• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Cap-3147
CYBA

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Cytochrome b-245 light chain; Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox
Gene Name: CYBA
Ensembl Gene: ENSCPOG00000001019.4
Ensembl Protein: ENSCPOP00000016000.2
Organism: Cavia porcellus
Taxa ID: 10141
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
ParaspecklePredicted from orthologs(View)

▼ FUNCTION

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGQIEWAMWA  NEQALASGLI  LVAGGIVATV  GRFAQWYFGA  YSIAAGALVC  LLEYPRGRRR  60
61    KGSTMERCGQ  KYVAAAVKLF  GPLTRNYYVR  AVLHLLLSVP  AGFLLATILG  TVCLAIASVI  120
121   YLLAAIRGEQ  WLPIESKPKE  RPQAEDIKPP  PSNPPPRPPA  EARKKPNEDE  VAAGGNPQVN  180
181   PIPVTDEVV  189
Nucleotide CDS Sequence (FASTA)
1     ATGGGGCAGA  TCGAGTGGGC  CATGTGGGCC  AACGAGCAGG  CTCTGGCGTC  CGGCCTGATC  60
61    CTCGTCGCCG  GGGGCATCGT  GGCCACCGTG  GGACGCTTTG  CCCAGTGGTA  CTTCGGTGCC  120
121   TACTCCATCG  CGGCGGGGGC  GCTCGTGTGC  CTGCTGGAGT  ACCCGCGGGG  CCGCAGGCGG  180
181   AAGGGTTCCA  CCATGGAGCG  CTGGCTGTCG  GTGCCCGCAG  GCTTCCTACT  GGCCACCATC  240
241   CTGGGAACCG  TGTGCCTGGC  CATCGCAAGT  GTCATCTACC  TGCTGGCGGC  CATTCGTGGT  300
301   GAGCAGTGGT  TGCCCATCGA  GTCCAAGCCC  AAGGAACGGC  CCCAGGCGGA  AGACATCAAG  360
361   CCACCACCCA  GCAACCCCCC  ACCTCGGCCT  CCAGCTGAAG  CCCGAAAGAA  GCCCAATGAA  420
421   GATGAGGTGG  CAGCAGGCGG  GAACCCCCAA  GTCAACCCCA  TCCCTGTGAC  TGACGAGGTG  480
481   GTGTGA  486

▼ KEYWORD

ID
Family
Cell membrane
Complete proteome
Electron transport
Heme
Iron
Membrane
Metal-binding
NADP
Oxidoreductase
Reference proteome
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endosome
Cellular Component
NADPH oxidase complex
Molecular Function
Electron transfer activity
Molecular Function
Heme binding
Molecular Function
Metal ion binding
Molecular Function
Protein heterodimerization activity
Molecular Function
SH3 domain binding
Molecular Function
Superoxide-generating NADPH oxidase activity
Biological Process
Cytochrome complex assembly
Biological Process
Inflammatory response
Biological Process
Innate immune response
Biological Process
Positive regulation of defense response to bacterium
Biological Process
Positive regulation of interleukin-6 production
Biological Process
Positive regulation of mucus secretion
Biological Process
Positive regulation of phagocytosis
Biological Process
Positive regulation of reactive oxygen species biosynthetic process
Biological Process
Positive regulation of toll-like receptor 2 signaling pathway
Biological Process
Positive regulation of tumor necrosis factor production
Biological Process
Regulation of release of sequestered calcium ion into cytosol
Biological Process
Respiratory burst
Biological Process
Superoxide anion generation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Nol-3432Nomascus leucogenys86.516e-72 223
LLPS-Fud-1659Fukomys damarensis86.473e-86 258
LLPS-Man-1658Macaca nemestrina84.925e-71 221
LLPS-Pat-2745Pan troglodytes84.922e-70 219
LLPS-Pap-3392Pan paniscus84.922e-70 219
LLPS-Hos-2542Homo sapiens84.922e-70 219
LLPS-Gog-1282Gorilla gorilla84.922e-70 219
LLPS-Maf-2470Macaca fascicularis84.925e-71 220
LLPS-Mal-2926Mandrillus leucophaeus84.925e-71 220
LLPS-Cas-3310Carlito syrichta84.481e-82 249
LLPS-Ran-4550Rattus norvegicus84.385e-95 281
LLPS-Mum-3463Mus musculus83.331e-97 288
LLPS-Mea-1632Mesocricetus auratus82.298e-98 288
LLPS-Mam-0433Macaca mulatta82.059e-93 276
LLPS-Paa-4146Papio anubis82.059e-93 276
LLPS-Aon-1397Aotus nancymaae81.873e-94 279
LLPS-Tut-1324Tursiops truncatus81.254e-92 274
LLPS-Eqc-1135Equus caballus80.932e-92 275
LLPS-Bot-0856Bos taurus80.832e-88 265
LLPS-Ict-0519Ictidomys tridecemlineatus80.512e-89 267
LLPS-Urm-3761Ursus maritimus80.433e-46 157
LLPS-Caj-4816Callithrix jacchus80.319e-92 273
LLPS-Ova-0424Ovis aries80.318e-88 263
LLPS-Rhb-1403Rhinopithecus bieti79.98e-89 266
LLPS-Sus-2909Sus scrofa79.271e-85 258
LLPS-Dio-2033Dipodomys ordii78.983e-75 231
LLPS-Chs-2990Chlorocebus sabaeus78.173e-86 259
LLPS-Caf-3966Canis familiaris77.954e-89 266
LLPS-Mup-4362Mustela putorius furo77.842e-89 267
LLPS-Fec-3892Felis catus77.324e-88 264
LLPS-Myl-3985Myotis lucifugus77.169e-87 261
LLPS-Fia-3304Ficedula albicollis75.388e-28 106
LLPS-Mod-0241Monodelphis domestica75.04e-71 221
LLPS-Anc-2759Anolis carolinensis74.472e-78 239
LLPS-Sah-1139Sarcophilus harrisii73.33e-69 216
LLPS-Cea-4810Cercocebus atys72.316e-88 263
LLPS-Otg-2874Otolemur garnettii72.161e-90 270
LLPS-Tag-1421Taeniopygia guttata71.333e-66 207
LLPS-Ora-1491Ornithorhynchus anatinus71.264e-41 140
LLPS-Aim-1026Ailuropoda melanoleuca69.072e-85 257
LLPS-Loa-3717Loxodonta africana68.212e-74 228
LLPS-Scm-0895Scophthalmus maximus66.672e-60 193
LLPS-Scf-3310Scleropages formosus66.315e-68 213
LLPS-Xet-1976Xenopus tropicalis66.145e-81 246
LLPS-Leo-3134Lepisosteus oculatus65.435e-65 205
LLPS-Meg-1138Meleagris gallopavo65.241e-69 216
LLPS-Gaga-3509Gallus gallus65.245e-70 218
LLPS-Gaa-1190Gasterosteus aculeatus63.641e-63 201
LLPS-Ten-3574Tetraodon nigroviridis63.446e-64 202
LLPS-Tar-2070Takifugu rubripes63.442e-64 203
LLPS-Icp-3350Ictalurus punctatus62.112e-61 196
LLPS-Orl-3591Oryzias latipes61.174e-53 174
LLPS-Dar-4237Danio rerio60.813e-57 185
LLPS-Orn-3982Oreochromis niloticus60.534e-59 190
LLPS-Asm-0764Astyanax mexicanus60.112e-57 185
LLPS-Xim-3578Xiphophorus maculatus59.172e-49 165
LLPS-Poa-2029Pongo abelii58.491e-2190.9
LLPS-Lac-3395Latimeria chalumnae58.382e-66 208
LLPS-Cii-0972Ciona intestinalis41.336e-27 106
LLPS-Cis-0310Ciona savignyi35.863e-2293.6