DrLLPS - Data resource of LLPS

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Property
Classification
Function
Cross Reference
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LLPS-Hos-2542
CYBA

▼ OVERVIEW


Status:	Reviewed
Protein Name:	Cytochrome b-245 light chain; Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phox
Gene Name:	CYBA
Ensembl Gene:	ENSG00000051523.10
Ensembl Protein:	ENSP00000455537.1
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	Client

PDB: 1WLP (A, B) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Paraspeckle	"...In total, we identified 325 proteins localized to distinct nuclear bodies, including nucleoli, promyelocytic leukemia nuclear bodies, nuclear speckles, paraspeckles, Cajal bodies, Sam68 nuclear bodies, Polycomb bodies, and uncharacterized nuclear bodies."	HeLa cells	24127217

▼ FUNCTION

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000565588.5	ENSP00000455537.1
Ensembl	ENST00000261623.7	ENSP00000261623.3
Ensembl	ENST00000568278.1	ENSP00000455506.1
Ensembl	ENST00000569359.5	ENSP00000456079.1
Ensembl	ENST00000567174.5	ENSP00000454951.1
Ensembl	ENST00000566229.1	ENSP00000457060.1
UniProt		P13498, CY24A_HUMAN, Q14090, Q9BR72
GeneBank	M21186, AC116552, BC006465, AH002664, BT006861	AAP35507.1, AAA90925.1, AAA52134.1, AAH06465.1
RefSeq	NM_000101.3	NP_000092.2
Entrez	1535

▼ SEQUENCE

Protein Sequence (FASTA)
1 MGQIEWAMWA NEQALASGLI LITGGIVATA GRFTQWYFGA YSIVAGVFVC LLEYPRGKRK 60 61 KGSTMERWGQ KYMTAVVKLF GPFTRNYYVR AVLHLLLSVP AGFLLATILG TACLAIASGI 120 121 YLLSQVPPAR RGNCPPLAVR LLVCVRGKGA ALSVYAFRVW KWSSVSSLTD LPPAELSFRT 180 181 PSCCQVLIWA VALFSGGHPH PPRLPAATHS 210
Nucleotide CDS Sequence (FASTA)
1 ATGGGGCAGA TCGAGTGGGC CATGTGGGCC AACGAACAGG CGCTGGCGTC CGGCCTGATC 60 61 CTCATCACCG GGGGCATCGT GGCCACAGCT GGGCGCTTCA CCCAGTGGTA CTTTGGTGCC 120 121 TACTCCATTG TGGCGGGCGT GTTTGTGTGC CTGCTGGAGT ACCCCCGGGG GAAGAGGAAG 180 181 AAGGGCTCCA CCATGGAGCG CTGGGGACAG AAGTACATGA CCGCCGTGGT GAAGCTGTTC 240 241 GGGCCCTTTA CCAGGAATTA CTATGTTCGG GCCGTCCTGC ATCTCCTGCT CTCGGTGCCC 300 301 GCCGGCTTCC TGCTGGCCAC CATCCTTGGG ACCGCCTGCC TGGCCATTGC GAGCGGCATC 360 361 TACCTACTGG CGGCTGTGCG TGGCGAGCAG TGGACGCCCA TCGAGCCCAA GCCCCGGGAG 420 421 CGGCCGCAGA TCGGAGGCAC CATCAAGCAG CCGCCCAGCA ACCCCCCGCC GCGGCCCCCG 480 481 GCCGAGGCCC GCAAGAAGCC CAGCGAGGAG GAGGCTGCGG TGGCGGCGGG GGGACCCCCG 540 541 GGAGGTCCCC AGGTCAACCC CATCCCGGTG ACCGACGAGG TCGTGTGA 588

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-1003	Cell membrane
KW-0161	Chronic granulomatous disease
KW-0181	Complete proteome
KW-0903	Direct protein sequencing
KW-0225	Disease mutation
KW-0249	Electron transport
KW-0349	Heme
KW-0408	Iron
KW-1017	Isopeptide bond
KW-0472	Membrane
KW-0479	Metal-binding
KW-0521	NADP
KW-0560	Oxidoreductase
KW-0597	Phosphoprotein
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0813	Transport
KW-0832	Ubl conjugation

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0016324	Cellular Component	Apical plasma membrane
GO:0030425	Cellular Component	Dendrite
GO:0005789	Cellular Component	Endoplasmic reticulum membrane
GO:0005768	Cellular Component	Endosome
GO:0005925	Cellular Component	Focal adhesion
GO:0005794	Cellular Component	Golgi apparatus
GO:0016020	Cellular Component	Membrane
GO:0043020	Cellular Component	NADPH oxidase complex
GO:0043025	Cellular Component	Neuronal cell body
GO:0005634	Cellular Component	Nucleus
GO:0097038	Cellular Component	Perinuclear endoplasmic reticulum
GO:0030670	Cellular Component	Phagocytic vesicle membrane
GO:0005886	Cellular Component	Plasma membrane
GO:0030141	Cellular Component	Secretory granule
GO:0035579	Cellular Component	Specific granule membrane
GO:0001725	Cellular Component	Stress fiber
GO:0070821	Cellular Component	Tertiary granule membrane
GO:0009055	Molecular Function	Electron transfer activity
GO:0020037	Molecular Function	Heme binding
GO:0046872	Molecular Function	Metal ion binding
GO:0046982	Molecular Function	Protein heterodimerization activity
GO:0017124	Molecular Function	SH3 domain binding
GO:0016175	Molecular Function	Superoxide-generating NADPH oxidase activity
GO:1904385	Biological Process	Cellular response to angiotensin
GO:0071480	Biological Process	Cellular response to gamma radiation
GO:0071333	Biological Process	Cellular response to glucose stimulus
GO:1904845	Biological Process	Cellular response to L-glutamine
GO:0071260	Biological Process	Cellular response to mechanical stimulus
GO:0071407	Biological Process	Cellular response to organic cyclic compound
GO:0034599	Biological Process	Cellular response to oxidative stress
GO:0071356	Biological Process	Cellular response to tumor necrosis factor
GO:0017004	Biological Process	Cytochrome complex assembly
GO:0050665	Biological Process	Hydrogen peroxide biosynthetic process
GO:0006954	Biological Process	Inflammatory response
GO:0045087	Biological Process	Innate immune response
GO:0003106	Biological Process	Negative regulation of glomerular filtration by angiotensin
GO:0043312	Biological Process	Neutrophil degranulation
GO:0055114	Biological Process	Oxidation-reduction process
GO:0030307	Biological Process	Positive regulation of cell growth
GO:1900426	Biological Process	Positive regulation of defense response to bacterium
GO:0001938	Biological Process	Positive regulation of endothelial cell proliferation
GO:0032755	Biological Process	Positive regulation of interleukin-6 production
GO:0070257	Biological Process	Positive regulation of mucus secretion
GO:0033864	Biological Process	Positive regulation of NAD(P)H oxidase activity
GO:0050766	Biological Process	Positive regulation of phagocytosis
GO:1903428	Biological Process	Positive regulation of reactive oxygen species biosynthetic process
GO:0048661	Biological Process	Positive regulation of smooth muscle cell proliferation
GO:0032930	Biological Process	Positive regulation of superoxide anion generation
GO:0034137	Biological Process	Positive regulation of toll-like receptor 2 signaling pathway
GO:0032760	Biological Process	Positive regulation of tumor necrosis factor production
GO:0051279	Biological Process	Regulation of release of sequestered calcium ion into cytosol
GO:0045730	Biological Process	Respiratory burst
GO:0014823	Biological Process	Response to activity
GO:1904044	Biological Process	Response to aldosterone
GO:0001666	Biological Process	Response to hypoxia
GO:0070555	Biological Process	Response to interleukin-1
GO:0014895	Biological Process	Smooth muscle hypertrophy
GO:0042554	Biological Process	Superoxide anion generation
GO:0006801	Biological Process	Superoxide metabolic process
GO:0048010	Biological Process	Vascular endothelial growth factor receptor signaling pathway

▼ KEGG

hsa:1535

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	HPRD
BioGRID	mUbiSiDa	PTMcode

Variation
dbSNP	VarCards	rSNPBase

Mutation
TCGA	ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	RAIN	Mentha
PINA	IID	iRefIndex	MIST	DifferentialNET
RNAct

Disease
OMIM	DisGeNET

Drug
DrugBank	CTD

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF	CellMarker

Proteomics
THPA	HPM

Structure
PDB	MMDB

Localization
COMPARTMENTS

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TISSUES	BioXpress	THPA

Element
UTRdb	circBase	CircNet	miRTarBase	miRWalk
miRcode	RAID	microRNA.org

Methylation
TCGA	ICGC	COSMIC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Gog-1282	Gorilla gorilla	98.1	1e-146	414
LLPS-Cea-4810	Cercocebus atys	96.83	8e-81	246
LLPS-Chs-2990	Chlorocebus sabaeus	96.83	6e-81	246
LLPS-Paa-4146	Papio anubis	96.83	4e-81	247
LLPS-Rhb-1403	Rhinopithecus bieti	96.83	5e-81	247
LLPS-Mam-0433	Macaca mulatta	96.83	4e-81	247
LLPS-Pat-2745	Pan troglodytes	96.67	1e-144	409
LLPS-Pap-3392	Pan paniscus	96.67	1e-144	409
LLPS-Aon-1397	Aotus nancymaae	96.03	1e-79	243
LLPS-Caj-4816	Callithrix jacchus	94.44	1e-78	240
LLPS-Myl-3985	Myotis lucifugus	92.06	2e-74	230
LLPS-Ran-4550	Rattus norvegicus	92.06	1e-75	233
LLPS-Nol-3432	Nomascus leucogenys	91.04	2e-131	375
LLPS-Fud-1659	Fukomys damarensis	90.57	2e-60	193
LLPS-Otg-2874	Otolemur garnettii	90.48	1e-75	233
LLPS-Ict-0519	Ictidomys tridecemlineatus	89.68	8e-74	228
LLPS-Eqc-1135	Equus caballus	89.68	1e-73	228
LLPS-Mum-3463	Mus musculus	88.89	8e-74	228
LLPS-Mea-1632	Mesocricetus auratus	88.89	9e-74	228
LLPS-Cas-3310	Carlito syrichta	88.79	1e-60	194
LLPS-Aim-1026	Ailuropoda melanoleuca	87.9	6e-71	221
LLPS-Caf-3966	Canis familiaris	87.9	4e-71	221
LLPS-Dio-2033	Dipodomys ordii	87.74	9e-58	187
LLPS-Bot-0856	Bos taurus	87.3	9e-72	223
LLPS-Mup-4362	Mustela putorius furo	86.51	3e-71	222
LLPS-Ova-0424	Ovis aries	86.51	9e-71	220
LLPS-Loa-3717	Loxodonta africana	85.98	1e-58	189
LLPS-Fec-3892	Felis catus	85.48	1e-70	220
LLPS-Cap-3147	Cavia porcellus	84.92	2e-70	219
LLPS-Urm-3761	Ursus maritimus	83.87	2e-47	161
LLPS-Tut-1324	Tursiops truncatus	83.33	2e-68	214
LLPS-Sus-2909	Sus scrofa	82.68	2e-66	209
LLPS-Mod-0241	Monodelphis domestica	81.31	9e-55	179
LLPS-Poa-2029	Pongo abelii	81.08	4e-09	56.2
LLPS-Maf-2470	Macaca fascicularis	80.98	9e-106	310
LLPS-Mal-2926	Mandrillus leucophaeus	80.49	7e-104	305
LLPS-Man-1658	Macaca nemestrina	80.49	3e-105	308
LLPS-Sah-1139	Sarcophilus harrisii	79.28	5e-54	178
LLPS-Fia-3304	Ficedula albicollis	78.46	3e-28	107
LLPS-Anc-2759	Anolis carolinensis	78.23	2e-64	204
LLPS-Meg-1138	Meleagris gallopavo	76.98	5e-57	185
LLPS-Gaga-3509	Gallus gallus	76.98	6e-57	185
LLPS-Xet-1976	Xenopus tropicalis	75.4	1e-61	197
LLPS-Ora-1491	Ornithorhynchus anatinus	74.71	2e-41	142
LLPS-Tag-1421	Taeniopygia guttata	71.43	1e-52	174
LLPS-Lac-3395	Latimeria chalumnae	70.97	2e-57	186
LLPS-Leo-3134	Lepisosteus oculatus	70.08	1e-54	179
LLPS-Scf-3310	Scleropages formosus	69.05	8e-55	179
LLPS-Gaa-1190	Gasterosteus aculeatus	68.25	3e-53	176
LLPS-Orl-3591	Oryzias latipes	67.46	2e-43	150
LLPS-Scm-0895	Scophthalmus maximus	67.46	1e-52	174
LLPS-Orn-3982	Oreochromis niloticus	67.19	2e-51	171
LLPS-Ten-3574	Tetraodon nigroviridis	66.67	1e-53	176
LLPS-Tar-2070	Takifugu rubripes	65.87	2e-53	176
LLPS-Dar-4237	Danio rerio	65.08	3e-50	167
LLPS-Asm-0764	Astyanax mexicanus	64.29	4e-49	165
LLPS-Icp-3350	Ictalurus punctatus	64.29	3e-51	170
LLPS-Xim-3578	Xiphophorus maculatus	61.68	2e-38	137
LLPS-Cii-0972	Ciona intestinalis	42.86	4e-20	89.0
LLPS-Cis-0310	Ciona savignyi	39.17	3e-16	77.8

LLPS-Hos-2542CYBA

Protein Sequence

Nucleotide Sequence

LLPS-Hos-2542
CYBA