LLPS-Fia-2096
EIF2A
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Eukaryotic translation initiation factor 2A |
| Gene Name: | EIF2A |
| Ensembl Gene: | ENSFALG00000005241.1 |
| Ensembl Protein: | ENSFALP00000005472.1 |
| Organism: | Ficedula albicollis |
| Taxa ID: | 59894 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Neuronal granule, Stress granule, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSFALT00000005498.1 | ENSFALP00000005472.1 |
| Ensembl | ENSFALT00000005496.1 | ENSFALP00000005470.1 |
| UniProt | U3JRR6, U3JRR6_FICAL | |
| GeneBank | AGTO01001528 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 LFPPAVRGSE GLYMVNGPPS FTESTAFQRD SGKNCKAVAF SKDGSLFAWC NGQKVNVVNI 60 61 TRAELLHSFD LPKTVCLEFS PKNNVLATWQ AYTTAKDGTA GVPNLQLHDL RTGKCLKSFI 120 121 QKKMQNWCPC WADDESICAR NVNNEVHFFE NNNFNTIANK LHLQKVSDFV LSPGAQPTKV 180 181 AVYVPGSKGA PSFVRLYQYP NFGGPQSALA NKSFFKADKV TMLWNKKATA VLVVASTEVD 240 241 KSGASYYGEQ TLHYVAASGE SAVVQLPKSG PIYDVAWSPN SVEFCAVYGF MPAKATVFNL 300 301 KCDPVFDFGT GPRNAAYYSP QGHVLVLAGF GNLRGQMEVW DVRSYRLLSK PVAADSTYFA 360 361 WCPDGEHMVT ATCAPRLRVG NGYKVWHCTG RVLHAHEVPG EQEVWQVCWQ PFPDGVFPER 420 421 AVRCPALPGE APRAPPPPPP PPPPPPLASR VCPSARLHED EPPQNMKPQL GGGDKPVSKT 480 481 ALKNQRKHEA KKAAKQEAKA DAHQGPAQVK PPQSAQQNTV PAMTTGDPEL DKKIKNLKKK 540 541 LKAIEQLKEQ AAAGKQLEKN QVEKIQKEAA LLKELEDLEL GV 582 |
| Nucleotide CDS Sequence (FASTA) |
1 TTGTTTCCTC CTGCAGTGAG AGGCTCCGAA GGGCTGTACA TGGTGAATGG GCCCCCCAGC 60 61 TTCACCGAGA GCACGGCGTT CCAAAGGGAT TCTGGAAAAA ATTGCAAAGC TGTTGCTTTT 120 121 AGCAAGGACG GCTCCCTCTT TGCCTGGTGC AATGGACAAA AAGTCAATGT TGTTAACATC 180 181 ACCAGAGCTG AGTTACTGCA TTCCTTTGAT CTCCCAAAGA CAGTTTGCCT TGAATTCTCA 240 241 CCAAAGAATA ATGTTCTGGC AACGTGGCAG GCCTATACAA CTGCTAAAGA TGGCACAGCA 300 301 GGGGTGCCCA ACCTGCAGCT CCATGATCTG AGAACTGGAA AATGCCTAAA GTCTTTTATA 360 361 CAGAAAAAGA TGCAGAACTG GTGTCCTTGC TGGGCAGATG ATGAAAGCAT TTGTGCCAGG 420 421 AATGTGAACA ATGAAGTGCA CTTCTTTGAA AACAACAACT TCAATACCAT TGCAAATAAG 480 481 CTGCATTTGC AGAAGGTCAG TGATTTCGTG TTGTCCCCAG GAGCACAGCC AACCAAGGTT 540 541 GCTGTTTATG TCCCAGGCAG CAAAGGTGCT CCATCCTTTG TCAGGCTCTA CCAGTACCCC 600 601 AACTTCGGGG GCCCGCAGTC AGCACTCGCC AACAAGAGCT TCTTCAAAGC TGACAAGGTG 660 661 ACAATGCTAT GGAACAAAAA AGCCACAGCA GTGCTGGTGG TTGCCAGCAC CGAGGTGGAC 720 721 AAGAGTGGAG CCTCCTACTA CGGCGAGCAG ACGCTGCACT ACGTGGCAGC CAGCGGGGAG 780 781 AGCGCCGTGG TGCAGCTGCC AAAAAGTGGC CCTATTTACG ACGTTGCCTG GAGCCCCAAT 840 841 TCCGTGGAGT TCTGTGCAGT GTATGGTTTC ATGCCTGCCA AAGCCACGGT TTTTAACCTG 900 901 AAGTGCGACC CCGTCTTCGA TTTCGGCACC GGGCCCCGCA ACGCCGCCTA CTACAGCCCG 960 961 CAGGGGCACG TGCTGGTGCT GGCGGGCTTC GGGAACCTGC GGGGGCAGAT GGAGGTGTGG 1020 1021 GACGTCAGGA GCTACCGGCT GCTCTCCAAG CCCGTGGCCG CCGACTCCAC CTACTTCGCC 1080 1081 TGGTGTCCCG ACGGGGAGCA CATGGTGACG GCCACGTGCG CGCCGCGCCT GCGCGTGGGC 1140 1141 AACGGCTACA AGGTGTGGCA CTGCACGGGC CGCGTGCTGC ACGCCCACGA GGTGCCCGGC 1200 1201 GAGCAGGAGG TGTGGCAGGT GTGCTGGCAG CCCTTCCCGG ACGGCGTGTT CCCCGAGAGA 1260 1261 GCCGTGCGCT GCCCGGCGCT GCCCGGCGAG GCGCCCCGCG CCCCCCCCCC CCCCCCCCCC 1320 1321 CCCCCCCCCC CCCCCCCCCT GGCCTCTCGT GTGTGCCCCA GCGCCAGGCT GCATGAGGAT 1380 1381 GAGCCACCCC AGAACATGAA ACCCCAGCTG GGAGGTGGTG ATAAGCCAGT GTCCAAAACA 1440 1441 GCTCTCAAAA ATCAGAGGAA ACATGAAGCA AAGAAAGCTG CTAAACAGGA AGCCAAAGCT 1500 1501 GATGCACACC AAGGCCCTGC CCAGGTCAAG CCCCCACAGA GTGCCCAGCA GAACACTGTG 1560 1561 CCTGCCATGA CCACGGGAGA TCCTGAACTG GACAAGAAGA TAAAGAATTT GAAAAAGAAA 1620 1621 CTAAAGGCAA TTGAGCAGTT GAAGGAACAG GCAGCTGCTG GCAAACAGCT GGAGAAGAAT 1680 1681 CAGGTGGAGA AGATTCAGAA AGAAGCTGCT CTCCTTAAGG AACTGGAAGA CCTAGAACTG 1740 1741 GGTGTTTAA 1749 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Eukaryotic translation initiation factor 2 complex | |
Molecular Function | Ribosome binding | |
Molecular Function | Translation initiation factor activity | |
Molecular Function | TRNA binding | |
Biological Process | Positive regulation of signal transduction | |
Biological Process | Protein phosphorylation | |
Biological Process | Regulation of translation | |
Biological Process | Ribosome assembly | |
Biological Process | SREBP signaling pathway |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Tag-1469 | Taeniopygia guttata | 90.28 | 0.0 | 934 |
| LLPS-Anp-1931 | Anas platyrhynchos | 83.6 | 0.0 | 856 |
| LLPS-Gaga-1450 | Gallus gallus | 82.21 | 0.0 | 853 |
| LLPS-Meg-0509 | Meleagris gallopavo | 81.48 | 0.0 | 808 |
| LLPS-Ora-2022 | Ornithorhynchus anatinus | 78.48 | 0.0 | 672 |
| LLPS-Pes-2100 | Pelodiscus sinensis | 77.76 | 0.0 | 818 |
| LLPS-Mod-2475 | Monodelphis domestica | 77.62 | 0.0 | 805 |
| LLPS-Ict-1757 | Ictidomys tridecemlineatus | 77.54 | 0.0 | 804 |
| LLPS-Orc-0232 | Oryctolagus cuniculus | 77.18 | 0.0 | 808 |
| LLPS-Mum-3758 | Mus musculus | 77.01 | 0.0 | 801 |
| LLPS-Mup-1383 | Mustela putorius furo | 76.83 | 0.0 | 811 |
| LLPS-Ova-1414 | Ovis aries | 76.83 | 0.0 | 807 |
| LLPS-Mea-0574 | Mesocricetus auratus | 76.83 | 0.0 | 798 |
| LLPS-Caf-1937 | Canis familiaris | 76.83 | 0.0 | 812 |
| LLPS-Cas-0128 | Carlito syrichta | 76.83 | 0.0 | 805 |
| LLPS-Ran-4017 | Rattus norvegicus | 76.65 | 0.0 | 795 |
| LLPS-Fec-1285 | Felis catus | 76.65 | 0.0 | 809 |
| LLPS-Aim-1128 | Ailuropoda melanoleuca | 76.47 | 0.0 | 808 |
| LLPS-Urm-0486 | Ursus maritimus | 76.47 | 0.0 | 810 |
| LLPS-Sus-1732 | Sus scrofa | 76.29 | 0.0 | 808 |
| LLPS-Hos-1098 | Homo sapiens | 76.29 | 0.0 | 801 |
| LLPS-Gog-1431 | Gorilla gorilla | 76.11 | 0.0 | 805 |
| LLPS-Otg-2228 | Otolemur garnettii | 76.11 | 0.0 | 799 |
| LLPS-Mal-2407 | Mandrillus leucophaeus | 75.94 | 0.0 | 796 |
| LLPS-Myl-0740 | Myotis lucifugus | 75.94 | 0.0 | 800 |
| LLPS-Aon-1320 | Aotus nancymaae | 75.94 | 0.0 | 803 |
| LLPS-Caj-1871 | Callithrix jacchus | 75.94 | 0.0 | 803 |
| LLPS-Pat-0227 | Pan troglodytes | 75.93 | 0.0 | 805 |
| LLPS-Pap-3474 | Pan paniscus | 75.93 | 0.0 | 805 |
| LLPS-Paa-2669 | Papio anubis | 75.89 | 0.0 | 796 |
| LLPS-Loa-1647 | Loxodonta africana | 75.71 | 0.0 | 805 |
| LLPS-Chs-2297 | Chlorocebus sabaeus | 75.58 | 0.0 | 800 |
| LLPS-Fud-1811 | Fukomys damarensis | 75.44 | 0.0 | 798 |
| LLPS-Maf-1188 | Macaca fascicularis | 75.4 | 0.0 | 796 |
| LLPS-Mam-0650 | Macaca mulatta | 75.4 | 0.0 | 796 |
| LLPS-Rhb-0761 | Rhinopithecus bieti | 75.4 | 0.0 | 798 |
| LLPS-Bot-0575 | Bos taurus | 75.27 | 0.0 | 796 |
| LLPS-Anc-2178 | Anolis carolinensis | 74.73 | 0.0 | 795 |
| LLPS-Eqc-2604 | Equus caballus | 74.67 | 0.0 | 763 |
| LLPS-Nol-4023 | Nomascus leucogenys | 74.17 | 0.0 | 771 |
| LLPS-Ere-0360 | Erinaceus europaeus | 73.67 | 0.0 | 796 |
| LLPS-Lac-1244 | Latimeria chalumnae | 72.78 | 0.0 | 748 |
| LLPS-Poa-2392 | Pongo abelii | 72.75 | 8e-156 | 458 |
| LLPS-Man-1256 | Macaca nemestrina | 72.57 | 0.0 | 769 |
| LLPS-Xet-0103 | Xenopus tropicalis | 72.24 | 0.0 | 754 |
| LLPS-Cea-0546 | Cercocebus atys | 72.04 | 0.0 | 747 |
| LLPS-Sah-0156 | Sarcophilus harrisii | 71.59 | 0.0 | 564 |
| LLPS-Dio-2357 | Dipodomys ordii | 71.05 | 0.0 | 647 |
| LLPS-Cap-2093 | Cavia porcellus | 70.71 | 0.0 | 712 |
| LLPS-Scf-2026 | Scleropages formosus | 68.68 | 0.0 | 692 |
| LLPS-Dar-0056 | Danio rerio | 68.5 | 0.0 | 687 |
| LLPS-Icp-2538 | Ictalurus punctatus | 67.67 | 0.0 | 694 |
| LLPS-Asm-2345 | Astyanax mexicanus | 67.43 | 0.0 | 696 |
| LLPS-Leo-1029 | Lepisosteus oculatus | 66.67 | 0.0 | 702 |
| LLPS-Orn-0031 | Oreochromis niloticus | 64.78 | 0.0 | 665 |
| LLPS-Scm-3399 | Scophthalmus maximus | 64.65 | 0.0 | 655 |
| LLPS-Pof-3456 | Poecilia formosa | 64.3 | 0.0 | 636 |
| LLPS-Xim-1207 | Xiphophorus maculatus | 64.12 | 0.0 | 635 |
| LLPS-Tar-0749 | Takifugu rubripes | 63.35 | 0.0 | 591 |
| LLPS-Ten-2047 | Tetraodon nigroviridis | 62.23 | 0.0 | 638 |
| LLPS-Gaa-0311 | Gasterosteus aculeatus | 60.25 | 0.0 | 620 |
| LLPS-Chc-0787 | Chondrus crispus | 44.87 | 4e-41 | 157 |
| LLPS-Drm-0549 | Drosophila melanogaster | 44.01 | 4e-111 | 352 |
| LLPS-Cis-1391 | Ciona savignyi | 42.36 | 2e-132 | 405 |
| LLPS-Mae-1567 | Manihot esculenta | 42.15 | 4e-24 | 105 |
| LLPS-Asn-0664 | Aspergillus nidulans | 40.78 | 3e-89 | 296 |
| LLPS-Cii-0146 | Ciona intestinalis | 39.9 | 5e-125 | 387 |
| LLPS-Cae-2015 | Caenorhabditis elegans | 39.52 | 1e-93 | 305 |
| LLPS-Ast-0276 | Aspergillus terreus | 39.47 | 1e-89 | 296 |
| LLPS-Nef-0610 | Neosartorya fischeri | 39.05 | 2e-88 | 294 |
| LLPS-Asf-0741 | Aspergillus flavus | 38.95 | 9e-84 | 282 |
| LLPS-Dos-1129 | Dothistroma septosporum | 38.85 | 1e-89 | 298 |
| LLPS-Asfu-0529 | Aspergillus fumigatus | 38.76 | 4e-88 | 293 |
| LLPS-Mao-1005 | Magnaporthe oryzae | 38.73 | 2e-87 | 292 |
| LLPS-Aso-0917 | Aspergillus oryzae | 38.52 | 4e-87 | 290 |
| LLPS-Beb-0118 | Beauveria bassiana | 38.5 | 6e-81 | 274 |
| LLPS-Coo-0901 | Colletotrichum orbiculare | 38.46 | 6e-84 | 282 |
| LLPS-Blg-0290 | Blumeria graminis | 38.44 | 3e-87 | 291 |
| LLPS-Phn-1209 | Phaeosphaeria nodorum | 38.39 | 5e-90 | 299 |
| LLPS-Zyt-1347 | Zymoseptoria tritici | 38.37 | 4e-88 | 294 |
| LLPS-Nec-1234 | Neurospora crassa | 38.3 | 7e-86 | 287 |
| LLPS-Asc-0510 | Aspergillus clavatus | 38.24 | 3e-87 | 291 |
| LLPS-Pyt-1032 | Pyrenophora teres | 38.21 | 2e-89 | 297 |
| LLPS-Miv-0311 | Microbotryum violaceum | 38.08 | 3e-87 | 290 |
| LLPS-Scp-0720 | Schizosaccharomyces pombe | 38.01 | 4e-75 | 256 |
| LLPS-Cogr-0558 | Colletotrichum graminicola | 37.98 | 2e-82 | 278 |
| LLPS-Yal-0466 | Yarrowia lipolytica | 37.97 | 4e-82 | 274 |
| LLPS-Pug-0773 | Puccinia graminis | 37.9 | 3e-89 | 296 |
| LLPS-Trv-1305 | Trichoderma virens | 37.74 | 4e-81 | 275 |
| LLPS-Pytr-0733 | Pyrenophora triticirepentis | 37.74 | 4e-90 | 300 |
| LLPS-Asni-0305 | Aspergillus niger | 37.68 | 3e-86 | 286 |
| LLPS-Map-0999 | Magnaporthe poae | 37.65 | 3e-85 | 286 |
| LLPS-Trr-0090 | Trichoderma reesei | 37.5 | 3e-81 | 275 |
| LLPS-Scj-1014 | Schizosaccharomyces japonicus | 37.38 | 6e-78 | 263 |
| LLPS-Gag-1578 | Gaeumannomyces graminis | 37.18 | 9e-82 | 277 |
| LLPS-Ved-0585 | Verticillium dahliae | 37.17 | 5e-78 | 267 |
| LLPS-Scc-0194 | Schizosaccharomyces cryophilus | 37.07 | 6e-76 | 258 |
| LLPS-Fus-1263 | Fusarium solani | 37.03 | 7e-82 | 277 |
| LLPS-Spr-0395 | Sporisorium reilianum | 36.97 | 1e-77 | 264 |
| LLPS-Lem-0526 | Leptosphaeria maculans | 36.89 | 7e-85 | 286 |
| LLPS-Put-0485 | Puccinia triticina | 36.83 | 1e-86 | 288 |
| LLPS-Php-2179 | Physcomitrella patens | 36.82 | 1e-70 | 243 |
| LLPS-Gas-0192 | Galdieria sulphuraria | 36.73 | 1e-62 | 222 |
| LLPS-Tum-1109 | Tuber melanosporum | 36.67 | 2e-81 | 276 |
| LLPS-Fuv-0728 | Fusarium verticillioides | 36.56 | 8e-81 | 274 |
| LLPS-Fuo-0394 | Fusarium oxysporum | 36.32 | 2e-80 | 272 |
| LLPS-Tra-2438 | Triticum aestivum | 36.23 | 2e-66 | 231 |
| LLPS-Sem-1001 | Selaginella moellendorffii | 36.08 | 9e-73 | 249 |
| LLPS-Via-1414 | Vigna angularis | 35.95 | 2e-60 | 217 |
| LLPS-Usm-0517 | Ustilago maydis | 35.87 | 6e-78 | 265 |
| LLPS-Hov-1140 | Hordeum vulgare | 35.71 | 6e-65 | 227 |
| LLPS-Sol-1593 | Solanum lycopersicum | 35.68 | 1e-64 | 226 |
| LLPS-Chr-1218 | Chlamydomonas reinhardtii | 35.53 | 3e-51 | 191 |
| LLPS-Glm-2197 | Glycine max | 35.27 | 5e-64 | 225 |
| LLPS-Osl-0862 | Ostreococcus lucimarinus | 35.06 | 9e-62 | 219 |
| LLPS-Hea-0048 | Helianthus annuus | 34.97 | 4e-56 | 202 |
| LLPS-Brd-0607 | Brachypodium distachyon | 34.78 | 2e-63 | 223 |
| LLPS-Prp-0644 | Prunus persica | 34.78 | 3e-65 | 228 |
| LLPS-Pot-1788 | Populus trichocarpa | 34.74 | 5e-63 | 222 |
| LLPS-Ori-1721 | Oryza indica | 34.68 | 4e-64 | 225 |
| LLPS-Coc-0757 | Corchorus capsularis | 34.6 | 2e-55 | 206 |
| LLPS-Org-1053 | Oryza glaberrima | 34.44 | 5e-62 | 219 |
| LLPS-Gor-1840 | Gossypium raimondii | 34.43 | 6e-59 | 211 |
| LLPS-Mel-0714 | Melampsora laricipopulina | 34.13 | 2e-86 | 288 |
| LLPS-Cus-1816 | Cucumis sativus | 34.12 | 2e-66 | 231 |
| LLPS-Viv-1630 | Vitis vinifera | 33.96 | 3e-59 | 213 |
| LLPS-Mua-0159 | Musa acuminata | 33.9 | 2e-62 | 220 |
| LLPS-Art-0842 | Arabidopsis thaliana | 33.9 | 5e-62 | 219 |
| LLPS-Bro-1206 | Brassica oleracea | 33.89 | 8e-62 | 220 |
| LLPS-Arl-0622 | Arabidopsis lyrata | 33.82 | 3e-61 | 217 |
| LLPS-Met-1084 | Medicago truncatula | 33.82 | 4e-60 | 214 |
| LLPS-Phv-0223 | Phaseolus vulgaris | 33.82 | 2e-59 | 212 |
| LLPS-Sei-0293 | Setaria italica | 33.81 | 5e-63 | 222 |
| LLPS-Brn-2169 | Brassica napus | 33.57 | 3e-61 | 217 |
| LLPS-Amt-0662 | Amborella trichopoda | 33.49 | 4e-61 | 216 |
| LLPS-Orbr-1842 | Oryza brachyantha | 33.49 | 2e-58 | 209 |
| LLPS-Brr-1916 | Brassica rapa | 33.41 | 1e-61 | 218 |
| LLPS-Lep-1595 | Leersia perrieri | 33.09 | 1e-55 | 202 |
| LLPS-Zem-1962 | Zea mays | 33.02 | 8e-60 | 213 |
| LLPS-Sob-1491 | Sorghum bicolor | 32.99 | 1e-57 | 207 |
| LLPS-Abg-0217 | Absidia glauca | 32.75 | 4e-78 | 263 |
| LLPS-Crn-0711 | Cryptococcus neoformans | 32.28 | 4e-62 | 222 |
| LLPS-Vir-0445 | Vigna radiata | 32.26 | 3e-50 | 189 |
| LLPS-Asg-1281 | Ashbya gossypii | 31.67 | 2e-50 | 189 |
| LLPS-Cym-0683 | Cyanidioschyzon merolae | 31.34 | 6e-37 | 149 |
| LLPS-Thc-0940 | Theobroma cacao | 31.18 | 3e-50 | 187 |
| LLPS-Orr-0132 | Oryza rufipogon | 31.03 | 8e-44 | 168 |
| LLPS-Orb-0661 | Oryza barthii | 30.88 | 6e-44 | 168 |
| LLPS-Orgl-1272 | Oryza glumaepatula | 30.64 | 5e-44 | 168 |
| LLPS-Orni-0922 | Oryza nivara | 30.64 | 6e-44 | 168 |
| LLPS-Orm-0391 | Oryza meridionalis | 30.64 | 4e-44 | 169 |
| LLPS-Kop-0043 | Komagataella pastoris | 30.37 | 1e-61 | 220 |
| LLPS-Orp-0387 | Oryza punctata | 29.93 | 7e-43 | 165 |
| LLPS-Tru-0970 | Triticum urartu | 29.76 | 9e-32 | 132 |
| LLPS-Dac-2298 | Daucus carota | 29.69 | 3e-26 | 113 |
| LLPS-Sac-1128 | Saccharomyces cerevisiae | 28.01 | 2e-45 | 174 |
| LLPS-Orl-0631 | Oryzias latipes | 23.5 | 7e-16 | 85.1 |
| LLPS-Ors-0106 | Oryza sativa | 22.69 | 1e-15 | 84.3 |
| LLPS-Sot-0194 | Solanum tuberosum | 22.25 | 2e-16 | 87.0 |