• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Meg-2918
HMGCS1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: 3-hydroxy-3-methylglutaryl coenzyme A synthase
Gene Name: HMGCS1
Ensembl Gene: ENSMGAG00000017189.1
Ensembl Protein: ENSMGAP00000017939.1
Organism: Meleagris gallopavo
Taxa ID: 9103
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPGSLPVNTE  SCWPKDVGIV  ALEIYFPSQY  VDQTELEKYD  GVDAGKYTIG  LGQSKMGFCS  60
61    DREDINSLCL  TVVQKLMERN  SLSYDCIGRL  EVGTETIIDK  SKSVKTVLMQ  LFEESGNTDV  120
121   EGIDTTNACY  GGTAALFNAI  NWIESSSWDG  RYALVVAGDI  AVYATGNARP  TGGAGAVAML  180
181   VGPNAPLIFE  RGLRGTHMQH  AYDFYKPDMV  SEYPVVDGKL  SIQCYLSALD  RCYSVYRNKI  240
241   HAQWQKGMSP  LEMLLNYVDN  VFDVVPCLCV  LHSLCRLLLF  AFSSCFPHTK  QHRFGIDAAE  300
301   DVKLEDTYFD  RDVEKAFMKA  SAELFNQKTK  ASLLVSNQNG  NMYTPSVYGC  LASLLAQYSP  360
361   EHLAGQRISV  FSYGSGFAAT  LYSIRVTQDA  TPGSALDKIT  ASLSDLKARL  DSRKCIAPDV  420
421   FAENMKIRQE  THHL  434
Nucleotide CDS Sequence (FASTA)
1     ATGCCTGGGT  CTCTTCCAGT  GAACACTGAA  TCCTGCTGGC  CCAAAGATGT  GGGTATTGTT  60
61    GCACTGGAAA  TCTATTTTCC  CTCTCAGTAT  GTTGACCAGA  CAGAGCTGGA  GAAGTATGAC  120
121   GGTGTGGATG  CAGGCAAATA  CACCATTGGG  TTAGGCCAGT  CAAAGATGGG  CTTCTGCTCT  180
181   GACCGAGAGG  ATATCAATTC  CCTCTGTTTG  ACTGTGGTTC  AGAAGCTTAT  GGAGAGGAAC  240
241   AGCCTTTCCT  ATGACTGCAT  TGGGAGACTG  GAGGTTGGAA  CGGAGACAAT  AATTGATAAA  300
301   TCAAAATCGG  TGAAGACGGT  CCTGATGCAG  CTGTTTGAAG  AATCCGGTAA  TACAGATGTA  360
361   GAAGGAATTG  ACACAACCAA  TGCGTGCTAT  GGAGGCACTG  CTGCTCTTTT  TAATGCTATT  420
421   AATTGGATTG  AATCCAGCTC  TTGGGATGGA  CGCTATGCAC  TTGTTGTTGC  TGGAGACATT  480
481   GCCGTGTATG  CGACTGGAAA  TGCCAGGCCA  ACAGGTGGAG  CTGGTGCTGT  TGCTATGCTA  540
541   GTCGGTCCAA  ATGCTCCTCT  AATTTTTGAG  AGAGGATTGC  GTGGAACTCA  CATGCAGCAC  600
601   GCTTATGACT  TCTATAAACC  AGATATGGTC  TCTGAATATC  CTGTAGTTGA  TGGCAAGCTG  660
661   TCTATACAGT  GCTACCTCAG  TGCATTAGAT  CGCTGCTATA  GTGTTTATCG  CAACAAAATC  720
721   CATGCCCAGT  GGCAAAAAGG  TATGTCACCT  CTTGAAATGT  TATTGAATTA  TGTAGATAAT  780
781   GTCTTTGATG  TAGTCCCCTG  TTTGTGTGTT  CTGCATAGTC  TCTGCAGGCT  CTTGTTGTTT  840
841   GCGTTTAGTA  GTTGCTTCCC  CCATACTAAG  CAGCATAGGT  TTGGGATAGA  TGCAGCAGAG  900
901   GATGTAAAGC  TTGAAGATAC  GTATTTTGAC  AGGGATGTGG  AAAAAGCTTT  TATGAAAGCT  960
961   AGTGCAGAGC  TCTTCAATCA  GAAAACCAAA  GCTTCTTTAC  TTGTGTCCAA  TCAGAATGGA  1020
1021  AACATGTACA  CACCTTCAGT  CTACGGTTGC  CTTGCTTCTC  TTCTAGCCCA  GTACTCTCCA  1080
1081  GAGCACCTTG  CAGGACAAAG  AATTAGTGTG  TTCTCATATG  GCTCTGGTTT  TGCTGCTACA  1140
1141  CTGTATTCCA  TCAGAGTTAC  ACAGGATGCT  ACTCCTGGTT  CTGCACTGGA  CAAAATAACT  1200
1201  GCCAGCCTTT  CTGATCTTAA  AGCAAGACTT  GACTCAAGAA  AATGCATTGC  ACCTGATGTC  1260
1261  TTTGCTGAAA  ACATGAAGAT  TAGACAGGAG  ACACATCACT  TG  1302

▼ KEYWORD

ID
Family
Complete proteome
Lipid biosynthesis
Lipid metabolism
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
Hydroxymethylglutaryl-CoA synthase activity
Biological Process
Isoprenoid biosynthetic process
Biological Process
Sterol biosynthetic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gaga-0903Gallus gallus89.240.0 778
LLPS-Anp-2768Anas platyrhynchos87.190.0 769
LLPS-Fia-0903Ficedula albicollis86.960.0 767
LLPS-Tag-0036Taeniopygia guttata86.530.0 763
LLPS-Pes-0328Pelodiscus sinensis84.440.0 748
LLPS-Anc-3520Anolis carolinensis83.140.0 734
LLPS-Ora-0792Ornithorhynchus anatinus81.460.0 729
LLPS-Mod-0801Monodelphis domestica80.590.0 728
LLPS-Sah-0563Sarcophilus harrisii80.590.0 727
LLPS-Lac-1646Latimeria chalumnae80.320.0 716
LLPS-Orc-3128Oryctolagus cuniculus80.140.0 721
LLPS-Caf-2031Canis familiaris80.140.0 721
LLPS-Loa-3273Loxodonta africana79.680.0 718
LLPS-Urm-2980Ursus maritimus79.680.0 717
LLPS-Aon-2854Aotus nancymaae79.680.0 715
LLPS-Aim-3593Ailuropoda melanoleuca79.680.0 718
LLPS-Eqc-3556Equus caballus79.450.0 717
LLPS-Fud-1107Fukomys damarensis79.450.0 717
LLPS-Caj-2099Callithrix jacchus79.450.0 716
LLPS-Dio-2516Dipodomys ordii79.450.0 720
LLPS-Mup-0403Mustela putorius furo79.450.0 717
LLPS-Ran-0771Rattus norvegicus79.450.0 718
LLPS-Man-4484Macaca nemestrina79.220.0 714
LLPS-Hos-3829Homo sapiens79.220.0 713
LLPS-Otg-2322Otolemur garnettii79.220.0 714
LLPS-Mam-3846Macaca mulatta79.220.0 714
LLPS-Ict-2503Ictidomys tridecemlineatus79.220.0 719
LLPS-Nol-4236Nomascus leucogenys79.220.0 714
LLPS-Cea-2629Cercocebus atys79.220.0 714
LLPS-Mea-4383Mesocricetus auratus79.220.0 719
LLPS-Maf-3971Macaca fascicularis79.220.0 714
LLPS-Chs-2150Chlorocebus sabaeus79.220.0 714
LLPS-Bot-4869Bos taurus79.220.0 718
LLPS-Paa-2071Papio anubis79.220.0 714
LLPS-Mal-1252Mandrillus leucophaeus79.220.0 714
LLPS-Ova-3397Ovis aries79.220.0 719
LLPS-Pat-4659Pan troglodytes79.00.0 707
LLPS-Pap-1637Pan paniscus79.00.0 707
LLPS-Cap-1728Cavia porcellus79.00.0 716
LLPS-Mum-0974Mus musculus79.00.0 716
LLPS-Gog-4404Gorilla gorilla79.00.0 710
LLPS-Fec-0802Felis catus78.770.0 716
LLPS-Rhb-3716Rhinopithecus bieti78.770.0 712
LLPS-Poa-4436Pongo abelii78.770.0 706
LLPS-Leo-2790Lepisosteus oculatus78.490.0 706
LLPS-Xet-0524Xenopus tropicalis78.260.0 697
LLPS-Sus-3258Sus scrofa78.080.0 711
LLPS-Myl-0681Myotis lucifugus78.080.0 708
LLPS-Asm-0147Astyanax mexicanus77.90.0 703
LLPS-Scf-3655Scleropages formosus77.120.0 687
LLPS-Icp-1582Ictalurus punctatus76.540.0 693
LLPS-Dar-0606Danio rerio76.480.0 688
LLPS-Orn-0318Oreochromis niloticus75.850.0 686
LLPS-Xim-1567Xiphophorus maculatus75.290.0 678
LLPS-Pof-0173Poecilia formosa75.060.0 675
LLPS-Gaa-1504Gasterosteus aculeatus74.370.0 674
LLPS-Orl-2145Oryzias latipes74.260.0 671
LLPS-Scm-0059Scophthalmus maximus73.910.0 671
LLPS-Tum-0184Tuber melanosporum71.25e-59 196
LLPS-Tar-1158Takifugu rubripes69.160.0 651
LLPS-Ten-2792Tetraodon nigroviridis68.780.0 593
LLPS-Gag-0102Gaeumannomyces graminis68.586e-110 339
LLPS-Drm-1629Drosophila melanogaster62.680.0 530
LLPS-Cas-3739Carlito syrichta59.220.0 538
LLPS-Cym-1117Cyanidioschyzon merolae57.024e-89 289
LLPS-Chr-0955Chlamydomonas reinhardtii54.552e-23 106
LLPS-Cis-0727Ciona savignyi54.078e-161 471
LLPS-Cii-1416Ciona intestinalis52.351e-158 465
LLPS-Cog-0539Colletotrichum gloeosporioides52.02e-142 421
LLPS-Dos-0610Dothistroma septosporum51.292e-144 427
LLPS-Pytr-1424Pyrenophora triticirepentis50.472e-140 417
LLPS-Pyt-0570Pyrenophora teres50.472e-140 417
LLPS-Beb-1178Beauveria bassiana49.884e-134 400
LLPS-Phn-1207Phaeosphaeria nodorum49.881e-133 399
LLPS-Fuv-1436Fusarium verticillioides49.777e-135 402
LLPS-Zyt-1029Zymoseptoria tritici49.772e-139 414
LLPS-Scs-0627Sclerotinia sclerotiorum49.668e-140 416
LLPS-Nec-0903Neurospora crassa49.657e-133 397
LLPS-Fuo-0855Fusarium oxysporum49.539e-135 402
LLPS-Lep-1177Leersia perrieri49.523e-133 399
LLPS-Lem-1105Leptosphaeria maculans49.421e-136 407
LLPS-Trr-0767Trichoderma reesei49.314e-135 403
LLPS-Blg-0322Blumeria graminis49.312e-135 404
LLPS-Zem-1296Zea mays49.292e-136 407
LLPS-Sei-0826Setaria italica49.294e-136 406
LLPS-Cogr-0461Colletotrichum graminicola49.24e-135 404
LLPS-Abg-1120Absidia glauca49.21e-139 414
LLPS-Nia-1129Nicotiana attenuata49.162e-128 386
LLPS-Kop-0138Komagataella pastoris49.065e-119 362
LLPS-Orp-0771Oryza punctata49.052e-133 399
LLPS-Ors-1230Oryza sativa49.052e-133 399
LLPS-Sob-2075Sorghum bicolor49.051e-136 407
LLPS-Orr-2294Oryza rufipogon49.054e-133 398
LLPS-Org-0075Oryza glaberrima49.052e-133 399
LLPS-Orb-2178Oryza barthii49.052e-133 399
LLPS-Orni-0345Oryza nivara49.052e-133 399
LLPS-Trv-1026Trichoderma virens48.846e-135 403
LLPS-Ved-1566Verticillium dahliae48.842e-133 399
LLPS-Mao-1426Magnaporthe oryzae48.835e-133 398
LLPS-Orgl-0787Oryza glumaepatula48.811e-132 397
LLPS-Fus-0468Fusarium solani48.733e-133 398
LLPS-Met-1094Medicago truncatula48.696e-127 383
LLPS-Coo-1314Colletotrichum orbiculare48.622e-132 397
LLPS-Orm-2047Oryza meridionalis48.53e-124 375
LLPS-Vir-1217Vigna radiata48.352e-122 369
LLPS-Orbr-1079Oryza brachyantha48.331e-134 402
LLPS-Brd-2067Brachypodium distachyon48.331e-130 392
LLPS-Glm-1399Glycine max48.253e-129 389
LLPS-Nef-0488Neosartorya fischeri48.163e-134 401
LLPS-Hov-0017Hordeum vulgare48.11e-130 396
LLPS-Tra-2777Triticum aestivum48.17e-131 393
LLPS-Scp-0942Schizosaccharomyces pombe48.095e-127 382
LLPS-Cus-0542Cucumis sativus48.04e-127 383
LLPS-Asfu-0829Aspergillus fumigatus47.917e-135 403
LLPS-Viv-1917Vitis vinifera47.893e-126 381
LLPS-Tut-1708Tursiops truncatus47.813e-126 379
LLPS-Mua-1407Musa acuminata47.756e-125 378
LLPS-Sot-0912Solanum tuberosum47.752e-127 384
LLPS-Prp-1100Prunus persica47.657e-124 375
LLPS-Tru-1536Triticum urartu47.623e-129 390
LLPS-Gor-1631Gossypium raimondii47.612e-130 392
LLPS-Scj-0794Schizosaccharomyces japonicus47.613e-127 383
LLPS-Asn-0973Aspergillus nidulans47.552e-131 394
LLPS-Asg-0444Ashbya gossypii47.544e-124 375
LLPS-Sol-2041Solanum lycopersicum47.524e-127 383
LLPS-Asc-0157Aspergillus clavatus47.51e-134 402
LLPS-Hea-1005Helianthus annuus47.457e-128 385
LLPS-Asf-0361Aspergillus flavus47.454e-132 395
LLPS-Usm-1512Ustilago maydis47.442e-125 379
LLPS-Pot-1818Populus trichocarpa47.421e-128 387
LLPS-Phv-1668Phaseolus vulgaris47.424e-129 388
LLPS-Bro-0240Brassica oleracea47.393e-124 375
LLPS-Brn-2794Brassica napus47.392e-125 379
LLPS-Ori-0807Oryza indica47.374e-123 373
LLPS-Sem-1815Selaginella moellendorffii47.379e-122 369
LLPS-Miv-1161Microbotryum violaceum47.293e-123 373
LLPS-Php-2177Physcomitrella patens47.243e-129 389
LLPS-Map-1130Magnaporthe poae47.222e-132 397
LLPS-Aso-1505Aspergillus oryzae47.221e-131 394
LLPS-Sac-1435Saccharomyces cerevisiae47.27e-122 370
LLPS-Mel-0825Melampsora laricipopulina47.142e-125 380
LLPS-Coc-0231Corchorus capsularis46.923e-127 383
LLPS-Mae-0914Manihot esculenta46.76e-129 388
LLPS-Via-2303Vigna angularis46.577e-125 377
LLPS-Spr-1149Sporisorium reilianum46.569e-121 367
LLPS-Pug-1035Puccinia graminis46.54e-122 373
LLPS-Art-2558Arabidopsis thaliana46.452e-124 376
LLPS-Gas-0407Galdieria sulphuraria46.437e-119 362
LLPS-Brr-0869Brassica rapa46.245e-125 378
LLPS-Ast-1367Aspergillus terreus46.151e-126 381
LLPS-Thc-1470Theobroma cacao46.149e-127 382
LLPS-Amt-2124Amborella trichopoda46.082e-116 355
LLPS-Put-1087Puccinia triticina46.056e-122 372
LLPS-Arl-1089Arabidopsis lyrata45.794e-125 378
LLPS-Asni-0107Aspergillus niger45.698e-127 382
LLPS-Dac-1527Daucus carota45.565e-123 372
LLPS-Scc-0893Schizosaccharomyces cryophilus44.711e-118 360
LLPS-Yal-0441Yarrowia lipolytica44.66e-114 348
LLPS-Chc-0916Chondrus crispus44.056e-100 313
LLPS-Cae-0238Caenorhabditis elegans42.382e-93 296
LLPS-Crn-0911Cryptococcus neoformans41.987e-110 340