LLPS-Cae-0121
vps-4

▼ OVERVIEW

Status: Reviewed
Protein Name: Related to yeast Vacuolar Protein Sorting factor
Gene Name: vps-4, CELE_Y34D9A.10, Y34D9A.10
Ensembl Gene: WBGene00021334
Ensembl Protein: Y34D9A.10
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: Regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
P-body
"...Here we describe a systematic RNAi screen in C. elegans that identified 224 genes with diverse cellular functions whose inactivations result in a dramatic increase in the number of P bodies."
Caenorhabditis elegans22180091
NucleolusPredicted from orthologsN/A(View)

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblY34D9A.10Y34D9A.10
UniProtQ9BL83, Q9BL83_CAEEL
GeneBankBX284601CCD68056.1
RefSeqNM_058415.5NP_490816.4
Entrez189590

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSVPALQKAI  ELVTKATEED  TAGRYDQALR  LYDQAIEYFL  HAIKYESQGD  KQRNAIRDKV  60
61    GQYLNRAEQI  KTHLKDGKTQ  KKPVKDGKDD  SDEDEDKKKF  QDKLSGAIVM  EKPNVKWTDI  120
121   AGLEGAKEAL  KEAVILPIKF  PQLFTGNRKP  WQGILLFGPP  GTGKSYIAKA  VATEAGESTF  180
181   FSISSSDLMS  KWLGESEKLV  KNLFALAREH  KPSIIFIDEI  DSLCSARSDN  ESESARRIKT  240
241   EFMVQMQGVG  LNNDGILVLG  ATNIPWILDS  AIRRRFEKRI  YIPLPDIHAR  KEMFRIDVGK  300
301   NYNTLTDQDF  KVLAERCEGY  SGYDISILVK  DALMQPVRRV  QSATHFKHVS  GPSPKDPNVI  360
361   AHDLLTPCSP  GDPHAIAMNW  LDVPGDKLAN  PPLSMQDISR  SLASVKPTVN  NTDLDRLEAF  420
421   KNDFGQDGQE  430
Nucleotide CDS Sequence (FASTA)
1     ATGTCGGTTC  CGGCACTTCA  GAAGGCCATA  GAATTGGTGA  CAAAAGCCAC  CGAGGAGGAT  60
61    ACAGCCGGCA  GATACGACCA  AGCGCTGAGA  TTATACGATC  AGGCCATTGA  ATACTTCCTT  120
121   CATGCGATAA  AATACGAGTC  ACAAGGCGAT  AAACAGCGTA  ATGCGATTCG  TGACAAAGTC  180
181   GGGCAGTATT  TGAATCGCGC  CGAGCAGATC  AAAACCCATC  TGAAAGACGG  AAAAACGCAG  240
241   AAAAAGCCGG  TGAAAGACGG  GAAAGACGAT  TCCGACGAGG  ATGAGGACAA  GAAAAAGTTT  300
301   CAGGACAAAC  TGTCGGGCGC  AATTGTGATG  GAGAAGCCGA  ATGTCAAGTG  GACCGATATT  360
361   GCAGGACTTG  AGGGAGCGAA  AGAGGCGCTC  AAGGAGGCCG  TCATTCTTCC  AATCAAATTT  420
421   CCACAGCTTT  TCACTGGAAA  CCGCAAGCCG  TGGCAAGGAA  TTTTGCTCTT  CGGACCACCG  480
481   GGAACCGGTA  AATCGTACAT  TGCAAAAGCC  GTCGCCACCG  AGGCCGGCGA  ATCGACGTTC  540
541   TTCTCGATTT  CCTCGTCCGA  TTTGATGTCG  AAATGGCTCG  GCGAGTCGGA  GAAGCTTGTC  600
601   AAGAATCTGT  TTGCGTTGGC  CCGCGAGCAC  AAGCCATCGA  TTATTTTTAT  TGATGAGATC  660
661   GATTCGCTCT  GCTCGGCCCG  TTCGGATAAC  GAAAGTGAAA  GTGCACGACG  CATCAAGACC  720
721   GAATTCATGG  TTCAAATGCA  GGGTGTCGGC  CTGAACAATG  ACGGAATTCT  CGTCCTAGGC  780
781   GCCACGAATA  TCCCATGGAT  TTTGGATTCG  GCTATTCGAA  GACGTTTCGA  GAAGCGAATC  840
841   TACATTCCAC  TGCCCGACAT  TCACGCTCGC  AAAGAAATGT  TCCGAATCGA  CGTTGGCAAG  900
901   AACTACAACA  CGCTGACAGA  TCAGGATTTC  AAGGTGCTCG  CCGAGCGATG  TGAAGGATAT  960
961   TCGGGTTATG  ATATCAGTAT  TCTTGTCAAG  GATGCACTCA  TGCAACCCGT  ACGACGAGTA  1020
1021  CAATCGGCCA  CACATTTCAA  ACACGTCAGC  GGTCCATCAC  CAAAGGATCC  AAATGTGATT  1080
1081  GCACATGATC  TACTGACACC  GTGCAGTCCA  GGAGATCCAC  ACGCGATTGC  AATGAATTGG  1140
1141  TTGGATGTTC  CAGGGGATAA  GCTGGCGAAT  CCACCACTTT  CCATGCAAGA  CATTTCGCGT  1200
1201  TCGCTGGCAT  CCGTAAAACC  GACAGTCAAC  AACACTGATC  TCGACCGTTT  GGAGGCGTTC  1260
1261  AAAAACGATT  TCGGACAGGA  TGGACAGGAA  TAA  1293

▼ ANNOTATION

Disorder
IUPred2A
Drug
CTD
Physicochemical
Compute pI/MwAAindex
Function
PIRSF

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dar-0141Danio rerio70.220.0 567
LLPS-Xim-0156Xiphophorus maculatus69.480.0 562
LLPS-Gaa-2483Gasterosteus aculeatus68.520.0 588
LLPS-Fia-0651Ficedula albicollis68.510.0 601
LLPS-Lac-0057Latimeria chalumnae68.450.0 590
LLPS-Bot-0837Bos taurus68.320.0 560
LLPS-Icp-1474Ictalurus punctatus68.20.0 587
LLPS-Ova-1169Ovis aries68.190.0 604
LLPS-Ere-0016Erinaceus europaeus68.090.0 541
LLPS-Eqc-1220Equus caballus68.070.0 562
LLPS-Pof-2988Poecilia formosa68.050.0 597
LLPS-Dio-0319Dipodomys ordii68.010.0 596
LLPS-Asm-0401Astyanax mexicanus67.980.0 590
LLPS-Cap-4162Cavia porcellus67.960.0 598
LLPS-Scf-0592Scleropages formosus67.960.0 602
LLPS-Fud-2888Fukomys damarensis67.960.0 600
LLPS-Urm-0919Ursus maritimus67.910.0 592
LLPS-Tar-0557Takifugu rubripes67.830.0 587
LLPS-Tag-2911Taeniopygia guttata67.820.0 600
LLPS-Aon-1898Aotus nancymaae67.820.0 597
LLPS-Ten-3539Tetraodon nigroviridis67.750.0 583
LLPS-Otg-0663Otolemur garnettii67.750.0 596
LLPS-Scm-3733Scophthalmus maximus67.730.0 596
LLPS-Mod-1502Monodelphis domestica67.670.0 591
LLPS-Orn-1736Oreochromis niloticus67.660.0 597
LLPS-Mam-3409Macaca mulatta67.650.0 603
LLPS-Poa-3996Pongo abelii67.650.0 602
LLPS-Rhb-3669Rhinopithecus bieti67.650.0 603
LLPS-Man-2082Macaca nemestrina67.650.0 601
LLPS-Hos-3929Homo sapiens67.650.0 602
LLPS-Mal-2989Mandrillus leucophaeus67.650.0 603
LLPS-Paa-0064Papio anubis67.650.0 600
LLPS-Gog-3079Gorilla gorilla67.650.0 602
LLPS-Cea-0596Cercocebus atys67.650.0 601
LLPS-Maf-4387Macaca fascicularis67.650.0 601
LLPS-Chs-4788Chlorocebus sabaeus67.650.0 603
LLPS-Nol-4462Nomascus leucogenys67.590.0 596
LLPS-Gaga-3964Gallus gallus67.590.0 595
LLPS-Pat-3891Pan troglodytes67.590.0 595
LLPS-Pap-1976Pan paniscus67.590.0 595
LLPS-Aim-2510Ailuropoda melanoleuca67.590.0 593
LLPS-Caj-4624Callithrix jacchus67.590.0 597
LLPS-Ora-0436Ornithorhynchus anatinus67.590.0 593
LLPS-Sah-1239Sarcophilus harrisii67.520.0 587
LLPS-Mea-3071Mesocricetus auratus67.520.0 591
LLPS-Anc-0212Anolis carolinensis67.510.0 596
LLPS-Xet-0204Xenopus tropicalis67.430.0 598
LLPS-Fec-0830Felis catus67.430.0 598
LLPS-Ran-0091Rattus norvegicus67.430.0 598
LLPS-Mum-1587Mus musculus67.430.0 598
LLPS-Caf-0571Canis familiaris67.360.0 594
LLPS-Meg-3132Meleagris gallopavo67.350.0 597
LLPS-Leo-1432Lepisosteus oculatus67.280.0 600
LLPS-Cas-0902Carlito syrichta67.20.0 597
LLPS-Orc-0586Oryctolagus cuniculus67.20.0 597
LLPS-Mup-2478Mustela putorius furo67.20.0 596
LLPS-Loa-3516Loxodonta africana67.050.0 589
LLPS-Ict-3080Ictidomys tridecemlineatus66.970.0 595
LLPS-Sus-0550Sus scrofa66.970.0 597
LLPS-Tut-1477Tursiops truncatus66.90.0 592
LLPS-Anp-3138Anas platyrhynchos66.590.0 586
LLPS-Drm-1454Drosophila melanogaster66.590.0 573
LLPS-Orl-3324Oryzias latipes66.280.0 585
LLPS-Pes-0723Pelodiscus sinensis66.210.0 593
LLPS-Myl-2869Myotis lucifugus66.060.0 588
LLPS-Cis-1612Ciona savignyi63.232e-100 305
LLPS-Cii-1044Ciona intestinalis61.110.0 539
LLPS-Asg-0429Ashbya gossypii57.742e-166 482
LLPS-Scp-1222Schizosaccharomyces pombe57.059e-159 462
LLPS-Sac-1212Saccharomyces cerevisiae56.853e-167 484
LLPS-Hov-0585Hordeum vulgare56.674e-128 387
LLPS-Pug-0580Puccinia graminis56.193e-163 474
LLPS-Scj-1478Schizosaccharomyces japonicus55.987e-159 463
LLPS-Scc-1154Schizosaccharomyces cryophilus55.914e-156 456
LLPS-Kop-0338Komagataella pastoris55.41e-163 475
LLPS-Lem-0542Leptosphaeria maculans55.332e-160 467
LLPS-Tum-1042Tuber melanosporum55.324e-164 476
LLPS-Yal-0634Yarrowia lipolytica55.158e-166 480
LLPS-Blg-0019Blumeria graminis54.922e-165 479
LLPS-Dos-0949Dothistroma septosporum54.824e-163 474
LLPS-Crn-0895Cryptococcus neoformans54.798e-160 466
LLPS-Nec-1292Neurospora crassa54.732e-163 475
LLPS-Cym-0316Cyanidioschyzon merolae54.491e-116 358
LLPS-Chr-1513Chlamydomonas reinhardtii54.482e-154 452
LLPS-Mel-0130Melampsora laricipopulina54.461e-158 462
LLPS-Pytr-0885Pyrenophora triticirepentis54.092e-155 454
LLPS-Miv-1422Microbotryum violaceum53.767e-159 463
LLPS-Pyt-0568Pyrenophora teres53.642e-152 447
LLPS-Asf-0380Aspergillus flavus53.554e-161 469
LLPS-Asn-0968Aspergillus nidulans53.552e-161 469
LLPS-Mua-2472Musa acuminata53.44e-148 435
LLPS-Asni-0022Aspergillus niger53.323e-159 464
LLPS-Asc-0067Aspergillus clavatus53.325e-162 471
LLPS-Zyt-0226Zymoseptoria tritici52.972e-157 459
LLPS-Gas-0335Galdieria sulphuraria52.937e-155 454
LLPS-Asfu-0833Aspergillus fumigatus52.862e-159 464
LLPS-Nef-0231Neosartorya fischeri52.637e-159 463
LLPS-Pot-0885Populus trichocarpa52.618e-144 424
LLPS-Ast-0832Aspergillus terreus52.519e-157 457
LLPS-Amt-0912Amborella trichopoda52.494e-146 431
LLPS-Gag-0359Gaeumannomyces graminis52.327e-147 433
LLPS-Mae-1865Manihot esculenta52.151e-144 426
LLPS-Viv-0676Vitis vinifera52.153e-146 431
LLPS-Via-0535Vigna angularis52.157e-142 419
LLPS-Hea-2551Helianthus annuus52.157e-140 414
LLPS-Spr-0962Sporisorium reilianum52.141e-158 464
LLPS-Thc-2121Theobroma cacao52.039e-146 430
LLPS-Vir-0212Vigna radiata51.938e-141 417
LLPS-Glm-2644Glycine max51.935e-143 422
LLPS-Phv-2579Phaseolus vulgaris51.812e-145 429
LLPS-Aso-1228Aspergillus oryzae51.771e-158 463
LLPS-Map-0592Magnaporthe poae51.765e-153 449
LLPS-Prp-0208Prunus persica51.78e-144 424
LLPS-Mao-0131Magnaporthe oryzae51.654e-151 443
LLPS-Gor-1335Gossypium raimondii51.582e-144 426
LLPS-Orgl-1181Oryza glumaepatula51.581e-93 305
LLPS-Osl-0483Ostreococcus lucimarinus51.493e-139 413
LLPS-Cogr-1560Colletotrichum graminicola51.482e-145 429
LLPS-Brn-1915Brassica napus51.486e-143 422
LLPS-Trv-0993Trichoderma virens51.363e-141 418
LLPS-Coc-0217Corchorus capsularis51.351e-144 427
LLPS-Nia-2320Nicotiana attenuata51.351e-142 422
LLPS-Usm-0594Ustilago maydis51.281e-159 466
LLPS-Brr-2945Brassica rapa51.264e-142 420
LLPS-Chc-0879Chondrus crispus51.252e-139 414
LLPS-Ved-0260Verticillium dahliae51.152e-149 439
LLPS-Bro-0918Brassica oleracea51.141e-141 419
LLPS-Cus-1022Cucumis sativus51.134e-139 412
LLPS-Sot-1975Solanum tuberosum51.033e-141 418
LLPS-Fuv-1141Fusarium verticillioides50.914e-140 415
LLPS-Arl-2110Arabidopsis lyrata50.94e-143 423
LLPS-Orr-2069Oryza rufipogon50.682e-135 415
LLPS-Orbr-1690Oryza brachyantha50.681e-141 419
LLPS-Sei-2178Setaria italica50.687e-144 425
LLPS-Fus-0219Fusarium solani50.578e-142 419
LLPS-Sol-2004Solanum lycopersicum50.562e-140 416
LLPS-Org-1671Oryza glaberrima50.453e-141 418
LLPS-Trr-0807Trichoderma reesei50.452e-141 418
LLPS-Beb-1235Beauveria bassiana50.455e-140 415
LLPS-Orp-1303Oryza punctata50.453e-141 418
LLPS-Art-2900Arabidopsis thaliana50.451e-142 421
LLPS-Orni-0044Oryza nivara50.452e-135 416
LLPS-Orb-0309Oryza barthii50.453e-97 315
LLPS-Ori-0496Oryza indica50.453e-141 418
LLPS-Sob-1314Sorghum bicolor50.345e-143 422
LLPS-Ors-0361Oryza sativa50.349e-138 409
LLPS-Met-0938Medicago truncatula50.348e-141 417
LLPS-Tra-0488Triticum aestivum50.341e-144 427
LLPS-Coo-1010Colletotrichum orbiculare50.341e-143 424
LLPS-Sem-1833Selaginella moellendorffii50.342e-139 414
LLPS-Php-1576Physcomitrella patens50.222e-141 419
LLPS-Brd-1758Brachypodium distachyon50.114e-142 420
LLPS-Dac-0537Daucus carota50.116e-137 407
LLPS-Cog-0741Colletotrichum gloeosporioides50.02e-144 426
LLPS-Orm-0701Oryza meridionalis49.894e-135 402
LLPS-Lep-2095Leersia perrieri49.891e-141 419
LLPS-Zem-2303Zea mays49.773e-142 421
LLPS-Fuo-0279Fusarium oxysporum49.773e-140 415
LLPS-Phn-0529Phaeosphaeria nodorum48.534e-134 400
LLPS-Tru-1948Triticum urartu44.356e-131 394