• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mup-4362
CYBA

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Cytochrome b-245 light chain; Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox
Gene Name: CYBA
Ensembl Gene: ENSMPUG00000008126.1
Ensembl Protein: ENSMPUP00000008069.1
Organism: Mustela putorius furo
Taxa ID: 9669
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
ParaspecklePredicted from orthologs(View)

▼ FUNCTION

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGQIEWAMWA  NEQALASGLI  LIMGGVVATA  GQFTKWYFGA  YSIGAGVFVC  LLEYPRGKRR  60
61    KGSTMERCGQ  KYMTKVLKVF  GPLTRNYYIR  AFLHLGLSVP  AGFLLATILG  TACLAIASSI  120
121   YLLAAVRGEQ  WVPIEPKPKE  RPQVGGTIKQ  PPSNPPPRPP  AEARKKPGEE  EAAGVAGVSG  180
181   GPQENPVPVI  DEVV  194
Nucleotide CDS Sequence (FASTA)
1     ATGGGGCAGA  TCGAGTGGGC  CATGTGGGCC  AACGAACAGG  CGCTGGCGTC  CGGCCTGATC  60
61    CTCATCATGG  GGGGCGTCGT  GGCCACGGCC  GGCCAGTTCA  CCAAGTGGTA  CTTCGGCGCG  120
121   TACTCCATTG  GCGCAGGCGT  GTTCGTCTGC  CTGCTGGAGT  ACCCCCGGGG  GAAGAGGAGG  180
181   AAGGGGTCCA  CCATGGAGAG  ATGCGGACAG  AAGTACATGA  CCAAAGTGCT  GAAGGTGTTC  240
241   GGGCCTCTCA  CCAGGAACTA  CTACATCCGG  GCCTTCCTGC  ACCTGGGGCT  ATCAGTACCT  300
301   GCCGGCTTCC  TGCTTGCCAC  CATCCTGGGG  ACGGCCTGCC  TGGCCATTGC  GAGCAGCATC  360
361   TATCTGCTGG  CGGCCGTCCG  TGGAGAGCAG  TGGGTCCCCA  TCGAGCCCAA  GCCCAAGGAG  420
421   CGGCCACAAG  TCGGAGGCAC  CATCAAGCAG  CCGCCCAGCA  ACCCCCCGCC  CCGGCCCCCA  480
481   GCCGAGGCCC  GAAAGAAGCC  TGGAGAAGAG  GAGGCTGCAG  GGGTGGCAGG  GGTTTCCGGT  540
541   GGCCCCCAGG  AAAACCCGGT  CCCGGTGATC  GACGAGGTCG  TGTGA  585

▼ KEYWORD

ID
Family
Cell membrane
Complete proteome
Electron transport
Heme
Iron
Membrane
Metal-binding
NADP
Oxidoreductase
Reference proteome
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endosome
Cellular Component
NADPH oxidase complex
Molecular Function
Electron transfer activity
Molecular Function
Heme binding
Molecular Function
Metal ion binding
Molecular Function
Protein heterodimerization activity
Molecular Function
SH3 domain binding
Molecular Function
Superoxide-generating NADPH oxidase activity
Biological Process
Cytochrome complex assembly
Biological Process
Inflammatory response
Biological Process
Innate immune response
Biological Process
Positive regulation of defense response to bacterium
Biological Process
Positive regulation of interleukin-6 production
Biological Process
Positive regulation of mucus secretion
Biological Process
Positive regulation of phagocytosis
Biological Process
Positive regulation of reactive oxygen species biosynthetic process
Biological Process
Positive regulation of toll-like receptor 2 signaling pathway
Biological Process
Positive regulation of tumor necrosis factor production
Biological Process
Regulation of release of sequestered calcium ion into cytosol
Biological Process
Respiratory burst
Biological Process
Superoxide anion generation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aim-1026Ailuropoda melanoleuca94.853e-94 280
LLPS-Caf-3966Canis familiaris93.852e-93 278
LLPS-Urm-3761Ursus maritimus90.323e-55 181
LLPS-Fec-3892Felis catus89.691e-89 268
LLPS-Nol-3432Nomascus leucogenys88.292e-63 202
LLPS-Man-1658Macaca nemestrina88.298e-64 202
LLPS-Mal-2926Mandrillus leucophaeus88.299e-64 202
LLPS-Maf-2470Macaca fascicularis88.299e-64 202
LLPS-Eqc-1135Equus caballus87.632e-91 273
LLPS-Pap-3392Pan paniscus87.391e-62 199
LLPS-Pat-2745Pan troglodytes87.391e-62 199
LLPS-Hos-2542Homo sapiens87.392e-62 199
LLPS-Gog-1282Gorilla gorilla87.391e-62 200
LLPS-Myl-3985Myotis lucifugus86.82e-85 257
LLPS-Otg-2874Otolemur garnettii86.62e-85 257
LLPS-Rhb-1403Rhinopithecus bieti85.576e-84 253
LLPS-Mam-0433Macaca mulatta85.132e-83 252
LLPS-Paa-4146Papio anubis85.132e-83 252
LLPS-Ict-0519Ictidomys tridecemlineatus84.15e-82 248
LLPS-Poa-2029Pongo abelii83.842e-1676.6
LLPS-Chs-2990Chlorocebus sabaeus83.761e-81 248
LLPS-Cea-4810Cercocebus atys83.083e-83 252
LLPS-Dio-2033Dipodomys ordii81.828e-67 209
LLPS-Aon-1397Aotus nancymaae80.934e-86 259
LLPS-Gaga-3509Gallus gallus80.06e-65 204
LLPS-Meg-1138Meleagris gallopavo80.04e-65 205
LLPS-Caj-4816Callithrix jacchus79.96e-86 258
LLPS-Anc-2759Anolis carolinensis78.674e-73 226
LLPS-Bot-0856Bos taurus77.321e-86 260
LLPS-Sus-2909Sus scrofa76.927e-83 251
LLPS-Ova-0424Ovis aries76.87e-86 258
LLPS-Ran-4550Rattus norvegicus76.82e-83 252
LLPS-Tut-1324Tursiops truncatus76.292e-83 252
LLPS-Cas-3310Carlito syrichta76.06e-68 212
LLPS-Ora-1491Ornithorhynchus anatinus75.861e-42 144
LLPS-Mum-3463Mus musculus75.771e-83 253
LLPS-Fia-3304Ficedula albicollis75.381e-28 108
LLPS-Mea-1632Mesocricetus auratus74.233e-84 254
LLPS-Tag-1421Taeniopygia guttata72.672e-60 192
LLPS-Loa-3717Loxodonta africana72.05e-66 207
LLPS-Fud-1659Fukomys damarensis71.841e-64 203
LLPS-Xet-1976Xenopus tropicalis71.811e-65 206
LLPS-Mod-0241Monodelphis domestica70.291e-61 196
LLPS-Sah-1139Sarcophilus harrisii69.274e-59 191
LLPS-Gaa-1190Gasterosteus aculeatus68.611e-54 178
LLPS-Cap-3147Cavia porcellus68.563e-75 231
LLPS-Lac-3395Latimeria chalumnae66.672e-58 188
LLPS-Scm-0895Scophthalmus maximus66.677e-55 179
LLPS-Scf-3310Scleropages formosus66.05e-58 187
LLPS-Leo-3134Lepisosteus oculatus66.06e-56 182
LLPS-Orn-3982Oreochromis niloticus65.561e-55 181
LLPS-Orl-3591Oryzias latipes64.679e-48 160
LLPS-Tar-2070Takifugu rubripes63.095e-54 177
LLPS-Ten-3574Tetraodon nigroviridis61.744e-53 174
LLPS-Asm-0764Astyanax mexicanus61.333e-52 172
LLPS-Icp-3350Ictalurus punctatus61.077e-53 174
LLPS-Xim-3578Xiphophorus maculatus60.772e-42 147
LLPS-Dar-4237Danio rerio60.674e-51 169
LLPS-Cii-0972Ciona intestinalis38.735e-1677.0
LLPS-Cis-0310Ciona savignyi35.173e-1471.2