• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Leo-1029

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 2A
Ensembl Gene: ENSLOCG00000001831.1
Ensembl Protein: ENSLOCP00000002120.1
Organism: Lepisosteus oculatus
Taxa ID: 7918
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Neuronal granule, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSLOCT00000002125.1ENSLOCP00000002120.1
UniProtW5M163, W5M163_LEPOC
GeneBankAHAT01022478, AHAT01022477

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAPPTPVLAV  RASNGTSMIY  GPPDCVENTV  FKRDGRASKF  VTFSRDGSLF  AWCNGDKVSV  60
61    LNVADGTVLQ  SLDLPKTACL  EFSPKSSILA  TWQPYSKTQE  SAQGDPNLHL  WDLQTGKCLK  120
121   SFYQKKMQGW  CPTWSDDESI  AVRNVNNELH  FFENNKFDTI  ANKLHLQKVT  EFVLSPGAQP  180
181   SKVAVYVPGS  KGAPSFVRLY  QYPNFAGPTS  ALANKSFFKS  DKVTMLWNKK  ASAVLVTAST  240
241   EVDKTGASYY  GEQTLHYLAV  NGESAVVQLP  KSGPIYDVVW  SPGSAEFCVV  YGFMPAKATV  300
301   FNLKCDPVFD  FGTGPRNAAY  YSPQGHILVL  AGFGNLRGQM  EVWDAKRYKQ  ISKPQAPDST  360
361   FFSWCPDGEH  IVTATCAPRL  RVGNGYKIWH  YTGTVLHKSD  VPADAELWEV  LWQPCAEGVF  420
421   PEKPIRYQAA  PSELGSAEPK  PAQAYRPPAL  RNRPAASSKL  HEEEPPQNMK  QPAGGERPLS  480
481   RAGGKVLLRL  HRRVSLAEPA  GADVSFSAWH  RTSSPACTTD  RTAFRVVTGS  HPLIPVWLLG  540
541   LELKIKAIEQ  LKEQQATGKQ  LEKNQIEKIQ  KESQLLQELE  DLELGL  586
Nucleotide CDS Sequence (FASTA)
1     ATGGCGCCCC  CCACACCAGT  GTTGGCAGTT  CGCGCATCGA  ATGGAACATC  CATGATCTAT  60
61    GGCCCTCCAG  ACTGTGTCGA  AAATACTGTC  TTTAAAAGGG  ATGGACGAGC  AAGTAAATTT  120
121   GTGACGTTTA  GCAGAGATGG  TTCCTTGTTC  GCCTGGTGCA  ATGGAGACAA  GGTCAGTGTA  180
181   CTTAATGTGG  CAGATGGCAC  AGTCCTGCAG  TCTCTCGACC  TCCCAAAGAC  GGCCTGTCTG  240
241   GAGTTCTCTC  CCAAGAGCTC  CATTCTGGCA  ACATGGCAGC  CTTATAGCAA  AACGCAGGAG  300
301   AGTGCTCAAG  GAGACCCTAA  CCTTCACCTG  TGGGATCTGC  AGACTGGGAA  GTGTCTTAAA  360
361   TCTTTCTACC  AGAAGAAAAT  GCAGGGCTGG  TGCCCAACCT  GGTCCGATGA  TGAAAGTATC  420
421   GCCGTCAGGA  ATGTAAACAA  CGAGCTCCAT  TTTTTCGAAA  ATAACAAATT  TGACACCATC  480
481   GCCAACAAGC  TGCACCTGCA  GAAGGTCACG  GAGTTCGTCC  TGTCTCCCGG  AGCTCAGCCC  540
541   AGCAAGGTCG  CTGTCTATGT  CCCAGGAAGC  AAAGGGGCCC  CCTCCTTCGT  GCGGCTGTAC  600
601   CAGTACCCCA  ACTTCGCAGG  GCCGACCTCA  GCTTTGGCCA  ACAAAAGCTT  CTTTAAGTCT  660
661   GACAAAGTGA  CGATGCTGTG  GAACAAGAAA  GCCTCCGCCG  TCCTAGTGAC  CGCTAGCACG  720
721   GAGGTGGACA  AGACGGGGGC  GTCGTACTAC  GGGGAGCAGA  CCCTCCACTA  CCTGGCGGTC  780
781   AACGGCGAGA  GTGCGGTCGT  GCAGCTGCCG  AAGAGCGGCC  CGATCTACGA  CGTGGTCTGG  840
841   AGCCCCGGCT  CCGCCGAGTT  CTGCGTAGTC  TACGGCTTCA  TGCCGGCCAA  GGCCACCGTG  900
901   TTCAACCTCA  AGTGTGACCC  CGTGTTCGAC  TTCGGCACGG  GCCCGAGGAA  CGCCGCCTAC  960
961   TACAGCCCCC  AGGGGCACAT  CCTGGTGCTG  GCGGGCTTCG  GCAACCTCCG  GGGGCAGATG  1020
1021  GAGGTCTGGG  ACGCGAAGAG  GTACAAGCAG  ATCTCCAAGC  CACAGGCGCC  GGACTCCACT  1080
1081  TTCTTCTCCT  GGTGCCCGGA  CGGGGAGCAC  ATCGTCACGG  CGACGTGCGC  CCCGAGACTG  1140
1141  AGGGTTGGCA  ACGGGTACAA  GATCTGGCAC  TACACCGGCA  CCGTGCTCCA  CAAGTCCGAC  1200
1201  GTGCCGGCCG  ACGCCGAGCT  CTGGGAGGTG  CTGTGGCAGC  CGTGTGCGGA  GGGGGTCTTC  1260
1261  CCCGAGAAGC  CCATCAGGTA  CCAGGCGGCG  CCCAGCGAGC  TGGGCAGCGC  GGAGCCCAAG  1320
1321  CCAGCCCAGG  CGTACAGACC  CCCGGCGCTG  AGGAACAGAC  CAGCCGCCAG  CTCGAAGCTG  1380
1381  CACGAGGAGG  AGCCGCCGCA  GAACATGAAG  CAGCCGGCCG  GAGGGGAGCG  GCCCCTGTCC  1440
1441  AGAGCGGGAG  GGAAGGTCCT  TCTCCGGCTG  CACCGCCGAG  TCTCTCTGGC  TGAACCAGCT  1500
1501  GGGGCTGACG  TGTCCTTCTC  CGCCTGGCAC  AGAACATCAT  CACCGGCTTG  TACTACAGAC  1560
1561  AGGACTGCAT  TCAGGGTTGT  TACTGGGTCA  CACCCACTTA  TACCTGTCTG  GTTACTCGGG  1620
1621  TTAGAACTCA  AAATCAAGGC  AATAGAGCAG  CTCAAGGAGC  AGCAGGCCAC  TGGCAAGCAG  1680
1681  CTGGAGAAAA  ACCAGATTGA  GAAGATACAG  AAGGAGTCCC  AGTTGTTACA  GGAATTGGAG  1740
1741  GATTTGGAAC  TGGGATTGTA  A  1761

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Initiation factor
Protein biosynthesis
Reference proteome
Translation regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosolic small ribosomal subunit
Molecular Function
Ribosome binding
Molecular Function
Translation initiation factor activity
Molecular Function
TRNA binding
Biological Process
Regulation of translation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scf-2026Scleropages formosus73.650.0 856
LLPS-Meg-0509Meleagris gallopavo71.590.0 793
LLPS-Gaga-1450Gallus gallus71.450.0 833
LLPS-Ora-2022Ornithorhynchus anatinus70.970.0 694
LLPS-Icp-2538Ictalurus punctatus70.880.0 835
LLPS-Tag-1469Taeniopygia guttata70.740.0 811
LLPS-Asm-2345Astyanax mexicanus70.580.0 844
LLPS-Tar-0749Takifugu rubripes70.350.0 717
LLPS-Lac-1244Latimeria chalumnae70.230.0 832
LLPS-Dar-0056Danio rerio69.820.0 823
LLPS-Anp-1931Anas platyrhynchos69.770.0 805
LLPS-Eqc-2604Equus caballus69.760.0 761
LLPS-Pes-2100Pelodiscus sinensis69.410.0 797
LLPS-Sah-0156Sarcophilus harrisii69.020.0 612
LLPS-Poa-2392Pongo abelii68.991e-164 481
LLPS-Orc-0232Oryctolagus cuniculus68.650.0 810
LLPS-Sus-1732Sus scrofa68.650.0 805
LLPS-Mum-3758Mus musculus68.60.0 803
LLPS-Orn-0031Oreochromis niloticus68.420.0 800
LLPS-Cas-0128Carlito syrichta68.420.0 798
LLPS-Mod-2475Monodelphis domestica68.290.0 813
LLPS-Mam-0650Macaca mulatta68.270.0 792
LLPS-Maf-1188Macaca fascicularis68.270.0 792
LLPS-Gog-1431Gorilla gorilla68.270.0 795
LLPS-Caf-1937Canis familiaris68.250.0 802
LLPS-Pat-0227Pan troglodytes68.090.0 791
LLPS-Pap-3474Pan paniscus68.090.0 791
LLPS-Ict-1757Ictidomys tridecemlineatus68.070.0 803
LLPS-Mup-1383Mustela putorius furo68.070.0 801
LLPS-Ere-0360Erinaceus europaeus68.070.0 800
LLPS-Urm-0486Ursus maritimus67.890.0 798
LLPS-Hos-1098Homo sapiens67.890.0 801
LLPS-Fec-1285Felis catus67.890.0 800
LLPS-Rhb-0761Rhinopithecus bieti67.890.0 803
LLPS-Chs-2297Chlorocebus sabaeus67.890.0 802
LLPS-Man-1256Macaca nemestrina67.740.0 793
LLPS-Fud-1811Fukomys damarensis67.720.0 793
LLPS-Ran-4017Rattus norvegicus67.720.0 795
LLPS-Anc-2178Anolis carolinensis67.60.0 813
LLPS-Caj-1871Callithrix jacchus67.60.0 796
LLPS-Dio-2357Dipodomys ordii67.550.0 672
LLPS-Mea-0574Mesocricetus auratus67.540.0 800
LLPS-Paa-2669Papio anubis67.540.0 796
LLPS-Bot-0575Bos taurus67.50.0 791
LLPS-Aon-1320Aotus nancymaae67.430.0 793
LLPS-Aim-1128Ailuropoda melanoleuca67.430.0 786
LLPS-Mal-2407Mandrillus leucophaeus67.370.0 790
LLPS-Ova-1414Ovis aries67.360.0 793
LLPS-Otg-2228Otolemur garnettii67.190.0 798
LLPS-Xim-1207Xiphophorus maculatus67.190.0 789
LLPS-Myl-0740Myotis lucifugus67.020.0 787
LLPS-Loa-1647Loxodonta africana66.840.0 795
LLPS-Fia-2096Ficedula albicollis66.610.0 748
LLPS-Pof-3456Poecilia formosa66.490.0 781
LLPS-Cea-0546Cercocebus atys66.490.0 758
LLPS-Scm-3399Scophthalmus maximus66.430.0 778
LLPS-Nol-4023Nomascus leucogenys66.020.0 764
LLPS-Xet-0103Xenopus tropicalis65.450.0 773
LLPS-Cap-2093Cavia porcellus63.570.0 710
LLPS-Gaa-0311Gasterosteus aculeatus63.370.0 746
LLPS-Ten-2047Tetraodon nigroviridis62.410.0 739
LLPS-Drm-0549Drosophila melanogaster42.275e-117 368
LLPS-Ved-0585Verticillium dahliae41.558e-97 317
LLPS-Mao-1005Magnaporthe oryzae41.312e-99 324
LLPS-Map-0999Magnaporthe poae40.612e-95 313
LLPS-Gag-1578Gaeumannomyces graminis40.472e-93 308
LLPS-Trv-1305Trichoderma virens40.387e-94 309
LLPS-Zyt-1347Zymoseptoria tritici40.334e-99 323
LLPS-Asn-0664Aspergillus nidulans39.952e-95 313
LLPS-Beb-0118Beauveria bassiana39.915e-96 314
LLPS-Fus-1263Fusarium solani39.918e-96 314
LLPS-Trr-0090Trichoderma reesei39.914e-93 307
LLPS-Cis-1391Ciona savignyi39.99e-144 435
LLPS-Cii-0146Ciona intestinalis39.91e-142 433
LLPS-Dos-1129Dothistroma septosporum39.661e-103 335
LLPS-Ast-0276Aspergillus terreus39.454e-99 322
LLPS-Chc-0787Chondrus crispus39.328e-44 165
LLPS-Php-2179Physcomitrella patens39.35e-88 290
LLPS-Nec-1234Neurospora crassa39.222e-95 313
LLPS-Blg-0290Blumeria graminis39.142e-100 327
LLPS-Asf-0741Aspergillus flavus39.122e-91 302
LLPS-Fuv-0728Fusarium verticillioides39.091e-93 308
LLPS-Fuo-0394Fusarium oxysporum39.046e-94 309
LLPS-Pyt-1032Pyrenophora teres38.811e-98 322
LLPS-Pug-0773Puccinia graminis38.797e-104 334
LLPS-Pytr-0733Pyrenophora triticirepentis38.597e-98 320
LLPS-Coo-0901Colletotrichum orbiculare38.469e-94 308
LLPS-Osl-0862Ostreococcus lucimarinus38.279e-77 260
LLPS-Mae-1567Manihot esculenta38.195e-30 122
LLPS-Tum-1109Tuber melanosporum38.074e-97 318
LLPS-Asc-0510Aspergillus clavatus37.975e-96 315
LLPS-Aso-0917Aspergillus oryzae37.975e-94 308
LLPS-Phn-1209Phaeosphaeria nodorum37.92e-95 314
LLPS-Put-0485Puccinia triticina37.855e-97 315
LLPS-Cogr-0558Colletotrichum graminicola37.826e-93 306
LLPS-Hea-0048Helianthus annuus37.742e-70 240
LLPS-Asfu-0529Aspergillus fumigatus37.737e-95 311
LLPS-Nef-0610Neosartorya fischeri37.533e-95 312
LLPS-Mel-0714Melampsora laricipopulina37.532e-94 309
LLPS-Via-1414Vigna angularis37.324e-70 243
LLPS-Sol-1593Solanum lycopersicum37.118e-73 248
LLPS-Lem-0526Leptosphaeria maculans36.973e-91 303
LLPS-Hov-1140Hordeum vulgare36.971e-79 266
LLPS-Tra-0596Triticum aestivum36.759e-79 265
LLPS-Pot-1788Populus trichocarpa36.61e-76 258
LLPS-Gor-1840Gossypium raimondii36.334e-73 250
LLPS-Orbr-1842Oryza brachyantha36.241e-72 248
LLPS-Viv-1630Vitis vinifera36.111e-76 260
LLPS-Sem-1001Selaginella moellendorffii36.093e-83 277
LLPS-Cae-2015Caenorhabditis elegans36.04e-109 345
LLPS-Coc-0757Corchorus capsularis35.922e-68 244
LLPS-Chr-1218Chlamydomonas reinhardtii35.751e-62 223
LLPS-Spr-0395Sporisorium reilianum35.642e-85 285
LLPS-Gas-0192Galdieria sulphuraria35.637e-74 253
LLPS-Miv-0311Microbotryum violaceum35.486e-102 328
LLPS-Brd-0607Brachypodium distachyon35.481e-74 253
LLPS-Org-1053Oryza glaberrima35.382e-74 253
LLPS-Ori-1721Oryza indica35.382e-76 258
LLPS-Scp-0720Schizosaccharomyces pombe35.315e-88 290
LLPS-Prp-0644Prunus persica35.263e-79 265
LLPS-Usm-0517Ustilago maydis35.234e-87 290
LLPS-Glm-1418Glycine max35.126e-76 257
LLPS-Cus-1816Cucumis sativus35.063e-83 276
LLPS-Asni-0305Aspergillus niger34.912e-95 310
LLPS-Brr-1916Brassica rapa34.813e-73 249
LLPS-Bro-1206Brassica oleracea34.742e-71 246
LLPS-Phv-0223Phaseolus vulgaris34.723e-72 247
LLPS-Lep-1595Leersia perrieri34.77e-68 235
LLPS-Scc-0194Schizosaccharomyces cryophilus34.678e-89 292
LLPS-Brn-2169Brassica napus34.612e-72 247
LLPS-Mua-0159Musa acuminata34.562e-76 258
LLPS-Sob-1491Sorghum bicolor34.543e-70 241
LLPS-Zem-1962Zea mays34.54e-73 249
LLPS-Abg-0217Absidia glauca34.411e-86 286
LLPS-Yal-0466Yarrowia lipolytica34.311e-93 305
LLPS-Vir-0445Vigna radiata34.241e-57 209
LLPS-Amt-0662Amborella trichopoda33.952e-71 244
LLPS-Met-1084Medicago truncatula33.933e-75 255
LLPS-Sei-0293Setaria italica33.862e-75 256
LLPS-Arl-0622Arabidopsis lyrata33.827e-71 243
LLPS-Art-0842Arabidopsis thaliana33.331e-70 242
LLPS-Scj-1014Schizosaccharomyces japonicus33.271e-89 294
LLPS-Orb-0661Oryza barthii32.997e-55 199
LLPS-Thc-0940Theobroma cacao32.881e-62 222
LLPS-Orgl-1272Oryza glumaepatula32.794e-55 200
LLPS-Orm-0391Oryza meridionalis32.589e-55 199
LLPS-Orni-0922Oryza nivara32.581e-54 199
LLPS-Orr-0132Oryza rufipogon32.385e-54 197
LLPS-Orp-0387Oryza punctata32.12e-54 198
LLPS-Crn-0711Cryptococcus neoformans30.915e-73 252
LLPS-Kop-0043Komagataella pastoris30.661e-78 266
LLPS-Asg-1281Ashbya gossypii30.371e-53 198
LLPS-Tru-0970Triticum urartu30.284e-42 162
LLPS-Dac-2298Daucus carota30.263e-30 125
LLPS-Sac-1128Saccharomyces cerevisiae28.426e-53 196
LLPS-Cym-0683Cyanidioschyzon merolae27.651e-50 189
LLPS-Orl-0631Oryzias latipes24.097e-21 100
LLPS-Ors-0106Oryza sativa22.151e-1687.8
LLPS-Sot-0194Solanum tuberosum21.258e-1994.7