DrLLPS - Data resource of LLPS

LLPS-Aso-1342
pfkB

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	ATP-dependent 6-phosphofructokinase 2
Gene Name:	pfkB, AO090010000444
Ensembl Gene:	AO090010000444
Ensembl Protein:	BAE66301
Organism:	Aspergillus oryzae
Taxa ID:	510516
LLPS Type:	Regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
P-body, Stress granule	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Saccharomyces cerevisiae	LLPS-Sac-0412	P16862	Regulator	P-body, Stress granule	66.76	0.0	852

▼ FUNCTION

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	BAE66301	BAE66301
UniProt		Q9HGZ0, PFKA2_ASPOR, Q2TWS2
GeneBank	AP007175, AB032271	BAB12231.1, BAE66301.1
RefSeq	XM_001827382.2	XP_001827434.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MTNTILDTYS SRRKPRRIGI LTSGGDAPGM NGAIRAVVRT AIQNGCEAWA IHEGYEGLIQ 60 61 GGAMMHPLYW EDVRGFLSRG GTLIGSVRCD RFREREGRLQ AARNMVLFGI DALVVCGGDG 120 121 SLTGADLFRS EWPELLNELV STGVLTVAQV APHQNLNIVG LLGSIDNDFS GTDATIGCYS 180 181 ALTRICEAVD AVFDTASSHR RGFVVEVMGR HCGWLALMAA IATGADWLFI PERPPRDGWE 240 241 DDMCSIITKN RNRGKRRTIV ILAEGAQDSN LDRISSSAVK DVLSKRLGLD TRVTVLGHIQ 300 301 RGGSPCAYDR WLSTLQGIHA VKAVLSMTPE SPSPVVIIQE NRIRTSSLAE TVALTKEANA 360 361 SMHAKEFEKA ATLRDPEFME YHSAYRHLNT SDHPKMVLPE DKRMRVAIIH VGAPAAGMNP 420 421 ATRAVVAYCL TRGHTPIAIH NGFPGLCRHH DDTPGSVREM HWLESGDWIN DGGSDIGTNA 480 481 GLPLDDIETT AQCFERYKFD ALFVIGGFEA FTAVSQLRKA RKQYLAFRIP LVLLPASMSN 540 541 NVPGTEYSLG SDTSLNTLVY FCDVVRQSAS SSGHSVFVVE AQGAEYQATA AALAAGAMTV 600 601 YTPERGITLQ SLSNDIEYLR QQFSKDHGAN RSGKLIIRND QTSTIYSTTE IANIIKHEAK 660 661 NRFDAQGVVP GHFQQGGKVS PIDRIRAFRL AVKCMEHLET FAGQSPEEIM NDENSATVIS 720 721 IKQSRILLLP MGGPTGVEAT DTDWKRQRPK TQNWLEIQEA VDSLSGRSSL YAIPN 775

Protein Sequence (FASTA)

1     MTNTILDTYS  SRRKPRRIGI  LTSGGDAPGM  NGAIRAVVRT  AIQNGCEAWA  IHEGYEGLIQ  60
61    GGAMMHPLYW  EDVRGFLSRG  GTLIGSVRCD  RFREREGRLQ  AARNMVLFGI  DALVVCGGDG  120
121   SLTGADLFRS  EWPELLNELV  STGVLTVAQV  APHQNLNIVG  LLGSIDNDFS  GTDATIGCYS  180
181   ALTRICEAVD  AVFDTASSHR  RGFVVEVMGR  HCGWLALMAA  IATGADWLFI  PERPPRDGWE  240
241   DDMCSIITKN  RNRGKRRTIV  ILAEGAQDSN  LDRISSSAVK  DVLSKRLGLD  TRVTVLGHIQ  300
301   RGGSPCAYDR  WLSTLQGIHA  VKAVLSMTPE  SPSPVVIIQE  NRIRTSSLAE  TVALTKEANA  360
361   SMHAKEFEKA  ATLRDPEFME  YHSAYRHLNT  SDHPKMVLPE  DKRMRVAIIH  VGAPAAGMNP  420
421   ATRAVVAYCL  TRGHTPIAIH  NGFPGLCRHH  DDTPGSVREM  HWLESGDWIN  DGGSDIGTNA  480
481   GLPLDDIETT  AQCFERYKFD  ALFVIGGFEA  FTAVSQLRKA  RKQYLAFRIP  LVLLPASMSN  540
541   NVPGTEYSLG  SDTSLNTLVY  FCDVVRQSAS  SSGHSVFVVE  AQGAEYQATA  AALAAGAMTV  600
601   YTPERGITLQ  SLSNDIEYLR  QQFSKDHGAN  RSGKLIIRND  QTSTIYSTTE  IANIIKHEAK  660
661   NRFDAQGVVP  GHFQQGGKVS  PIDRIRAFRL  AVKCMEHLET  FAGQSPEEIM  NDENSATVIS  720
721   IKQSRILLLP  MGGPTGVEAT  DTDWKRQRPK  TQNWLEIQEA  VDSLSGRSSL  YAIPN  775

▼ KEYWORD

ID	Family
KW-0021	Allosteric enzyme
KW-0067	ATP-binding
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0324	Glycolysis
KW-0418	Kinase
KW-0460	Magnesium
KW-0479	Metal-binding
KW-0547	Nucleotide-binding
KW-1185	Reference proteome
KW-0808	Transferase

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0003872	Molecular Function	6-phosphofructokinase activity
GO:0005524	Molecular Function	ATP binding
GO:0046872	Molecular Function	Metal ion binding
GO:0006002	Biological Process	Fructose 6-phosphate metabolic process

▼ KEGG

aor:AO090010000444

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Asf-1112	Aspergillus flavus	99.68	0.0	1236
LLPS-Ast-0448	Aspergillus terreus	75.88	0.0	1101
LLPS-Asfu-1419	Aspergillus fumigatus	70.53	0.0	1085
LLPS-Nef-1245	Neosartorya fischeri	70.26	0.0	1085
LLPS-Asc-0084	Aspergillus clavatus	69.43	0.0	1074
LLPS-Asni-0090	Aspergillus niger	68.46	0.0	1068
LLPS-Asn-1372	Aspergillus nidulans	67.28	0.0	1047
LLPS-Tag-2200	Taeniopygia guttata	59.9	1e-70	236
LLPS-Dos-0945	Dothistroma septosporum	59.5	0.0	942
LLPS-Lem-1131	Leptosphaeria maculans	59.29	0.0	937
LLPS-Pytr-1140	Pyrenophora triticirepentis	58.82	0.0	941
LLPS-Usm-1259	Ustilago maydis	58.33	2e-10	68.6
LLPS-Phn-1026	Phaeosphaeria nodorum	57.25	0.0	900
LLPS-Cog-0759	Colletotrichum gloeosporioides	55.57	0.0	830
LLPS-Map-0973	Magnaporthe poae	52.59	0.0	806
LLPS-Scc-0468	Schizosaccharomyces cryophilus	52.18	0.0	758
LLPS-Kop-1480	Komagataella pastoris	51.07	0.0	778
LLPS-Asg-0716	Ashbya gossypii	50.85	0.0	757
LLPS-Sac-0412	Saccharomyces cerevisiae	50.32	0.0	751
LLPS-Spr-0794	Sporisorium reilianum	49.68	0.0	705
LLPS-Abg-0238	Absidia glauca	48.31	0.0	694
LLPS-Ora-0863	Ornithorhynchus anatinus	44.88	0.0	581
LLPS-Eqc-3401	Equus caballus	44.58	0.0	593
LLPS-Fec-0079	Felis catus	44.58	0.0	590
LLPS-Pof-3822	Poecilia formosa	44.55	0.0	607
LLPS-Xim-4111	Xiphophorus maculatus	44.5	0.0	597
LLPS-Caf-0713	Canis familiaris	44.44	0.0	587
LLPS-Hos-4968	Homo sapiens	44.39	0.0	596
LLPS-Pat-4530	Pan troglodytes	44.39	0.0	596
LLPS-Paa-2942	Papio anubis	44.25	0.0	592
LLPS-Maf-3368	Macaca fascicularis	44.25	0.0	593
LLPS-Sah-2879	Sarcophilus harrisii	44.24	0.0	592
LLPS-Anc-2842	Anolis carolinensis	44.22	0.0	591
LLPS-Dar-1019	Danio rerio	44.19	0.0	586
LLPS-Gaga-1065	Gallus gallus	44.03	0.0	587
LLPS-Myl-3619	Myotis lucifugus	44.01	0.0	577
LLPS-Fia-1639	Ficedula albicollis	43.92	0.0	576
LLPS-Orc-3475	Oryctolagus cuniculus	43.8	0.0	592
LLPS-Mel-1375	Melampsora laricipopulina	43.79	0.0	639
LLPS-Dio-3134	Dipodomys ordii	43.74	0.0	572
LLPS-Mal-2659	Mandrillus leucophaeus	43.59	0.0	574
LLPS-Rhb-4328	Rhinopithecus bieti	43.52	0.0	588
LLPS-Ran-2738	Rattus norvegicus	43.52	0.0	591
LLPS-Mea-3354	Mesocricetus auratus	43.52	0.0	592
LLPS-Mam-1643	Macaca mulatta	43.46	0.0	574
LLPS-Meg-1133	Meleagris gallopavo	43.45	5e-177	533
LLPS-Sus-4399	Sus scrofa	43.44	0.0	592
LLPS-Orn-2342	Oreochromis niloticus	43.39	0.0	591
LLPS-Mum-4455	Mus musculus	43.39	0.0	589
LLPS-Man-4089	Macaca nemestrina	43.31	0.0	587
LLPS-Bot-1957	Bos taurus	43.31	0.0	589
LLPS-Chs-3978	Chlorocebus sabaeus	43.31	0.0	587
LLPS-Cea-1426	Cercocebus atys	43.31	0.0	587
LLPS-Pap-4644	Pan paniscus	43.25	0.0	586
LLPS-Otg-4170	Otolemur garnettii	43.25	0.0	585
LLPS-Mup-0465	Mustela putorius furo	43.25	0.0	587
LLPS-Scm-0523	Scophthalmus maximus	43.2	0.0	583
LLPS-Leo-1200	Lepisosteus oculatus	43.19	0.0	569
LLPS-Cap-2401	Cavia porcellus	43.18	0.0	585
LLPS-Cas-1179	Carlito syrichta	43.17	0.0	546
LLPS-Aon-4656	Aotus nancymaae	43.14	0.0	552
LLPS-Nol-1703	Nomascus leucogenys	43.12	0.0	581
LLPS-Ict-3662	Ictidomys tridecemlineatus	43.12	0.0	586
LLPS-Aim-0056	Ailuropoda melanoleuca	42.99	0.0	581
LLPS-Asm-2203	Astyanax mexicanus	42.88	0.0	558
LLPS-Ova-1289	Ovis aries	42.86	0.0	576
LLPS-Gaa-2531	Gasterosteus aculeatus	42.5	0.0	570
LLPS-Gog-2307	Gorilla gorilla	42.5	2e-180	544
LLPS-Icp-2024	Ictalurus punctatus	42.46	0.0	567
LLPS-Ten-2750	Tetraodon nigroviridis	42.35	0.0	581
LLPS-Orl-3989	Oryzias latipes	42.35	0.0	582
LLPS-Fud-4456	Fukomys damarensis	42.18	1e-178	537
LLPS-Xet-2537	Xenopus tropicalis	42.08	0.0	565
LLPS-Put-0611	Puccinia triticina	41.9	1e-170	518
LLPS-Tar-3767	Takifugu rubripes	41.83	0.0	586
LLPS-Caj-3275	Callithrix jacchus	41.54	0.0	585
LLPS-Ori-2089	Oryza indica	41.08	1e-52	189
LLPS-Urm-3158	Ursus maritimus	41.01	2e-177	538
LLPS-Pes-2933	Pelodiscus sinensis	40.62	1e-175	531
LLPS-Scf-2914	Scleropages formosus	40.15	0.0	568
LLPS-Poa-3391	Pongo abelii	39.35	1e-168	512
LLPS-Loa-1417	Loxodonta africana	39.33	5e-157	482
LLPS-Lac-2556	Latimeria chalumnae	38.28	2e-142	444
LLPS-Mod-4084	Monodelphis domestica	37.91	5e-34	135
LLPS-Cae-0984	Caenorhabditis elegans	33.94	1e-124	398
LLPS-Dac-2317	Daucus carota	31.2	3e-12	73.9
LLPS-Gor-2670	Gossypium raimondii	30.74	6e-12	73.2
LLPS-Php-0236	Physcomitrella patens	30.19	6e-13	76.3
LLPS-Sot-2248	Solanum tuberosum	29.91	1e-11	72.4
LLPS-Sol-0908	Solanum lycopersicum	29.91	7e-12	72.8
LLPS-Coc-0112	Corchorus capsularis	29.87	5e-11	70.1
LLPS-Mae-2393	Manihot esculenta	29.86	1e-12	75.1
LLPS-Orr-2153	Oryza rufipogon	29.71	4e-17	90.1
LLPS-Orgl-0453	Oryza glumaepatula	29.71	5e-17	90.1
LLPS-Orm-1308	Oryza meridionalis	29.6	1e-17	91.3
LLPS-Orp-1193	Oryza punctata	29.6	2e-17	90.1
LLPS-Orb-0145	Oryza barthii	29.6	2e-17	90.5
LLPS-Orni-0222	Oryza nivara	29.6	2e-17	90.5
LLPS-Art-3039	Arabidopsis thaliana	29.49	3e-12	73.9
LLPS-Thc-1815	Theobroma cacao	29.49	2e-11	71.2
LLPS-Lep-1650	Leersia perrieri	29.24	6e-17	89.0
LLPS-Osl-1292	Ostreococcus lucimarinus	29.14	4e-12	73.2
LLPS-Pot-1922	Populus trichocarpa	29.06	2e-11	71.2
LLPS-Nia-2098	Nicotiana attenuata	29.06	1e-12	75.5
LLPS-Sem-1118	Selaginella moellendorffii	29.01	5e-16	85.5
LLPS-Zem-1910	Zea mays	28.99	3e-17	90.5
LLPS-Brd-1915	Brachypodium distachyon	28.99	3e-16	87.4
LLPS-Viv-1241	Vitis vinifera	28.83	7e-12	72.8
LLPS-Amt-2312	Amborella trichopoda	28.83	2e-10	68.2
LLPS-Sei-2427	Setaria italica	28.78	2e-16	86.7
LLPS-Phv-2182	Phaseolus vulgaris	28.63	2e-11	71.2
LLPS-Bro-2958	Brassica oleracea	28.62	1e-14	81.3
LLPS-Brr-1562	Brassica rapa	28.62	1e-14	81.3
LLPS-Brn-2036	Brassica napus	28.62	1e-14	81.3
LLPS-Met-1419	Medicago truncatula	28.32	8e-11	69.3
LLPS-Tra-0062	Triticum aestivum	28.06	4e-12	73.6
LLPS-Hov-0252	Hordeum vulgare	28.06	2e-12	74.3
LLPS-Arl-2328	Arabidopsis lyrata	27.9	1e-12	75.5
LLPS-Sob-0591	Sorghum bicolor	27.54	3e-16	87.0
LLPS-Glm-1540	Glycine max	27.51	2e-11	71.2
LLPS-Via-2380	Vigna angularis	27.3	6e-12	72.8
LLPS-Orbr-0719	Oryza brachyantha	27.21	3e-10	67.8
LLPS-Prp-0243	Prunus persica	27.12	3e-12	73.9
LLPS-Cus-1362	Cucumis sativus	27.09	2e-12	74.3
LLPS-Vir-2113	Vigna radiata	27.08	3e-11	71.2
LLPS-Hea-1248	Helianthus annuus	26.98	2e-12	74.3
LLPS-Tru-1652	Triticum urartu	26.93	2e-16	88.2
LLPS-Mua-0905	Musa acuminata	26.73	2e-12	74.7
LLPS-Org-1039	Oryza glaberrima	26.41	7e-12	72.8
LLPS-Ors-1378	Oryza sativa	26.41	7e-12	72.8
LLPS-Chc-1089	Chondrus crispus	25.97	3e-12	73.9
LLPS-Gas-1104	Galdieria sulphuraria	25.0	4e-08	60.8
LLPS-Cym-0836	Cyanidioschyzon merolae	24.91	9e-12	72.4

LLPS-Aso-1342pfkB

Protein Sequence

Nucleotide Sequence

LLPS-Aso-1342
pfkB