• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Cis-1651

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Ensembl Gene: ENSCSAVG00000007321.1
Ensembl Protein: ENSCSAVP00000012471.1
Organism: Ciona savignyi
Taxa ID: 51511
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLPKSLVSVL  ILTFVATSTA  TLVNEDVNRV  INLKSHLVKV  TTTVVLKNTG  TSPVSAFVFN  60
61    VDPSHIKELA  YISISKSGED  DVFFKLEEKS  GEKGTFTVSL  PQPLASKSTV  TFIAEEIYSS  120
121   ALSPFPKEIT  QSQNQLLIFR  GNHFYYSPYL  SETQTTSVEL  PSSTIETYTK  FGNPSLEDTT  180
181   IKYGDNKEFE  NVPAMSQSAM  KVHYENNNPF  LTVSKLTRVI  EISHWGNIAV  EETLDIRHTG  240
241   AKLKGSFSRY  DYQRQPNSGV  SSVKSFKTIL  PASALDVYYR  DEIGNISTSN  LFKADEAVEF  300
301   EIRPRFPLFG  GWKTHYYIGY  NLPSYNYLFT  RGDVNALKMR  FVDHIMDDQV  VEDLTIKIIL  360
361   PEGAKNIKTE  LPYPAKREDD  SLHFTYLDTV  GRPVITFTKK  NLVEQHIDDF  VVSYTFNRLL  420
421   LLQEPLLIVG  AFFILFFTVI  IIVRLDFSIA  HDKVQEARMR  VQGVIEQVQS  HQAKRQGCYE  480
481   AYQAAVTKYK  STKDHSSLVA  TRKSIESSHK  EATNTINQLL  VKLREDAVEA  ADKVQQLNQI  540
541   DATLKDKISH  SIQLAEKLVQ  GKINREQYMD  QDGKNQKVIE  ENVTKIEKLA  NSL  593
Nucleotide CDS Sequence (FASTA)
1     ATGCTCCCCA  AAAGTTTAGT  TTCTGTCCTA  ATATTAACTT  TTGTTGCAAC  TTCCACTGCA  60
61    ACATTGGTCA  ACGAAGATGT  TAACCGAGTC  ATCAACCTTA  AATCCCATTT  GGTAAAAGTT  120
121   ACAACAACAG  TGGTATTGAA  AAATACTGGA  ACTTCTCCTG  TTTCCGCTTT  CGTATTCAAT  180
181   GTGGATCCTT  CACATATAAA  AGAACTCGCT  TACATCTCCA  TTTCCAAGAG  TGGTGAGGAT  240
241   GATGTTTTTT  TCAAATTGGA  AGAAAAAAGT  GGAGAAAAGG  GGACATTTAC  CGTCTCTTTG  300
301   CCCCAGCCAT  TAGCTTCCAA  ATCCACCGTC  ACCTTCATAG  CCGAGGAAAT  TTATTCCAGC  360
361   GCTCTCAGCC  CCTTTCCCAA  GGAAATCACC  CAGTCACAAA  ACCAACTGCT  TATTTTCCGT  420
421   GGGAATCATT  TCTACTATTC  CCCGTACTTA  TCCGAAACCC  AAACTACTTC  AGTGGAACTG  480
481   CCATCAAGCA  CAATTGAAAC  TTACACAAAG  TTCGGCAACC  CATCGCTTGA  AGACACCACT  540
541   ATCAAATATG  GAGACAATAA  AGAATTTGAG  AATGTTCCAG  CAATGAGTCA  GAGCGCCATG  600
601   AAAGTTCACT  ACGAAAACAA  CAACCCGTTT  TTGACTGTAA  GCAAATTAAC  CAGAGTGATT  660
661   GAAATATCGC  ATTGGGGAAA  TATTGCTGTG  GAGGAGACAC  TGGATATCAG  ACACACTGGA  720
721   GCCAAACTGA  AGGGTTCCTT  CAGTAGATAT  GACTACCAGC  GACAACCCAA  CAGTGGAGTG  780
781   TCCTCGGTAA  AGTCATTCAA  AACCATCCTT  CCTGCCTCAG  CTTTGGATGT  TTACTACAGA  840
841   GATGAAATTG  GAAACATTTC  AACCTCGAAC  CTGTTCAAAG  CTGATGAAGC  AGTTGAGTTT  900
901   GAGATTCGAC  CTCGATTCCC  GTTGTTCGGA  GGTTGGAAGA  CTCACTACTA  CATCGGGTAC  960
961   AACTTGCCAA  GTTACAACTA  TTTGTTCACA  AGAGGTGATG  TAAACGCCCT  GAAAATGCGA  1020
1021  TTTGTCGACC  ACATAATGGA  TGACCAGGTG  GTGGAAGACC  TCACAATCAA  GATCATTCTC  1080
1081  CCTGAAGGAG  CAAAGAATAT  AAAGACAGAG  CTCCCGTACC  CAGCGAAGCG  TGAAGACGAC  1140
1141  TCGCTTCACT  TCACGTATCT  GGACACGGTT  GGACGACCCG  TGATCACATT  CACAAAGAAG  1200
1201  AACCTCGTTG  AACAGCACAT  CGATGATTTT  GTGGTGTCGT  ACACATTCAA  TCGACTCCTG  1260
1261  CTGCTGCAAG  AACCTCTTCT  CATCGTCGGA  GCTTTCTTCA  TTCTCTTCTT  CACAGTGATC  1320
1321  ATCATCGTTC  GATTGGATTT  CTCCATCGCG  CACGACAAGG  TGCAGGAGGC  CAGGATGAGG  1380
1381  GTGCAGGGAG  TCATTGAGCA  GGTCCAATCA  CACCAAGCAA  AACGACAAGG  TTGCTATGAA  1440
1441  GCCTATCAAG  CCGCTGTTAC  CAAATATAAG  TCGACGAAGG  ACCACTCTTC  GCTTGTTGCC  1500
1501  ACTCGAAAAT  CAATTGAGAG  TAGCCACAAG  GAGGCGACCA  ACACAATCAA  CCAACTCCTG  1560
1561  GTTAAACTTC  GTGAAGATGC  CGTTGAAGCT  GCTGATAAAG  TGCAACAGCT  GAACCAAATC  1620
1621  GATGCAACTT  TGAAGGATAA  GATTTCGCAT  TCCATCCAAC  TCGCTGAGAA  ACTGGTCCAG  1680
1681  GGGAAGATCA  ACCGAGAACA  ATACATGGAT  CAGGATGGGA  AGAATCAGAA  AGTTATCGAG  1740
1741  GAAAATGTGA  CGAAGATTGA  GAAGTTGGCG  AATTCACTT  1779

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Endoplasmic reticulum
Membrane
Reference proteome
Signal
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Integral component of membrane
Molecular Function
Dolichyl-diphosphooligosaccharide-protein glycotransferase activity
Biological Process
Protein glycosylation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cii-1298Ciona intestinalis81.050.0 723
LLPS-Mal-3537Mandrillus leucophaeus58.544e-158 466
LLPS-Cas-3098Carlito syrichta58.297e-158 465
LLPS-Meg-1815Meleagris gallopavo56.580.0 578
LLPS-Aon-4087Aotus nancymaae56.41e-154 467
LLPS-Anp-1575Anas platyrhynchos56.390.0 578
LLPS-Fia-0374Ficedula albicollis55.990.0 573
LLPS-Tag-0725Taeniopygia guttata55.990.0 575
LLPS-Pes-0990Pelodiscus sinensis55.210.0 569
LLPS-Pap-1556Pan paniscus55.170.0 565
LLPS-Poa-1009Pongo abelii55.170.0 565
LLPS-Leo-2009Lepisosteus oculatus54.750.0 575
LLPS-Urm-0141Ursus maritimus54.190.0 558
LLPS-Ora-0057Ornithorhynchus anatinus53.81e-111 344
LLPS-Anc-3055Anolis carolinensis53.780.0 599
LLPS-Gaa-2647Gasterosteus aculeatus53.530.0 587
LLPS-Man-0989Macaca nemestrina53.50.0 564
LLPS-Ten-2170Tetraodon nigroviridis53.50.0 590
LLPS-Icp-0139Ictalurus punctatus53.380.0 597
LLPS-Orn-1488Oreochromis niloticus53.360.0 596
LLPS-Mum-4056Mus musculus53.280.0 594
LLPS-Mup-3450Mustela putorius furo53.250.0 591
LLPS-Scf-0792Scleropages formosus53.180.0 607
LLPS-Eqc-2088Equus caballus53.080.0 587
LLPS-Tar-3389Takifugu rubripes52.990.0 587
LLPS-Gaga-2017Gallus gallus52.990.0 592
LLPS-Dar-0592Danio rerio52.960.0 592
LLPS-Ran-1204Rattus norvegicus52.930.0 591
LLPS-Pat-1433Pan troglodytes52.910.0 590
LLPS-Hos-1291Homo sapiens52.910.0 588
LLPS-Nol-1156Nomascus leucogenys52.910.0 587
LLPS-Caj-1780Callithrix jacchus52.80.0 581
LLPS-Mea-4314Mesocricetus auratus52.760.0 593
LLPS-Cea-0408Cercocebus atys52.740.0 587
LLPS-Chs-0180Chlorocebus sabaeus52.740.0 587
LLPS-Maf-1094Macaca fascicularis52.740.0 587
LLPS-Aim-2958Ailuropoda melanoleuca52.740.0 587
LLPS-Paa-0624Papio anubis52.740.0 587
LLPS-Loa-3398Loxodonta africana52.740.0 584
LLPS-Fec-3269Felis catus52.740.0 588
LLPS-Mam-3995Macaca mulatta52.740.0 587
LLPS-Orc-4031Oryctolagus cuniculus52.570.0 586
LLPS-Caf-0051Canis familiaris52.570.0 588
LLPS-Cap-3127Cavia porcellus52.40.0 580
LLPS-Scm-2478Scophthalmus maximus52.390.0 588
LLPS-Rhb-1358Rhinopithecus bieti52.370.0 588
LLPS-Orl-0732Oryzias latipes52.240.0 591
LLPS-Mod-1022Monodelphis domestica52.170.0 591
LLPS-Asm-2653Astyanax mexicanus52.090.0 585
LLPS-Xim-0128Xiphophorus maculatus52.070.0 596
LLPS-Bot-3444Bos taurus51.880.0 577
LLPS-Sah-3080Sarcophilus harrisii51.540.0 571
LLPS-Sus-1378Sus scrofa51.540.0 576
LLPS-Fud-2682Fukomys damarensis51.520.0 578
LLPS-Lac-1608Latimeria chalumnae51.410.0 587
LLPS-Otg-1428Otolemur garnettii51.320.0 587
LLPS-Xet-0497Xenopus tropicalis51.20.0 581
LLPS-Pof-0429Poecilia formosa51.070.0 585
LLPS-Gog-1870Gorilla gorilla50.910.0 575
LLPS-Ova-1052Ovis aries50.340.0 545
LLPS-Myl-4035Myotis lucifugus50.260.0 574
LLPS-Drm-0499Drosophila melanogaster47.091e-122 377
LLPS-Dio-3263Dipodomys ordii46.593e-144 436
LLPS-Ori-0202Oryza indica39.242e-92 303
LLPS-Orgl-0380Oryza glumaepatula39.241e-92 300
LLPS-Ors-1703Oryza sativa39.242e-92 303
LLPS-Orr-1232Oryza rufipogon39.242e-92 303
LLPS-Vir-0090Vigna radiata39.143e-85 281
LLPS-Orb-0983Oryza barthii39.019e-92 301
LLPS-Org-0742Oryza glaberrima39.019e-92 301
LLPS-Cae-1532Caenorhabditis elegans38.017e-102 327
LLPS-Abg-1264Absidia glauca37.674e-39 149
LLPS-Sol-1009Solanum lycopersicum37.597e-79 264
LLPS-Hea-1498Helianthus annuus37.392e-90 298
LLPS-Dac-0021Daucus carota37.253e-91 300
LLPS-Nia-0935Nicotiana attenuata37.174e-90 297
LLPS-Php-0376Physcomitrella patens37.161e-80 273
LLPS-Orm-1048Oryza meridionalis37.14e-92 303
LLPS-Orni-0384Oryza nivara36.942e-92 303
LLPS-Coc-1176Corchorus capsularis36.741e-89 296
LLPS-Met-0203Medicago truncatula36.41e-99 322
LLPS-Brn-2746Brassica napus36.151e-90 298
LLPS-Bro-1350Brassica oleracea36.151e-90 298
LLPS-Glm-1448Glycine max35.945e-97 315
LLPS-Art-0536Arabidopsis thaliana35.98e-90 296
LLPS-Orp-0712Oryza punctata35.773e-95 311
LLPS-Brd-0070Brachypodium distachyon35.747e-98 318
LLPS-Phv-2265Phaseolus vulgaris35.731e-93 307
LLPS-Pot-1743Populus trichocarpa35.661e-96 315
LLPS-Brr-0245Brassica rapa35.616e-90 297
LLPS-Sei-0800Setaria italica35.587e-99 323
LLPS-Arl-1117Arabidopsis lyrata35.533e-89 295
LLPS-Tra-0918Triticum aestivum35.511e-97 317
LLPS-Prp-1684Prunus persica35.512e-95 311
LLPS-Orbr-0396Oryza brachyantha35.211e-92 304
LLPS-Cus-2286Cucumis sativus35.141e-85 285
LLPS-Viv-2037Vitis vinifera35.092e-94 308
LLPS-Sem-0306Selaginella moellendorffii34.967e-91 299
LLPS-Hov-0598Hordeum vulgare34.877e-96 312
LLPS-Lep-0771Leersia perrieri34.773e-94 308
LLPS-Thc-1903Theobroma cacao34.72e-94 308
LLPS-Mua-0181Musa acuminata34.623e-94 308
LLPS-Sot-2013Solanum tuberosum34.476e-86 286
LLPS-Via-1547Vigna angularis34.392e-87 290
LLPS-Gor-0026Gossypium raimondii34.351e-90 298
LLPS-Zem-1214Zea mays34.337e-97 315
LLPS-Mel-0771Melampsora laricipopulina34.281e-36 147
LLPS-Sob-2395Sorghum bicolor34.165e-97 315
LLPS-Amt-0753Amborella trichopoda34.134e-91 300
LLPS-Mae-0897Manihot esculenta33.938e-91 299
LLPS-Nec-1253Neurospora crassa33.892e-48 181
LLPS-Pug-0323Puccinia graminis33.811e-37 150
LLPS-Fus-0581Fusarium solani33.817e-44 168
LLPS-Cogr-1080Colletotrichum graminicola33.431e-44 170
LLPS-Asn-1462Aspergillus nidulans33.339e-45 171
LLPS-Beb-0455Beauveria bassiana33.332e-44 170
LLPS-Put-0557Puccinia triticina33.339e-34 138
LLPS-Chr-1448Chlamydomonas reinhardtii33.272e-85 284
LLPS-Tru-0058Triticum urartu33.279e-85 283
LLPS-Gag-1506Gaeumannomyces graminis33.162e-49 184
LLPS-Aso-1328Aspergillus oryzae32.994e-46 175
LLPS-Asf-1125Aspergillus flavus32.994e-46 175
LLPS-Nef-1269Neosartorya fischeri32.993e-41 160
LLPS-Blg-1557Blumeria graminis32.743e-43 167
LLPS-Map-0118Magnaporthe poae32.669e-48 179
LLPS-Miv-0966Microbotryum violaceum32.573e-31 131
LLPS-Phn-1522Phaeosphaeria nodorum32.531e-52 193
LLPS-Asfu-0780Aspergillus fumigatus32.477e-42 162
LLPS-Mao-1562Magnaporthe oryzae32.293e-47 178
LLPS-Coo-1405Colletotrichum orbiculare32.293e-43 166
LLPS-Asc-0017Aspergillus clavatus32.219e-45 171
LLPS-Ved-1147Verticillium dahliae31.914e-44 169
LLPS-Trr-1588Trichoderma reesei31.91e-43 167
LLPS-Ast-1048Aspergillus terreus31.856e-45 171
LLPS-Dos-1283Dothistroma septosporum31.751e-39 155
LLPS-Pyt-1539Pyrenophora teres31.664e-55 200
LLPS-Cog-0742Colletotrichum gloeosporioides31.592e-46 175
LLPS-Scs-0901Sclerotinia sclerotiorum31.554e-46 175
LLPS-Pytr-0743Pyrenophora triticirepentis31.458e-50 185
LLPS-Fuo-1261Fusarium oxysporum31.284e-43 166
LLPS-Asni-1533Aspergillus niger31.252e-40 158
LLPS-Lem-1253Leptosphaeria maculans31.21e-49 185
LLPS-Gas-1317Galdieria sulphuraria31.162e-43 168
LLPS-Fuv-0686Fusarium verticillioides31.092e-42 164
LLPS-Trv-0707Trichoderma virens30.952e-42 164
LLPS-Tum-1273Tuber melanosporum30.528e-47 176
LLPS-Spr-0368Sporisorium reilianum30.342e-39 155
LLPS-Zyt-1266Zymoseptoria tritici30.325e-40 157
LLPS-Yal-0849Yarrowia lipolytica30.23e-48 180
LLPS-Crn-0929Cryptococcus neoformans30.02e-43 167
LLPS-Usm-0219Ustilago maydis29.684e-37 148
LLPS-Asg-1243Ashbya gossypii27.342e-2099.0
LLPS-Sac-1420Saccharomyces cerevisiae27.226e-25 112
LLPS-Scc-1262Schizosaccharomyces cryophilus27.172e-32 133
LLPS-Kop-0887Komagataella pastoris26.972e-21 101
LLPS-Scp-0812Schizosaccharomyces pombe24.544e-27 118
LLPS-Scj-0533Schizosaccharomyces japonicus23.463e-28 122