DrLLPS - Data resource of LLPS

Overview
Property
Classification
Function
Cross Reference
Sequence
GO
Annotation
Orthology
TOP

Disorder▼
- D²P²
- IUPred2A
Domain▼
PTM▼
Variation▼
Mutation▼
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Interaction▼
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Drug▼
Physicochemical▼
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Function▼
Proteomics▼
Structure▼
Localization▼
- COMPARTMENTS
Expression▼
Element▼
Methylation▼

LLPS-Mum-3463
Cyba

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Cytochrome b-245 light chain; Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phox
Gene Name:	Cyba
Ensembl Gene:	ENSMUSG00000006519.11
Ensembl Protein:	ENSMUSP00000148320.1
Organism:	Mus musculus
Taxa ID:	10090
LLPS Type:	Client

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Paraspeckle	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-2542	P13498	Client	Paraspeckle	88.89	8e-74	228

▼ FUNCTION

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSMUST00000212600.1	ENSMUSP00000148320.1
Ensembl	ENSMUST00000017604.9	ENSMUSP00000017604.8
UniProt		Q61462, CY24A_MOUSE, Q3U820, Q9CWB9, Q9D2W2
GeneBank	M31775, AK018713, AK152414, AK021200, BC026791	BAE31199.1, AAA37513.1, BAB32327.1, AAH26791.1, BAB31361.1
RefSeq	NM_001301284.1, NM_007806.3	NP_001288213.1, NP_031832.2
Entrez	13057

▼ SEQUENCE

Protein Sequence (FASTA)
1 MGQIEWAMWA NEQALASGLI LITGGIVATA GRFTQWYFGA YSIAAGVLIC LLEYPRGKRK 60 61 KGSTMERCGQ KYLTSVVKLF GPLTRNYYVR AALHFLLSVP AGFLLATILG TVCLAIASVI 120 121 YLLAAIRGEQ WTPIEPKPKE RPQVGGTIKQ PPTNPPPRPP AEVRKKPSEG EEEAASAGGP 180 181 QVNPMPVTDE VV 192
Nucleotide CDS Sequence (FASTA)
1 ATGGGGCAGA TCGAGTGGGC CATGTGGGCC AACGAACAGG CGCTGGCGTC TGGCCTGATT 60 61 CTCATCACTG GGGGCATCGT GGCTACTGCT GGACGTTTCA CACAGTGGTA TTTCGGCGCC 120 121 TACTCTATCG CTGCAGGTGT GCTCATCTGT CTGCTGGAGT ATCCCCGGGG AAAGAGGAAA 180 181 AAGGGGTCCA CCATGGAGCG ATGTGGACAG AAGTACCTGA CCTCTGTGGT GAAGCTTTTC 240 241 GGGCCCCTCA CCAGGAATTA CTACGTCCGG GCTGCCCTCC ACTTCCTGTT GTCGGTGCCT 300 301 GCAGGCTTCC TCCTGGCCAC CATCCTGGGG ACCGTCTGCT TGGCCATTGC CAGTGTGATC 360 361 TATCTGCTGG CAGCCATCCG AGGTGAGCAG TGGACTCCCA TTGAGCCTAA ACCCAAGGAG 420 421 CGGCCACAGG TTGGAGGCAC CATCAAGCAA CCACCTACCA ACCCCCCACC CCGGCCACCC 480 481 GCAGAGGTCC GAAAGAAGCC GAGTGAGGGT GAAGAGGAGG CAGCCTCAGC TGGAGGACCC 540 541 CAGGTTAACC CAATGCCAGT GACAGATGAG GTCGTGTGA 579

▼ KEYWORD

ID	Family
KW-0025	Alternative splicing
KW-1003	Cell membrane
KW-0181	Complete proteome
KW-0249	Electron transport
KW-0349	Heme
KW-0408	Iron
KW-1017	Isopeptide bond
KW-0472	Membrane
KW-0479	Metal-binding
KW-0521	NADP
KW-0560	Oxidoreductase
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0813	Transport
KW-0832	Ubl conjugation

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0016324	Cellular Component	Apical plasma membrane
GO:0005737	Cellular Component	Cytoplasm
GO:0030425	Cellular Component	Dendrite
GO:0005768	Cellular Component	Endosome
GO:0005925	Cellular Component	Focal adhesion
GO:0005794	Cellular Component	Golgi apparatus
GO:0005739	Cellular Component	Mitochondrion
GO:0043020	Cellular Component	NADPH oxidase complex
GO:0043025	Cellular Component	Neuronal cell body
GO:0005634	Cellular Component	Nucleus
GO:0097038	Cellular Component	Perinuclear endoplasmic reticulum
GO:0001725	Cellular Component	Stress fiber
GO:0009055	Molecular Function	Electron transfer activity
GO:0020037	Molecular Function	Heme binding
GO:0046872	Molecular Function	Metal ion binding
GO:0046982	Molecular Function	Protein heterodimerization activity
GO:0017124	Molecular Function	SH3 domain binding
GO:0016175	Molecular Function	Superoxide-generating NADPH oxidase activity
GO:1904385	Biological Process	Cellular response to angiotensin
GO:0071480	Biological Process	Cellular response to gamma radiation
GO:0071333	Biological Process	Cellular response to glucose stimulus
GO:1904845	Biological Process	Cellular response to L-glutamine
GO:0071260	Biological Process	Cellular response to mechanical stimulus
GO:0071407	Biological Process	Cellular response to organic cyclic compound
GO:0071310	Biological Process	Cellular response to organic substance
GO:0071356	Biological Process	Cellular response to tumor necrosis factor
GO:0017004	Biological Process	Cytochrome complex assembly
GO:0050665	Biological Process	Hydrogen peroxide biosynthetic process
GO:0006954	Biological Process	Inflammatory response
GO:0045087	Biological Process	Innate immune response
GO:0003106	Biological Process	Negative regulation of glomerular filtration by angiotensin
GO:0055114	Biological Process	Oxidation-reduction process
GO:0045777	Biological Process	Positive regulation of blood pressure
GO:0030307	Biological Process	Positive regulation of cell growth
GO:1900426	Biological Process	Positive regulation of defense response to bacterium
GO:0001938	Biological Process	Positive regulation of endothelial cell proliferation
GO:0032755	Biological Process	Positive regulation of interleukin-6 production
GO:0070257	Biological Process	Positive regulation of mucus secretion
GO:0033864	Biological Process	Positive regulation of NAD(P)H oxidase activity
GO:0050766	Biological Process	Positive regulation of phagocytosis
GO:1903428	Biological Process	Positive regulation of reactive oxygen species biosynthetic process
GO:0048661	Biological Process	Positive regulation of smooth muscle cell proliferation
GO:0032930	Biological Process	Positive regulation of superoxide anion generation
GO:0034137	Biological Process	Positive regulation of toll-like receptor 2 signaling pathway
GO:0032760	Biological Process	Positive regulation of tumor necrosis factor production
GO:0072593	Biological Process	Reactive oxygen species metabolic process
GO:0051279	Biological Process	Regulation of release of sequestered calcium ion into cytosol
GO:0045730	Biological Process	Respiratory burst
GO:0014823	Biological Process	Response to activity
GO:1904044	Biological Process	Response to aldosterone
GO:0001666	Biological Process	Response to hypoxia
GO:0070555	Biological Process	Response to interleukin-1
GO:0014895	Biological Process	Smooth muscle hypertrophy
GO:0042554	Biological Process	Superoxide anion generation
GO:0006801	Biological Process	Superoxide metabolic process

▼ KEGG

mmu:13057

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD

PTM
EPSD	PhosphoSitePlus	dbPTM	PTMcode

Mutation
CGAP

Interaction
HINT	RISE	RAIN	Mentha	PINA
IID	iRefIndex	MIST	RNAct

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF	CellMarker	RaftProt

Localization
COMPARTMENTS

Expression
ArrayExpress	GXD	TISSUES

Element
miRWalk	RAID	microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Ran-4550	Rattus norvegicus	96.88	8e-113	327
LLPS-Mea-1632	Mesocricetus auratus	96.35	4e-114	330
LLPS-Maf-2470	Macaca fascicularis	90.48	2e-75	231
LLPS-Mal-2926	Mandrillus leucophaeus	90.48	3e-75	231
LLPS-Man-1658	Macaca nemestrina	90.48	2e-75	232
LLPS-Nol-3432	Nomascus leucogenys	90.48	2e-75	232
LLPS-Cas-3310	Carlito syrichta	89.08	2e-92	274
LLPS-Gog-1282	Gorilla gorilla	88.89	8e-74	228
LLPS-Pap-3392	Pan paniscus	88.89	9e-74	228
LLPS-Pat-2745	Pan troglodytes	88.89	9e-74	228
LLPS-Hos-2542	Homo sapiens	88.89	1e-73	228
LLPS-Paa-4146	Papio anubis	87.18	2e-105	308
LLPS-Mam-0433	Macaca mulatta	87.18	2e-105	308
LLPS-Rhb-1403	Rhinopithecus bieti	87.11	5e-104	304
LLPS-Aon-1397	Aotus nancymaae	86.53	3e-107	312
LLPS-Dio-2033	Dipodomys ordii	86.36	1e-92	275
LLPS-Caj-4816	Callithrix jacchus	86.01	4e-105	307
LLPS-Bot-0856	Bos taurus	85.94	2e-103	303
LLPS-Tut-1324	Tursiops truncatus	85.94	3e-102	300
LLPS-Myl-3985	Myotis lucifugus	85.79	2e-101	298
LLPS-Ova-0424	Ovis aries	85.42	1e-102	301
LLPS-Chs-2990	Chlorocebus sabaeus	85.28	2e-103	303
LLPS-Cea-4810	Cercocebus atys	85.13	1e-103	303
LLPS-Fud-1659	Fukomys damarensis	84.3	1e-85	257
LLPS-Ict-0519	Ictidomys tridecemlineatus	84.1	2e-103	303
LLPS-Otg-2874	Otolemur garnettii	84.02	5e-102	299
LLPS-Sus-2909	Sus scrofa	83.42	4e-100	295
LLPS-Cap-3147	Cavia porcellus	83.33	1e-98	291
LLPS-Fia-3304	Ficedula albicollis	83.08	2e-31	115
LLPS-Eqc-1135	Equus caballus	82.99	3e-101	298
LLPS-Urm-3761	Ursus maritimus	82.61	1e-48	164
LLPS-Caf-3966	Canis familiaris	82.56	2e-98	290
LLPS-Aim-1026	Ailuropoda melanoleuca	82.47	1e-99	293
LLPS-Fec-3892	Felis catus	81.44	4e-99	292
LLPS-Anc-2759	Anolis carolinensis	81.44	2e-86	259
LLPS-Mup-4362	Mustela putorius furo	80.93	3e-100	295
LLPS-Mod-0241	Monodelphis domestica	80.35	1e-78	240
LLPS-Poa-2029	Pongo abelii	80.0	2e-34	124
LLPS-Ora-1491	Ornithorhynchus anatinus	79.07	1e-44	149
LLPS-Sah-1139	Sarcophilus harrisii	78.53	3e-77	237
LLPS-Loa-3717	Loxodonta africana	76.84	9e-82	247
LLPS-Tag-1421	Taeniopygia guttata	74.7	2e-74	228
LLPS-Xet-1976	Xenopus tropicalis	70.83	4e-83	251
LLPS-Scm-0895	Scophthalmus maximus	70.21	3e-65	205
LLPS-Meg-1138	Meleagris gallopavo	70.0	5e-74	228
LLPS-Gaga-3509	Gallus gallus	70.0	6e-74	228
LLPS-Leo-3134	Lepisosteus oculatus	68.67	2e-67	211
LLPS-Tar-2070	Takifugu rubripes	66.27	2e-67	211
LLPS-Ten-3574	Tetraodon nigroviridis	66.27	1e-66	209
LLPS-Scf-3310	Scleropages formosus	64.89	2e-70	219
LLPS-Orn-3982	Oreochromis niloticus	63.54	8e-68	212
LLPS-Gaa-1190	Gasterosteus aculeatus	63.49	3e-65	205
LLPS-Lac-3395	Latimeria chalumnae	62.77	9e-72	222
LLPS-Orl-3591	Oryzias latipes	62.11	8e-59	189
LLPS-Icp-3350	Ictalurus punctatus	61.05	2e-67	211
LLPS-Asm-0764	Astyanax mexicanus	60.64	2e-64	203
LLPS-Dar-4237	Danio rerio	60.11	6e-62	197
LLPS-Xim-3578	Xiphophorus maculatus	59.06	4e-53	175
LLPS-Cii-0972	Ciona intestinalis	41.55	9e-27	105
LLPS-Cis-0310	Ciona savignyi	37.93	1e-20	89.0

LLPS-Mum-3463Cyba

Protein Sequence

Nucleotide Sequence

LLPS-Mum-3463
Cyba