• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mod-1965
PPIH

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Peptidyl-prolyl cis-trans isomerase
Gene Name: PPIH
Ensembl Gene: ENSMODG00000017226.2
Ensembl Protein: ENSMODP00000021488.2
Organism: Monodelphis domestica
Taxa ID: 13616
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAVANSSPVN  PIVFFDVSIG  GQEVGRMKIE  LFADIVPKTA  ENFRQFCTGE  FRKDGVPIGY  60
61    KGSTFHRVIK  DFMIQGGDFV  NGDGTGVASI  YRGPFADENF  KLRHSAPGLL  SMANSGPSTN  120
121   GCQFFITCSK  CDWLDGKHVV  FGKIIDGLLV  MRKIENVPTG  PNNKPKLPVV  ISQCGEM  177
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGTGG  CAAATTCAAG  CCCAGTCAAT  CCTATCGTCT  TCTTTGATGT  TAGCATCGGT  60
61    GGCCAGGAGG  TTGGCCGAAT  GAAGATTGAG  CTCTTCGCGG  ACATTGTGCC  CAAGACTGCG  120
121   GAGAATTTCA  GGCAATTCTG  CACAGGGGAA  TTCAGGAAAG  ATGGAGTCCC  TATTGGATAC  180
181   AAGGGGAGCA  CCTTTCACAG  GGTTATAAAA  GATTTCATGA  TTCAAGGAGG  AGACTTTGTA  240
241   AATGGAGATG  GCACTGGAGT  TGCAAGCATT  TACCGGGGAC  CATTTGCAGA  TGAAAATTTT  300
301   AAATTAAGGC  ACTCGGCTCC  AGGTCTGCTT  TCCATGGCAA  ACAGTGGCCC  CAGTACCAAT  360
361   GGCTGCCAGT  TCTTTATTAC  CTGCTCCAAA  TGTGATTGGC  TGGATGGGAA  ACATGTGGTT  420
421   TTTGGAAAAA  TAATTGATGG  ACTTCTAGTG  ATGAGAAAAA  TCGAGAATGT  TCCCACTGGA  480
481   CCTAACAATA  AGCCCAAACT  GCCTGTAGTC  ATCTCACAGT  GTGGGGAGAT  GTAA  534

▼ KEYWORD

ID
Family
Complete proteome
Isomerase
Reference proteome
Rotamase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Nuclear speck
Cellular Component
U4/U6 snRNP
Cellular Component
U4/U6 x U5 tri-snRNP complex
Molecular Function
Cyclosporin A binding
Molecular Function
Peptidyl-prolyl cis-trans isomerase activity
Molecular Function
Ribonucleoprotein complex binding
Molecular Function
Unfolded protein binding
Biological Process
Angiogenesis
Biological Process
Positive regulation of viral genome replication
Biological Process
Protein refolding

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cea-0733Cercocebus atys98.872e-127 362
LLPS-Aon-1019Aotus nancymaae98.872e-127 362
LLPS-Sus-4057Sus scrofa98.872e-127 362
LLPS-Mea-3732Mesocricetus auratus98.872e-127 362
LLPS-Mum-4909Mus musculus98.872e-127 362
LLPS-Maf-3489Macaca fascicularis98.872e-127 362
LLPS-Chs-2765Chlorocebus sabaeus98.872e-127 362
LLPS-Caj-4638Callithrix jacchus98.872e-127 362
LLPS-Gog-0249Gorilla gorilla98.872e-127 362
LLPS-Dio-4388Dipodomys ordii98.872e-127 362
LLPS-Tut-0054Tursiops truncatus98.872e-127 362
LLPS-Paa-3834Papio anubis98.872e-127 362
LLPS-Mal-4203Mandrillus leucophaeus98.872e-127 362
LLPS-Ova-0469Ovis aries98.872e-127 362
LLPS-Mup-3004Mustela putorius furo98.872e-127 362
LLPS-Aim-1869Ailuropoda melanoleuca98.872e-127 362
LLPS-Man-2158Macaca nemestrina98.872e-127 362
LLPS-Loa-1513Loxodonta africana98.872e-127 362
LLPS-Urm-3010Ursus maritimus98.872e-127 362
LLPS-Pap-2401Pan paniscus98.872e-127 362
LLPS-Pat-1483Pan troglodytes98.872e-127 362
LLPS-Hos-0035Homo sapiens98.872e-127 362
LLPS-Fec-0939Felis catus98.872e-127 362
LLPS-Orc-4221Oryctolagus cuniculus98.872e-127 362
LLPS-Rhb-1727Rhinopithecus bieti98.872e-127 362
LLPS-Otg-0721Otolemur garnettii98.872e-127 362
LLPS-Mam-2863Macaca mulatta98.872e-127 362
LLPS-Caf-1591Canis familiaris98.872e-127 362
LLPS-Poa-4258Pongo abelii98.872e-127 362
LLPS-Cap-2230Cavia porcellus98.872e-127 362
LLPS-Ict-3842Ictidomys tridecemlineatus98.872e-127 362
LLPS-Cas-4035Carlito syrichta98.872e-127 362
LLPS-Fud-2490Fukomys damarensis98.713e-110 319
LLPS-Anp-1729Anas platyrhynchos98.511e-94 278
LLPS-Ran-4535Rattus norvegicus98.311e-124 356
LLPS-Nol-4481Nomascus leucogenys98.316e-125 356
LLPS-Ere-0931Erinaceus europaeus98.35e-124 354
LLPS-Ora-1235Ornithorhynchus anatinus98.11e-70 216
LLPS-Tag-3149Taeniopygia guttata98.062e-110 319
LLPS-Pes-2729Pelodiscus sinensis98.011e-107 311
LLPS-Eqc-2554Equus caballus95.735e-110 323
LLPS-Gaga-2823Gallus gallus94.352e-122 350
LLPS-Fia-0044Ficedula albicollis93.222e-121 347
LLPS-Myl-2944Myotis lucifugus92.73e-119 342
LLPS-Xet-3366Xenopus tropicalis92.663e-119 342
LLPS-Leo-2041Lepisosteus oculatus92.311e-107 312
LLPS-Lac-3406Latimeria chalumnae91.238e-115 330
LLPS-Scf-1739Scleropages formosus89.836e-117 336
LLPS-Icp-1639Ictalurus punctatus88.74e-116 334
LLPS-Orn-2626Oreochromis niloticus88.462e-103 301
LLPS-Orl-4090Oryzias latipes87.012e-115 332
LLPS-Xim-3900Xiphophorus maculatus87.012e-116 335
LLPS-Pof-1814Poecilia formosa87.018e-116 333
LLPS-Gaa-0648Gasterosteus aculeatus84.522e-98 288
LLPS-Tar-3024Takifugu rubripes84.184e-112 324
LLPS-Dar-2876Danio rerio83.076e-113 326
LLPS-Scm-3804Scophthalmus maximus83.057e-109 315
LLPS-Ten-1541Tetraodon nigroviridis83.051e-110 320
LLPS-Drm-1431Drosophila melanogaster77.785e-99 291
LLPS-Cii-1719Ciona intestinalis76.333e-95 281
LLPS-Cis-0000Ciona savignyi75.744e-95 280
LLPS-Asm-3531Astyanax mexicanus75.711e-91 271
LLPS-Met-0140Medicago truncatula75.02e-92 274
LLPS-Php-0190Physcomitrella patens74.568e-89 265
LLPS-Gas-1080Galdieria sulphuraria74.431e-95 282
LLPS-Cus-1494Cucumis sativus74.422e-91 272
LLPS-Glm-2280Glycine max73.841e-90 270
LLPS-Hea-2174Helianthus annuus73.841e-92 275
LLPS-Phv-1524Phaseolus vulgaris73.842e-91 272
LLPS-Brn-2458Brassica napus73.267e-89 266
LLPS-Arl-2197Arabidopsis lyrata73.268e-90 268
LLPS-Viv-1787Vitis vinifera73.266e-91 270
LLPS-Art-2319Arabidopsis thaliana73.265e-90 268
LLPS-Brr-1885Brassica rapa73.264e-89 266
LLPS-Mae-2282Manihot esculenta73.263e-91 271
LLPS-Prp-1185Prunus persica73.263e-91 271
LLPS-Sem-1622Selaginella moellendorffii72.837e-90 267
LLPS-Lep-2049Leersia perrieri72.675e-85 265
LLPS-Pot-0230Populus trichocarpa72.674e-91 271
LLPS-Gor-0942Gossypium raimondii72.678e-91 270
LLPS-Orbr-0050Oryza brachyantha72.671e-87 263
LLPS-Tru-2114Triticum urartu72.674e-77 234
LLPS-Bro-2020Brassica oleracea72.672e-88 264
LLPS-Pug-1426Puccinia graminis72.193e-86 258
LLPS-Put-0612Puccinia triticina72.193e-86 258
LLPS-Mua-2500Musa acuminata72.092e-89 267
LLPS-Sei-1820Setaria italica72.092e-87 268
LLPS-Tra-2086Triticum aestivum72.091e-88 265
LLPS-Orb-1878Oryza barthii71.511e-86 260
LLPS-Orni-1307Oryza nivara71.513e-87 261
LLPS-Orgl-2293Oryza glumaepatula71.511e-86 260
LLPS-Hov-1420Hordeum vulgare71.513e-88 264
LLPS-Orp-0958Oryza punctata71.514e-86 258
LLPS-Ors-2038Oryza sativa71.511e-86 260
LLPS-Sob-1317Sorghum bicolor71.512e-86 259
LLPS-Orm-1283Oryza meridionalis71.513e-87 261
LLPS-Sol-0600Solanum lycopersicum71.353e-87 261
LLPS-Sot-2180Solanum tuberosum71.352e-87 261
LLPS-Nia-1205Nicotiana attenuata71.011e-86 259
LLPS-Brd-1217Brachypodium distachyon70.932e-86 259
LLPS-Usm-0242Ustilago maydis70.781e-77 235
LLPS-Mel-0910Melampsora laricipopulina70.733e-80 244
LLPS-Zem-1210Zea mays70.712e-66 212
LLPS-Cae-1141Caenorhabditis elegans70.598e-89 265
LLPS-Osl-1435Ostreococcus lucimarinus70.01e-83 251
LLPS-Crn-1486Cryptococcus neoformans69.823e-83 251
LLPS-Chr-1024Chlamydomonas reinhardtii68.392e-84 254
LLPS-Spr-1566Sporisorium reilianum68.269e-84 252
LLPS-Coc-1585Corchorus capsularis68.023e-81 246
LLPS-Miv-0851Microbotryum violaceum67.431e-81 249
LLPS-Dos-1014Dothistroma septosporum66.097e-78 236
LLPS-Scs-1129Sclerotinia sclerotiorum65.885e-76 232
LLPS-Blg-0382Blumeria graminis65.75e-73 224
LLPS-Chc-1182Chondrus crispus65.01e-83 252
LLPS-Nef-0900Neosartorya fischeri64.97e-63 197
LLPS-Asfu-1659Aspergillus fumigatus64.92e-63 199
LLPS-Asni-0281Aspergillus niger64.712e-73 226
LLPS-Ast-0926Aspergillus terreus64.714e-72 222
LLPS-Scc-1624Schizosaccharomyces cryophilus64.52e-73 225
LLPS-Orr-2048Oryza rufipogon64.49e-83 251
LLPS-Aso-0927Aspergillus oryzae64.121e-72 224
LLPS-Asf-1464Aspergillus flavus64.121e-72 224
LLPS-Gag-0966Gaeumannomyces graminis63.929e-65 204
LLPS-Map-0665Magnaporthe poae63.375e-72 222
LLPS-Nec-0972Neurospora crassa63.372e-71 221
LLPS-Beb-0049Beauveria bassiana63.014e-70 217
LLPS-Mao-0246Magnaporthe oryzae62.793e-70 218
LLPS-Lem-1448Leptosphaeria maculans62.728e-63 199
LLPS-Coo-1533Colletotrichum orbiculare62.211e-68 213
LLPS-Fus-0830Fusarium solani62.217e-68 211
LLPS-Thc-1649Theobroma cacao61.718e-63 211
LLPS-Zyt-1549Zymoseptoria tritici61.453e-70 217
LLPS-Scp-1616Schizosaccharomyces pombe61.44e-71 219
LLPS-Ved-0640Verticillium dahliae61.46e-69 214
LLPS-Tum-0696Tuber melanosporum61.181e-67 211
LLPS-Trr-1587Trichoderma reesei61.059e-67 209
LLPS-Pyt-1025Pyrenophora teres60.774e-69 214
LLPS-Fuv-1587Fusarium verticillioides60.471e-67 211
LLPS-Trv-0692Trichoderma virens60.475e-67 209
LLPS-Fuo-0296Fusarium oxysporum60.472e-67 211
LLPS-Cogr-1062Colletotrichum graminicola60.473e-67 209
LLPS-Pytr-0975Pyrenophora triticirepentis60.225e-70 217
LLPS-Via-0507Vigna angularis59.414e-66 207
LLPS-Abg-1657Absidia glauca59.399e-64 204
LLPS-Ori-1838Oryza indica58.825e-65 204
LLPS-Org-1037Oryza glaberrima58.825e-65 204
LLPS-Dac-1303Daucus carota58.241e-65 205
LLPS-Vir-0950Vigna radiata57.659e-65 203
LLPS-Phn-0241Phaeosphaeria nodorum57.063e-62 197