LLPS-Maf-3489
PPIH
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Peptidyl-prolyl cis-trans isomerase |
| Gene Name: | PPIH, EGM_20286 |
| Ensembl Gene: | ENSMFAG00000034307.1 |
| Ensembl Protein: | ENSMFAP00000035963.1 |
| Organism: | Macaca fascicularis |
| Taxa ID: | 9541 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMFAT00000010204.1 | ENSMFAP00000035963.1 |
| Ensembl | ENSMFAT00000010214.1 | ENSMFAP00000035973.1 |
| Ensembl | ENSMFAT00000010211.1 | ENSMFAP00000035970.1 |
| UniProt | G8F480, G8F480_MACFA | |
| GeneBank | AQIA01004481, JH330672 | , EHH62094.1 |
| RefSeq | XM_005543722.2, XM_005543723.2, XM_005543724.2, XM_005543725.2, XM_015437455.1 | XP_005543779.1, XP_005543780.1, XP_005543781.1, XP_005543782.1, XP_015292941.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAVANSSPVN PVVFFDVSIG GQEVGRMKIE LFADVVPKTA ENFRQFCTGE FRKDGVPIGY 60 61 KGSTFHRVIK DFMIQGGDFV NGDGTGVASI YRGPFADENF KLRHSAPGLL SMANSGPSTN 120 121 GCQFFITCSK CDWLDGKHVV FGKIIDGLLV MRKIENVPTG PNNKPKLPVV ISQCGEM 177 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGTGG CAAATTCAAG TCCTGTTAAC CCCGTGGTGT TCTTTGATGT CAGCATTGGC 60 61 GGTCAGGAAG TTGGCCGCAT GAAGATCGAG CTCTTTGCAG ACGTTGTGCC TAAGACGGCC 120 121 GAGAACTTTA GGCAGTTCTG CACCGGAGAA TTCAGAAAAG ATGGGGTTCC AATAGGATAC 180 181 AAAGGAAGCA CCTTCCACAG GGTCATAAAG GATTTCATGA TTCAGGGTGG AGATTTTGTT 240 241 AATGGAGATG GTACTGGAGT TGCCAGTATT TACCGGGGGC CATTTGCAGA TGAAAATTTT 300 301 AAACTTAGAC ACTCAGCCCC AGGCCTGCTT TCCATGGCAA ATAGTGGTCC GAGTACAAAT 360 361 GGCTGTCAGT TCTTTATCAC CTGCTCTAAG TGCGATTGGC TGGATGGGAA GCATGTGGTG 420 421 TTTGGAAAAA TCATCGATGG ACTTCTAGTG ATGAGAAAGA TTGAGAATGT TCCCACAGGC 480 481 CCCAACAATA AGCCCAAGCT GCCTGTGGTG ATCTCACAGT GTGGGGAGAT GTAG 534 |
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nuclear speck | |
Cellular Component | U4/U6 snRNP | |
Cellular Component | U4/U6 x U5 tri-snRNP complex | |
Molecular Function | Cyclosporin A binding | |
Molecular Function | Peptidyl-prolyl cis-trans isomerase activity | |
Molecular Function | Ribonucleoprotein complex binding | |
Biological Process | Positive regulation of viral genome replication | |
Biological Process | Protein folding |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Otg-0721 | Otolemur garnettii | 100.0 | 8e-128 | 363 |
| LLPS-Rhb-1727 | Rhinopithecus bieti | 100.0 | 8e-128 | 363 |
| LLPS-Orc-4221 | Oryctolagus cuniculus | 100.0 | 8e-128 | 363 |
| LLPS-Fec-0939 | Felis catus | 100.0 | 8e-128 | 363 |
| LLPS-Hos-0035 | Homo sapiens | 100.0 | 8e-128 | 363 |
| LLPS-Urm-3010 | Ursus maritimus | 100.0 | 8e-128 | 363 |
| LLPS-Pap-2401 | Pan paniscus | 100.0 | 8e-128 | 363 |
| LLPS-Pat-1483 | Pan troglodytes | 100.0 | 8e-128 | 363 |
| LLPS-Loa-1513 | Loxodonta africana | 100.0 | 8e-128 | 363 |
| LLPS-Man-2158 | Macaca nemestrina | 100.0 | 8e-128 | 363 |
| LLPS-Cas-4035 | Carlito syrichta | 100.0 | 8e-128 | 363 |
| LLPS-Ict-3842 | Ictidomys tridecemlineatus | 100.0 | 8e-128 | 363 |
| LLPS-Cap-2230 | Cavia porcellus | 100.0 | 8e-128 | 363 |
| LLPS-Caf-1591 | Canis familiaris | 100.0 | 8e-128 | 363 |
| LLPS-Poa-4258 | Pongo abelii | 100.0 | 8e-128 | 363 |
| LLPS-Mam-2863 | Macaca mulatta | 100.0 | 8e-128 | 363 |
| LLPS-Gog-0249 | Gorilla gorilla | 100.0 | 8e-128 | 363 |
| LLPS-Caj-4638 | Callithrix jacchus | 100.0 | 8e-128 | 363 |
| LLPS-Fud-2490 | Fukomys damarensis | 100.0 | 1e-110 | 320 |
| LLPS-Chs-2765 | Chlorocebus sabaeus | 100.0 | 8e-128 | 363 |
| LLPS-Mum-2980 | Mus musculus | 100.0 | 2e-110 | 320 |
| LLPS-Mea-3732 | Mesocricetus auratus | 100.0 | 8e-128 | 363 |
| LLPS-Sus-4057 | Sus scrofa | 100.0 | 8e-128 | 363 |
| LLPS-Cea-0733 | Cercocebus atys | 100.0 | 8e-128 | 363 |
| LLPS-Aon-1019 | Aotus nancymaae | 100.0 | 8e-128 | 363 |
| LLPS-Ova-0469 | Ovis aries | 100.0 | 8e-128 | 363 |
| LLPS-Mup-3004 | Mustela putorius furo | 100.0 | 8e-128 | 363 |
| LLPS-Aim-1869 | Ailuropoda melanoleuca | 100.0 | 8e-128 | 363 |
| LLPS-Paa-3834 | Papio anubis | 100.0 | 8e-128 | 363 |
| LLPS-Mal-4203 | Mandrillus leucophaeus | 100.0 | 8e-128 | 363 |
| LLPS-Tut-0054 | Tursiops truncatus | 100.0 | 8e-128 | 363 |
| LLPS-Dio-4388 | Dipodomys ordii | 100.0 | 8e-128 | 363 |
| LLPS-Nol-4481 | Nomascus leucogenys | 99.44 | 3e-125 | 357 |
| LLPS-Ran-4535 | Rattus norvegicus | 99.44 | 4e-125 | 357 |
| LLPS-Ere-0931 | Erinaceus europaeus | 99.43 | 2e-124 | 355 |
| LLPS-Mod-1965 | Monodelphis domestica | 98.87 | 2e-127 | 362 |
| LLPS-Tag-3149 | Taeniopygia guttata | 98.71 | 1e-110 | 319 |
| LLPS-Pes-2729 | Pelodiscus sinensis | 98.68 | 8e-108 | 312 |
| LLPS-Anp-1729 | Anas platyrhynchos | 98.51 | 1e-94 | 278 |
| LLPS-Ora-1235 | Ornithorhynchus anatinus | 98.1 | 9e-71 | 216 |
| LLPS-Eqc-2554 | Equus caballus | 96.34 | 3e-110 | 323 |
| LLPS-Gaga-2823 | Gallus gallus | 95.48 | 9e-123 | 351 |
| LLPS-Fia-0044 | Ficedula albicollis | 94.35 | 8e-122 | 348 |
| LLPS-Myl-2944 | Myotis lucifugus | 93.82 | 1e-119 | 343 |
| LLPS-Leo-2041 | Lepisosteus oculatus | 92.95 | 1e-107 | 312 |
| LLPS-Xet-3366 | Xenopus tropicalis | 91.53 | 7e-119 | 341 |
| LLPS-Lac-3406 | Latimeria chalumnae | 91.23 | 6e-115 | 331 |
| LLPS-Scf-1739 | Scleropages formosus | 89.83 | 6e-117 | 336 |
| LLPS-Orn-2626 | Oreochromis niloticus | 89.1 | 1e-103 | 301 |
| LLPS-Icp-1639 | Ictalurus punctatus | 88.7 | 4e-116 | 334 |
| LLPS-Pof-1814 | Poecilia formosa | 87.01 | 8e-116 | 333 |
| LLPS-Orl-4090 | Oryzias latipes | 87.01 | 2e-115 | 332 |
| LLPS-Xim-3900 | Xiphophorus maculatus | 87.01 | 2e-116 | 334 |
| LLPS-Tar-3024 | Takifugu rubripes | 85.31 | 1e-112 | 325 |
| LLPS-Gaa-0648 | Gasterosteus aculeatus | 84.52 | 2e-98 | 288 |
| LLPS-Ten-1541 | Tetraodon nigroviridis | 84.18 | 5e-111 | 321 |
| LLPS-Scm-3804 | Scophthalmus maximus | 83.05 | 6e-109 | 315 |
| LLPS-Dar-2876 | Danio rerio | 82.01 | 2e-112 | 325 |
| LLPS-Drm-1431 | Drosophila melanogaster | 78.36 | 2e-99 | 291 |
| LLPS-Asm-3531 | Astyanax mexicanus | 75.71 | 1e-91 | 271 |
| LLPS-Cii-1719 | Ciona intestinalis | 75.15 | 8e-95 | 280 |
| LLPS-Cis-0000 | Ciona savignyi | 74.56 | 1e-94 | 279 |
| LLPS-Gas-1080 | Galdieria sulphuraria | 74.43 | 1e-95 | 282 |
| LLPS-Met-0140 | Medicago truncatula | 73.84 | 6e-92 | 273 |
| LLPS-Php-0190 | Physcomitrella patens | 73.37 | 2e-88 | 264 |
| LLPS-Brr-1885 | Brassica rapa | 73.26 | 4e-89 | 266 |
| LLPS-Art-2319 | Arabidopsis thaliana | 73.26 | 5e-90 | 268 |
| LLPS-Prp-1185 | Prunus persica | 73.26 | 3e-91 | 271 |
| LLPS-Brn-2458 | Brassica napus | 73.26 | 8e-89 | 266 |
| LLPS-Cus-1494 | Cucumis sativus | 73.26 | 5e-91 | 271 |
| LLPS-Arl-2197 | Arabidopsis lyrata | 73.26 | 9e-90 | 268 |
| LLPS-Sem-1622 | Selaginella moellendorffii | 72.83 | 9e-90 | 267 |
| LLPS-Orbr-0050 | Oryza brachyantha | 72.67 | 1e-87 | 262 |
| LLPS-Phv-1524 | Phaseolus vulgaris | 72.67 | 5e-91 | 271 |
| LLPS-Bro-2020 | Brassica oleracea | 72.67 | 2e-88 | 264 |
| LLPS-Hea-2174 | Helianthus annuus | 72.67 | 3e-92 | 274 |
| LLPS-Glm-2280 | Glycine max | 72.67 | 3e-90 | 269 |
| LLPS-Lep-2049 | Leersia perrieri | 72.67 | 5e-85 | 265 |
| LLPS-Mae-2282 | Manihot esculenta | 72.09 | 7e-91 | 270 |
| LLPS-Viv-1787 | Vitis vinifera | 72.09 | 2e-90 | 269 |
| LLPS-Tra-2086 | Triticum aestivum | 72.09 | 1e-88 | 265 |
| LLPS-Hov-1420 | Hordeum vulgare | 72.09 | 2e-88 | 264 |
| LLPS-Sei-1820 | Setaria italica | 72.09 | 2e-87 | 268 |
| LLPS-Tru-2114 | Triticum urartu | 72.0 | 7e-77 | 233 |
| LLPS-Sob-1317 | Sorghum bicolor | 71.51 | 2e-86 | 259 |
| LLPS-Ors-2038 | Oryza sativa | 71.51 | 9e-87 | 260 |
| LLPS-Gor-0942 | Gossypium raimondii | 71.51 | 2e-90 | 269 |
| LLPS-Orp-0958 | Oryza punctata | 71.51 | 4e-86 | 259 |
| LLPS-Pot-0230 | Populus trichocarpa | 71.51 | 1e-90 | 270 |
| LLPS-Orm-1283 | Oryza meridionalis | 71.51 | 3e-87 | 261 |
| LLPS-Orni-1307 | Oryza nivara | 71.51 | 3e-87 | 261 |
| LLPS-Orb-1878 | Oryza barthii | 71.51 | 9e-87 | 260 |
| LLPS-Orgl-2293 | Oryza glumaepatula | 71.51 | 9e-87 | 260 |
| LLPS-Sol-0600 | Solanum lycopersicum | 71.35 | 3e-87 | 261 |
| LLPS-Sot-2180 | Solanum tuberosum | 71.35 | 3e-87 | 261 |
| LLPS-Osl-1435 | Ostreococcus lucimarinus | 71.18 | 7e-84 | 252 |
| LLPS-Nia-1205 | Nicotiana attenuata | 71.01 | 1e-86 | 259 |
| LLPS-Pug-1426 | Puccinia graminis | 71.01 | 9e-86 | 257 |
| LLPS-Put-0612 | Puccinia triticina | 71.01 | 9e-86 | 257 |
| LLPS-Mua-2500 | Musa acuminata | 70.93 | 5e-89 | 266 |
| LLPS-Brd-1217 | Brachypodium distachyon | 70.93 | 2e-86 | 259 |
| LLPS-Zem-1210 | Zea mays | 70.71 | 2e-66 | 212 |
| LLPS-Cae-1141 | Caenorhabditis elegans | 70.59 | 8e-89 | 265 |
| LLPS-Usm-0242 | Ustilago maydis | 70.13 | 2e-77 | 235 |
| LLPS-Mel-0910 | Melampsora laricipopulina | 69.51 | 7e-80 | 243 |
| LLPS-Crn-1486 | Cryptococcus neoformans | 68.64 | 6e-83 | 249 |
| LLPS-Chr-1024 | Chlamydomonas reinhardtii | 68.39 | 2e-84 | 254 |
| LLPS-Spr-1566 | Sporisorium reilianum | 68.26 | 1e-83 | 252 |
| LLPS-Miv-0851 | Microbotryum violaceum | 67.43 | 1e-81 | 249 |
| LLPS-Dos-1014 | Dothistroma septosporum | 67.24 | 3e-78 | 238 |
| LLPS-Coc-1585 | Corchorus capsularis | 66.86 | 6e-81 | 244 |
| LLPS-Scs-1129 | Sclerotinia sclerotiorum | 66.47 | 5e-76 | 232 |
| LLPS-Asni-0281 | Aspergillus niger | 65.88 | 7e-74 | 227 |
| LLPS-Blg-0382 | Blumeria graminis | 65.7 | 5e-73 | 224 |
| LLPS-Nef-0900 | Neosartorya fischeri | 65.56 | 5e-63 | 198 |
| LLPS-Asfu-1659 | Aspergillus fumigatus | 65.56 | 1e-63 | 199 |
| LLPS-Scc-1624 | Schizosaccharomyces cryophilus | 65.09 | 6e-74 | 226 |
| LLPS-Chc-1182 | Chondrus crispus | 65.0 | 1e-83 | 252 |
| LLPS-Gag-0966 | Gaeumannomyces graminis | 64.56 | 5e-65 | 204 |
| LLPS-Orr-2048 | Oryza rufipogon | 64.4 | 1e-82 | 251 |
| LLPS-Asf-1464 | Aspergillus flavus | 64.12 | 1e-72 | 224 |
| LLPS-Aso-0927 | Aspergillus oryzae | 64.12 | 1e-72 | 224 |
| LLPS-Map-0665 | Magnaporthe poae | 63.95 | 5e-72 | 222 |
| LLPS-Nec-0972 | Neurospora crassa | 63.95 | 1e-71 | 221 |
| LLPS-Lem-1448 | Leptosphaeria maculans | 63.91 | 5e-63 | 200 |
| LLPS-Beb-0049 | Beauveria bassiana | 63.58 | 3e-70 | 217 |
| LLPS-Ast-0926 | Aspergillus terreus | 63.53 | 1e-71 | 221 |
| LLPS-Mao-0246 | Magnaporthe oryzae | 63.37 | 3e-70 | 218 |
| LLPS-Fus-0830 | Fusarium solani | 62.79 | 6e-68 | 211 |
| LLPS-Coo-1533 | Colletotrichum orbiculare | 62.79 | 1e-68 | 213 |
| LLPS-Thc-1649 | Theobroma cacao | 62.29 | 7e-63 | 211 |
| LLPS-Trr-1587 | Trichoderma reesei | 61.63 | 8e-67 | 209 |
| LLPS-Zyt-1549 | Zymoseptoria tritici | 61.45 | 3e-70 | 217 |
| LLPS-Ved-0640 | Verticillium dahliae | 61.4 | 6e-69 | 214 |
| LLPS-Scp-1616 | Schizosaccharomyces pombe | 61.4 | 4e-71 | 219 |
| LLPS-Tum-0696 | Tuber melanosporum | 61.18 | 1e-67 | 211 |
| LLPS-Cogr-1062 | Colletotrichum graminicola | 61.05 | 3e-67 | 210 |
| LLPS-Fuo-0296 | Fusarium oxysporum | 61.05 | 1e-67 | 211 |
| LLPS-Trv-0692 | Trichoderma virens | 61.05 | 5e-67 | 209 |
| LLPS-Fuv-1587 | Fusarium verticillioides | 61.05 | 1e-67 | 211 |
| LLPS-Pyt-1025 | Pyrenophora teres | 60.77 | 4e-69 | 214 |
| LLPS-Pytr-0975 | Pyrenophora triticirepentis | 60.22 | 5e-70 | 217 |
| LLPS-Via-0507 | Vigna angularis | 59.41 | 3e-66 | 207 |
| LLPS-Abg-1657 | Absidia glauca | 59.39 | 6e-64 | 204 |
| LLPS-Org-1037 | Oryza glaberrima | 58.82 | 4e-65 | 204 |
| LLPS-Ori-1838 | Oryza indica | 58.82 | 4e-65 | 204 |
| LLPS-Dac-1303 | Daucus carota | 58.24 | 8e-66 | 206 |
| LLPS-Vir-0950 | Vigna radiata | 57.65 | 7e-65 | 203 |
| LLPS-Phn-0241 | Phaeosphaeria nodorum | 57.06 | 2e-62 | 197 |