• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Bot-1957
PFKM

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: ATP-dependent 6-phosphofructokinase, muscle type
Gene Name: PFKM
Ensembl Gene: ENSBTAG00000000286.6
Ensembl Protein: ENSBTAP00000073553.1
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-body, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MRKVELHLKF  FMCVTQSRQL  VRTPQRTAEE  ASTSSMLMQK  PPSRTDVLKS  LDTVDDPDTV  60
61    EGIPIFANEW  IMTHEHHAAK  TLGIGKAIAV  LTSGGDAQGM  NAAVRAVVRV  GIYTGARVFF  120
121   VHEGYQGLVD  GGDNIREATW  ESVSMMLQLG  GTVIGSARCK  DFREREGRLR  AAHNLVKRGI  180
181   TNLCVIGGDG  SLTGADTFRS  EWSDLLSDLQ  KSGKITAEEA  TKSSYLNIVG  LVGSIDNDFC  240
241   GTDMTIGTDS  ALHRIIEIVD  AITTTAQSHQ  RTFVLEVMGR  HCGYLALVTS  LSCGADWVFI  300
301   PECPPDDDWE  EHLCRRLSET  RNRGSRLNII  IVAEGAIDKN  GKPITSEDIK  NLVVKRLGYD  360
361   TRVTVLGHVQ  RGGTPSAFDR  ILGSRMGVEA  VMALLEGTPD  TPACVVSLSG  NQAVRLPLME  420
421   CVQVTKDVTR  AMDERRFDEA  LKLRGRSFMN  NWEVYKLLAH  VRPPKSKSGS  HTVAVMNVGA  480
481   PAAGMNAAVR  STVRIGLIQG  NRMLVVHDGF  EGLAKGQIEE  AGWSYVGGWT  GQGGSKLGTK  540
541   RTLPKKSFEQ  ISANITKFNI  QGLVIIGGFE  AYTGGLELME  GRKQYDELCI  PFVVIPATVS  600
601   NNVPGSDFSV  GADTALNTIC  MTCDRIKQSA  AGTKRRVFII  ETMGGYCGYL  ATMAGLAAGA  660
661   DAAYIFEDPF  TIRDLQVNVE  HLVQKMKTTV  KRGLVLRNEK  CNENYTTDFI  FNLYSEEGKG  720
721   IFDSRKNVLG  HMQQGGSPTP  FDRNFATKMG  AKAMNWMSGK  IKESYRNGRI  FANSPDSGCV  780
781   LGMRKRALVF  QPVTELKEQT  DFEHRIPKEQ  WWLKLRPILK  ILAKYEIDLD  TSEHAHLEHI  840
841   SRKRSGEANV  850
Nucleotide CDS Sequence (FASTA)
1     ATGACCCATG  AGCACCATGC  AGCCAAAACC  CTGGGAATCG  GCAAAGCCAT  CGCCGTGTTA  60
61    ACCTCTGGTG  GCGATGCCCA  AGGTATGAAT  GCTGCTGTCA  GGGCTGTGGT  TCGTGTTGGC  120
121   ATCTATACTG  GTGCCCGTGT  CTTCTTTGTC  CATGAGGGTT  ATCAAGGCCT  GGTAGATGGT  180
181   GGAGATAACA  TCCGGGAAGC  CACATGGGAG  AGTGTCTCGA  TGATGCTTCA  GCTGGGAGGC  240
241   ACGGTGATTG  GAAGCGCCCG  GTGCAAGGAC  TTTCGGGAAC  GGGAAGGCCG  GCTCCGAGCT  300
301   GCCCACAACC  TGGTGAAACG  TGGGATCACC  AACCTGTGTG  TCATTGGGGG  AGACGGCAGC  360
361   CTGACTGGGG  CCGACACCTT  CCGCTCTGAG  TGGAGTGACT  TGTTGAGTGA  CCTCCAGAAA  420
421   TCAGGCAAGA  TTACAGCAGA  GGAGGCTACC  AAGTCCAGCT  ACCTGAACAT  CGTGGGGCTG  480
481   GTTGGCTCAA  TTGACAATGA  CTTCTGTGGC  ACTGATATGA  CCATTGGCAC  CGACTCTGCC  540
541   CTGCACCGGA  TCATAGAGAT  TGTAGATGCC  ATCACTACTA  CCGCTCAGAG  CCACCAGAGG  600
601   ACCTTTGTGT  TGGAGGTGAT  GGGCCGGCAC  TGTGGATACC  TGGCCCTTGT  CACTTCCCTC  660
661   TCCTGTGGGG  CCGACTGGGT  CTTTATTCCC  GAGTGTCCAC  CAGATGACGA  CTGGGAGGAA  720
721   CACCTTTGTC  GCCGGCTCAG  CGAGACAAGG  AACCGTGGTT  CTCGTCTCAA  CATCATCATC  780
781   GTAGCTGAGG  GTGCGATTGA  CAAGAATGGG  AAACCAATCA  CCTCTGAAGA  CATCAAAAAC  840
841   CTGGTGGTTA  AGCGTCTGGG  ATATGACACC  CGAGTCACCG  TCTTGGGGCA  CGTGCAGCGG  900
901   GGTGGGACAC  CGTCGGCCTT  TGACAGAATC  CTGGGCAGCA  GGATGGGTGT  GGAAGCAGTA  960
961   ATGGCACTTT  TGGAGGGGAC  CCCGGACACC  CCAGCCTGTG  TGGTGAGCCT  CTCTGGTAAC  1020
1021  CAGGCTGTGC  GCCTGCCCCT  CATGGAGTGT  GTCCAGGTGA  CCAAGGACGT  GACCAGGGCC  1080
1081  ATGGATGAAA  GGAGATTCGA  TGAGGCCTTG  AAGCTGAGGG  GCCGGAGCTT  CATGAACAAC  1140
1141  TGGGAGGTAT  ACAAGCTTCT  GGCTCACGTC  AGACCCCCAA  AGTCTAAGAG  TGGCTCCCAC  1200
1201  ACGGTGGCCG  TGATGAACGT  GGGAGCGCCG  GCCGCAGGCA  TGAACGCAGC  CGTTCGCTCC  1260
1261  ACTGTGAGAA  TCGGCCTCAT  CCAGGGCAAC  CGAATGCTGG  TGGTGCACGA  TGGCTTCGAG  1320
1321  GGCCTGGCCA  AGGGTCAGAT  CGAGGAAGCT  GGATGGAGCT  ACGTCGGGGG  CTGGACTGGC  1380
1381  CAAGGTGGTT  CTAAACTTGG  GACTAAAAGG  ACTCTACCCA  AGAAGAGCTT  TGAACAGATC  1440
1441  AGTGCCAACA  TCACGAAGTT  TAATATTCAG  GGCCTTGTCA  TTATCGGGGG  CTTTGAGGCT  1500
1501  TACACGGGGG  GCCTGGAGCT  GATGGAAGGC  AGGAAGCAGT  ATGATGAGCT  CTGCATCCCC  1560
1561  TTCGTGGTCA  TCCCTGCCAC  GGTCTCCAAC  AATGTGCCCG  GCTCGGACTT  CAGCGTGGGG  1620
1621  GCTGACACTG  CCCTCAACAC  CATCTGCATG  ACGTGTGACC  GCATCAAGCA  GTCAGCGGCA  1680
1681  GGCACCAAGC  GCCGTGTGTT  TATCATTGAA  ACGATGGGCG  GCTACTGTGG  CTACCTGGCC  1740
1741  ACCATGGCAG  GCCTGGCAGC  TGGGGCTGAT  GCTGCGTATA  TTTTTGAGGA  CCCCTTCACC  1800
1801  ATTCGAGACC  TGCAGGTGAA  TGTGGAGCAT  CTGGTGCAGA  AGATGAAAAC  GACTGTGAAG  1860
1861  AGGGGCCTGG  TGTTAAGGAA  CGAGAAGTGC  AATGAGAACT  ACACCACTGA  CTTCATCTTC  1920
1921  AACTTGTACT  CTGAGGAGGG  GAAGGGCATC  TTCGACAGCA  GGAAGAACGT  GCTGGGCCAC  1980
1981  ATGCAGCAGG  GTGGGAGCCC  AACTCCATTT  GACAGGAATT  TTGCCACTAA  GATGGGTGCA  2040
2041  AAGGCTATGA  ACTGGATGTC  AGGGAAAATC  AAAGAGAGTT  ACCGTAATGG  GCGGATCTTT  2100
2101  GCCAATTCCC  CAGACTCGGG  CTGTGTTCTG  GGGATGCGTA  AGAGGGCCCT  GGTCTTCCAA  2160
2161  CCAGTGACTG  AGTTGAAGGA  ACAGACGGAT  TTTGAGCACC  GCATCCCCAA  GGAGCAGTGG  2220
2221  TGGCTGAAGC  TGAGGCCCAT  CCTCAAGATC  CTCGCCAAGT  ACGAGATTGA  CTTGGATACC  2280
2281  TCAGAGCACG  CCCACCTGGA  GCACATCTCT  CGGAAGCGGT  CCGGAGAAGC  TAACGTCTAG  2340

▼ KEYWORD

ID
Family
Acetylation
Allosteric enzyme
ATP-binding
Complete proteome
Cytoplasm
Glycolysis
Glycoprotein
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
6-phosphofructokinase complex
Cellular Component
Apical plasma membrane
Cellular Component
Nucleus
Cellular Component
Sperm principal piece
Molecular Function
6-phosphofructokinase activity
Molecular Function
AMP binding
Molecular Function
ATP binding
Molecular Function
Fructose-6-phosphate binding
Molecular Function
Metal ion binding
Molecular Function
Monosaccharide binding
Molecular Function
Protein homodimerization activity
Biological Process
Canonical glycolysis
Biological Process
Fructose 1,6-bisphosphate metabolic process
Biological Process
Fructose 6-phosphate metabolic process
Biological Process
Glucose catabolic process
Biological Process
Muscle cell cellular homeostasis

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cap-2401Cavia porcellus97.180.01542
LLPS-Ict-3662Ictidomys tridecemlineatus96.790.01539
LLPS-Mum-4455Mus musculus96.790.01537
LLPS-Mup-0465Mustela putorius furo96.550.01535
LLPS-Ova-1289Ovis aries96.370.01669
LLPS-Mea-3354Mesocricetus auratus96.150.01528
LLPS-Orc-3475Oryctolagus cuniculus95.90.01529
LLPS-Otg-4170Otolemur garnettii95.50.01516
LLPS-Pap-4644Pan paniscus95.30.01656
LLPS-Rhb-4328Rhinopithecus bieti95.30.01658
LLPS-Nol-1703Nomascus leucogenys95.080.01650
LLPS-Man-4089Macaca nemestrina94.950.01650
LLPS-Maf-1952Macaca fascicularis94.950.01650
LLPS-Cea-1426Cercocebus atys94.950.01650
LLPS-Chs-3978Chlorocebus sabaeus94.710.01646
LLPS-Aim-0056Ailuropoda melanoleuca94.610.01638
LLPS-Fec-2644Felis catus94.260.01632
LLPS-Caf-1672Canis familiaris94.140.01639
LLPS-Ran-2738Rattus norvegicus93.30.01623
LLPS-Eqc-1916Equus caballus92.230.01586
LLPS-Sus-4399Sus scrofa91.770.01577
LLPS-Poa-3391Pongo abelii90.610.01346
LLPS-Urm-3158Ursus maritimus89.360.01543
LLPS-Tag-2200Taeniopygia guttata87.313e-120 369
LLPS-Leo-1200Lepisosteus oculatus83.940.01301
LLPS-Orl-3989Oryzias latipes78.930.01258
LLPS-Pat-3613Pan troglodytes72.70.01142
LLPS-Hos-3107Homo sapiens72.70.01145
LLPS-Paa-4204Papio anubis72.70.01146
LLPS-Gaa-2758Gasterosteus aculeatus72.430.01164
LLPS-Dio-4205Dipodomys ordii72.40.01140
LLPS-Caj-3275Callithrix jacchus72.310.01138
LLPS-Xet-2537Xenopus tropicalis72.120.01080
LLPS-Anc-2842Anolis carolinensis72.010.01165
LLPS-Gaga-1065Gallus gallus71.880.01161
LLPS-Fia-1639Ficedula albicollis71.560.01154
LLPS-Tar-3767Takifugu rubripes71.520.01152
LLPS-Myl-3619Myotis lucifugus71.410.01134
LLPS-Meg-1133Meleagris gallopavo71.370.01075
LLPS-Ten-2750Tetraodon nigroviridis71.30.01135
LLPS-Ora-0863Ornithorhynchus anatinus71.240.01131
LLPS-Sah-2879Sarcophilus harrisii71.220.01153
LLPS-Mal-2659Mandrillus leucophaeus70.070.01120
LLPS-Mam-0948Macaca mulatta69.690.01068
LLPS-Cas-1179Carlito syrichta69.490.01072
LLPS-Orn-2342Oreochromis niloticus69.080.01098
LLPS-Pes-2933Pelodiscus sinensis69.070.01048
LLPS-Scm-2597Scophthalmus maximus69.010.01115
LLPS-Scf-2914Scleropages formosus68.860.01154
LLPS-Aon-4656Aotus nancymaae68.770.01101
LLPS-Icp-2024Ictalurus punctatus68.730.01120
LLPS-Dar-1019Danio rerio68.460.01124
LLPS-Pof-3822Poecilia formosa68.320.01097
LLPS-Xim-4111Xiphophorus maculatus68.190.01095
LLPS-Asm-2203Astyanax mexicanus67.810.01078
LLPS-Fud-4456Fukomys damarensis67.740.01054
LLPS-Mod-4084Monodelphis domestica67.612e-91 293
LLPS-Gog-2307Gorilla gorilla66.80.01078
LLPS-Loa-1417Loxodonta africana64.240.0 980
LLPS-Lac-2556Latimeria chalumnae60.030.0 864
LLPS-Usm-1259Ustilago maydis53.064e-0758.2
LLPS-Abg-0238Absidia glauca49.60.0 704
LLPS-Asf-1112Aspergillus flavus47.770.0 547
LLPS-Aso-0853Aspergillus oryzae47.110.0 639
LLPS-Ast-0349Aspergillus terreus46.840.0 650
LLPS-Nef-1245Neosartorya fischeri46.570.0 630
LLPS-Asfu-1419Aspergillus fumigatus46.570.0 628
LLPS-Scc-0468Schizosaccharomyces cryophilus46.510.0 633
LLPS-Asn-1372Aspergillus nidulans46.50.0 640
LLPS-Asni-0090Aspergillus niger46.250.0 625
LLPS-Asc-0084Aspergillus clavatus46.180.0 626
LLPS-Cog-0759Colletotrichum gloeosporioides45.980.0 632
LLPS-Map-0973Magnaporthe poae45.420.0 630
LLPS-Dos-0945Dothistroma septosporum44.850.0 628
LLPS-Pytr-1140Pyrenophora triticirepentis44.460.0 647
LLPS-Asg-0716Ashbya gossypii44.150.0 611
LLPS-Kop-1480Komagataella pastoris43.870.0 627
LLPS-Lem-1131Leptosphaeria maculans43.860.0 642
LLPS-Spr-0794Sporisorium reilianum43.70.0 615
LLPS-Phn-1026Phaeosphaeria nodorum43.270.0 620
LLPS-Sac-0201Saccharomyces cerevisiae42.370.0 560
LLPS-Mel-1375Melampsora laricipopulina41.250.0 592
LLPS-Cae-0984Caenorhabditis elegans40.192e-179 543
LLPS-Ori-2089Oryza indica39.04e-51 186
LLPS-Put-0611Puccinia triticina38.563e-163 501
LLPS-Brd-1915Brachypodium distachyon29.32e-1688.6
LLPS-Tru-1652Triticum urartu29.023e-1687.4
LLPS-Sem-0561Selaginella moellendorffii28.851e-1482.0
LLPS-Lep-1650Leersia perrieri28.633e-1687.0
LLPS-Orbr-0719Oryza brachyantha28.463e-1481.3
LLPS-Zem-1910Zea mays28.245e-1686.7
LLPS-Sei-2427Setaria italica28.242e-1584.0
LLPS-Hov-2159Hordeum vulgare28.171e-1378.6
LLPS-Tra-1810Triticum aestivum28.171e-1378.6
LLPS-Sol-1883Solanum lycopersicum28.122e-1584.0
LLPS-Glm-1540Glycine max27.851e-1172.4
LLPS-Orp-1193Oryza punctata27.846e-1685.9
LLPS-Sob-0591Sorghum bicolor27.846e-1686.7
LLPS-Orm-1308Oryza meridionalis27.844e-1687.0
LLPS-Orr-2153Oryza rufipogon27.841e-1585.9
LLPS-Orb-0145Oryza barthii27.846e-1686.3
LLPS-Orni-0222Oryza nivara27.846e-1686.3
LLPS-Orgl-0453Oryza glumaepatula27.841e-1585.9
LLPS-Ors-1378Oryza sativa27.677e-1376.3
LLPS-Org-1039Oryza glaberrima27.677e-1376.3
LLPS-Via-0697Vigna angularis27.477e-1582.8
LLPS-Nia-1787Nicotiana attenuata27.341e-1481.6
LLPS-Thc-1424Theobroma cacao27.133e-0758.2
LLPS-Vir-0185Vigna radiata27.111e-1482.4
LLPS-Art-1722Arabidopsis thaliana27.063e-1273.9
LLPS-Phv-2182Phaseolus vulgaris27.062e-1068.6
LLPS-Sot-0352Solanum tuberosum27.061e-1275.5
LLPS-Hea-1248Helianthus annuus27.047e-1479.3
LLPS-Met-1419Medicago truncatula26.982e-1171.6
LLPS-Viv-0705Vitis vinifera26.943e-1273.9
LLPS-Mua-1967Musa acuminata26.843e-1377.4
LLPS-Pot-2140Populus trichocarpa26.772e-0758.9
LLPS-Dac-2369Daucus carota26.672e-1274.3
LLPS-Arl-0463Arabidopsis lyrata26.677e-1375.9
LLPS-Brr-1803Brassica rapa26.441e-1481.6
LLPS-Bro-1325Brassica oleracea26.34e-1170.5
LLPS-Brn-2034Brassica napus26.34e-1170.5
LLPS-Cus-1362Cucumis sativus26.222e-1377.4
LLPS-Prp-2415Prunus persica26.074e-1273.9
LLPS-Amt-0078Amborella trichopoda25.911e-1378.6
LLPS-Osl-1292Ostreococcus lucimarinus25.913e-1170.5
LLPS-Chc-1089Chondrus crispus25.791e-1069.3
LLPS-Php-0236Physcomitrella patens25.755e-1376.6
LLPS-Mae-2519Manihot esculenta25.564e-1377.0
LLPS-Coc-0319Corchorus capsularis25.483e-0655.1
LLPS-Gor-2030Gossypium raimondii25.367e-1273.2
LLPS-Gas-1104Galdieria sulphuraria25.35e-0963.9