• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Gor-1840
B456_005G012500

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 2A
Gene Name: B456_005G012500
Ensembl Gene: B456_005G012500
Ensembl Protein: KJB27836
Organism: Gossypium raimondii
Taxa ID: 29730
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblKJB27836KJB27836
EnsemblKJB27837KJB27837
EnsemblKJB27838KJB27838
EnsemblKJB27839KJB27839
UniProtA0A0D2PL86, A0A0D2PL86_GOSRA
GeneBankCM001744KJB27838.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MVSRSGKFSI  ADLQEKKVQP  TAAQIARYDH  PMAAAVEISP  VLEILVREPD  GYSIWNGPPF  60
61    KNNNQPGIKL  EKVPCNNAKY  SEDGSRIMVT  KTDSAIGIYD  SNTLKEIRCF  QIPNVVASAL  120
121   SPCGAYLQTF  QKSTTPQEKN  VVLWSIETGD  PVYEQFQKNM  TKATWPLIRF  SSDEAVACRL  180
181   ATNEIQFFDA  ADFSKGISHR  LRVPGVAAVE  LSRAPGSHVA  AFVPESKGSP  ASVQIYACAK  240
241   ELQSQPLARR  SFFRCSTVQL  HWNHGSTGLL  VVVQSDVDKT  NQSYYGESKL  HYLTTDGAFE  300
301   GLVPLRKEGP  IHDVQWSYSG  KEFAVVYGFM  PASATVFDKK  CKPVHELGSG  PYNTVRWNPK  360
361   GKLLCLAGFG  NLPGDMAFWD  IIDKKQLGTT  RAECSVTSEW  SADGCYFMTA  TTAPRLQVDN  420
421   CVKIFSYNGS  LLFKKMFNKL  FQADWKPESP  DKFGEIAELI  KSVGSVKIEE  TKSLGQGSTT  480
481   KKPASANPPA  QKPAAYRPPH  AKNAAAVQAE  LFGGSSTGEM  SKNALKNKKK  REKQKEKKAA  540
541   EAAAASGAT  549
Nucleotide CDS Sequence (FASTA)
1     ATGGTGTCAC  GGAGCGGCAA  GTTTTCAATA  GCTGATTTGC  AAGAAAAAAA  GGTTCAGCCA  60
61    ACGGCAGCAC  AGATCGCCCG  ATACGACCAT  CCAATGGCAG  CAGCTGTGGA  AATTTCACCA  120
121   GTTTTAGAGA  TTTTAGTTCG  AGAACCAGAT  GGATATTCTA  TCTGGAATGG  ACCTCCATTC  180
181   AAGAATAATA  ATCAACCTGG  GATTAAGCTT  GAAAAAGTTC  CTTGCAATAA  TGCTAAGTAT  240
241   AGTGAGGATG  GTTCAAGGAT  TATGGTGACA  AAAACAGACT  CTGCTATTGG  TATCTATGAT  300
301   TCCAACACTT  TGAAAGAGAT  AAGGTGTTTT  CAAATCCCGA  ATGTAGTCGC  TTCGGCTTTG  360
361   TCCCCGTGTG  GGGCTTATCT  TCAAACCTTT  CAGAAATCTA  CTACGCCGCA  GGAAAAGAAT  420
421   GTGGTCTTAT  GGAGCATAGA  GACCGGGGAT  CCTGTTTACG  AGCAGTTCCA  GAAAAACATG  480
481   ACAAAAGCTA  CATGGCCATT  AATCCGATTC  AGCTCTGATG  AAGCTGTTGC  ATGCCGGCTT  540
541   GCTACAAATG  AAATACAGTT  TTTCGATGCT  GCTGATTTCT  CTAAAGGAAT  TTCACATCGG  600
601   CTAAGAGTTC  CTGGGGTGGC  TGCAGTGGAG  CTTTCCAGAG  CTCCTGGGTC  CCATGTGGCA  660
661   GCATTTGTTC  CAGAATCAAA  GGGGAGTCCA  GCTAGTGTCC  AGATATATGC  GTGTGCGAAA  720
721   GAGTTGCAGA  GCCAACCTCT  AGCTCGACGA  AGCTTTTTTC  GATGTTCTAC  TGTGCAGTTA  780
781   CATTGGAACC  ATGGTTCAAC  AGGACTTCTA  GTTGTGGTTC  AATCTGATGT  TGATAAGACT  840
841   AACCAGAGCT  ATTACGGAGA  GTCGAAGCTG  CACTACCTTA  CAACTGATGG  AGCCTTTGAA  900
901   GGACTTGTTC  CCCTTCGTAA  GGAGGGGCCT  ATTCATGATG  TTCAATGGTC  ATATTCCGGG  960
961   AAAGAGTTTG  CTGTTGTTTA  TGGATTTATG  CCTGCCAGTG  CAACAGTATT  TGACAAGAAG  1020
1021  TGCAAACCAG  TACATGAGCT  AGGATCTGGT  CCTTACAATA  CCGTTCGATG  GAATCCGAAG  1080
1081  GGGAAATTAC  TGTGTTTGGC  CGGTTTCGGT  AACTTGCCTG  GCGATATGGC  ATTCTGGGAT  1140
1141  ATTATAGACA  AAAAGCAGCT  TGGAACAACT  AGGGCTGAAT  GCTCGGTAAC  AAGTGAGTGG  1200
1201  TCTGCGGATG  GATGCTATTT  CATGACTGCT  ACAACAGCTC  CCAGACTCCA  AGTCGACAAT  1260
1261  TGTGTTAAAA  TTTTTAGCTA  CAATGGATCG  TTGCTCTTCA  AGAAGATGTT  TAACAAGTTG  1320
1321  TTCCAGGCTG  ATTGGAAGCC  GGAGTCACCA  GATAAGTTCG  GTGAAATTGC  TGAACTTATA  1380
1381  AAGTCCGTTG  GTTCTGTGAA  GATTGAAGAA  ACCAAATCAC  TAGGACAAGG  GTCAACCACC  1440
1441  AAAAAGCCTG  CATCGGCTAA  CCCTCCCGCA  CAGAAGCCTG  CTGCTTATCG  TCCTCCGCAT  1500
1501  GCTAAGAATG  CAGCGGCAGT  TCAGGCAGAG  GTACTTCTCT  GA  1542

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Initiation factor
Protein biosynthesis
Reference proteome
Translation regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Plasma membrane
Molecular Function
Translation initiation factor activity
Biological Process
Regulation of translation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Coc-0757Corchorus capsularis87.390.0 873
LLPS-Thc-0940Theobroma cacao81.170.0 885
LLPS-Mae-1567Manihot esculenta80.732e-109 333
LLPS-Prp-0644Prunus persica77.850.0 812
LLPS-Via-1414Vigna angularis77.720.0 676
LLPS-Pot-1788Populus trichocarpa76.840.0 781
LLPS-Phv-0223Phaseolus vulgaris76.670.0 771
LLPS-Glm-2197Glycine max76.040.0 766
LLPS-Viv-1630Vitis vinifera75.310.0 783
LLPS-Cus-1816Cucumis sativus74.530.0 756
LLPS-Hea-0048Helianthus annuus73.00.0 657
LLPS-Met-1084Medicago truncatula72.480.0 749
LLPS-Sol-1593Solanum lycopersicum71.710.0 733
LLPS-Arl-0622Arabidopsis lyrata70.810.0 740
LLPS-Art-0842Arabidopsis thaliana70.810.0 746
LLPS-Dac-2298Daucus carota69.074e-149 438
LLPS-Vir-0445Vigna radiata68.840.0 608
LLPS-Brn-2169Brassica napus68.740.0 729
LLPS-Brr-1916Brassica rapa68.530.0 729
LLPS-Mua-0159Musa acuminata68.230.0 722
LLPS-Bro-1206Brassica oleracea67.690.0 726
LLPS-Amt-0662Amborella trichopoda66.740.0 677
LLPS-Ori-1721Oryza indica64.750.0 699
LLPS-Orbr-1842Oryza brachyantha64.20.0 686
LLPS-Org-1053Oryza glaberrima64.140.0 688
LLPS-Lep-1595Leersia perrieri63.990.0 674
LLPS-Sob-1491Sorghum bicolor62.780.0 662
LLPS-Sei-0293Setaria italica62.530.0 675
LLPS-Hov-1140Hordeum vulgare62.370.0 654
LLPS-Brd-0607Brachypodium distachyon62.170.0 654
LLPS-Tra-0596Triticum aestivum61.760.0 645
LLPS-Zem-1962Zea mays61.350.0 661
LLPS-Orni-0922Oryza nivara60.290.0 630
LLPS-Orr-0132Oryza rufipogon60.290.0 630
LLPS-Orm-0391Oryza meridionalis60.290.0 630
LLPS-Orb-0661Oryza barthii60.080.0 624
LLPS-Orgl-1272Oryza glumaepatula60.080.0 628
LLPS-Orp-0387Oryza punctata59.880.0 625
LLPS-Ors-1784Oryza sativa59.38e-2193.2
LLPS-Php-2179Physcomitrella patens54.430.0 532
LLPS-Tru-0970Triticum urartu51.275e-161 474
LLPS-Sem-1001Selaginella moellendorffii49.362e-160 476
LLPS-Poa-2392Pongo abelii47.126e-51 184
LLPS-Osl-0862Ostreococcus lucimarinus42.371e-108 343
LLPS-Put-0485Puccinia triticina38.464e-90 296
LLPS-Sah-0156Sarcophilus harrisii38.352e-65 226
LLPS-Pug-0773Puccinia graminis38.132e-97 316
LLPS-Tum-1109Tuber melanosporum38.056e-85 285
LLPS-Chr-1218Chlamydomonas reinhardtii38.033e-83 278
LLPS-Mel-0714Melampsora laricipopulina37.761e-85 285
LLPS-Fuo-0394Fusarium oxysporum37.321e-81 275
LLPS-Pyt-1032Pyrenophora teres37.272e-84 283
LLPS-Lem-0526Leptosphaeria maculans37.263e-81 275
LLPS-Nef-0610Neosartorya fischeri37.122e-78 266
LLPS-Pytr-0733Pyrenophora triticirepentis37.053e-83 280
LLPS-Ved-0585Verticillium dahliae36.982e-80 273
LLPS-Pof-3456Poecilia formosa36.898e-71 244
LLPS-Fus-1263Fusarium solani36.851e-81 275
LLPS-Miv-0311Microbotryum violaceum36.831e-87 289
LLPS-Coo-0901Colletotrichum orbiculare36.737e-79 268
LLPS-Cap-2093Cavia porcellus36.681e-65 228
LLPS-Ora-2022Ornithorhynchus anatinus36.642e-66 230
LLPS-Fuv-0728Fusarium verticillioides36.624e-81 273
LLPS-Beb-0118Beauveria bassiana36.629e-79 267
LLPS-Phn-1209Phaeosphaeria nodorum36.556e-83 279
LLPS-Trv-1305Trichoderma virens36.532e-77 264
LLPS-Scp-0720Schizosaccharomyces pombe36.477e-84 278
LLPS-Ict-1757Ictidomys tridecemlineatus36.477e-72 246
LLPS-Asn-0664Aspergillus nidulans36.366e-79 268
LLPS-Asc-0510Aspergillus clavatus36.349e-79 268
LLPS-Leo-1029Lepisosteus oculatus36.335e-73 249
LLPS-Trr-0090Trichoderma reesei36.39e-78 265
LLPS-Aso-0917Aspergillus oryzae36.263e-77 263
LLPS-Asf-0741Aspergillus flavus36.266e-77 262
LLPS-Asfu-0529Aspergillus fumigatus36.174e-78 266
LLPS-Asni-0305Aspergillus niger36.155e-79 266
LLPS-Xet-0103Xenopus tropicalis36.063e-79 266
LLPS-Xim-1207Xiphophorus maculatus35.982e-71 245
LLPS-Blg-0290Blumeria graminis35.953e-80 271
LLPS-Ast-0276Aspergillus terreus35.783e-76 260
LLPS-Icp-2538Ictalurus punctatus35.712e-77 261
LLPS-Yal-0466Yarrowia lipolytica35.594e-79 265
LLPS-Cogr-0558Colletotrichum graminicola35.551e-78 268
LLPS-Asm-2345Astyanax mexicanus35.435e-75 255
LLPS-Chc-0787Chondrus crispus35.383e-37 145
LLPS-Mea-0574Mesocricetus auratus35.348e-75 254
LLPS-Dar-0056Danio rerio35.316e-78 263
LLPS-Gas-0192Galdieria sulphuraria35.251e-68 237
LLPS-Map-0999Magnaporthe poae35.21e-79 270
LLPS-Meg-0509Meleagris gallopavo35.199e-71 243
LLPS-Scc-0194Schizosaccharomyces cryophilus35.182e-83 277
LLPS-Gag-1578Gaeumannomyces graminis35.151e-77 265
LLPS-Ten-2047Tetraodon nigroviridis35.154e-71 245
LLPS-Fia-2096Ficedula albicollis35.142e-65 229
LLPS-Scj-1014Schizosaccharomyces japonicus35.014e-85 281
LLPS-Tar-0749Takifugu rubripes34.992e-71 244
LLPS-Gaga-1450Gallus gallus34.929e-74 252
LLPS-Lac-1244Latimeria chalumnae34.875e-73 249
LLPS-Ova-1414Ovis aries34.868e-74 252
LLPS-Scf-2026Scleropages formosus34.842e-69 240
LLPS-Ran-4017Rattus norvegicus34.783e-75 256
LLPS-Orn-0031Oreochromis niloticus34.765e-75 255
LLPS-Zyt-1347Zymoseptoria tritici34.758e-82 276
LLPS-Anc-2178Anolis carolinensis34.71e-73 251
LLPS-Dos-1129Dothistroma septosporum34.696e-81 274
LLPS-Anp-1931Anas platyrhynchos34.513e-73 250
LLPS-Gaa-0311Gasterosteus aculeatus34.59e-70 241
LLPS-Mao-1005Magnaporthe oryzae34.421e-78 267
LLPS-Scm-3399Scophthalmus maximus34.413e-69 240
LLPS-Kop-0043Komagataella pastoris34.382e-79 267
LLPS-Drm-0549Drosophila melanogaster34.242e-63 225
LLPS-Bot-0575Bos taurus34.242e-72 249
LLPS-Orc-0232Oryctolagus cuniculus34.241e-72 249
LLPS-Nec-1234Neurospora crassa34.184e-77 263
LLPS-Mum-3758Mus musculus34.177e-74 252
LLPS-Cis-1391Ciona savignyi34.172e-63 223
LLPS-Tag-1469Taeniopygia guttata34.169e-70 241
LLPS-Otg-2228Otolemur garnettii34.18e-74 252
LLPS-Cas-0128Carlito syrichta33.965e-74 252
LLPS-Sus-1732Sus scrofa33.892e-74 253
LLPS-Gog-1431Gorilla gorilla33.754e-73 250
LLPS-Dio-2357Dipodomys ordii33.759e-65 226
LLPS-Pat-0227Pan troglodytes33.753e-73 250
LLPS-Pap-3474Pan paniscus33.753e-73 250
LLPS-Fec-1285Felis catus33.756e-73 249
LLPS-Mod-2475Monodelphis domestica33.752e-72 248
LLPS-Man-1256Macaca nemestrina33.754e-72 247
LLPS-Fud-1811Fukomys damarensis33.682e-72 248
LLPS-Ere-0360Erinaceus europaeus33.684e-74 253
LLPS-Mup-1383Mustela putorius furo33.682e-74 253
LLPS-Caf-1937Canis familiaris33.681e-74 254
LLPS-Eqc-2604Equus caballus33.681e-74 254
LLPS-Usm-0517Ustilago maydis33.562e-77 263
LLPS-Maf-1188Macaca fascicularis33.541e-71 246
LLPS-Myl-0740Myotis lucifugus33.542e-73 251
LLPS-Mam-0650Macaca mulatta33.549e-72 246
LLPS-Crn-0711Cryptococcus neoformans33.492e-64 228
LLPS-Pes-2100Pelodiscus sinensis33.472e-70 243
LLPS-Aim-1128Ailuropoda melanoleuca33.41e-74 254
LLPS-Loa-1647Loxodonta africana33.43e-72 248
LLPS-Nol-4023Nomascus leucogenys33.42e-71 246
LLPS-Cii-0146Ciona intestinalis33.332e-68 237
LLPS-Mal-2407Mandrillus leucophaeus33.333e-71 245
LLPS-Chs-2297Chlorocebus sabaeus33.268e-72 246
LLPS-Hos-1098Homo sapiens33.264e-71 244
LLPS-Urm-0486Ursus maritimus33.261e-73 251
LLPS-Abg-0217Absidia glauca33.197e-73 248
LLPS-Caj-1871Callithrix jacchus33.122e-72 248
LLPS-Paa-2669Papio anubis33.052e-71 246
LLPS-Rhb-0761Rhinopithecus bieti33.051e-71 246
LLPS-Aon-1320Aotus nancymaae32.917e-72 247
LLPS-Cea-0546Cercocebus atys32.784e-68 236
LLPS-Spr-0395Sporisorium reilianum32.657e-76 259
LLPS-Cae-2015Caenorhabditis elegans31.261e-63 224
LLPS-Sac-1128Saccharomyces cerevisiae30.695e-49 184
LLPS-Asg-1281Ashbya gossypii29.83e-57 207
LLPS-Cym-0683Cyanidioschyzon merolae29.552e-58 210
LLPS-Orl-0631Oryzias latipes23.973e-27 120
LLPS-Sot-0194Solanum tuberosum23.215e-21 101