048 | Oryza meridionalis | 35.84 | 1e-102 | 331 |
| LLPS-Orb-0983 | Oryza barthii | 35.84 | 5e-102 | 329 |
| LLPS-Pot-0842 | Populus trichocarpa | 35.71 | 2e-99 | 322 |
| LLPS-Pug-0323 | Puccinia graminis | 34.91 | 4e-39 | 155 |
| LLPS-Mua-0181 | Musa acuminata | 34.83 | 3e-100 | 325 |
| LLPS-Bro-1350 | Brassica oleracea | 34.46 | 4e-106 | 340 |
| LLPS-Brn-2746 | Brassica napus | 34.46 | 4e-106 | 340 |
| LLPS-Art-0536 | Arabidopsis thaliana | 34.41 | 3e-104 | 335 |
| LLPS-Prp-1684 | Prunus persica | 34.3 | 2e-100 | 325 |
| LLPS-Php-0376 | Physcomitrella patens | 34.29 | 9e-87 | 289 |
| LLPS-Brr-0245 | Brassica rapa | 34.12 | 7e-105 | 337 |
| LLPS-Amt-0753 | Amborella trichopoda | 34.04 | 5e-102 | 329 |
| LLPS-Glm-1448 | Glycine max | 33.84 | 8e-102 | 328 |
| LLPS-Met-0203 | Medicago truncatula | 33.84 | 9e-102 | 328 |
| LLPS-Arl-1117 | Arabidopsis lyrata | 33.79 | 4e-103 | 332 |
| LLPS-Yal-0849 | Yarrowia lipolytica | 33.51 | 2e-56 | 203 |
| LLPS-Sei-0800 | Setaria italica | 33.39 | 3e-103 | 335 |
| LLPS-Via-1547 | Vigna angularis | 33.33 | 2e-94 | 309 |
| LLPS-Mae-0897 | Manihot esculenta | 33.28 | 6e-99 | 321 |
| LLPS-Tra-0918 | Triticum aestivum | 33.28 | 4e-105 | 337 |
| LLPS-Orbr-0396 | Oryza brachyantha | 33.22 | 1e-103 | 333 |
| LLPS-Viv-2037 | Vitis vinifera | 32.99 | 4e-103 | 332 |
| LLPS-Lep-0771 | Leersia perrieri | 32.99 | 4e-102 | 329 |
| LLPS-Sot-2013 | Solanum tuberosum | 32.96 | 2e-90 | 298 |
| LLPS-Hov-0598 | Hordeum vulgare | 32.94 | 1e-102 | 331 |
| LLPS-Ved-1147 | Verticillium dahliae | 32.88 | 3e-50 | 186 |
| LLPS-Phv-2265 | Phaseolus vulgaris | 32.83 | 2e-99 | 322 |
| LLPS-Thc-1903 | Theobroma cacao | 32.82 | 3e-99 | 322 |
| LLPS-Zem-1214 | Zea mays | 32.77 | 2e-104 | 335 |
| LLPS-Sob-2395 | Sorghum bicolor | 32.72 | 9e-104 | 333 |
| LLPS-Orp-0712 | Oryza punctata | 32.71 | 2e-103 | 333 |
| LLPS-Hea-1498 | Helianthus annuus | 32.71 | 2e-96 | 315 |
| LLPS-Nec-1253 | Neurospora crassa | 32.67 | 7e-55 | 200 |
| LLPS-Nef-1269 | Neosartorya fischeri | 32.55 | 8e-45 | 171 |
| LLPS-Crn-0929 | Cryptococcus neoformans | 32.31 | 2e-51 | 190 |
| LLPS-Sem-0306 | Selaginella moellendorffii | 32.19 | 8e-91 | 299 |
| LLPS-Dac-0021 | Daucus carota | 32.14 | 1e-96 | 315 |
| LLPS-Nia-0935 | Nicotiana attenuata | 32.03 | 1e-97 | 317 |
| LLPS-Pytr-0743 | Pyrenophora triticirepentis | 32.01 | 1e-48 | 182 |
| LLPS-Pyt-1539 | Pyrenophora teres | 32.01 | 1e-52 | 193 |
| LLPS-Gag-1506 | Gaeumannomyces graminis | 31.98 | 2e-52 | 192 |
| LLPS-Asfu-0780 | Aspergillus fumigatus | 31.75 | 3e-45 | 172 |
| LLPS-Gor-0026 | Gossypium raimondii | 31.74 | 6e-96 | 313 |
| LLPS-Mao-1562 | Magnaporthe oryzae | 31.69 | 3e-49 | 184 |
| LLPS-Fus-0581 | Fusarium solani | 31.58 | 1e-46 | 176 |
| LLPS-Asc-0017 | Aspergillus clavatus | 31.5 | 3e-46 | 176 |
| LLPS-Scs-0901 | Sclerotinia sclerotiorum | 31.49 | 2e-54 | 198 |
| LLPS-Asni-1533 | Aspergillus niger | 31.45 | 2e-44 | 170 |
| LLPS-Tru-0058 | Triticum urartu | 31.25 | 1e-90 | 299 |
| LLPS-Map-0118 | Magnaporthe poae | 31.25 | 3e-50 | 186 |
| LLPS-Lem-1253 | Leptosphaeria maculans | 31.17 | 3e-52 | 192 |
| LLPS-Ast-1048 | Aspergillus terreus | 31.16 | 1e-44 | 171 |
| LLPS-Put-0557 | Puccinia triticina | 31.13 | 2e-38 | 152 |
| LLPS-Phn-1522 | Phaeosphaeria nodorum | 31.03 | 2e-52 | 193 |
| LLPS-Coo-1405 | Colletotrichum orbiculare | 30.91 | 3e-46 | 175 |
| LLPS-Tum-1273 | Tuber melanosporum | 30.89 | 2e-50 | 187 |
| LLPS-Trr-1588 | Trichoderma reesei | 30.58 | 1e-46 | 176 |
| LLPS-Spr-0368 | Sporisorium reilianum | 30.52 | 3e-50 | 187 |
| LLPS-Asf-1125 | Aspergillus flavus | 30.49 | 1e-43 | 167 |
| LLPS-Aso-1328 | Aspergillus oryzae | 30.49 | 1e-43 | 167 |
| LLPS-Cog-0742 | Colletotrichum gloeosporioides | 30.4 | 2e-45 | 172 |
| LLPS-Blg-1557 | Blumeria graminis | 30.38 | 2e-49 | 186 |
| LLPS-Chr-1448 | Chlamydomonas reinhardtii | 30.24 | 4e-79 | 268 |
| LLPS-Zyt-1266 | Zymoseptoria tritici | 30.16 | 8e-44 | 168 |
| LLPS-Dos-1283 | Dothistroma septosporum | 30.13 | 2e-44 | 169 |
| LLPS-Gas-1317 | Galdieria sulphuraria | 30.11 | 4e-48 | 182 |
| LLPS-Usm-0219 | Ustilago maydis | 30.05 | 5e-49 | 183 |
| LLPS-Asn-1462 | Aspergillus nidulans | 29.9 | 3e-44 | 169 |
| LLPS-Trv-0707 | Trichoderma virens | 29.83 | 6e-44 | 168 |
| LLPS-Beb-0455 | Beauveria bassiana | 29.78 | 6e-46 | 174 |
| LLPS-Fuo-1261 | Fusarium oxysporum | 29.78 | 2e-45 | 172 |
| LLPS-Scc-1262 | Schizosaccharomyces cryophilus | 29.74 | 5e-35 | 141 |
| LLPS-Fuv-0686 | Fusarium verticillioides | 29.23 | 2e-44 | 170 |
| LLPS-Cogr-1080 | Colletotrichum graminicola | 28.85 | 1e-41 | 162 |
| LLPS-Mel-0771 | Melampsora laricipopulina | 28.3 | 2e-37 | 149 |
| LLPS-Miv-0966 | Microbotryum violaceum | 28.13 | 2e-34 | 140 |
| LLPS-Sac-1420 | Saccharomyces cerevisiae | 26.97 | 1e-38 | 152 |
| LLPS-Kop-0887 | Komagataella pastoris | 26.58 | 7e-26 | 115 |
| LLPS-Asg-1243 | Ashbya gossypii | 26.05 | 2e-30 | 128 |
| LLPS-Scp-0812 | Schizosaccharomyces pombe | 25.49 | 4e-27 | 118 |
| LLPS-Scj-0533 | Schizosaccharomyces japonicus | 25.14 | 3e-31 | 130 |