• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Ere-0016
VPS4B

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: vacuolar protein sorting-associated protein 4B
Gene Name: VPS4B
Ensembl Gene: ENSEEUG00000000646.1
Ensembl Protein: ENSEEUP00000000565.1
Organism: Erinaceus europaeus
Taxa ID: 9365
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-bodyPredicted from orthologs(View)

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     EAQGDKAKQS  IRAKCTEYLD  RAEKLKEYLK  RKEKKPQKPV  KEGQPSPADE  NMRNDSDGEG  60
61    ESDDPEKKKL  QNQLQGAIVI  ERPNVKWSDV  AGLEGAKEAL  KEAVILPIKF  PHLFTGKRTP  120
121   WRGILLFGPP  GTGKSYLAKA  VATEANNSTF  FSISSSDLVS  KWLGESEKLV  KNLFQLAREN  180
181   KPSIIFIDEI  DSLCGSRSEN  ESEAARRIKT  EFLVQMQGVG  VDNDGILVLG  ATNIPWVLDS  240
241   AIRRRFEKRI  YIPLPEAHAR  AAMFKLHLGT  TQNSLTEADF  RDLGKKTDGY  SGADISVIVR  300
301   DALMQPVRKV  QSATHFKKAQ  GPSRADPNNI  VDDLLTPCSP  GDPGAIEMTW  MDVPGDKLLE  360
361   PVVCMSDMLR  SLSSTKPTVN  EHDLLKLKKF  TEDFGQEG  398
Nucleotide CDS Sequence (FASTA)
1     GAAGCACAGG  GAGATAAAGC  CAAGCAAAGT  ATCAGGGCAA  AGTGCACAGA  GTATCTTGAT  60
61    AGAGCAGAAA  AGCTCAAGGA  GTACCTGAAG  AGAAAAGAGA  AGAAGCCACA  GAAGCCAGTG  120
121   AAAGAAGGAC  AGCCAAGCCC  AGCTGATGAG  AATATGAGGA  ATGACAGTGA  TGGAGAAGGA  180
181   GAATCTGATG  ATCCTGAAAA  AAAGAAACTA  CAGAATCAAC  TTCAAGGTGC  CATTGTTATA  240
241   GAGCGACCAA  ATGTGAAGTG  GAGTGATGTC  GCCGGTCTGG  AAGGAGCCAA  AGAAGCACTT  300
301   AAAGAAGCCG  TGATATTGCC  TATTAAATTT  CCTCACCTTT  TTACAGGTAA  GAGAACGCCT  360
361   TGGAGGGGAA  TCCTGTTATT  TGGGCCACCT  GGGACAGGAA  AGTCCTATTT  AGCCAAAGCT  420
421   GTAGCAACAG  AAGCGAACAA  CTCAACATTT  TTTTCAATAT  CTTCCTCTGA  CCTTGTTTCT  480
481   AAGTGGCTAG  GAGAAAGTGA  AAAGTTAGTT  AAGAATTTAT  TCCAACTAGC  AAGAGAGAAC  540
541   AAACCTTCCA  TTATCTTCAT  TGATGAAATT  GATTCTCTGT  GTGGTTCAAG  GAGCGAAAAT  600
601   GAAAGTGAAG  CCGCTCGTAG  GATTAAGACG  GAATTCCTAG  TTCAGATGCA  AGGGGTTGGT  660
661   GTGGACAATG  ATGGAATTTT  GGTTCTGGGA  GCCACAAATA  TACCCTGGGT  TCTGGACTCT  720
721   GCCATTAGGC  GAAGATTTGA  GAAACGAATT  TATATCCCTT  TGCCCGAGGC  CCATGCCCGA  780
781   GCAGCCATGT  TCAAACTGCA  CCTAGGGACC  ACTCAGAACA  GTCTAACGGA  AGCAGACTTT  840
841   CGAGACCTGG  GGAAGAAAAC  AGATGGCTAT  TCGGGAGCCG  ACATAAGTGT  CATTGTCCGG  900
901   GATGCACTCA  TGCAGCCTGT  CAGAAAAGTG  CAGTCAGCTA  CTCACTTCAA  AAAGGCTCAA  960
961   GGGCCATCAC  GAGCTGATCC  TAACAACATA  GTTGATGATC  TGCTGACACC  CTGTTCTCCA  1020
1021  GGGGACCCGG  GTGCCATTGA  AATGACCTGG  ATGGACGTTC  CTGGGGATAA  GCTTCTGGAG  1080
1081  CCGGTTGTTT  GCATGTCGGA  TATGTTACGC  TCACTCTCCA  GCACAAAGCC  CACAGTCAAT  1140
1141  GAGCACGACT  TGTTGAAATT  AAAGAAGTTT  ACAGAAGATT  TTGGCCAAGA  AGGCTAA  1197

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Bot-4434Bos taurus97.490.0 731
LLPS-Ova-1169Ovis aries96.730.0 728
LLPS-Paa-0064Papio anubis96.480.0 719
LLPS-Mal-2989Mandrillus leucophaeus96.480.0 723
LLPS-Caj-4624Callithrix jacchus96.480.0 721
LLPS-Maf-4387Macaca fascicularis96.480.0 719
LLPS-Chs-4788Chlorocebus sabaeus96.480.0 723
LLPS-Cea-0596Cercocebus atys96.480.0 719
LLPS-Aon-1898Aotus nancymaae96.480.0 720
LLPS-Nol-4462Nomascus leucogenys96.480.0 720
LLPS-Mam-3409Macaca mulatta96.480.0 723
LLPS-Rhb-3669Rhinopithecus bieti96.480.0 724
LLPS-Man-2082Macaca nemestrina96.480.0 719
LLPS-Dio-0504Dipodomys ordii96.230.0 714
LLPS-Fud-2888Fukomys damarensis96.230.0 719
LLPS-Poa-3996Pongo abelii96.230.0 722
LLPS-Pap-1976Pan paniscus96.230.0 721
LLPS-Pat-3891Pan troglodytes96.230.0 721
LLPS-Hos-3929Homo sapiens96.230.0 722
LLPS-Gog-3079Gorilla gorilla95.980.0 721
LLPS-Loa-3516Loxodonta africana95.980.0 722
LLPS-Cap-4162Cavia porcellus95.230.0 714
LLPS-Pes-0723Pelodiscus sinensis89.20.0 664
LLPS-Gaga-3964Gallus gallus88.440.0 657
LLPS-Meg-3132Meleagris gallopavo88.440.0 660
LLPS-Fia-0651Ficedula albicollis87.940.0 659
LLPS-Tag-2911Taeniopygia guttata87.440.0 655
LLPS-Anp-3138Anas platyrhynchos87.190.0 653
LLPS-Dar-0802Danio rerio85.180.0 651
LLPS-Icp-1474Ictalurus punctatus84.920.0 647
LLPS-Scm-3733Scophthalmus maximus82.210.0 631
LLPS-Gaa-2483Gasterosteus aculeatus81.950.0 633
LLPS-Orn-1902Oreochromis niloticus80.90.0 635
LLPS-Asm-0401Astyanax mexicanus80.80.0 632
LLPS-Xet-0204Xenopus tropicalis80.80.0 631
LLPS-Xim-3389Xiphophorus maculatus80.650.0 628
LLPS-Anc-0212Anolis carolinensis80.40.0 630
LLPS-Pof-2988Poecilia formosa80.40.0 626
LLPS-Lac-0057Latimeria chalumnae80.40.0 623
LLPS-Myl-2869Myotis lucifugus79.850.0 619
LLPS-Orc-0586Oryctolagus cuniculus79.350.0 626
LLPS-Scf-0592Scleropages formosus79.250.0 627
LLPS-Leo-1432Lepisosteus oculatus79.250.0 629
LLPS-Mod-1502Monodelphis domestica79.150.0 626
LLPS-Tar-0557Takifugu rubripes78.950.0 623
LLPS-Eqc-1220Equus caballus78.90.0 573
LLPS-Sah-1239Sarcophilus harrisii78.890.0 626
LLPS-Ten-3539Tetraodon nigroviridis78.890.0 617
LLPS-Ran-0091Rattus norvegicus78.840.0 625
LLPS-Mup-2478Mustela putorius furo78.840.0 627
LLPS-Aim-2510Ailuropoda melanoleuca78.840.0 625
LLPS-Caf-0571Canis familiaris78.790.0 624
LLPS-Sus-0550Sus scrofa78.590.0 624
LLPS-Urm-0919Ursus maritimus78.590.0 623
LLPS-Otg-0663Otolemur garnettii78.550.0 629
LLPS-Fec-0830Felis catus78.340.0 623
LLPS-Ora-0436Ornithorhynchus anatinus78.140.0 624
LLPS-Mum-1587Mus musculus78.050.0 625
LLPS-Cas-0902Carlito syrichta78.050.0 625
LLPS-Mea-3071Mesocricetus auratus77.810.0 623
LLPS-Orl-3324Oryzias latipes77.390.0 610
LLPS-Ict-3080Ictidomys tridecemlineatus77.310.0 619
LLPS-Tut-1477Tursiops truncatus77.080.0 616
LLPS-Put-0907Puccinia triticina76.361e-84 265
LLPS-Drm-1454Drosophila melanogaster74.870.0 578
LLPS-Cis-1612Ciona savignyi71.753e-116 345
LLPS-Cii-1044Ciona intestinalis68.670.0 553
LLPS-Cae-0121Caenorhabditis elegans67.340.0 531
LLPS-Mao-0131Magnaporthe oryzae65.373e-156 455
LLPS-Yal-0634Yarrowia lipolytica65.076e-156 454
LLPS-Fus-0219Fusarium solani64.564e-147 431
LLPS-Beb-1235Beauveria bassiana64.269e-147 431
LLPS-Fuv-1141Fusarium verticillioides63.963e-147 432
LLPS-Fuo-0279Fusarium oxysporum63.965e-147 431
LLPS-Asg-0429Ashbya gossypii63.737e-164 474
LLPS-Lem-0542Leptosphaeria maculans63.668e-150 439
LLPS-Pytr-0885Pyrenophora triticirepentis63.661e-150 441
LLPS-Trr-0807Trichoderma reesei63.668e-147 431
LLPS-Orgl-1181Oryza glumaepatula63.42e-93 303
LLPS-Sac-1212Saccharomyces cerevisiae62.781e-165 479
LLPS-Trv-0993Trichoderma virens62.762e-144 425
LLPS-Miv-1422Microbotryum violaceum62.722e-158 461
LLPS-Map-0592Magnaporthe poae62.693e-149 438
LLPS-Pug-0580Puccinia graminis62.63e-160 466
LLPS-Crn-0895Cryptococcus neoformans61.872e-157 458
LLPS-Sob-1314Sorghum bicolor61.839e-144 423
LLPS-Mua-2472Musa acuminata61.795e-141 415
LLPS-Orb-0309Oryza barthii61.792e-93 303
LLPS-Mel-0130Melampsora laricipopulina61.711e-158 461
LLPS-Php-1576Physcomitrella patens61.651e-144 426
LLPS-Pyt-0568Pyrenophora teres61.566e-141 416
LLPS-Hea-0104Helianthus annuus61.498e-138 408
LLPS-Arl-2110Arabidopsis lyrata61.365e-142 419
LLPS-Kop-0338Komagataella pastoris61.171e-162 471
LLPS-Brn-1915Brassica napus61.068e-141 416
LLPS-Art-2900Arabidopsis thaliana61.062e-141 417
LLPS-Brr-2381Brassica rapa61.066e-141 416
LLPS-Pot-0885Populus trichocarpa61.062e-140 414
LLPS-Hov-0585Hordeum vulgare60.959e-141 419
LLPS-Tra-0488Triticum aestivum60.954e-143 422
LLPS-Bro-0918Brassica oleracea60.953e-140 414
LLPS-Thc-2121Theobroma cacao60.94e-139 411
LLPS-Dac-0537Daucus carota60.472e-137 407
LLPS-Amt-0912Amborella trichopoda60.473e-140 414
LLPS-Nia-2320Nicotiana attenuata60.471e-140 415
LLPS-Viv-0676Vitis vinifera60.472e-141 417
LLPS-Orni-0044Oryza nivara60.361e-134 413
LLPS-Ori-0496Oryza indica60.361e-140 415
LLPS-Org-1671Oryza glaberrima60.361e-140 415
LLPS-Orr-2069Oryza rufipogon60.361e-135 414
LLPS-Orbr-1690Oryza brachyantha60.365e-140 414
LLPS-Orp-1303Oryza punctata60.361e-140 415
LLPS-Blg-0019Blumeria graminis60.33e-160 465
LLPS-Coc-0217Corchorus capsularis60.32e-138 410
LLPS-Sem-1833Selaginella moellendorffii60.184e-140 414
LLPS-Nec-1292Neurospora crassa60.151e-158 461
LLPS-Phv-2579Phaseolus vulgaris60.124e-135 401
LLPS-Brd-1758Brachypodium distachyon60.061e-141 418
LLPS-Prp-0208Prunus persica59.884e-140 414
LLPS-Gor-0325Gossypium raimondii59.882e-138 409
LLPS-Scp-1222Schizosaccharomyces pombe59.859e-149 436
LLPS-Glm-2644Glycine max59.763e-136 404
LLPS-Met-0938Medicago truncatula59.591e-136 405
LLPS-Sot-1975Solanum tuberosum59.593e-137 406
LLPS-Osl-0483Ostreococcus lucimarinus59.593e-134 399
LLPS-Tum-1042Tuber melanosporum59.551e-160 466
LLPS-Dos-0949Dothistroma septosporum59.491e-155 453
LLPS-Ors-0361Oryza sativa59.471e-136 405
LLPS-Orm-0701Oryza meridionalis59.292e-135 402
LLPS-Lep-2095Leersia perrieri59.172e-137 407
LLPS-Cogr-1560Colletotrichum graminicola58.882e-144 425
LLPS-Coo-1010Colletotrichum orbiculare58.591e-146 431
LLPS-Zyt-0226Zymoseptoria tritici58.523e-153 447
LLPS-Ast-0832Aspergillus terreus58.463e-157 457
LLPS-Spr-0962Sporisorium reilianum58.416e-158 461
LLPS-Gag-0359Gaeumannomyces graminis58.48e-143 422
LLPS-Cog-0741Colletotrichum gloeosporioides58.235e-146 429
LLPS-Asni-0022Aspergillus niger58.13e-157 457
LLPS-Asf-0380Aspergillus flavus57.972e-157 458
LLPS-Asc-0067Aspergillus clavatus57.972e-158 460
LLPS-Ved-0260Verticillium dahliae57.979e-146 428
LLPS-Usm-0594Ustilago maydis57.944e-157 459
LLPS-Scj-1478Schizosaccharomyces japonicus57.873e-148 435
LLPS-Asfu-0833Aspergillus fumigatus57.724e-157 457
LLPS-Scc-1154Schizosaccharomyces cryophilus57.714e-147 432
LLPS-Asn-0968Aspergillus nidulans57.512e-159 463
LLPS-Nef-0231Neosartorya fischeri57.474e-156 455
LLPS-Sei-2178Setaria italica57.048e-144 423
LLPS-Cym-0316Cyanidioschyzon merolae57.022e-127 385
LLPS-Zem-2303Zea mays56.782e-144 425
LLPS-Chc-0879Chondrus crispus56.722e-142 420
LLPS-Aso-1228Aspergillus oryzae56.721e-155 454
LLPS-Sol-2004Solanum lycopersicum56.648e-137 405
LLPS-Gas-0335Galdieria sulphuraria56.581e-153 449
LLPS-Chr-1513Chlamydomonas reinhardtii56.52e-149 438
LLPS-Mae-1865Manihot esculenta54.816e-139 410
LLPS-Cus-1022Cucumis sativus54.34e-137 406
LLPS-Phn-0529Phaeosphaeria nodorum54.035e-121 365
LLPS-Via-0535Vigna angularis53.718e-135 400
LLPS-Vir-0212Vigna radiata53.473e-134 399
LLPS-Tru-0904Triticum urartu49.292e-78 254