• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Ova-0424
CYBA

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Cytochrome b-245 light chain; Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox
Gene Name: CYBA
Ensembl Gene: ENSOARG00000012901.1
Ensembl Protein: ENSOARP00000013819.1
Organism: Ovis aries
Taxa ID: 9940
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
ParaspecklePredicted from orthologs(View)

▼ FUNCTION

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGQIEWAMWA  NEHALASGLI  LITGGIVATA  GQFTQWYLGA  YSIAAGVLVC  LLEYPRGKRT  60
61    KGSTMERCGQ  KYLTRVVKLF  GPLTRNYYIR  AFLHLGLAVP  AGFLLATILG  TACLAIASGI  120
121   YLLAAIRGEQ  WSPIEPKPKE  RPQIGGTIKQ  PPSNPPPRPP  AEARKKPSEE  AAGVPTGGPQ  180
181   ENPMPVNDEV  V  191
Nucleotide CDS Sequence (FASTA)
1     ATGGGGCAGA  TCGAGTGGGC  CATGTGGGCC  AACGAGCACG  CGCTGGCGTC  CGGCCTGATC  60
61    CTTATCACCG  GGGGCATTGT  GGCCACGGCC  GGGCAGTTCA  CCCAGTGGTA  CCTGGGCGCC  120
121   TACTCCATAG  CAGCGGGTGT  ATTGGTCTGC  CTGCTGGAGT  ACCCTCGAGG  GAAGAGGACC  180
181   AAGGGCTCCA  CCATGGAGAG  GTGTGGACAG  AAGTATCTGA  CCAGAGTGGT  GAAGCTGTTT  240
241   GGGCCCCTCA  CCAGGAACTA  CTACATCCGG  GCCTTCCTGC  ACCTCGGGCT  GGCGGTACCT  300
301   GCTGGCTTCC  TGCTCGCCAC  CATCCTGGGG  ACAGCCTGCT  TGGCCATCGC  AAGTGGCATC  360
361   TATCTGCTGG  CGGCCATCCG  TGGGGAGCAG  TGGAGCCCCA  TCGAGCCCAA  GCCCAAGGAG  420
421   CGGCCACAGA  TTGGGGGCAC  CATCAAGCAG  CCGCCCAGCA  ACCCTCCACC  CCGGCCCCCG  480
481   GCTGAGGCCC  GCAAGAAGCC  GAGTGAGGAG  GCGGCGGGGG  TCCCCACGGG  TGGTCCCCAG  540
541   GAAAACCCCA  TGCCGGTGAA  CGACGAGGTC  GTGTGA  576

▼ KEYWORD

ID
Family
Cell membrane
Complete proteome
Electron transport
Heme
Iron
Membrane
Metal-binding
NADP
Oxidoreductase
Reference proteome
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endosome
Cellular Component
NADPH oxidase complex
Molecular Function
Electron transfer activity
Molecular Function
Heme binding
Molecular Function
Metal ion binding
Molecular Function
Protein heterodimerization activity
Molecular Function
SH3 domain binding
Molecular Function
Superoxide-generating NADPH oxidase activity
Biological Process
Cytochrome complex assembly
Biological Process
Inflammatory response
Biological Process
Innate immune response
Biological Process
Positive regulation of defense response to bacterium
Biological Process
Positive regulation of interleukin-6 production
Biological Process
Positive regulation of mucus secretion
Biological Process
Positive regulation of phagocytosis
Biological Process
Positive regulation of reactive oxygen species biosynthetic process
Biological Process
Positive regulation of toll-like receptor 2 signaling pathway
Biological Process
Positive regulation of tumor necrosis factor production
Biological Process
Regulation of release of sequestered calcium ion into cytosol
Biological Process
Respiratory burst
Biological Process
Superoxide anion generation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Bot-0856Bos taurus98.953e-118 340
LLPS-Sus-2909Sus scrofa91.197e-108 314
LLPS-Tut-1324Tursiops truncatus89.581e-106 311
LLPS-Mal-2926Mandrillus leucophaeus87.36e-72 223
LLPS-Maf-2470Macaca fascicularis87.37e-72 223
LLPS-Man-1658Macaca nemestrina87.35e-72 223
LLPS-Aon-1397Aotus nancymaae87.054e-103 302
LLPS-Paa-4146Papio anubis86.671e-100 296
LLPS-Mam-0433Macaca mulatta86.671e-100 296
LLPS-Mup-4362Mustela putorius furo86.61e-102 301
LLPS-Rhb-1403Rhinopithecus bieti86.63e-95 282
LLPS-Gog-1282Gorilla gorilla86.518e-71 220
LLPS-Nol-3432Nomascus leucogenys86.515e-70 218
LLPS-Hos-2542Homo sapiens86.511e-70 220
LLPS-Pat-2745Pan troglodytes86.519e-71 220
LLPS-Pap-3392Pan paniscus86.519e-71 220
LLPS-Mum-3463Mus musculus86.465e-101 297
LLPS-Eqc-1135Equus caballus86.083e-104 305
LLPS-Otg-2874Otolemur garnettii86.081e-101 298
LLPS-Caj-4816Callithrix jacchus86.014e-102 300
LLPS-Caf-3966Canis familiaris85.714e-100 295
LLPS-Cas-3310Carlito syrichta85.631e-88 265
LLPS-Urm-3761Ursus maritimus84.781e-50 169
LLPS-Fia-3304Ficedula albicollis84.628e-31 114
LLPS-Ran-4550Rattus norvegicus84.381e-97 288
LLPS-Myl-3985Myotis lucifugus84.344e-98 290
LLPS-Chs-2990Chlorocebus sabaeus84.262e-93 278
LLPS-Aim-1026Ailuropoda melanoleuca84.025e-96 284
LLPS-Fud-1659Fukomys damarensis83.632e-81 246
LLPS-Fec-3892Felis catus83.512e-100 295
LLPS-Mea-1632Mesocricetus auratus83.338e-100 294
LLPS-Mod-0241Monodelphis domestica81.981e-82 250
LLPS-Ict-0519Ictidomys tridecemlineatus81.544e-90 269
LLPS-Cap-3147Cavia porcellus80.311e-87 263
LLPS-Dio-2033Dipodomys ordii80.111e-77 237
LLPS-Sah-1139Sarcophilus harrisii79.554e-78 239
LLPS-Ora-1491Ornithorhynchus anatinus79.312e-43 146
LLPS-Cea-4810Cercocebus atys78.465e-95 281
LLPS-Tag-1421Taeniopygia guttata74.671e-71 221
LLPS-Anc-2759Anolis carolinensis74.64e-84 253
LLPS-Loa-3717Loxodonta africana74.422e-82 248
LLPS-Gaga-3509Gallus gallus73.022e-75 231
LLPS-Meg-1138Meleagris gallopavo73.022e-75 231
LLPS-Poa-2029Pongo abelii70.711e-27 106
LLPS-Xet-1976Xenopus tropicalis70.163e-78 239
LLPS-Scm-0895Scophthalmus maximus69.52e-64 203
LLPS-Lac-3395Latimeria chalumnae66.672e-67 211
LLPS-Scf-3310Scleropages formosus64.178e-67 209
LLPS-Tar-2070Takifugu rubripes63.766e-64 202
LLPS-Leo-3134Lepisosteus oculatus63.36e-64 202
LLPS-Asm-0764Astyanax mexicanus62.678e-60 191
LLPS-Gaa-1190Gasterosteus aculeatus62.234e-64 202
LLPS-Dar-4237Danio rerio62.06e-59 189
LLPS-Ten-3574Tetraodon nigroviridis61.743e-61 195
LLPS-Xim-3578Xiphophorus maculatus61.541e-50 168
LLPS-Orl-3591Oryzias latipes59.793e-56 182
LLPS-Icp-3350Ictalurus punctatus59.263e-62 197
LLPS-Orn-3982Oreochromis niloticus58.127e-65 204
LLPS-Cii-0972Ciona intestinalis43.363e-26 104
LLPS-Cis-0310Ciona savignyi36.557e-2190.1